Drug Formulary Update, January 2018 Commercial and State Programs

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Drug Formulary Update, January 2018 Commercial and State Programs Updates to the HealthPartners Commercial and State Program Drug Formularies are listed below. Updates apply to all Commercial groups (PreferredRx, GenericsPlusRx, EnhancedRx, and GenericsAdvantageRx) and to HealthPartners Minnesota Health Care Programs (Medicaid and Minnesota Care State Programs ) Drug Formulary. Please see www.healthpartners.com/formularies for details. Positive changes (additions) are effective January 1, and negative changes (deletions) are effective April 1. Abemaciclib (Verzenio) F PA 1/1/2018 Verzenio has been added to formulary, and prior authorization criteria have been added. Verzenio is a specialty medication. Albiglutide (Tanzeum) NF 4/1/2018 Tanzeum remains NF, and PA has been added: reserved for patients with an inadequate response to Victoza, Trulicity, and Bydureon. Amlodipine/ olmesartan (Azor, Amlodipine/ valsartan NF ST F 1/1/2018 (Exforge Aquoral Not 4/1/2018 Aquoral is a medical device, not an FDAapproved medication. Armodafinil (Nuvigil F PA QL F QL 1/1/2018 Prior authorization is no longer required. Azelaic acid 20% cream (Azelex) NF 4/1/2018 Azelex will be non formulary with PA: response to one drug from each of these three categories, retinoids, benzoyl peroxide, and oral antibiotics.

Drug Formulary Update, page 2 of 8. Betrixaban (Bevyxxa) 1/1/2018 Prior authorization has been added: response to preferred anticoagulants (Xarelto and Eliquis), or with contraindications to their use. Biafine emulsion Not 4/1/2018 Biafine is not an FDA approved medication. Brimonidine (Mirvaso) NF Excluded 4/1/2018 Cosmetic Budesonide nasal (Rhinocort) OTC Not F* 1/1/2018 Budesonide nasal has been added to the State Programs Drug Formulary, as a covered OTC medication. Budesonide nebulization F PA F 1/1/2018 Prior authorization is no longer required. suspension Budesonide/ formoterol (Symbicort) F F AE 4/1/2018 For State Programs only, fluticasone/ salmeterol (AirDuo will be preferred. Exceptions will be made for younger children (<= age 11) and for treating COPD. Bupropion (Forfivo XL) NF 4/1/2018 Prior authorization has been added: reserved for FDA approved indications (depression), for patients with an inadequate response or medical contraindications to preferred products. Bupropion XL (Wellbutrin XL, C1 Esterase Inhibitor (Haegarda) Calcipotriene/ betamethasone ointment (Taclonex Celecoxib (Celebrex, Clonazepam disintegrating tablet F PA 1/1/2018 Haegarda has been added to formulary, and prior authorization criteria have been added. Haegarda is a specialty medication. F PA* NF 4/1/2018 Taclonex generic is NF for all formularies. Taclonex Brand is non formulary with prior authorization. NF QL F QL 1/1/2018

Drug Formulary Update, page 3 of 8. Clonidine ER (Kapvay) QL QL 1/1/2018 Prior authorization has been updated: Reserved for patients with a documented Cyclobenzaprine 7.5 mg tablet F AE Excluded/ 4/1/2018 This strength is excluded for groups with this contract language, and NF PA for others: reserved for patients with an inadequate response to cyclobenzaprine 5mg, and documented adverse reactions to cyclobenzaprine 10mg. Dapagliflozin (Farxiga) NF 4/1/2018 Farxiga remains NF, and prior authorization has been added: Reserved for patients with an inadequate response to Invokana and Jardiance. Dapagliflozin/ metformin XR (Xigduo XR) Deutetrabenazine (Austedo) Dexamethasone injection Diclofenac (Zipsor) NF Excluded/ Diclofenac (Zorvolex) NF Excluded/ Dihydroergotamine injection (DHE Dihydroergotamine nasal (Migranal Diltiazem CD 24h capsule (Cardizem CD, 360mg NF 4/1/2018 Xigduo remains NF, and prior authorization has been added: reserved for patients with an inadequate response to Invokamet and Synjardy. F PA F PA 1/1/2018 Prior authorization has been updated. Austedo is a specialty medication. NF F 1/1/2018 4/1/2018 Zipsor is excluded for groups with this contract language, and NF PA for others: response to three preferred NSAIDs. 4/1/2018 Zorvolex is excluded for groups with this contract language, and NF PA for others: response to three preferred NSAIDs. F PA 4/1/2018 Dihydroergotamine injection will be nonformulary with PA: Reserved for patients with an inadequate response to two preferred triptan medications. 4/1/2018 Prior authorization has been updated: Reserved for patients with an inadequate response to two preferred triptan medications. F NF 4/1/2018

Drug Formulary Update, page 4 of 8. Diltiazem CD 24h capsule (Cardizem CD, Brandonly) Diltiazem ER 12h capsules Diltiazem ER 24h capsule (Tiazac, F NF 4/1/2018 Diltiazem ER 24h tablets NF 4/1/2018 Diltiazem LA (Cardizem LA, Doxepin cream (Zonalon Doxycycline hyclate (Morgidox and Vibramycin) Doxycycline hyclate 100 mg capsule Elbasvir/ grazoprevir (Zepatier) NF QL 4/1/2018 Prior authorization and a quantity limit have been added. PA: reserved for FDA approved indications (pruritus). QL: one tube (30 grams) per Rx. F 1/1/2018 F PA 1/1/2018 Zepatier has been removed from the formulary, and PA has been updated. Zepatier is a specialty medication. Enasidenib (Idhifa) F PA 1/1/2018 Idhifa has been added to formulary, and PA has been added. Idhifa is a specialty medication. Epinephrine (Epipen, Flucytosine (Ancobon Fluorouracil 0.5% cream (Carac, NF 4/1/2018 PA: reserved for patients with a documented allergic reaction to the equivalent generic. NF 4/1/2018 Flucytosine remains NF, and PA have been added: reserved for FDA approved indications (severe fungal infections), for patients with an inadequate response or medical contra indications to preferred antifungal products Reserved for patients with a documented

Drug Formulary Update, page 5 of 8. Fluticasone inhaler (ArmonAir) Fluticasone/ salmeterol (Advair) Gabapentin ER (Horizant ER) Glecaprevir/ pibrentasvir (Mavyret) Glucose test strips 1/1/2018 Prior authorization has been added: reserved for patients who have tried and failed Flovent and one other preferred alternative product. F F AE* 4/1/2018 For State Programs only, fluticasone/ salmeterol (AirDuo will be preferred. Exceptions will be made for younger children (<= age 11) and for treating COPD. QL QL 4/1/2018 QL have been updated, to a FDA maximum dose of 1,200 mg daily. F PA 1/1/2018 Mavyret has been added to formulary, and prior authorization has been added. Mavyret is a specialty medication. QL 1/1/2018 Quantity limits have been removed, for both preferred and non preferred glucose test strips. Guselkumab (Tremfya) 1/1/2018 Prior authorization has been updated. Tremfya is a specialty medication. Interferon (Betaseron) QL QL 1/1/2018 Prior authorization has been updated: response to Extavia plus two preferred products. Betaseron is a specialty medication. Isotretinoin (Absorica) Reserved for patients with a documented allergic reaction to preferred generics. Ixekizumab (Taltz) 1/1/2018 Prior authorization has been updated. Taltz is a specialty medication. Lamotrigine ODT (Lamictal ODT, Brandonly) Lansoprazole tablet (Prevacid Solutab) Ledipasvir/ sofosbuvir (Harvoni) Lipase/ protease/ amylase (Ultresa) NF 4/1/2018 Lamictal ODT is reserved for patients with a documented allergic reaction to the equivalent generic. NF AE F AE* 1/1/2018 for GenericsAdvantageRx only. F PA F PA 1/1/2018 Prior authorization has been updated. Harvoni is a specialty medication NF 4/1/2018 Ultresa remains NF, and PA has been added: reserved for patients with an inadequate response to preferred products (Creon).

Drug Formulary Update, page 6 of 8. Lurasidone (Latuda) F PA F PA QL 4/1/2018 A Quantity limit of one tablet per day will be added. Latuda has also been added to the Half Tablet program. This is a voluntary program, allowing tablet splitting, and sharing cost savings back to members (e.g. two months for one co pay). Methylnaltrexone (Relistor) 4/1/2018 Update to NF PA: reserved for opioidinduced constipation, for patients with an inadequate response to Symproic and Movantik. Modafinil (Provigil F PA QL F QL 1/1/2018 Prior authorization is no longer required. Mometasone/ formoterol (Dulera) F F PA 4/1/2018 For State Programs only: reserved for patients with an inadequate response or medical contraindications to AirDuo generic. F PA F 1/1/2018 Moxifloxacin ophthalmic 0.5% (Vigamox Naldemedine (Symproic) NF F PA 1/1/2018 Prior authorization has been added: reserved for opioid induced constipation, for patients with an inadequate response to laxative therapy. Naloxegol (Movantik) F PA QL F PA QL 1/1/2018 Prior authorization has been updated: reserved for opioid induced constipation, for patients with an inadequate response to laxative therapy. Naloxone (Evzio) Excluded/ Naproxen CR (Naprelan CR) NF Excluded/ 1/1/2018 Evzio remains excluded for groups with this contract language, and NF PA for others: reserved for patients with a medical contraindication to preferred alternatives (naloxone nasal). 4/1/2018 Naprelan CR will be excluded for groups with this contract language, and NF PA for others: reserved for patients with an inadequate response to three preferred NSAIDs. Nebivolol (Bystolic) NF 4/1/2018 Bystolic remains NF, and PA has been added: Reserved for patients with an inadequate response or medical contraindications to two preferred products.

Drug Formulary Update, page 7 of 8. Olmesartan/ amlodipine/ HCTZ (Tribenzor, Brandonly) Omeprazole/ bicarbonate (Zegerid, Ondansetron film (Zuplenz) Oxymetazoline (Rhofade) Excluded Promiseb Not Propranolol (Inderal XL and Innopran XL, Brandonly) Rosuvastatin (Crestor, Excluded/ 1/1/2018 Zegerid is excluded for groups with this contract language, and NF PA for others: NF 4/1/2018 Zuplenz remains NF, and PA has been added: reserved for patients with an inadequate response or medical contraindications to preferred products. 4/1/2018 Cosmetic 4/1/2018 Promiseb is a medical device, not an FDAapproved medication. Reserved for patients with a documented allergic reaction to preferred generics. Scopolamine NF F 1/1/2018 transdermal patch Secukinumab (Cosentyx) F PA 1/1/2018 Cosentyx has been added to formulary, and prior authorization has been updated. Cosentyx is a specialty medication. Sildenafil suspension (Revatio) F PA 4/1/2018 Revatio suspension is NF PA: reserved for patients with documented swallowing difficulties, unable to use crushed tablet. Revatio is a specialty medication. Sofosbuvir (Sovaldi) F PA 1/1/2018 Sovaldi has been removed from the formulary, and prior authorization has been updated. Sovaldi is a specialty medication. Sofosbuvir/ velpatasvir/ voxilaprevir (Vosevi) Temazepam (Restoril, F PA 1/1/2018 Vosevi has been added to formulary, and prior authorization has been added. Vosevi is a specialty medication. NF QL QL 4/1/2018 Restoril remains NF, and PA has been added: Reserved for patients with a documented allergic reaction to the equivalent generic.

Drug Formulary Update, page 8 of 8. Terbutaline F NF 4/1/2018 Tiotropium (Spiriva) for COPD, reserved for patients with an inadequate response or medical contraindications to umeclidinium (Incruse). for asthma: reserved for patients with an inadequate response to inhaled steroids and long acting beta agonists. Triamcinolone nasal (Nasacort) OTC NF F* 1/1/2018 Triamcinolone nasal has been added to the State Programs Drug Formulary, as a Vigabatrin powder packet (Sabril, Brandonly) covered OTC. 1/1/2018 Sabril powder packet remains NF PA: Sabril is a specialty medication.