TECHNICAL NOTICE The CPT coding in this notice is effective January 1, 2013 and replaces the coding currently in use for these assays December 2012 The notation (MAAA) indicates "Multianalyte Assay with Algorithmic Analyses" which comprise a new subsection of the CPT code set for 2013. Some payers, including Medicare, will not recognize these MAAA codes for payment and will continue to require the individual CPTs for each analyte in the analysis. Consult the payer being billed to determine which CPT code(s) to use for these tests. SBMF 44509 Acetylcholine Receptor Blocking Antibody 83516 44510 Acetylcholine Receptor Modulating Antibody 83516 45145 ADmark Alzheimers Evaluation 81401; 83520x3 33112 ADmark ApoE Genotype Analysis and Interpretation (Symptomatic) 81401 45532 Alpha Thalassemia (HBA1 and HBA2) 7 Deletions 81257 44737 Alpha-1-Antitrypsin (SERPINA1) Enzyme Concentration and 2 81332; 82103 Mutations with A1AT Phenotype if Indicated 45793 Angelman Syndrome and Prader-Willi Syndrome, Methylation 81331 44421 Apolipoprotein E (APOE) 2 Mutations, Cardiovascular Risk 81401 44805 Ashkenazi Jewish Diseases (BLM, ASPA, IKBKAP, FANCC, GBA, MCOLN1, SMPD1, HEXA) 81200 ; 81209; 81242; 81251; 81255; 81260; 81290; 81330 36168 B-Cell and T-Cell Gene Rearrangement, PCR 81261; 81264; 81340; 81342 36169 B-Cell Gene Rearrangement, PCR 81261; 81264 36149 BCR/ABL Gene Detection, Qualitative RT-PCR, Diagnostic Assay 81206; 81207 36145 BCR/ABL Gene Major Breakpoint (p210), Quantitative RT-PCR, 81206 Monitoring Assay 36146 BCR/ABL Gene Minor Breakpoint (p190), Quantitative RT-PCR, 81207 Monitoring Assay 45932 BCR-ABL1 Kinase Domain Mutation Analysis 81403 44989 Beta Globin (HBB) HbS, HbC, and HbE Mutations 81401
44978 Beta Globin (HBB) Sequencing 81404 45893 BIRC2-MALT1 (API2-MALT1) Translocation, t(11;18), RT-PCR 36320 Celiac-Associated HLA-DQ Typing, PCR 81376x2 45590 Circulating Tumor Cell Count 86152 44152 Clomipramine and Metabolite, Serum or Plasma 80299 36125 Congenital Bilateral Absence of the Vas Deferens, Cystic Fibrosis 81224 Mutation Panel 45726 Connexin 26 (GJB2), Sequencing 81252 36050 Cystic Fibrosis (CFTR) Mutation Panel 81220 44804 Cystic Fibrosis (CFTR), Sequencing 81223 45287 Cytochrome P450 2C19 (CYP2C19), 9 Mutations 81225 45286 Cytochrome P450 2C9 (CYP2C9), 2 Mutations 81227 45288 Cytochrome P450 2D6 (CYP2D6), 14 Mutations and Gene Duplication 81226 45863 Epidermal Growth Factor Receptor (EGFR) Mutation Analysis 81235; 88381 45892 Epidermal Growth Factor Receptor (EGFR) Mutation Analysis with 81235; 88381 ALK Rearrangement FISH if Indicated 36001 Factor V Leiden Mutation Analysis 81241 45739 Factor V R2 DNA Test 81400 45714 Familial Mediterranean Fever (MEFV) Sequencing 81404 45867 Familial Mutation, Targeted Sequencing VARIES 45780 Fanconi Anemia, Group C (FANCC) 2 Mutations 81242 44092 Fluoxetine and Metabolite, Serum or Plasma 80299 36003 Fragile X Syndrome DNA Testing, Southern Blot and PCR 81243; 81244 44922 Galactosemia (GALT) 9 Mutations 81401 44923 Galactosemia (GALT) Enzyme Activity and 9 Mutations 81401; 82775 45730 Hearing Loss, Nonsyndromic Panel (GJB2) Sequencing, (GJB6) 2 Deletions and Mitochondrial DNA 2 Mutations 81252; 81254; 81401 45727 Hearing Loss, Nonsyndromic, Connexin 26 (GJB2) 35delG Mutation 81253 45728 Hearing Loss, Nonsyndromic, Connexin 30 (GJB6) 2 Deletions 81254 45729 Hearing Loss, Nonsyndromic, Mitochondrial DNA 2 Mutations 81401 36126 Hemochromatosis Mutation Detection (S65C, H63D, and C282Y), 81256 Hereditary 45703 Hepatitis B Virus Genotyping 87912 43190 Hepatitis C Virus (HCV) FibroSURE 0001M (MAAA) 44946 Hereditary Hemorrhagic Telangiectasia (ACVRL1 and ENG) 44947 Hereditary Hemorrhagic Telangiectasia (ACVRL1 and ENG) Sequencing x2
44945 Hereditary Hemorrhagic Telangiectasia (ACVRL1 and ENG) Sequencing and x3 44940 HLA Bone Marrow Transplantation Evaluation 81380x2; 81382 45954 HLA-A Genotype 81380 45692 HLA-A Sequencing 81380 45695 HLA-ABC Sequencing 81379 45955 HLA-B Genotype 81380 45693 HLA-B Sequencing 81380 44877 HLA-B*5701 Associated Variant Genotyping for Abacavir Sensitivity 81381 25256 HLA-B27 Confirmatory Assay, RT-PCR 81374 45956 HLA-C Genotype 81380 45694 HLA-C Sequencing 81380 44941 HLA-DQB Genotype 81382 44942 HLA-DR Genotype 81382 45696 HLA-DRB1 Sequencing 81382 44934 HNPCC/Lynch Syndrome (MLH1) Sequencing and 81292; 81294 44930 HNPCC/Lynch Syndrome (MSH2) Sequencing and 81295; 81297 44931 HNPCC/Lynch Syndrome (MSH6) Sequencing and 81298; 81300 45844 HNPCC/Lynch Syndrome (PMS2) Pseudogene Analysis (Reflex Orders Only) 44933 HNPCC/Lynch Syndrome (PMS2) Sequencing and 81317; 81319, with Pseudogene Analysis if Indicated 38547 HNPCC/Lynch Syndrome, Microsatellite Instability, PCR 81301 36132 Huntington Disease DNA Testing 81401 44749 IgVH Mutation Analysis, Sequencing 81263 36154 Influenza Virus A and B and Respiratory Syncytial Virus (RSV) Panel, 87631 Qualitative RT-PCR 45924 Inosine Triphosphate (ITPA) and Interleukin 28 B (IL28B)-Associated x2 Variants, 4 SNPs 45804 Interleukin 28 B (IL28B)-Associated Variants, 2 SNPs 36140 JAK2 (V617F) Mutation Analysis 81270 44949 JAK2 Exon 12 Mutation Analysis 81403 36167 K-ras/BRAF Mutation Analysis 81210; 81275 44954 Legius Syndrome (SPRED1) Sequencing and (NF1) Sequencing Exon 22 81405; (Exon 17) 45868 Marfan Syndrome, FBN1
45869 Marfan Syndrome, FBN1 Sequencing 81408 45870 Marfan Syndrome, FBN1 Sequencing and 81408; 36130 Methylenetetrahydrofolate Reductase (MTHFR) Mutation Analysis 81291 45889 Mitochondrial Disorders (108 Nuclear Genes) Sequencing 81403x2; 81404x2; 81405x5; 81406x3; 45890 Mitochondrial Disorders (mtdna) Sequencing 81403x2; 45891 Mitochondrial Disorders Panel (mtdna and 108 Nuclear Genes) Sequencing and 81403x2; 81404x2; 81405x5; 81406x3; x2 45888 Mitochondrial Genome (mtdna and 108 Nuclear Genes) 45944 Multiple Endocrine Neoplasia Type 1 (MEN1) 81404 45945 Multiple Endocrine Neoplasia Type 1 (MEN1) Sequencing 81405 45946 Multiple Endocrine Neoplasia Type 1 (MEN1) Sequencing and 81404; 81405 45400 Multiple Endocrine Neoplasia Type 2 (MEN2), RET Gene Mutations, 81405 Sequencing 45406 Multiple Endocrine Neoplasia, Type 2B (RET) 2 Mutations 81404 44235 Narcolepsy-Associated HLA Typing, PCR 81383 43554 NASH Fibrosure 0003M (MAAA) 44951 Neurofibromatosis Type 1 (NF1) 45764 Noonan Syndrome (PTPN11) Sequencing 81406 45765 Noonan Syndrome (PTPN11) Sequencing with (SOS1) Sequencing if 81406 Indicated 45766 Noonan Syndrome (SOS1) Sequencing 81406 33064 OVA1 81503 (MAAA) 44991 Pancreatitis, Hereditary (PRSS1) Sequencing 81404 44990 Pancreatitis, Idiopathic (CFTR, PRSS1, SPINK1) Sequencing 81223; 81404; 44992 Pancreatitis, Idiopathic (SPINK1) Sequencing 45751 PCA3 - Prostate Cancer Biomarker 36160 Plasminogen Activator Inhibitor-1 4G/5G Polymorphism Detection 81400 45433 Platelet Antigen 1 Genotyping (HPA-1) 81400 45439 Platelet Antigen 15 Genotyping (HPA-15) 81400 45434 Platelet Antigen 2 Genotyping (HPA-2) 81400 45435 Platelet Antigen 3 Genotyping (HPA-3) 81400 45436 Platelet Antigen 4 Genotyping (HPA-4) 81400 45437 Platelet Antigen 5 Genotyping (HPA-5) 81400
45438 Platelet Antigen 6 Genotyping (HPA-6) 81400 45432 Platelet Antigen Genotyping Panel 81400x7 44929 PML/RARa, t(15;17) Translocation, Quantitative RT-PCR 81315 30480 Prenatal Risk Assessment, First Trimester Screen (With NT) 81508 (MAAA) 45382 Prenatal Risk Assessment, Penta Screen 81512 (MAAA) 30180 Prenatal Risk Assessment, Quadruple Marker 81511 (MAAA) 30485 Prenatal Risk Assessment, Sequential Screening, Part 1 (First 81508 (MAAA) Trimester; With NT) 30487 Prenatal Risk Assessment, Sequential Screening, Part 2 (Second 81511 (MAAA) Trimester; With NT) 30484 Prenatal Risk Assessment, Serum Integrated Screening, Part 2 81511 (MAAA) (Second Trimester; Without NT) 30080 Prenatal Risk Assessment, Triple Marker 81510 (MAAA) 45787 PROMETHEUS Crohn s Prognostic 81401; 83520x5; 88347x2 45832 PROMETHEUS IBD sgi Diagnostic x4; 82397x3; 83520x8; 86140; 88347x2 45786 PROMETHEUS NOD2/CARD15 81401 45105 PROMETHEUS TPMT Genetics 81401 45776 Prothrombin IgG and IgM Antibodies 86849x2 44867 Prothrombin IgG Antibody 86849 44868 Prothrombin IgM Antibody 86849 36010 Prothrombin Nucleotide 20210 G/A Gene Mutation (Factor II) 81240 45885 PTEN-Related Disorders (PTEN) 81323 45886 PTEN-Related Disorders (PTEN) Sequencing 81321 45887 PTEN-Related Disorders (PTEN) Sequencing and 81321; 81323 36172 Respiratory Pathogens Panel, Qualitative RT-PCR 87633 45412 Rett Syndrome (MECP2), Deletion and Duplication 81304 45413 Rett Syndrome (MECP2), Full Gene Analysis 81302; 81304 45411 Rett Syndrome (MECP2), Full Gene Sequencing 81302 45876 RUNX1-RUNX1T1 (AML1-ETO) Translocation, t(8;21), RT-PCR 81401 45950 SCN1A-Related Seizure Disorders (SCN1A), Sequencing and 81407; 45810 Septin 9 (SEPT9), Methylated DNA Detection, Real-Time PCR 81401 43547 STRATIFY JCV Antibody Inhibition Assay (Reflex Orders Only) 86711 43530 STRATIFY JCV Antibody with Inhibition Assay if Indicated 86711 36170 T-Cell Gene Rearrangement, PCR 81340; 81342
36131 Thrombosis DNA Mutations Panel 81240; 81241; 81291 44549 Twin Zygosity Testing 81265 45491 UDP Glucuronosyltransferase 1A1 (UGT1A1) Genotyping 81350 45716 Very Long-Chain Acyl-CoA Dehydrogenase Deficiency (ACADVL) 45715 Very Long-Chain Acyl-CoA Dehydrogenase Deficiency (ACADVL) 81406 Sequencing 45717 Very Long-Chain Acyl-CoA Dehydrogenase Deficiency (ACADVL) 81406; Sequencing and 45873 von Hippel-Lindau (VHL) 81403 45874 von Hippel-Lindau (VHL) Sequencing 81404 45875 von Hippel-Lindau (VHL) Sequencing and 81403; 81404 44809 Warfarin Sensitivity (CYP2C9 and VKORC1), 3 Mutations 81227 ; 81355 45943 X Chromosome Ultra-High Density Microarray, 954 Genes 44997 Y Chromosome Microdeletion 81403 Please direct any questions, or comments regarding this notice to Robert J. Tomec, M.D. (rtomec@sbmf.org) or Diane Janowiak (djanowiak@sbmf.org) or call South Bend Medical Foundation, (574) 234-4176 or (800) 544-0925.