CONTENTS Preface... v Contributors...xi I. INTRODUCTION 1 Historical Issues in the Study of Behavioral Dysfunction in Movement Disorders... 3 Christopher G. Goetz II. MENTAL PROCESSING IN THE MOTOR STRUCTURES OF THE BRAIN 2 Fundamental and Clinical Evidence for Basal Ganglia Influences on Cognition... 13 Frank A. Middleton 3 Integrating Cognition and Motivation into the Basal Ganglia Pathways of Action... 35 Suzanne N. Haber 4 Understanding Corticobasal Ganglia Networks as Part of a Habit Formation System... 51 Ann M. Graybiel and Yasuo Kubota 5 The Role of the Cerebellum in Cognition and Emotion... 59 Jeremy D. Schmahmann III. COGNITION IN MOVEMENT DISORDERS 6 Assessing Cognition in Movement Disorders... 85 Julie C. Stout and Jane S. Paulsen 7 Disorders of Intention in Parkinsonian Syndromes... 101 Richard G. Brown 8 Cognitive Control in Frontostriatal Disorders... 113 Francois Richer and Sylvain Chouinard 9 Disorders of Speech and Language in Parkinson s Disease... 125 Henri Cohen 10 Distinctive Features of Apraxia in Corticobasal Degeneration and Other Neurological Illnesses... 135 Ramón Leiguarda 11 Neuropsychological Deficits in Cerebellar Syndromes... 147 Hermann Ackermann and Irene Daum IV. NEUROPHYSIOLOGY OF COGNITION IN MOVEMENT DISORDERS 12 Induction and Reversal of Cognitive Deficits in a Primate Model of Huntington s Disease... 159 Stéphane Palfi, Emmanuel Brouillet, Françoise Condé, and Philippe Hantraye vii
viii Contents 13 Induction and Reversal of Cognitive Deficits in a Primate Model of Parkinson s Disease... 173 Jay S. Schneider 14 Catecholamines and Cognition: Bridging the Gap Between Animal Studies and Clinical Syndromes... 183 Trevor W. Robbins, Harriet S. Crofts, Roshan Cools, and Angela C. Roberts 15 Nondopaminergic Influences on Cognition in Parkinson s Disease... 201 Marc-André Bédard, Maxime Lévesque, Simon Lemay, and François Paquet 16 Cognitive Consequences of Neurosurgery for Parkinson s Disease... 211 Jean A. Saint-Cyr V. DEMENTIA IN MOVEMENT DISORDERS 17 The Clinical Spectrum of Dementia in Movement Disorders: An Overview... 223 Andrew Kertesz 18 Neuropathological Distinctions and Similarities in Movement Disorders with Dementia... 231 Kurt A. Jellinger 19 Homologies Between the Genetic Etiology and Pathogenesis of the Synucleinopathies and Tauopathies... 255 John Hardy 20 Prevalence, Incidence, and Risk Factors for Dementia in Parkinson s Disease... 259 Gilberto Levy and Karen Marder 21 Neuropsychiatric Co-Morbidity in Dementia With and Without Movement Disorders... 271 Clive G. Ballard and Alan Thomas 22 Neurotransmitter Correlates of Neuropsychiatric Symptoms in Dementia with Lewy Bodies... 285 Elaine K. Perry, Margaret A. Piggott, Mary Johnson, Clive G. Ballard, Ian G. McKeith, Robert Perry, and David Burn 23 Acetylcholinesterase Inhibitors in the Treatment of Dementia in Parkinson s Disease... 295 Amos D. Korczyn and Nir Giladi
Contents ix VI. NEUROPSYCHIATRIC ASPECTS OF MOVEMENT DISORDERS 24 Mood Disorders and the Globus Pallidus... 305 Edward C. Lauterbach 25 Cortical-Limbic-Striatal Dysfunction in Depression: Converging Findings in Basal Ganglia Diseases and Primary Affective Disorders... 321 Taresa L. Stefurak and Helen S. Mayberg 26 Agitation and Apathy in Hyper- and Hypokinetic Movement Disorders... 339 Irene Litvan and Jaime Kulisevsky 27 Diagnosis and Treatment of Depression in Parkinson s Disease... 351 Vladimir S. Kostić, Elka Stefanova, Nataša Dragašević, and Saška Potrebić 28 Diagnosis and Treatment of Hallucinations and Delusions in Parkinson s Disease... 369 Dag Aarsland and Jan Petter Larsen 29 REM Sleep Behavior Disorder in Parkinson s Disease, Dementia with Lewy Bodies, and Multiple System Atrophy... 383 Bradley F. Boeve, Michael H. Silber, Tanis J. Ferman, Joseph E. Parisi, Dennis W. Dickson, Glenn E. Smith, John Lucas, and Ronald C. Petersen 30 Psychogenic Parkinsonism and Dystonia... 399 Daniel S. Sa and Anthony E. Lang 31 Clinical Management of Psychosis and Mood Disorders in Huntington s Disease... 409 Mark Guttman, Meneske Alpay, Sylvain Chouinard, Peter Como, Anthony Feinstein, Ira Leroi, and Adam Rosenblatt 32 Clinical Management of Aggression and Frontal Symptoms in Huntington s Disease... 427 Adam Rosenblatt, Karen Anderson, Alex D. Goumeniouk, Paul Lespérance, Martha A. Nance, Jane S. Paulsen, Allen Rubin, Jean A. Saint-Cyr, Russ Sethna, and Mark Guttman 33 Heterogeneous Psychopathology of Tourette Syndrome... 443 Mary M. Robertson 34 In Search of the Pathophysiology of Tourette Syndrome... 467 James F. Leckman
x Contents 35 Obsessive Compulsive Disorder as a Frontostriatal-Thalamic Dysfunction... 477 Tiffany R. Farchione, Shauna N. MacMillan, and David R. Rosenberg 36 Dyskinesia in Patients with Schizophrenia Never Treated with Antipsychotics: Conceptual and Pathophysiological Implications... 489 Christian Bocti, Deborah N. Black, and John L. Waddington VII. QUALITY OF LIFE IN PARKINSON S DISEASE 37 Medical and Psychosocial Determinants of Quality of Life in Parkinson s Disease... 501 Anette Schrag and Caroline Selai 38 Sexuality and Parkinson s Disease... 517 Gila Bronner, Vladimir Royter, Amos D. Korczyn, and Nir Giladi 39 Daytime Sleepiness and Sleep Attacks in Idiopathic Parkinson s Disease... 527 David B. Rye, Joseph T. Daley, Amanda A. Freeman, and Donald L. Bliwise 40 Natural Evolution and Life Expectancy in Parkinson s Disease... 539 Werner Poewe Index... 545
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