Panel # Panel CPT Code Price 2010 AUTOIMMUNE PROFILE - BASIC 99.00

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2010 AUTOIMMUNE PROFILE - BASIC 99.00 Anti-Nuclear Antibody (ANA) 86038 33.00 Rheumatoid Factor 86431 33.00 C1Q Immune Complex 86332 33.00 2011 AUTOIMMUNE PROFILE (COMPREHENSIVE) 210.00 Anti-Nuclear Antibody (ANA) 86038 33.00 Extractable Nuclear Antigen (ENA) Antibody 86235 33.00 Double-Stranded DNA (dsdna) Antibody 86226 33.00 Rheumatoid Factor 86431 33.00 C1Q Immune Complex 86332 33.00 Actin (Smooth Muscle) Antibody 83520 33.00 Mitochondrial Antibody 83516 33.00 2013 AUTOIMMUNE LIVER DISEASE 66.00 Actin (Smooth Muscle) Antibody 83520 33.00 Mitochondrial Antibody 83516 33.00

2015 B. BURGDORFERI IgG, IgM BY ELISA 100.00 Borrelia burgdorferi IgG 86618 50.00 Borrelia burgdorferi IgM 86618 50.00 2016 B. BURGDORFERI IgG, IgM BY WESTERN BLOT 120.00 Borrelia burgdorferi IgG, WB 84181 60.00 Borrelia burgdorferi IgM, WB 84181 60.00 2017 IMMUNOSEROLOGY OF LYME PANEL A 450.00 The Multi-Peptide ELISA for the detection of Lyme disease is covered by Patent # US 7,390,626 B2 awarded to Aristo Vojdani and Immunosciences Lab., Inc. Borrelia burgdorferi (IgG, IgM) 86618 x 2 OspA + OspC Peptides (IgG, IgM) 86618 x 2 OspE Peptide (IgG, IgM) 86618 x 2 Leukocyte Function Associated Antigen (IgG, IgM) 86618 x 2 Immunodominant Protein (IgG, IgM) 86618 x 2 Variable Major Protein (IgG, IgM) 86618 x 2 Borrelia Subspecies Antibodies B. b. sensu stricto (IgG, IgM) 86618 x 2 B. garinii (IgG, IgM) 86618 x 2 B. afzelii (IgG, IgM) 86618 x 2 Lyme Co-Infection Babesia (IgG, IgM) 86618 x 2 Ehrlichia (IgG, IgM) 86666 x 2 Bartonella (IgG, IgM) 86618 x 2

2018 IMMUNOSEROLOGY OF LYME PANEL B 550.00 The Multi-Peptide ELISA for the detection of Lyme disease is covered by Patent # US 7,390,626 B2 awarded to Aristo Vojdani and Immunosciences Lab., Inc. Lyme-Specific Antibodies Borrelia burgdorferi (IgG, IgM) 86618 x 2 OspA + OspC Peptides (IgG, IgM) 86618 x 2 OspE Peptide (IgG, IgM) 86618 x 2 Leukocyte Function Associated Antigen (IgG, IgM) 86618 x 2 Immunodominant Protein (IgG, IgM) 86618 x 2 Variable Major Protein (IgG, IgM) 86618 x 2 Borrelia Subspecies Antibodies B. b. sensu stricto (IgG, IgM) 86618 x 2 B. garinii (IgG, IgM) 86618 x 2 B. afzelii (IgG, IgM) 86618 x 2 Lyme Co-Infection Babesia (IgG, IgM) 86618 x 2 Ehrlichia (IgG, IgM) 86666 x 2 Bartonella (IgG, IgM) 86618 x 2 Western Blot Assay B. burgdorferi (IgG, IgM) 84181 x 2 2019 EPSTEIN-BARR VIRUS (EBV) PANEL 150.00 2020 VIRAL SCREEN 180.00

2022 VIRAL PANEL PREMIER 360.00 Human Herpes Type 6 (HHV-6) IgG 86694 33.00 Human Herpes Type 6 (HHV-6) IgM 86694 33.00 Varicella zoster (VZV) IgG 86787 33.00 2023 VIRAL PANEL COMPREHENSIVE 420.00 Human Herpes Type 6 (HHV-6) IgG 86694 33.00 Human Herpes Type 6 (HHV-6) IgM 86694 33.00 Varicella zoster (VZV) IgG 86787 33.00 Rubeola (Measles) IgG 86765 33.00 Rubeola (Measles) IgM 86765 33.00

Mechanism responsible for Borrelia induction of autoimmunity and its detection by Multi-Peptide ELISA Based on the above mechanism responsible for Borrelia-induced neuroautoimmunity, Immunosciences Lab uses the most sensitive patented method for the detection of antibodies against Lyme and other tick-borne diseases (Babesia, Ehrlichia, Bartonella). Immunosciences new generation assessments for Lyme disease cover the measurements of antibodies to antigens of Borrelia grown in culture (the traditional method), as well as the antibodies to proteins associated with the spirochete s expression of a variety of antigens during human infection. As shown above, once the spirochete enters the host, it hides from immune attack by changing its antigenic structure. This allows the spirochete to move, undetected, through the blood stream or burrow deep into any tissue. Traditional testing cannot reveal antibodies made against these new antigens. In addition, ISL s Lyme profiles assess infection with three different subspecies of Borrelia and examines their cross-reaction with Babesia, Ehrlichia and Bartonella. Utilization of this methodology will increase the accuracy of the diagnostic process and abridge the time to treatment, resulting in improved quality of care and disease prognosis. For more information, see Vojdani et al., Novel diagnosis of Lyme disease: potential for CAM intervention, ecam, 2009 6(3):283-295.