UNIVERSITY CLUB PORTLAND, OR

UNIVERSITY CLUB PORTLAND, OR

THURSDAY, MARCH 15TH Morning 7:00 am Breakfast and registration Main Dining Room 7:30 Welcome 7:35-9:20 BBB Disruption (BBBD) Therapies and Biomarkers Joseph Frank Patrick Reynolds Lubbock, Texas BBB Disruption Therapies 7:35 Safety of Intra-Arterial Chemotherapy with Osmotic Opening of the BBB 7:45 Primary CNS Lymphoma (PCNSL): BBBD Outcomes, and New Multi-Center Randomized Maintenance Obinutuzumab Trial Nancy Doolittle 7:55 Update from Finland on BBBD/ASCT in PCNSL Clinical Outcomes Hanne Kuitunen Oulu, Finland 8:10 The Effects of Pulse Focused Ultrasound on the Opening of the BBB Joseph Frank 8:25 Radiation Enhanced Delivery Across the Neurovascular Unit Prakash Ambady Biomarkers 8:35 Understanding Transcriptomic Differences in Glioblastoma Regions to Improve Therapeutic Targeting Cymon Kersch 8:50 Pembrolizumab for Brain Metastases and Glioblastoma Multiforme Trials Prakash Ambady 9:05 Group Discussion 9:20 Break 9:30-10:40 Chemoprotection Rosty Raykov Research Triangle Park, North Carolina Yoon-Jae Cho Susan Lindemulder 9:30 Oxaliplatin Toxicity and Thiols: The Next Clinical Trial in Adults Matthew Tipping 9:40 Hearing Loss and Quality of Life in Survivors of Pediatric Cancer Kristin Knight 9:50 Economic Impact of Sodium Thiosulfate (STS) on Cisplatin-Induced Hearing Loss Rochelle Fu 4 24th Annual Blood-Brain Barrier Consortium Meeting

Morning cont. 10:00 Proposed Randomized Phase II Study: STS in Standard Risk Medulloblastoma Susan Lindemulder 10:10 Impact of Genetic Heterogeneity on Blood Tumor Barrier in Medulloblastoma: The Good and the Bad Yoon-Jae Cho 10:20 Roundtable Discussion: Road to the FDA and Discussion with Patient Advocate 10:40 Break 10:50-12:00 Ferumoxytol Imaging Ramon Barajas Paula Jacobs 10:50 Current Status of Imaging Multicenter Trials and Future Studies Csanad Varallyay 11:00 Retrospective Analysis: Head to Head Assessment of Enhancement on T1- Weighted Images Using Gadolinium and Ferumoxytol 11:10 Surgical Targeting Gadolinium Versus Ferumoxytol and Using Ferumoxytol to Diagnose Pseudoprogression Laszlo Szidonya Ramon Barajas 11:20 Imaged Guided Resection Using Ferumoxytol for Malignant Gliomas Seunggu Jude Han 11:30 Intracranial Vessel Imaging: Gadolinium Versus Ferumoxytol Gerda Teglassy 11:40 Group Discussion 12:00 pm Lunch: Concurrent Informal Small Group Discussion with Input from Industry [Lunch will be served in the Main Dining Room and for those participating in the small group breakout discussions, lunch will be served in the Faculty Room (3rd Level)] 1. BBB Disruption Therapies and Biomarkers Alumni Room (3rd Level) Facilitators: Joseph Frank and Patrick Reynolds 2. Chemoprotection Foundation Room (3rd Level) Facilitators: Rosty Raykov, Yoon-Jae Cho, Susan Lindemulder 3. Ferumoxytol Imaging President s Room (3rd Level) Facilitators: Ramon Barajas and Paula Jacobs University Club, Portland, OR 5

THURSDAY, MARCH 15TH CONT. Afternoon William Rooney Robert McDonald 1:00 pm Introduction 1:10 Intracranial Gadolinium Deposition: Overview of Scientific Findings and Clinical Significance 1:30 Intracranial Gadolinium Deposition Following Gadodiamide-Enhanced Magnetic Resonance Imaging in Pediatric Patients Robert McDonald Jennifer McDonald 1:50 The Basics of Gadolinium Chemistry and Imaging Mark Woods 2:10 Roundtable Discussion: Pathologic Correlation and Clinical Significance of Intracranial Gadolinium Deposition Panel: Jennifer McDonald Robert McDonald William Rooney Mark Woods 2:30 Break Sadhana Jackson Bjoern Bauer Lexington, Kentucky 2:40 Introduction: Multitasking Nature of the BBB When Does it Start? Norman Saunders Melbourne, Australia 3:00 Multi-Omics Analyses of Human BBB Model Krishna Kalari 3:20 Zebrafish CNS Barriergenesis Michael Taylor Madison, Wisconsin 3:40 Development and the BBB: Clinical Perspective Barbara Stonestreet Providence, Rhode Island 4:00 Roundtable Discussion 4:15 Adjourn 6 24th Annual Blood-Brain Barrier Consortium Meeting

Evening 4:30-6:00 pm Poster session Lower Level 4:45 Travel scholarship awardee abstract presentations DCE-MRI Pipeline for Improved BBB Characterization in Brain Tumors Blast Exposure Elicits Biphasic BBB Disruption Mediated by Nitric Oxide Elucidating Neuronal Vascular Endothelial Growth Factor s Role in CD8 T Cell- Mediated BBB Disruption Yannick Bliesener Los Angeles, California Aric Logsdon Seattle, Washington Vanessa Ruiz 6:15 Dinner Main Dining Room Welcome and Introductions 6:45-7:15 Brain Injury: Linking Basic Science with Clinical Management and Public Health Outreach Clinical Management Injury Prevention Keynote 7:15 Panel Discussion Jim Chesnutt David Brody Moderator: Robert Thorne Panel: Jim Chesnutt,, and David Brody University Club, Portland, OR 7

FRIDAY, MARCH 16TH Morning 7:00 am Breakfast and registration Main Dining Room 7:30 NIH Roundtable Paula Jacobs Joseph Frank Prakash Ambady Robert Thorne Madison, Wisconsin 8:25 Introduction: CAR-T Cell Therapy in Brain Cancer Reality or a Dream? Maciej Mrugala Phoenix, Arizona 8:45 Systemic Antibody Delivery to the Brain: Is Barrier Disruption Necessary? Matthias Holdhoff Baltimore, Maryland 9:05 Central Distribution of Antibodies (CSF Brain) in Normal Brain and Brain Cancer Animal Models: Diffusion and Perivascular Flow 9:25 Breast and Lung Cancer Brain Metastasis Models: Lessons Learned and New Questions Robert Thorne Madison, Wisconsin Tiffany Lyle South Bend, Indiana 9:45 Break 9:55 State of the Art for Delivery of Antibodies, Antibody Drug Conjugates (ADCs), and Other Biologics Across the BBB Danica Stanimirovic Ottawa, Canada 10:15 Route of Delivery and ADC Efficacy in Brain Tumor Models Leslie Muldoon 10:35 Intra-Arterial NEO100 Transiently Opens up the BBB Thomas Chen Los Angeles, California 10:45 High Dose Acetaminophen Inhibits STAT3 and Demonstrates Anti-Cancer Stem Cell Activity Alexander Neuwelt Denver, Colorado 10:55 Methotrexate Dosing in the Elderly: A Discussion of Dose and Safety Joseph Bubalo 11:10 Break 11:15 Group photo 11:30 One-on-One Mentoring Session Main Dining Room Lester Drewes Joseph Frank Rochelle Fu Jennifer McDonald Robert McDonald Martha O Donnell Norman Saunders Danica Stanimirovic Robert Thorne 12:30 pm Lunch 8 24th Annual Blood-Brain Barrier Consortium Meeting

Afternoon Brian Eliceiri Sand Diego, California Craig Newgard 1:30 pm Introduction: Traumatic Brain Injury Imaging David Brody 1:50 TBI and NVU Animal Models Adam Chodobski Providence, Rhode Island 2:10 Concussion Policy and Prevention James Chesnutt 2:30 Stratifying Acute TBI Across the Injury Spectrum Holly Hinson 2:50 An Example of T4 Population-Level Outcomes Research: Pediatric Trauma and TBI Craig Newgard 3:10 Roundtable Discussion: The Path Forward to NIH Funding 3:30 Meeting Wrap-Up 4:00 Adjourn Take Home Messages from Each Session University Club, Portland, OR 9