Contact Address Faculty of Nursing and Health Sciences Notre Dame University-Louaize Zouk Mosbeh, Lebanon P.O Box: 72 Zouk Mikael Phone: 961-9-208902 Mobile: 961-71-991331 Fax:961-9-218771 Email: jboumosleh@ndu.edu.lb EDUCATION Aug. 2002-June2006 Doctor of Philosophy Epidemiology, University of Pittsburgh, PA, USA Aug.1999-May2000 Non-degree -Health Economics, University of Alabama, Tuscaloosa, AL, USA Oct.1992- July 1994 Master of Public Health -Hospital Service Administration, AUB, Beirut, Lebanon Oct.1989-July1992 Bachelor of Science -Environmental Health Pre-med, AUB, Beirut, Lebanon PROFESSIONAL POSITIONS AND MAJOR APPOINTMENTS Oct2010-Present Assistant Professor in Epidemiology, Notre Dame University,Lebanon Oct. 2008-Aug.2010 Postdoctoral Fellow, The UT Southwestern Medical Center at Dallas, Center of Human Nutrition Oct. 2006- Oct. 2008 Assistant Professor in Epidemiology, University of Balamand, Lebanon Feb.1997-July 1999 Network Director, MedNet Liban, Beirut, Lebanon, Dec.1995-Feb.1997 Consultant to the Minister of Health- Ministry of Public Health, Beirut, Lebanon ACADEMIC AWARDS Sep. 2005-Dec.2005 Teacher assistant - Graduate School of Public Health, University of Pittsburgh, PA, USA Aug. 2002-June 2006 Graduate Research Assistant - Graduate School of Public Health, University of Pittsburgh, PA, USA Oct.1992-June.1994 Graduate Research Assistant - Faculty of Health Sciences, AUB, Beirut, Lebanon PROFESSIONAL MEMBERSHIPS AND SOCIETIES June 2007-present Feb. 2007-present The Endocrine society, USA (Member) Lebanese Epidemiological Association, Lebanon (Member) 1
TEACHING EXPERIENCE Oct 2010-Present Assistant Professor- Faculty of Nursing and Health sciences, Notre Dame University, Zouk Mosbeh, Lebanon. Taught courses to graduate and undergraduate Public Health students (Research methods in Human Nutrition, Principles of Epidemiology and biostatistics, Health Awareness and Contemporary Health Issues). Also taught courses in Epidemiology to Medical students (Med I and MEDII) Oct.2008-Aug.2010 Postdoctoral Fellow Center of human Nutrition, The University of Texas Southwestern Medical center, Dallas, USA. Taught a lecture titled Role of Diet in Polycystic Ovary Syndrome to undergraduate nutrition students. Oct. 2006-Oct.2008 Assistant Professor- Faculties of Health sciences and Medicine, University of Balamand, Beirut, Lebanon. Taught courses to graduate and undergraduate Public Health students (Research methods in Health sciences, Principles of Epidemiology and biostatistics, and Epidemiology for public Health Practice). Also taught courses in Epidemiology to Medical students (Med I and MEDII) Sep. 2005-Dec.2005 Teacher assistant - Graduate School of Public Health, University of Pittsburgh, PA, USA. Taught some lectures in a graduate course (Principles in Epidemiology).Also assisted in developing material, personal instruction and grading exams in this course. RESEARCH EXPERIENCE 2008-2010 UTSW-Dallas, TX, Postdoctoral research fellow, Trained in Dr(s) Vega/Grundy labs to o execute experiments to study the characteristics of human adipocytes from different depots (abdominal and gluteofemoral) o perform experiments to measure non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHP) and Triglycerides in human plasma samples. Developed and wrote a research protocol titled Adipose Tissue Cellularity in Polycystic Ovarian Syndrome (PCOS). This protocol centers on role of obesity in relation in metabolic abnormalities in PCOS women. The primary aim of this pilot study is to determine whether women with polycystic ovarian syndrome (PCOS) have reduced number of subcutaneous adipocytes compared with women without PCOS. It is postulated that reduced cellularity is an underlying defect of the metabolic 2
syndrome, a syndrome that is characterized by central obesity, dyslipidemia, impaired glucose tolerance, hypertension, and prothrombotic and inflammatory state, in PCOS. This protocol has been approved by the IRB and by Moss Heart Foundation for funding. We are in the process of recruitment for the study; so far, we have attained 80% of the targeted sample size. Wrote a research project titled Body Fat content and distribution and Metabolic Risk Factors in Polycystic Ovarian Syndrome (PCOS). The purpose of this project is to examine the relative distribution of truncal-tolower body fat and of subcutaneous- to- intraperitoneal + retroperitoneal fat in PCOS cases and their age-and BMI-matched normal cycling controls. The design is cross-sectional study of a nested cohort from a multi-ethnic population-based sample (Dallas Heart Study). Measurements of body composition by dual x-ray absorptiometry (DXA), abdominal fat by MRI, lipids and lipoprotein cholesterol, NMR lipoprotein, insulin resistance (HOMA-IR) as well as leptin and adiponectin levels will be used to achieve the purpose of the project. The Reynolds Cardiovascular Clinical Research Center has provided us with the database. I have performed the statistical analyses associated with the manuscript and I am currently involved in the write-up of the manuscript. Wrote a review PCOS and its Complications: Is it Visceral Fat, Upper-tolower Body Fat Ratio or BOTH. The purpose of this review is to examine the evidence, in the past 10 years, regarding the association of each truncal-to-lower body fat distribution and visceral fat to PCOS. Wrote another review Adipocyte size and number in PCOS. The purpose of this review is to examine the number and size of adipose cells reported in the PCOS population. Started writing a grant titled Relation of Body Composition and Fat Distribution to Insulin Resistance in Adolescents of high risk ethnicity. The purpose of this grant is to examine differences in insulin resistance according to body composition and fat distribution in adolescents of high risk ethnicity (African Americans, Asian Indians and Hispanics). Strengthened oral and written communication skills by lecturing nutrition students and writing grants and manuscripts, and by presenting orally at scientific meetings 2002-2006 University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA Graduate Research Assistant (PhD program). Carried out a Research Study Funded by a Grant From the National Cancer Institute (NCI) titled Molecular Epidemiology of Prostate cancer, Tobagonians. Trained in Dr Bunker s laboratory to carry out the following. I used organic solvents to extract antioxidants from serum collected in Trinidad 3
and Tobago. I then separated and quantitated individual antioxidants (alpha- and gamma-tocopherol; retinol; and the carotenoids: alpha- and beta-carotene, cryptoxanthin and lycopene) by HPLC. The components were monitored using a photodiode array detector and the internal standards were retinol acetate and tocopherol acetate. The results were evaluated in relation to prostate cancer. Developed and carried out a Research Study Funded by a Grant from the National Institute of Child Health and Human Development (NICHD) titled Genetics of Insulin Resistance: The PPAR Pathway. 1993-1995 Graduate Research Assistant (M.P.H program), AUB, Beirut, Lebanon Worked, under the supervision of Dr. Mary Deeb, on a research study titled The Mental Health Status of Sensorially Adolescents in the aftermath of War. Worked, under the supervision of Dr. Shaar, K., on a research study titled Prevalence of Gynecological Disease in Greater Beirut. OTHER WORK EXPERIENCE 1997-1999 Network Director, MedNet Liban, Beirut, Lebanon Controlled and supervised the implementation of contractual agreements involving health care providers (Hospitals, Laboratories and pharmacies) and third party payers (Insurance Companies and Mutual Societies). Conducted a meticulous selection of network providers according to need. This includes personal investigation of a candidate s fulfillment of the basic criteria set for admission. 1995-1997 MoPH, Beirut, Lebanon, Consultant to the Minister of Public Health, Designed and implemented a project concerning the rehabilitation of the government hospitals in Lebanon. This project aimed at surveying the country for most prevalent diseases, analyzing results to identify possible causes for widespread diseases and developing appropriate preventive measures, efficient allocation of resources to handle prevalent health problems in each region and regular training of medical and paramedical staff. 1994-1995Advanced Medical Imaging, Beirut, Lebanon, Accountant Compiled and analyzed financial information to prepare entries to accounts, such as general ledger accounts, and document business transactions. Established, maintained, and coordinated the implementation of accounting and accounting control procedures. Analyzed and reviewed expenditures. Monitored and reviewed accounting and related system reports for accuracy and completeness. Reviewed revenue, expense, payroll entries, invoices, and other accounting documents. Daily controls, reconciliations, accounts payable and receivable and collections. 4
PRESENTATIONS AT INTERNATIONAL SCIENTIFIC CONFERENCES ENDO Scientific Meeting, Toronto, Canada, 2007. Jocelyne Matar,Ph.D; Candace Kammerer,PhD;Evelyn Talbott,DRPH;Selma Witchel, MD.2007. Genetics of Insulin Resistance in families with Polycystic Ovary Syndrome. The Seventh Annual Postdoctoral Symposium and Poster Session, 2010. Jocelyne Boumosleh, M.PH., Ph.D.; Alice Chang, M.D.;Scott M. Grundy, M.D.; Ph.D and Gloria Lena Vega. Body Composition Phenotype and Metabolic Risk Factors in Polycystic Ovary Syndrome (PCOS) in the Reynolds Women s Study. PEER REVIEWED PUBLICATIONS Bunker CH, McDonald AC, Evans RW, de la Rosa N, Boumosleh JM, Patrick AL. A Randomized Trial of Lycopene Supplementation in Tobago Men with High Prostate Cancer Risk, Nutrition and Cancer, 2007; 57 (2):130-7 17571945 Jocelyne Matar, Ph.D ;Vega L. Gloria, PhD; Grundy, S, PhD, M.D.; Chang, A; Hewett, B. Body Fat content and distribution and Metabolic Risk Factors in Polycystic Ovarian Syndrome (PCOS)(In progress). Jocelyne Matar, Ph.D ;Vega L. Gloria, PhD; Grundy, S, PhD, M.D.; Chang,A; Hewett, B. Adipose Tissue Cellularity in Polycystic Ovarian Syndrome(In progress). Jocelyne Matar, Ph.D ;Vega L. Gloria, PhD; Grundy, S, PhD, M.D. PCOS and its Complications: Is it Visceral Fat, Upper-to-lower Body Fat Ratio or BOTH. Review. (In progress). Jocelyne Matar, Ph.D ;Vega L. Gloria, PhD; Grundy, S, PhD, Jocelyne Matar, Ph.D; M.D., Chang,A; Hewett, B. Adipocyte size and number in PCOS. Review. (In progress). Jocelyne Matar,Ph.D;Candace Kammerer,PhD;Evelyn Talbott,DRPH;Selma Witchel, MD. Linkage and association between the loci of PPAR-gamma and IL6 genes with putative disease loci of common phenotypes in multigenerational, multiplex PCOS families. (proceedings of ENDO 07; Toronto, Canada) (In progress). Jocelyne Matar,Ph.D;Candace Kammerer,PhD;Evelyn Talbott,DRPH;Selma Witchel, MD. Increased prevalence rates of impaired Fasting Glucose (IFG), T2DM and metabolic syndrome in the adolescent and adult sub-populations in multigenerational, multiplex PCOS families as compared to the general population. (proceedings of ENDO 07; ; Toronto, Canada) (In progress). RESEARCH FUNDING 5
June 2004-June 2006 Genetics of Insulin Resistance: The PPAR Pathway ; PI - Evelyn Talbott, Dr.PH ( NICHD R03 HD044693-01). As an investigator in this grant, I developed the protocol to explore the relationship between PCOS genotype and insulin resistance by examining a well-established population of polycystic ovary syndrome cases and their first and second-degree family members. Specifically, I developed new markers of insulin resistance and inflammation that are specific to my doctoral thesis and proposed new scientific hypotheses. To test my hypotheses, I worked on recruiting families with polycystic Ovary syndrome, extracting DNA from collected blood samples and genotyping analyzing data and writing the manuscripts. Oct.2008-Present. Adipose Tissue Cellularity in Polycystic Ovarian Syndrome ; PI- Gloria L. Vega PhD/Grundy Scott, M.D., Ph.D (Funding Source: Moss Heart Foundation). As an investigator in this grant, I developed the protocol to determine whether women with polycystic ovarian syndrome (PCOS) have reduced number of subcutaneous adipocytes compared with women without PCOS. The hypothesis to be tested is that PCOS women have a deficiency of subcutaneous adipose tissue cellularity. It is postulated that reduced subcutaneous adipose tissue cellularity is an underlying defect of the metabolic syndrome in PCOS. The long-term goal of this project is to determine whether hyperandrogenemia in women causes reduced adipose tissue cellularity. GRANTS SUBMITTED I and Dr Jessy El Hayek developed and submitted to the CNRS a research project titled Prevalence of Pre-hypertension and Primary Hypertension among Lebanese School Students: a Cross-Sectional Study. The purpose of the project is to assess the prevalence of pre-hypertension and primary hypertension among Lebanese School Students as well as examine the association between elevated blood pressure and its anthropometric, dietary and lifestyle risk factors. IN PROGRESS I am in the process of writing a grant titled Relation between Body fat Composition and Distribution and Metabolic Syndrome in Lebanese Adolescents. The purpose of this grant is to examine differences in prevalence of metabolic syndrome between adolescents with upper-body fat and lower-body fat distributions. I am writing a grant titled Epidemiological Differences in Breast Cancer Incidence Rates between Female Muslims and Christians in Beirut. The specific goal in this grant is to develop the existing national cancer registry in Lebanon through implementing standardized guidelines for cancer registries; this will allow us to collect incidence data over a five year period and test our hypothesis that in Beirut, the age-standardized incidence rate of Breast Cancer in Female Muslims is lower than that in Female Christians (For Breast Cancer, ASIR Muslims<ASIR Christians). 6
REFERENCES: Kevin E. Kip, Ph.D. Associate Professor, Executive Director, Research Center University of South Florida, College of Nursing MDC 22, Room 2010 12901 Bruce B. Downs Blvd. Tampa, FL 33612-4476 Phone: (813) 974-9266 Fax : (813) 974-7903 Email: kkip@health.usf.edu Scott Grundy, M.D., Ph.D. Professor and Director of Center of Human Nutrition, UT Southwestern Medical Center Center for Human Nutrition 5323 Harry Hines Blvd Dallas, TX 75390 Phone: (214)-648-2869 Fax : (214)648-7150 Email: scott.grundy@utsouthwestern.edu Gloria Lena Vega, Ph.D. Professor, UT Southwestern Medical Center Center for Human Nutrition 5323 Harry Hines Blvd Dallas, TX 75390 Phone: (214)-648-2869 Fax : (214)648-7150 Email: gloria.vega@utsouthwestern.edu 7