Drug Formulary Update, January 2017 Commercial and State Programs

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Drug Formulary Update, January 2017 Commercial and State Programs Updates to the HealthPartners Commercial and State Program Drug Formularies are listed below. Updates apply to all Commercial groups (PreferredRx, GenericsPlusRx, EnhancedRx, and GenericsAdvantageRx) and to HealthPartners Minnesota Health Care Programs (Medicaid and Minnesota Care State Programs ) Drug Formulary. Please see www.healthpartners.com/formularies for details. Positive changes (additions) are generally effective January 1st, and negative changes (deletions) are generally effective April 1st. Additional communications are sent to all affected members and their providers. Acyclovir (Zovirax), Aripiprazole (Abilify), NF NF PA 4/1/2017 Zovirax Brands will be reserved for: 1. patients who have tried and failed the equivalent generic due to a documented allergic reaction, and 2. patients who have tried and failed at least one additional preferred alternative such as valacyclovir and famciclovir. Acyclovir remains on formulary. NF NF PA 4/1/2017 Abilify Brand is reserved for patients who Aripiprazole (generic Abilify) remains on formulary). Canakinumab (Ilaris) F PA F PA 1/1/2017 Coverage criteria have been updated.

Drug Formulary Update, January 2017, page 2 of 7 Coenzyme Q10 powder Desvenlafaxine (Khedezla) Dexamethasone dose pack (Dexpak) Dexmethylphenidate XR Dextroamphetamine (Dexedrine), Brandonly Doxycycline monohydrate 40mg NF NF PA 4/1/2017 Coenzyme Q10 powder has been added to the PA required compounding list. NF PA NF 1/1/2017 Desvenlafaxine (Khedezla) prior authorization criteria have been removed for State Programs, and desvenlafaxine is nonformulary for all formularies. NF NF PA 4/1/2017 Dexpak is reserved for: patients who have tried and failed generic dexamethasone due to a documented allergic reaction. NF F 1/1/2017 Dexmethylphenidate XR (generic Focalin XR) has been added to formulary. NF NF PA 4/1/2017 Dexedrine Brand is reserved for 1. patients who have tried and failed the equivalent generic due to a documented allergic reaction, and 2. patients who have tried and failed at least one additional preferred alternative such as amphetamine/ dextroamphetamine and Vyvanse. Dextroamphetamine (generic Dexedrine) remains on formulary. NF NF PA 4/1/2017 Doxycycline monohydrate 40mg (Brand Oracea and generic) are non formulary with prior authorization. Oracea Brand is reserved for patients who Doxycycline monohydrate 40mg (generic Oracea) is reserved for patients who have tried preferred generic doxycycline products, with significant clinical rationale suggesting improved outcomes.

Drug Formulary Update, January 2017, page 3 of 7 Dutasteride NF F 1/1/2017 Dutasteride (generic Avodart) has been added to State Programs, and is now on all Drug Formularies. Dutoprol (metoprolol/ HCTZ) ER Efinaconazole (Jublia) Epiduo Forte (adapalene 0.3%/ benzoyl peroxide 2.5%) gel NF NF PA 4/1/2017 Dutoprol (Brand and generic) are reserved for patients who have tried and failed metoprolol and hydrochlorothiazide given separately, due to a documented allergic reaction. NF PA NF PA 1/1/2017 Jublia coverage criteria have been updated. NF PA NF PA 1/1/2017 Epiduo Forte coverage criteria have been updated. Epiduo Forteo is reserved for patients who have tried and failed adapalene 0.3% and benzoyl peroxide given separately, Eplerenone F PA F 1/1/2017 Eplerenone (generic Inspra) coverage criteria have been removed, and eplerenone is on formulary with no restrictions. Fluoxetine (Prozac), NF NF PA 4/1/2017 Prozac Brand is reserved for patients who Fluoxetine remains on formulary. Hepatitis C 1/1/2017 Coverage criteria have been updated, removing fibrosis requirements. Preferred products have been updated for State Programs. Zepatier (elbasvir/ grazoprevir) is preferred for genotypes 1 and 4. Insulin glargine (Basaglar) NF F 1/1/2017 Basaglar has been added to formulary, and will replace Lantus and Toujeo.

Drug Formulary Update, January 2017, page 4 of 7 Insulin glargine (Lantus and Toujeo) F NF PA 2/1/2017 Lantus and Toujeo are being removed from the formulary. Basaglar will be preferred. Lantus and Toujeo will be reserved for patients who have tried and failed Basaglar due to documented allergic reactions. Itraconazole F PA F PA 1/1/2017 Itraconazole coverage criteria have been updated. Ivermectin (Soolantra) cream Levetiracetam (Keppra), NF NF PA 4/1/2017 Soolantra will be reserved for patients with an inadequate response to topical tretinoin or adapalene. NF NF PA 4/1/2017 Keppra Brands will be reserved for patients who have tried and failed the equivalent generic, due to a documented allergic reaction. Levetiracetam (generic Keppra) remains on formulary. Levetiracetam XR NF F 1/1/2017 Levetiracetam XR (generic Keppra XR) has been added to formulary. Lidocaine ointment F NF 4/1/2017 Lidocaine ointment has been removed from the formulary. Metformin GR NF NF PA 4/1/2017 Metformin GR (Glumetza and generics) requires prior authorization. Naproxen sodium F NF 4/1/2017 Naproxen sodium (generic Anaprox) has been removed from the formulary. Novacort (hydrocortisone/ pramoxine) gel NF NF PA 4/1/2017 Novacort will be reserved for patients with an inadequate response to two or more topical steroids, with significant clinical rationale suggesting improved outcomes.

Drug Formulary Update, January 2017, page 5 of 7 Orkambi (lumacaftor/ ivacaftor) Paliperidone (Invega) Pantoprazole (Protonix), Brandonly Quetiapine (Seroquel), Brandonly Quetiapine XR (Seroquel XR), F PA F PA 1/1/2017 Orkambi coverage criteria have been updated. NF PA NF PA 1/1/2017 Paliperidone (Brand Invega) coverage criteria have been updated. Invega is reserved for patients who have tried and failed the equivalent generic due to a documented allergic reaction. Paliperidone remains non formulary with prior authorization. NF NF PA 4/1/2017 Protonix Brand is reserved for patients who have tried the equivalent generic, due to a documented allergic reaction. Pantoprazole (generic Protonix) remains on formulary. Protonix (and all PPIs) remain excluded for the GenericsPlusRx Drug formulary. NF NF PA 4/1/2017 Seroquel Brand is reserved for patients who have tried the equivalent generic, due to a documented allergic reaction. Quetiapine remains on formulary. NF PA NF PA 1/1/2017 Coverage criteria have been updated. Seroquel XR is reserved for patients with significant documented compliance concerns with quetiapine regular release, or patients currently stable on this medication. Approvals are given for 3 years.

Drug Formulary Update, January 2017, page 6 of 7 Quetiapine XR F PA F PA 1/1/2017 Quetiapine XR (Seroquel XR) coverage criteria have been updated. Quetiapine XR is reserved for patients with significant documented compliance concerns with quetiapine regular release, or patients currently stable on this medication. Approvals are given for 3 years. Rabeprazole NF F 1/1/2017 Rabeprazole (generic Aciphex) has been added to the formulary. Rabeprazole (and all PPIs) remain excluded for the GenericsPlusRx Drug formulary. Rabeprazole (Aciphex), Brandonly NF NF PA 4/1/2017 Aciphex Brand is reserved for patients who Rabeprazole is on formulary. Aciphex (and all PPIs) remain excluded for the GenericsPlusRx Drug formulary. Rifaximin (Xifaxan) F PA F PA 1/1/2017 Coverage criteria have been updated. Tavaborole (Kerydin) NF PA NF PA 1/1/2017 Kerydin coverage criteria have been updated. Testosterone (Androgel and generics, Androderm, cypionate, and enanthate) F PA F PA 1/1/2017 The prior authorization criteria for preferred testosterone products have been updated. These are reserved for: 1. Members with a diagnosis of gender dysphoria, or 2. Male patients with a documented testosterone deficiency of less than 300 ng/ dl. Renewal Criteria: Reauthorizations are given for members who have been examined by the provider within the previous 14 months, have a positive response, and continue to require this medication. Coverage Duration: Approvals are given for three years.

Drug Formulary Update, January 2017, page 7 of 7 Testosterone (Axiron, Fortesta, Testim, Vogelxo) NF PA NF PA 1/1/2017 The prior authorization criteria for nonpreferred forms of testosterone have been updated. These are reserved for the following indications: 1. Members with a diagnosis of gender dysphoria, or 2. Male patients with a documented testosterone deficiency of less than 300 ng/ dl, AND an inadequate response to both Androderm AND Androgel. Renewal Criteria: Reauthorizations are given for members who have been examined by the provider within the previous 14 months, have a positive response, and continue to require this medication. Coverage Duration: Approvals are given for three years. Tolmetin F NF 4/1/2017 Tolmetin has been removed from the formulary. VGo DS PA DS 1/1/2017 Coverage criteria have been removed. V Go is a wearable insulin delivery device used with insulin, covered as a diabetic supply.