Appendix A: International Classification of Diseases, 10th Revision, Clinical Modification Codes (ICD-10) Utilized for VTE Events

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Online Appendices to Mahan et al. External validation of a risk assessment model for venous thromboembolism in the hospitalised acutely-ill medical patient (VTE-VALOURR) (Thromb Haemost 2014; 112.4) Appendix A: International Classification of Diseases, 10th Revision, Clinical Modification Codes (ICD-10) Utilized for VTE Events ICD-10 Code I26 Pulmonary embolism I26.9 Pulmonary embolism without mention of acute cor pulmonale I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities I80.1 Phlebitis and thrombophlebitis of femoral vein I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities Deep vein thrombosis NOS I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified Embolism or thrombosis of lower extremity NOS I80.8 Phlebitis and thrombophlebitis of other sites I80.9 Phlebitis and thrombophlebitis of unspecified site I82.1 Thrombophlebitis migrans I82.8 Embolism and thrombosis of other specified veins I82.9 Embolism and thrombosis of unspecified vein 1

Appendix B: Exclusion Diagnoses Codes at Index Hospitalization ICD-10 Diagnosis Code Pregnancy O00.0 O99.8 Atrial Fibrillation and Flutter I48 Mental disorder F00.0 F99.0 S00.0 S99.9, T00.0-T07.0, T08.0 T14.9, T15.0 T 19.9, T20.0 T 32.9, T33.0 T 35.7, T36.0 - T45.4, T45.6 - T50.9, T51.0 T65.9, T66.0 78.9, T80.0 - T80.9, T81.1 - T88.9, Trauma, acute spinal cord injury T79.0 - T79.9, T90.0- T90.9, T91.0 T91.9, T92.0 T92.9, T93.0-T93.9, T94.0 T94.1, T95.0 T95.9, T97.0, T98.0, T98.2, V0.1.0 V99.9, W00.0 W99.9, X40.0, X41.0, X42.0, X43.0, X45.0 X99.0, Y10.0 Y36.9, Y85.0 Y89.9 2

Appendix C: Codes for Exclusionary Surgeries and Procedures within three months or during index hospitalization Operations on the nervous system Operations on the Sympathetic Nerves, Brachial Plexus, Phrenic Nerve, and Vagus Nerves Operations on the head and neck Operations on the upper arm, elbow, forearm, hand and wrist Operations on the Musculoskeletal system of the head, nasal cavity and sinuses Operations on the eye Other miscellaneous diagnostic and therapeutic procedures Operations on the ear CCI Procedure Code 1.AA.52.^^ - 1.AA.87.^^, 1.AB.52.^^ - 1.AB.87.^^, 1.AC.50.^^ - 1.AC.87.^^, 1.AE.09.^^, 1.AE.53.^^ - 1.AE.87.^^, 1.AF.52.^^ - 1.AF.87.^^, 1.AG.52.^^ - 1.AG.87.^^, 1.AJ.53.^^ - 1.AN.26.^^, 1.AN.52.^^ 1.AP.09.^^, 1.AP.52.^^ - 1.AW.09.^^, 1.AW.59.^^ - 1.AX.11.^^, 1.AX.16.^^, 1.AX.52.^^ - 1.AZ.94.^^, 1.BA.09.^^, 1.BA.53.^^ - 1.BA.87.^^, 1.BS.09.^^, 1.BS.11.^^, 1.BS.58.^^ - 1.BT.11.^^, 1.BT.58.^^ - 1.BX.11.^^, 1.BX.53.^^ - 1.BZ.94.^^ 1.BF.59.^^ - 1.BG.11.^^, 1BG.72.^^ - 1.BJ.09.^^, 1.BJ.53.^^ - 1.BK.09.^^, 1.BK.59.^^ 1.BB.11.^^, 1.BB.53.^^ 1.BB.87.^^, 1.BM.11.^^, 1.BM.58.^^ - 1.BQ.87.^^ 1.EA.55.^^ - 1EF.80.^^, 1.EG.74.^^ - 1.EL.05.^^, 1.EL.52.^^ - 1.EP.09.^^, 1.EP.58.^^ - 1.EQ.12.^^, 1.EQ.14.^^ - 1.EQ.26.^^, 1.EQ.52.^^ - 1.ET.03.^^, 1.ET.37.^^ - 1.EX.87.^^, 1.EY.52.^^ - 1.FD.12.^^, 1.FD.14.^^, 1.FD.52.^^ - 1.FE.29.^^, 1.FE.37.^^ - 1.FE.94.^^, 1.FF.53.^^ - 1.FF.89.^^, 1.FG.26.^^, 1.FG.52.^^ - 1.FH.87.^^, 1.FJ.26.^^, 1.FJ.52.^^ - 1.FM.91.^^, 1.FN.50.^^ - 1.FP.26.^^, 1.FP.53.^^ - 1.FQ.89.^^, 1.FR.52.^^ - 1.FR.89.^^, 1.FU.52.^^ - 1.FX.11.^^, 1.FX.26.^^, 1.FX.52.^^ - 1.FX.91.^^ 1.CC.07.^^ - 1.CD.87.^^, 1.CE.55.^^ - 1.CH.87.^^, 1.CJ.52.^^ - 1.CL.89.^^, 1.CM.59.^^ - 1.CN.12.^^, 1.CN.52.^^ - 1.CP.91.^^, 1.CQ.59.^^ - 1.CQ.87.^^, 1.CR.80.^^ - 1.CR.87.^^, 1.CS.52.^^ - 1.CS.87.^^, 1.CT.51.^^ - 1.CU.12.^^, 1.CU.50.^^ - 1.CX.14.^^, 1.CX.52.^^ - 1.CZ.26.^^, 1.CZ.37.^^ - 1.CZ.94.^^ 1.ZZ.71.^^, 2.AA.71.^^, 2.AC.70.^^ - 2.AC.71.^^, 2.AE.71.^^, 2.AF.70.^^ - 2.AF.71.^^, 2.AG.71.^^, 2.AJ.71.^^,2.AK.71.^^, 2.AN.71.^^, 2.AP.71.^^, 2.AW.71.^^, 2.AX.70.^^, 2.BA.70.^^ - 2.BA.71.^^, 2.BB.70.^^ - 2.BB.71.^^, 2.BD.70.^^ - 2.BD.71.^^, 2.BF.70.^^ - 2.BF.71.^^, 2.BG.70.^^ - 2.BG.71.^^, 2.BL.70.^^ - 2.BL.71.^^ 1.BD.11.^^, 1.BD.58.^^ - 1.BD.87.^^, 1.BD.59.^^ - 1.BD.87.^^, 1.DA.14.^^, 1.DA.52.^^ - 1.DE.14.^^, 1.DE.52.^^ - 1.DG.84.^^, 1.DJ.50.^^ - 1.DZ.94.^^ 3

Operations on the respiratory system Operations on the cardiovascular system Operations on the hemic and lymphatic system Operations on the digestive system Operations on the genito-urinary system Operations on the male genital organs 1.GA.50.^^ - 1.GC.59.^^, 1.GD.53.^^ - 1.GD.89.^^, 1.GE.37.^^ - 1.GH.84.^^, 1.GJ.26.^^, 1.GJ.50.^^ - 1.GJ.59.^^, 1.GJ.80.^^ - 1.GM.07.^^, 1.GM.26.^^, 1.GM.50.^^, 1.GR.58.^^ - 1.GR.91.^^, 1.GT.58.^^ - 1.GT.91.^^, 1.GW.59.^^ 1.GW.87.^^, 1.GX.80.^^ - 1.GX.87.^^ 1.HJ.76.^^ - 1.HZ.03.^^, 1.HZ.57.^^ - 1.IF.83.^^, 1.IJ.57.^^ - 1.IN.87.^^, 1.IS.57.^^ - 1.IS.87.^^, 1.JD.59.^^ - 1.KT.87.^^, 1.KV.54.^^ - 1.KV.80.^^, 1.KY.50.^^ - 1.LD.84.^^, 1.LZ.37.^^ - 1.LZ.38.^^ 1.MB.87.^^, 1.MC.87.^^ - 1.MC.91.^^, 1.MD.87.^^ - 1.MD.89.^^, 1.ME.87.^^ - 1.ME.89.^^, 1.MF.87.^^, 1.MG.87.^^ - 1.MG.89.^^, 1.MH.87.^^ - 1.MH.89.^^,1.MJ.87.^^ - 1.MJ.91.^^, 1.MK.87.^^ - 1.MK.89.^^, 1.ML.59.^^ - 1.MN.51.^^, 1.MN.59.^^ - 1.MN.87.^^, 1.MP.50.^^ - 1.MP.51.^^, 1.MP.59.^^ - 1.MP.87.^^, 1.MR.50.^^ - 1.MR.51.^^, 1.MR.59.^^ - 1.MR.91.^^, 1.MS.50.^^ - 1.MS.51.^^, 1.MS.59.^^ - 1.MS.91.^^, 1.MZ.94.^^ 1.NA.56.^^ - 1.NA.92.^^, 1.NE.50.^^ - 1.NE.80.^^, 1.NF.59.^^ - 1.NF.92.^^, 1.NK.56.^^ - 1.NK.87.^^, 1.NM.56.^^ - 1.NM.91.^^, 1.NP.58.^^ - 1.NP.86.^^, 1.NQ.56.^^ - 1.NQ.89.^^, 1.NT.56.^^ - 1.NT.87.^^, 1.OA.56.^^ - 1.OA.87.^^, 1.OB.59.^^ - 1.OB.89.^^, 1.OD.52.^^ - 1.OD.89.^^, 1.OE.37.^^ - 1.OE.89.^^, 1.OJ.26.^^, 1.OJ.52.^^ - 1.OK.91.^^, 1.OT.38.^^ - 1.OW.89.^^, 1.OZ.94.^^ 1.PB.52.^^ - 1.PB.89.^^, 1.PC.51.^^ - 1.PC.91.^^,1.PE.50.^^ - 1.PC.87.^^, 1.PG.50.^^ - 1.PG.89.^^, 1.PL.53.^^ - 1.PM.11.^^, 1.PM.26.^^, 1.PM.53.^^ - 1.PM.92.^^, 1.PQ.53.^^ - 1.PQ.89.^^, 1.PV.50.^^ - 1.PV.80.^^, 1.QE.26.^^, 1.QE.52.^^ - 1.QE.89.^^, 1.QG.26.^^, 1.QG.52.^^ - 1.QJ.89.^^, 1.QM.52.^^ - 1.QQ.89.^^, 1.QT.26.^^, 1.QT.50.^^ - 1.QZ.94.^^ 4

Operations on the female genital organs Operations on the musculoskeletal system Operations on the integumentary system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

Appendix D: Codes for Inclusion in the VTE and Control Cohorts at Discharge Date ICD-10-CM Diagnosis Code Heart failure I11.0, I13.0, I13.2, I50.0 I 50.9 Thromboembolic stroke I63.0 I63.9, I64, I69.3 Cancer C15.0 D0.9.9 Severe lung Disease Acute infection Rheumatic inflammatory disease J40.0 J95.0, J95.4 -J99.8 A00.0 A99.9, B00.0 B19.9, B25.0 - B99.9, J00.0 J22.9, L00.0 L08.9, M00.0 M01.8, M63.0 M63.8, I00.0 I02.9, I05.0 to I09.9, Inflammatory bowel disease K50.0 K52.9 Diabetes mellitus, pancreatitis, and cholecystitis E10 E14, K81.0 K 81.9, K85.0 K85.9, K86.0 K86.1 6

Appendix E: Logistic regression models adjusting for any or appropriate use of thromboprophylaxis. Parameter Estimate Standard Error Wald Chi-Square Pr > ChiSq AUC Model 1 0.7856 Intercept -2.6534 0.2872 85.3694 <.0001 score 0.7400 0.0905 66.8321 <.0001 VTE prophylaxis 0.5621 0.2460 5.2194 0.0223 Model 2 0.7727 Intercept -2.4589 0.2899 71.9589 <.0001 score 0.7507 0.0899 69.6760 <.0001 Appropriate VTE prophylaxis 0.2094 0.2430 0.7427 0.3888 Model 3 0.7731 Intercept -2.3170 0.2347 97.4954 <.0001 score 0.7442 0.0894 69.2757 <.0001 7

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