page 1 CURRENT WORK PLAN New monographs for inclusion in The International Pharmacopoeia and revision of related monographs 2011 The following categories are included in this work programme: 1. Medicines used in HIV/AIDS treatment (antiretrovirals - ARVs) 2. Medicines used in malaria treatment 3. Medicines used in TB treatment 4. Anti-infectives (antibacterials, antiprotozoal, antifungal, antiviral, and antimycobacterial agents, anthelmintics) 5. Oral rehydration therapy 6. Other medicines (other antivirals, analgesics, antipyretics, palliative care agents, anti-epileptics, large volume parenterals, reproductive health, vitamins, cytotoxic agents, insulins) Entries highlighted in red correspond to new additions. Where a draft monograph has already been provided to the Secretariat for discussion, this is indicated by means of the symbol *.
page 2 1. Medicines used in HIV/AIDS treatment (antiretrovirals - ARVs) : Atazanavir : Emtricitabine oral solution Ritonavir capsules Ritonavir oral solution Stavudine powder for oral solution Zidovudine tablets Atazanavir capsules Fixed-dose combinations (FDC): Tenofovir and lamivudine tablets Tenofovir, efavirenz and lamivudine tablets Atazanavir and ritonavir tablets Lamivudine and abacavir tablets Lamivudine, abacavir and nevirapine tablets Lopinavir and ritonavir capsules Lopinavir and ritonavir oral solution Lamivudine and stavudine tablets Lamivudine, stavudine and nevirapine tablets, as available for: Lamivudine + Zidovudine + Efavirenz** ** to confirm with the Disease Programme
page 3 2. Medicines used in Malaria treatment Piperaquine phosphate Artesunate rectal capsules Fixed-dose combinations (FDC): Artemether and lumefantrine capsules Artemether and lumefantrine dispersible tablets Artesunate and amodiaquine tablets Dihydroartemisinin and piperaquine phosphate tablets Revision Artemisinin derivatives ( and dosage forms) (see http://www.who.int/medicines/publications/pharmacopoeia/mon_mal/en/index.html)
page 4 3. Medicines used in Tuberculosis (TB) treatment : Moxifloxacin p-aminosalicylic acid Terizidone : Moxifloxacin tablets/capsules Ethambutol oral liquid Pyrazinamide oral syrup p-aminosalicylic acid granules Ethionamide tablets/capsules Protionamide tablets Terizidone tablets/capsules
page 5 4. Anti-infectives (antibacterials, antiprotozoals, antifungals, antivirals, anthelminthics and antimycobacterial agents) Azithromycin Aciclovir Cefixime Rifabutin Ceftriaxone sodium Fluconazole Ivermectin Azithromycin capsules Azithromycin oral liquid Sulfadiazine tablets Clindamycin capsules Clindamycin injection Clindamycin oral liquid Aciclovir tablets Aciclovir powder for injection Aciclovir oral liquid Spectinomycin powder for injection Cefixime capsules Rifabutin capsules Albendazole chewable tablets Ceftriaxone injection Doxycycline dispersible tablets Fluconazole capsules Fluconazole injection Fluconazole oral solution/suspension Ivermectin tablets Pyrantel chewable tablets* Pyrantel oral solution* Pyrimethamine tablets Fixed-dose combinations (FDC): Sulfamethoxazole and trimethoprim injection Sulfamethoxazole and trimethoprim oral solution/suspension
page 6 5. Oral rehydration therapy Zinc acetate Zinc gluconate Paediatric zinc acetate tablets Paediatric zinc acetate oral solution Paediatric zinc gluconate oral solution Paediatric zinc gluconate tablets
page 7 6. Other medicines (other antivirals, analgesics, antipyretics, palliative care agents, anti-epileptics, LVPs 1, reproductive health, vitamins, cytotoxic agents, insulins) Morphine oral solution Paediatric Retinol oral solution Antiepileptics Carbamazepine oral liquid Carbamazepine chewable tablets Phenobarbital oral liquid Phenytoin oral liquid Phenytoin chewable tablets Valproic acid oral liquid Valproic acid crushable tablets Large volume parenterals Glucose intravenous infusion Sodium chloride intravenous infusion Sodium chloride and glucose intravenous infusion Reproductive health Mifepristone Misoprostol Norgestrel Mifepristone tablets Misoprostol tablets Norgestrel tablets Norethisterone tablets Norethisterone injection Note from Secretariat: used in co-blisters with Misoprostol tablets Ethinylestradiol + levonorgestrel tablets Medroxyprogesterone acetate (DMPA), depot injection 1 LVPs: Large Volume Parenterals
page 8 Cytotoxic medicines Bleomycin powder for injection Etoposide capsules Vinblastine powder for injection Vincristine powder for injection Calcium folinate tablets Calcium folinate injection Insulins Insulin, human Insulin, bovine Insulin, porcine Insulin preparations - General monograph Insulin injection (soluble) Insulin zinc suspension Isophane insulin injection Insulin zinc suspension (amorphous)** Insulin zinc suspension (crystalline)** Biphasic insulin injection** Biphasic isophane insulin injection ** Protamine zinc insulin injection** ** to confirm with the Disease Programme ***