ARTERIAL STIFFNESS ASSESSMENT COMMENTS:

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ARTERIAL STIFFNESS ASSESSMENT 10% Low small artery stiffness risk. However, we detect mild vasoconstriction in small artery. No large arterial stiffness has been detected. High Blood Pressure & Arterial Stiffness BLOOD PRESSURE PULSE VOLUME ANALYSIS CASP (Unit of measure: mmhg) Central Aortic Systolic Pressure is an important marker of hypertension treatment management. Peripheral AIx (Unit of measure: %) Peripheral Augmentation Index is commonly accepted as a measure of aortic arterial stiffness and central aortic. 93 mmhg 123 BORDERLINE 125 AB 48 % 75 BORDERLINE 99 AB LEFT bapwv (Unit of measure: cm/s) 104 cm/s Left Brachial Ankle Pulse Wave Velocity (PWV) is used clinically as a measure of lower extremity arterial stiffness. 1550 1800 BORDERLINE AB RIGHT bapwv (Unit of measure: cm/s) Right Brachial Ankle Pulse Wave Velocity (PWV) is used clinically as a measure of lower extremity arterial stiffness. 118 cm/s 1550 BORDERLINE 1800 AB Page 1 of 6

PERIPHERAL ARTERY DISEASE ASSESSMENT 30% Ankle Brachial Indices are in normal range. Peripheral Artery Disease ANKLE BRACHIAL INDEX LEFT ABI (Unit of measure: ratio) Left Ankle Brachial Index (ABI) is used clinically as a marker of peripheral artery disease (PAD). AB 0.9 BORDERLINE 1.0 1.3 1.4 NC RIGHT ABI (Unit of measure: ratio) Right Ankle Brachial Index (ABI) is used clinically as a marker of peripheral artery disease (PAD). LEFT PVV (Unit of measure: ml/min) Left Ankle Pulse Volume Velocity represents the return of the blood volume over time after occlusion. RIGHT PVV (Unit of measure: ml/min) Right Ankle Pulse Volume Velocity represents the return of the blood volume over time after occlusion. AB 0.9 BORDERLINE 1.0 1.4 NC 82 ml/min AB 80 BORDERLINE 120 94 ml/min 1.3 AB 80 BORDERLINE 120 Page 2 of 6

SUDOMOTOR FUNCTION ASSESSMENT 85% Small Fiber Neuropathy 10% Skin Microcirculatory Disorder Moderate microcirculation disorder in left foot. Treating the underlying condition or lifestyle change as well as lab tests (Vitamin B 12: Folate test) are suggested. Low sudomotor response in both feet. Moderate decrease in C-Fiber density. In case of symptom, the patient should be referred to a Neurologist for further examination and treatment option. GALVANIC SKIN RESPONSE & METABOREFLEX LF PEAK CF (Unit of measure: mv) Marker of left foot sweat output response related to the C-Fiber density. RF PEAK CF (Unit of measure: mv) Marker of right foot sweat output response related to the C-Fiber density. LF PEAK M (Unit of measure: mv) Marker of left foot sweat output response related to the skin microcirculation. RF PEAK M (Unit of measure: mv) Marker of right foot sweat output response related to the skin microcirculation. 640 mv AB 768 BORDERLINE 1000 666 mv AB 768 BORDERLINE 1000 558 mv AB 576 BORDERLINE 832 580 mv AB 576 BORDERLINE 832 Page 3 of 6

AUTONOMIC REGULATION ASSESSMENT 70% Total Power is reduced. Increased physical activity as well as 25-hydroxyvitamin D test are suggested. Mild reduction of VO2 Max. Possibility of mild exercise intolerance. Moderately reduced parasympathetic function at rest. Mild mental stress has been detected. Autonomic Dysregulation HEART RATE VARIABILITY TOTAL POWER (Unit of measure: ms2) Total Power is maker of the overall ANS activity at rest. HF (Unit of measure: ms2) HF is a marker of the parasympathetic activity at rest. LF/HF (Unit of measure: ratio) LF/HF is a marker of mental stress. SDANN (Unit of measure: ms) SDANN is a marker of both sympathetic and parasympathetic. AB 500 BORDERLINE 780 132 ms2 AB 150 BORDERLINE 220 2.1 647 ms2 2 BORDERLINE 3.5 AB 30 AB 25 BORDERLINE 40 Page 4 of 6

CARDIAC AUTONOMIC NEUROPATHY ASSESSMENT 65% Mild cardiovagal failure has been detected. Mild impairment of cardiovagal regulation. Moderate impairment in cardiovagal innervation response. Cardiac Autonomic Neuropathy CARDIAC AUTONOMIC REFLEX TESTS VALSALVA RATIO (Unit of measure: ratio) Marker of baroreceptor sensitivity response. E/I RATIO (Unit of measure: ratio) Expiration/Inspiration Ratio is a marker of cardiovagal response. K3015 RATIO (Unit of measure: ratio) Heart rate change during standing at 30 and 15 second. AB 1.15 BORDERLINE 1.18 1.0 AB 1.12 BORDERLINE 1.15 1.0 1.2 AB 1.02 BORDERLINE 1.05 SPRS (Unit of measure: mmhg) Systolic Pressure Response to Standing is a marker of sympathetic adrenergic function. -5 mmhg 10 BORDERLINE 29 AB Page 5 of 6

CARDIOMETABOLIC RISK ASSESSMENT HEART DISEASE RISK ASSESSMENT 70% 30% Cardiometabolic Risk Score Heart Disease Risk Score DIABETES MARKERS HEART DISEASE MARKERS Systolic Pressure 113 mmhg PTGi 4 V/s Diastolic Pressure 64 mmhg PTGVLFi 94.5 m2/µs Reflection Index 15 % CASP 86 mmhg LF/HF 1.3 Pulse Pressure 49 mmhg PTGTP 213 ms2 bapvw 980 cm2/s Stress Index 45 % ABI 1.2 Total Power 4792 ms2 CAN Score 0 Sweat Baseline 1036 mv Fat Mass 15.9 % No heart disease risk has been detected. Mild metabolic syndrome has been detected. Page 6 of 6