"Immunooncology 2018 and beyond" supported by Bristol-Myers Squibb

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Tuesday, 15 May 2018 08:00-09:30 Foyer Registration and Welcome Coffee 09:30-10:00 Congress Hall Welcome Address CIMT President Christoph Huber 09:30-10:00 10:00-11:30 Congress Hall Cellular Therapy Chair: Michael Kalos (The Janssen Pharmaceutical Companies, Spring House, PA, United States) Chair: Harpreet Singh (Immatics Biotechnologies, Houston, United States) New modes of T-cell cancer recognition by dissection of immunotherapy successes Speaker: Andrew Sewell (Cardiff University, Cardiff, United Kingdom) ADAPting to solid tumors, advances and challenges for TCR T-cell therapy Speaker: Gwen Binder-Scholl (Adaptimmune, Philadelphia, United States) TIL therapy in melanoma: history of clinical development, current status and plans for the future Speaker: Rodabe Amaria (University of Texas MD Anderson Cancer Center, Houston, United States) 10:00-10:30 10:30-11:00 11:00-11:30 11:30-13:30 Foyer Lunch Corporate Supported Symposium 12:00-13:00 Congress Hall "Immunooncology 2018 and beyond" supported by Bristol-Myers Squibb Chair: Dirk Jäger (National Center for Tumor Diseases, Heidelberg, Germany) Page 1 / 6

Immunooncology from mono- to combination therapy - a clinical perspective Speaker: Viktor Grünwald (Hanover, Germany) Resistance to Immunotherapy Speaker: Guy Ungerechts (National Center for Tumor Diseases, Heidelberg, Germany) Biomarkers in Immunooncology - can we predict the outcome of therapy? Speaker: Andreas Jung (Ludwig-Maximilians-Universität, Munich, Germany) 12:00-12:20 12:20-12:40 12:40-13:00 13:30-15:00 Congress Hall Counteracting Immune Escape Chair: Cornelis Melief (ISA Pharmaceuticals, Leiden, Netherlands) Chair: Thorbald van Hall (Leiden University Medical Center, Leiden, Netherlands) TNFR family members and cancer immunotherapy: lessons from chronic infection Speaker: Tania Watts (University of Toronto, Toronto, Canada) title of talk to be announced Speaker: Melody Swartz (University of Chicago, Chicago, United States) Regulation of dendritic cells in tumors Speaker: Jan P. Böttcher (Technical University Munich, Munich, Germany) 13:30-14:00 14:00-14:30 14:30-15:00 15:00-16:00 Foyer Coffee Poster Session 15:00-18:00 East and West Foyers Poster Session I 18:00-19:00 Congress Hall Keynote Lecture Chair: Christoph Huber (CIMT, Mainz, Germany) Highly multiplex 2D and 3D imaging of the immune system and tumors Speaker: Ronald Germain (NIAD, NIH, Bethesda, United States) 18:00-19:00 Page 2 / 6

Wednesday, 16 May 2018 08:00-09:30 Congress Hall Tumor Microenvironment Chair: Viktor Umansky (German Cancer Research Center DKFZ, Heidelberg, Germany) Potent and durable tumor immunity induced by ADU-S100, a first-in-class STING agonist Speaker: Andrea van Elsas (Aduro Biotech, Oss, Netherlands) The Ying and Yang of TAM: Macrophages as effector cells for cytotoxic antibodies in vivo Speaker: Falk Nimmerjahn (Friedrich-Alexander-University, Erlangen, Germany) Myelopoiesis and cancer: "Flipping" over monocytes into immune suppressive cells Speaker: Vincenzo Bronte (University of Verona, Verona, Italy) 08:00-08:30 08:30-09:00 09:00-09:30 09:30-10:00 Foyer Coffee Short Talk Session 10:00-11:30 Gutenberg Hall Short Talk Session I, II, III 11:30-14:00 Foyer Lunch 12:00-13:30 Congress Hall CAR T-Cell Therapy organized by CARAT Chimeric antigen receptor T cells: advances in cellular engineering and clinical development Speaker: Bruce Levine (University of Pennsylvania, Philadelphia, United States) 'T-cell engineering for cancer applications Speaker: Martin Pule (University College London, London, United Kingdom) Cell therapy between academic research and company driven drug development Speaker: Peter Borchmann (University Hospital of Cologne, Cologne, Germany) 12:00-12:30 12:30-13:00 13:00-13:30 Page 3 / 6

14:00-15:30 Congress Hall Combination Therapies Chair: Sjoerd H. van der Burg (Leiden Univesrity Medical Center, Leiden, Netherlands) Chair: Dirk Jäger (National Center for Tumor Diseases, Heidelberg, Germany) Stromal Activation in Cancer Immunology and Immunotherapy Speaker: Shannon Turley (Genentech, San Francisco, United States) Mechanistic insights into the immune adjuvant effect of radiotherapy Speaker: Sandra Demaria (Weill Cornell Medicine, New York, United States) The Anti-TGFβ Neutralizing Antibody, SAR439459, Blocks Immunosuppression and Exhibits Anti-tumor Activity in Combination with anti-pd1 Speaker: Jack Pollard (Sanofi Oncology, Cambridge, United States) 14:00-14:30 14:30-15:00 15:00-15:30 15:30-16:30 Foyer Coffee Poster Session 15:30-18:30 East and West Foyers Poster Session II CIMT Members Meeting 17:30-19:00 Dijon Room General Members Assembly of the Association for Cancer Immunotherapy CIMT 19:30-24:00 Foyer Social Event & Poster Award Ceremony Page 4 / 6

Thursday, 17 May 2018 08:30-10:00 Congress Hall Immunoguiding Chair: Marij J.P. Welters (Leiden University Medical Center, Leiden, Netherlands) Chair: Sine Reker Hadrup (Technical University of Denmark, Copenhagen, Denmark) Reprogramming the tumor microenvironment for efficient cancer immunotherapy Speaker: Günter J. Hämmerling (German Cancer Research Center DKFZ, Heidelberg, Germany) Complement in cancer: untangling an intricate relationship Speaker: Dimitrios Mastellos (National Center for Scientific Research 'Demokritos', Athens, Greece) Lung cancer evolution and immune escape Speaker: Nicholas McGranahan (Cancer Research UK Lung Cancer Centre of Excellence, London, United Kingdom) 08:30-09:00 09:00-09:30 09:30-10:00 10:00-10:30 Foyer Coffee 10:30-12:30 Congress Hall Regulatory Research organized by CIMT-RRG and CARAT Chair: Ulrich Kalinke (TWINCORE, Hanover, Germany) Chair: Christian Buchholz (Paul-Ehrlich-Institut, Langen, Germany) Chimeric antigen receptor (CAT) modified T cells - EU regulatory considerations Speaker: Martina Schüssler-Lenz (Committee for Advanced Therapies (CAT), European Medicines Agency, London, United Kingdom) Translation of CAR-based innovations into clinics: how to overcome the regulatory hurdles Speaker: Bernd Schröder (Miltenyi Biotech, Teterow, Germany) From Karl Landsteiner to CAR-T Cells: from processes to products and patients Speaker: Martin Hildebrandt (Technical University Munich, Munich, Germany) 10:30-11:10 11:10-11:50 11:50-12:30 Short Talk Session 10:30-13:00 Gutenberg Hall Short Talk Session IV, V, VI, VII Page 5 / 6

Powered by TCPDF (www.tcpdf.org) 13:00-14:00 Foyer Lunch 14:00-15:30 Congress Hall Therapeutic Vaccination Dendritic cell-based vaccination against cancer Speaker: Jolanda de Vries (Radboud University, Nijmegen, Netherlands) Personalized RNA vaccines Speaker: Özlem Türeci (German Cluster of Individualized Immunointervention (CI3), Mainz, Germany) Therapeutic cancer vaccine for combination with immune checkpoint blockade therapy: formulation matters Speaker: Yared Hailemichael (MD Anderson Cancer Center, Houston, United States) 14:00-14:30 14:30-15:00 15:00-15:30 Page 6 / 6