M. Pharm. (Pharmacognosy & Phytochemistry) TERMINOLOGY:- S MEANS SEMESTER. MPN MEANS MASTER OF PHARMACOGNOSY & PHYTOCHEMISTRY. L MEANS LECTURE. T MEANS TUTORIAL. P MEANS PRACTICAL. Hours/week Marks Semester Second Subject code Subject L T P Mid Sem. Exam. Assign. / Quiz T. A. End Sem. Exam. Total S2-MPN-1P Research Project (P) 00 00 16 40 00 10 100 150 S2-MPN-2 Advances In Pharmacognosy & Phytochemistry -I 03 01 00 30 10 10 100 150 S2-MPN-2P S2-MPN-3 Advances In Pharmacognosy & Phytochemistry I (P) Advances In Pharmacognosy & Phytochemistry - II 00 00 08 30 10 10 100 150 03 01 00 30 10 10 100 150 S2-MPN-4 Elective 1 03 01 00 30 10 10 100 150 Total 09 03 24 160 40 50 500 750 1
Name of the Course : Research Project (P) Course code: S2-MPN-1 P Duration : 120 Hrs Maximum Marks : 150 Practical : 16 Hrs/week Mid Semester Exam: 40Marks Assignment & Quiz: 00Marks T. A. : 10 Marks End Semester Exam: 100Marks Name of the Course : Advances In Pharmacognosy & Phytochemistry - I Course code: S2-MPN-2 Duration : 40 Hrs Maximum Marks : 150 Theory : 03 Hrs/week Mid Semester Exam: 30 Marks Tutorial: 01 Hrs/week Unit -1 Assignment & Quiz:10 Marks T. A.: 10 Marks End Semester Exam: 100 Marks Content Chemotaxonomy: Significance in classification of medicinal plants, distribution of chemotaxonomic groups of constituents in plant kingdom like alkaloids, glycosides and terpenoids. Hrs 07 Unit -2 Unit -3 Unit -4 Unit -5 Unit -6 Biogenetic pathways for the production of phytopharmaceuticals, such as cardiac glycosides,coumarins, flavones, menthol, nicotinic acid, quinidine, papaverine and ergocryptine. Industrially important volatile oils: Natural occurrence, their chemistry, ontogenic variation and trade. Application of UV, IR, NMR, 1 HNMR, 13 CNMR and Mass spectroscopy for structural elucidation of phytosterols, flavonoids and terpenoids. Recent advances in the field of Pharmacognosy and Phytochemistry with special reference to anticancer, antidiabetic, anti-inflammatory, hepatoprotective, adaptogenic and immunomodulators, memory enhancers, antiviral agents and antihyperlipidemics. Marine Pharmacognosy: Definition, present status, classification of important bioactive agents, general methods of isolation and purification, study of important bioactive agents, chemistry and uses. 07 05 06 07 03 2
Unit -7 Nutraceuticals: Global market prospects and study of five important 03 plants and their products in the international market. Unit-8 Poisonous and toxic plants with special reference to mushrooms. 02 Total 40 Text Books: It is strongly recommended that some standard book/s be used for practicals. The choice of book/s is left to the concerned teachers. Reference books : 1. W.C. Evans, 2002. Trease& Evan s Pharmacognosy. WB.Saunders& co., London. 2. T. Swain, 1963. Chemical plant Taxonomy. Academic Press, London. 3. C.A Stace, 1985. Plant Taxonomy and Biosystematics. Edward Arnold, London. 4. C.K. Atal, Cultivation and Utilization of Medicinal plants. R.R.L. Jammu 5. H.E. Street, 1997. Plant Cell and Tissue Culture. Blackwell Scientific, London. 6. N. Takashashi, 1986. Chemistry of Plant Hormones CRC Press Inc., Florida. 7. A.R. Gennaro, 2000. Remington: The Science & Practice of Pharmacy. Lippincott Williams & Wilkins, Philadelphia. 8. Kaufmann, Natural products for plants. CRC press New York. 9. K. Nakanishi, 1977. Chemistry of Natural Products. Kodansha Book Publishing Company, Osaka (Japan). 3
Name of the Course : Advances In Pharmacognosy & Phytochemistry I (P) Course code: S2-MPN-2P Duration : 120 Hrs Maximum Marks : 150 Practical : 08 Hrs/week Mid Semester Exam:30 Marks Assignment & Quiz:10 Marks T. A.: 10 Marks End Semester Exam: 100 Marks Suggested List of Laboratory Experiments : 1. Isolation of Rutin from Rutagraveolens 2. Hesperidin from Orange peel 3. Aloin from Aloes 4. Rhein from rhizome of Rheum species 5. piperine from piper nigrum 6. Quinine from Cinchona bark 7. berberine from Berberisaristata 8. Caffeine from Tea leaves 9. Menthol from Mentha species 10. Diosgenin from Dioscorea and Trigonella species. Determination of Antharacene derivatives insenna by spectrophotometric method (Fair Buarian 1975) 11. Reserpine in Rauwolfia by photometric method 12. Carvone content of Umbelliferous fruits 13. Citral content in Lemon grass oil 14. Bitter principles of Chirata 15. Solanaceous drugs 16. Tropane alkaloids using Vitali Morin reaction 17. quantitative estimation of Saponin as per W.H.O. protocol in suitable plant material 18. Resin content in sample of podophyllum by B.P.C. method 19. Optical rotation of oil of Lemon 20. Acid value of Colophony resin by B.P. method. Antimicrobial activity of some volatile oils. 21. Examination of Rhubarb for the presence of Rhapontic Rhubarb by the use of paper chromatography and ultraviolet light. 4
Name of the Course : Advances In Pharmacognosy & Phytochemistry II (Standardization and Evaluation of Natural Product Drugs and Formulations) Course code: S2-MPN-3 Duration : 40 Hrs Maximum Marks : 150 Theory : 03 Hrs/week Mid Semester Exam:30 Marks Tutorial: 01 Hrs/week Unit-1 Unit-2 Unit-3 Unit-4 Unit-5 Unit-6 Unit-7 Assignment & Quiz: 10 Marks T. A.: 10 Marks End Semester Exam: 100Marks Content Introduction: Factors affecting quality of crude drugs, methods for documentation and preservation of crude drugs and their products, detection of common adulterants, microbial contamination, toxic metals, pesticides, insecticides and insect infestation in whole and powdered drugs. Standardization requirements of herbal medicines, traditional and folklore remedies and preparations: their quality, safety and efficacy assessment. Importance of monographs of medicinal plants, their comparative study as per IP, API, Unani, Pharmacopoeia, Homoeopathic Pharmacopoeia, Siddha Pharmacopoeia, BHP, Japanese Pharmacopoeia, Chinese Pharmacopoeia, European Pharmacopoeia, USP (dietary supplements), WHO and EMEA guidelines and ESCOP monographs for medicinal products. Quantitative assays to determine extraction efficiency: general methods of analysis: estimation of alkaloids, steroids, terpenoids and flavonoids: active component analysis and purity determination using UV, GLC, HPTLC and electrophoretic methods. Quality control of single and multicomponent plant drugs and plantderived classical Ayurvedic and Unani formulations by study of HPTLC and HPLC fingerprints. Natural products-derived combinatorial libraries and their significance in drug discovery programs. Shelf life study, protocols to study stabilization of herbal based products. Assessment of physical, physic-chemical and chemical parameters at different stages. Bioavailability and pharmacokinetic significance for herbal drugs with examples of clinically used herbal drugs. Hrs 06 Unit-8 Preparation of DMF for herbal medicines. 02 Unit-9 Patents: IPR and Regulatory Affairs related to plants and plant products. 05 07 06 05 03 04 02 Total 40 5
Text Books: It is strongly recommended that some standard book/s be used for practicals. The choice of book/s is left to the concerned teachers. Reference books : 1. Indian Herbal Pharmacopoeia, Vol. 1&2, RRL, IDMA, 1998, 2000. 2. Indian Pharmacopoeia, 2010. 3. V. Rajpal, 2002. Standardization of Botanicals, Eastern Publishers, New Delhi. 4. J.B. Harborne, 1998. Phytochemical methods, Chapman and Hall. 5. K. Paech, 1956. Modern methods of plant analysis., Springer-Verlag. 6
Name of the Course : Elective - 1 Course code: S2-MPN-4 Duration : 40 Hrs Maximum Marks : 150 Theory : 03 Hrs/week Mid Semester Exam: 20Marks Tutorial: 01 Hrs/week Assignment & Quiz:10 Marks T. A.: 10 Marks NOTE: Students have to choose either PART A or PART B. Unit-1 Unit-2 Unit-3 Unit-4 Unit-5 Unit-6 Unit-1 Unit-2 Unit-3 Unit-4 Unit-5 Unit-6 Content PART - A General methods of processing of herbs. Methods of preparation of extracts. Isolation and estimation of Phytoconstituents. Herbal formulation development. Quality assurance of Herbal formulations End Semester Exam: 100 Marks Biological evaluation of Herbal drugs Total 40 PART B Scope of plant cultivation, factors affecting quality of plant and animal drugs. Substitution and adulteration of crude drugs. WHO guidelines on good agricultural and collection practices (GACP) for medicinal plants. Problems and recent trends in pest management, scope of biological control and use of environment friendly pesticides especially plant derived products, Pyrethroids, pheromones and juvenile hormones. Text Books: N A GMP for the production of quality botanicals. Herbal cosmetics for skin, hair and dental care. Determination of shelf life of raw drugs, powered drugs, extracts, fractions and finished products. Global regulatory status of herbal medicines, patents. Hrs Total 40 7
References: Herbal Drug Industry by R. D. Choudhary. 1 st Edition, Eastern Publisher, New Delhi, 1996. GMP for Botanicals Regulatory and Quality issues on Phytomedicine Business horizons, New Delhi, 1 st Edition, 2003, Robert Verpoorte, Pulok K Mukharjee. Herbal Cosmetics H. Pande, Asia Pacific Business press, New Delhi. H. Pande, The complete technology book on herbal perfumes and cosmetics, National Institute of Industrial Research, Delhi. Quality control of herbal drugs by Pulok K Mukarjee, 1 st edition, Business horizons pharmaceuticals publisher, New Delhi, 2002. PDR for herbal medicines, 2 nd Edition, Medicinal economic company, New Jersey, 2000. Indian Herbal Pharmacopoeia, Volume 1 st & 2 nd, RRL,LDMA. Text book of Pharmacognosy by C. K. Kokate, Purohit, Gokhlae, 4 th Edition, Nirali Prakashan, 1996. Text book of Pharmacognosy and Phytochemistry by Rangare. Plant drug Analysis, 2 nd edition by Wagner, Bladt. Biological standardization by J. N. Barn, D. J. finley and L. G. Good win. 8