Molecular Oncology molecular oncology services ATIENTS.ANSWERS.RESULTS. www.aruplab.com/oncology MARCH 2018 Information in this brochure is current as of March 2018. All content is subject to change. lease contact ARU Client Services at (800) 522-2787 with any questions or concerns.
ARU LABORATORIES As a nonprofit, academic institution of the University of Utah and its Department of athology, ARU believes in collaborating, sharing knowledge, and contributing to laboratory science in ways that benefit our clients and their patients. Our test menu is one of the broadest in the industry, encompassing more than 3,000 tests, including highly specialized and esoteric assays. We offer comprehensive testing in the areas of genetics, molecular oncology, pediatrics, and pain management, among others. ARU s clients include many of the nation s university teaching hospitals and children s hospitals, as well as multihospital groups, major commercial laboratories, and group purchasing organizations. We do not compete with our clients for physician office business, choosing instead to support clients existing test menus by offering highly complex assays and accompanying consultative support so clients can provide exceptional patient care in their local communities. Offering analytics, consulting, and decision support services, ARU provides clients with the utilization management tools necessary to prosper in this time of value-based care. Our UM+ program helps clients control utilization, reduce costs, and improve patient care. In addition, ARU is a worldwide leader in innovative laboratory research and development, led by the efforts of the ARU Institute for Clinical and Experimental athology. ARU s reputation for quality is supported by our ability to meet or exceed the requirements of multiple regulatory and accrediting agencies and organizations. ARU participates in the CA laboratory accreditation program and has CLIA certification through the Centers of Medicare and Medicaid Services. In December 2016, ARU earned accreditation to the ISO 15189:2012 standard under CA. We believe in collaborating, sharing knowledge, and contributing to laboratory science in ways that provide the best value for the patient. Together, ARU and its clients will improve patient care today and in the future. patients. answers. results. A laboratory test is more than a number; it is a person, an answer, a diagnosis............................................
ARU LABORATORIES MOLECULAR ONCOLOGY SERVICES Molecular diagnostics is an important component of clinical oncology, supplying pertinent information for diagnosis, prognosis, and prediction of response to tailored chemotherapeutic agents. ARU Laboratories offers a wide range of molecular diagnostic tests designed to answer important clinical questions regarding diagnosis, prognosis, and pharmacogenetics. Using state-of-the-art methodologies, including fluorescence in situ hybridization (FISH), polymerase chain reaction (CR), and next-generation sequencing analysis, ARU Laboratories supplies pertinent clinical information for a variety of cancers. This brochure has been organized into two sections: 1 Test Categories, which includes diagnostic markers, pharmacogenetic markers, and prognostic markers 2 Diagnostic Categories/Tumor ARU Laboratories is committed to supplying high-quality molecular diagnostic testing in a timely fashion and will continuously expand its test menu as new procedures and markers of clinical utility are identified.
TEST CATEGORIES Diagnostic Markers 2008604 1p/19q Deletion by FISH 2002647 Acute Lymphocytic Leukemia anel by FISH, Adult, BM 2002719 Acute Lymphocytic Leukemia anel by FISH, ediatric, BM 2011132 Acute Myeloid Leukemia anel by FISH, BM 2002653 Acute Myelogenous Leukemia (AML) with Myelodysplastic Syndrome (MDS) or Therapy- Related AML by FISH 2012710 Aggressive B-Cell Lymphoma FISH Reflex, Tissue 2006102 ALK Gene Rearrangements by FISH, Lung, BM 2006193 B-Cell Clonality Screening (IgH and IgK) by CR, BM, FF 2010107 BCL6 (3q27) Gene Rearrangement by FISH BCL6 Rearrangement (3q27), BM BCR-ABL1 Fusion t(9;22)(q34;q11.2) by FISH, BM 2005017 BCR-ABL1 Major (p210),, BM 2005016 BCR-ABL1 Minor (p190),, BM 2005010 BCR-ABL1, Qualitative with Reflex to BCR-ABL1,, BM MALT1 (18q21) gene rearrangement by FISH, BM 2002498 0051750 BRAF Codon 600 Mutation Detection by yrosequencing BRAF Codon 600 Mutation Detection with Reflex to MLH1 romoter Methylation 2002378 Eosinophilia anel by FISH, BM ETV6-RUNX1 (TEL-AML1) Fusion, t(12;21)(p13;q22) by FISH EWSR1 (22q12) Rearrangement by FISH + 2007225 EWSR1 (22q12) Gene Rearrangement by FISH 2004863 Familial Adenomatous olyposis (AC) 2004915 2001961 Familial Adenomatous olyposis anel: AC, (AC) and Deletion/, (MUTYH) 2 Mutations Familial Mutation, Target (HNCC/ Lynch Syndrome) FOXO1 (FKHR) (13q13) Gene Rearrangement by FISH + 2001497 2013449 FOXO1 (FKHR) (13q14) Gene Rearrangement by FISH Gastrointestinal Hereditary Cancer anel, and, 16 Genes 2002674 Gastrointestinal Stromal Tumor Mutation 2010757 2007167 2007108 Hereditary Cancer anel,, 36 Genes Hereditary araganglioma-heochromocytoma (SDHB, SDHC, and SDHD) and Deletion/ anel Hereditary araganglioma-heochromocytoma (SDHB) and, BM 2007132 BRAF V600E Mutation Detection in Hairy Cell Leukemia by Real-Time CR,, BM 2007117 Hereditary araganglioma-heochromocytoma (SDHC) and 2010673 CALR (Calreticulin) Exon 9 Mutation Analysis by CR, BM 2007122 Hereditary araganglioma-heochromocytoma (SDHD) and CBFB Rearrangement inv(16)(p13.3q22) by FISH, BM 2011114 CBFB-MYH11 inv(16) Detection,, BM 0051650 HNCC/Lynch Syndrome (MLH1) and 2010188 Central Nervous System Hereditary Cancer anel, and, 15 Genes 0051654 HNCC/Lynch Syndrome (MSH2) and 2002292 Chromosone Analysis, Bone Marrow BM 2002300 Chromosome Analysis, Lymph Node + 0051656 HNCC/Lynch Syndrome (MSH6) and 2002290 Chromosome Analysis, Leukemic Blood 2002296 Chromosone Analysis, Solid Tumor + 0051737 HNCC/Lynch Syndrome (MS2) and 2010229 Cytogenomic Molecular Inversion robe Array, FFE Tissue Oncology 2001728 HNCC/Lynch Syndrome MLH1, MSH2, MSH6, or MS2 2006325 Cytogenomic SN Microarray, Oncology, BM DDIT3 (CHO) (12q13) Gene Rearrangement by FISH 2007223 DDIT3 (CHO) (12q13) Gene Rearrangement by FISH +, T 2002440 EGFR Mutation Detection by yrosequencing, FNA 2010193 Endocrine Hereditary Cancer anel, and, 13 Genes Hyperdiploidy with Trisomy 4 and 10 for ediatric ALL, BM IGH Rearrangement 14q32, BM 2001536 IGH-BCL2 Fusion, t(14;18) by FISH IGH-BCL2 Fusion, t(14;18)(q32;q21) by FISH, BM 2007226 IGH-CCND1 Fusion, t(11;14) by FISH IGH-CCND1 Fusion, t(11;14)(q13;q32) by FISH, BM + Fresh tissue, unfixed specimen. Use test code to order and specify probe. BM bone marrow FF fresh frozen tissue For more on ARU Molecular Oncology, please visit
TEST CATEGORIES Diagnostic Markers, continued 2001538 IGH-MYC Fusion, t(8;14) by FISH 2002357 JAK2 Exon 12 Mutation Analysis by CR, BM 0051245 JAK2 Gene, V617F Mutation, Qualitative, BM 2012085 2012084 JAK2 Gene, V617F Mutation, Qualitative with Reflex to JAK2 Exon 12 Mutation Analysis by CR JAK2 Gene, V617F Mutation, Qualitative with Reflex to CALR (Calreticulin) Exon 9 Mutation Analysis by CR with Reflex to ML codon 515 Mutation Detection by yrosequencing, 0040168 JAK2 Gene, V617F Mutation, 0051510 Juvenile olyposis (SMAD4) 2001971 Juvenile olyposis (SMAD4) and, BM, BM 2004988 Juvenile olyposis Syndrome (BMR1A) 2004992 Juvenile olyposis Syndrome (BMR1A) and 0040137 KIT (D816V) Mutation by CR 2002437 KIT Mutations in AML by Fragment Analysis and 2002695 KIT Mutations, Melanoma 2009302 Li-Fraumeni (T53) 2009313 2010209 Li-Fraumeni (T53) and Deletion/ Melanoma Hereditary Cancer anel, and, 6 Genes 2009310 MGMT Methylation Detection by CR 0051740 Microsatellite Instability (MSI), HNCC/Lynch Syndrome by CR, BM,, FF, BM 2009318 MYD88 L265 Mutation Detection by CR,, BM, 2002528 ancreatobiliary FISH VARIES 2010102 CA3 rostate Cancer Biomarker UR DGFRA Rearrangement 4q12 by FISH, BM DGFRB Rearrangement 5q33.1 by FISH, BM 2002871 ML-RARA Translocation, t(15;17) by RT-CR, 2002363 ML-RARA Translocation by FISH BM 2002722 TEN-Related Disorders (TEN) 2002470 2010214 2010138 TEN-Related Disorders (TEN) and Renal Hereditary Cancer anel, and, 15 Genes RUNX1-RUNX1T1 (AML1-ETO) Fusion, t(8;21) (q22;q22) by FISH RUNX1-RUNX1T1 (AML1-ETO) t(8;21) Detection, 2007222 SS18 (SYT) (18q11) Gene Rearrangement by FISH, BM, BM, BM SS18 (SYT) Rearrangement by FISH +, T 0055567 T-Cell Clonality Screening by CR, BM, FF, TCF3 (E2A) Rearrangement 19p13 by FISH, BM 2001181 UroVysion FISH UR 2002970 von Hippel-Lindau (VHL) 2002965 von Hippel-Lindau (VHL) and Deletion/ 2002499 MLH1 romoter Methylation, araffin 2005545 ML Codon 515 Mutation Detection by yrosequencing, 2005359 Multiple Endocrine Neoplasia (MEN1) 2005360 0051390 Multiple Endocrine Neoplasia (MEN1) and Multiple Endocrine Neoplasia 2 (MEN2), RET Gene Mutations by 2004911 MUTYH-Associated olyposis (MUTYH) 2 Mutations 2006307 MUTYH-Associated olyposis (MUTYH) 2 Mutations with Reflex to 2006191 MUTYH-Associated olyposis (MUTYH) 2002345 MYC (8q24) Gene Rearrangement by FISH MYC Rearrangement 8q24 by FISH, BM 2007227 MYCN (N-MYC) Gene Rearrangement by FISH FNA FNA smear paraffinized tissue L plasma T touch prep whole blood UR urine www.aruplab.com/oncology
TEST CATEGORIES harmacogenetic and Targeted Therapy Markers 2007228 5-Fluorouracil (5-FU) Toxicity and Chemotherapeutic Response, 7 Mutations 0040137 KIT (D816V) Mutation by CR, BM,, FF 2006102 ALK Gene Rearrangements by FISH, Lung BCR-ABL1 Fusion, t(9;22)(q34;q11.2) by FISH + 2002695 KIT Mutations, Melanoma 0040248 KRAS Mutation Detection 2008420 BCR-ABL1 Mutation Analysis by Next-Generation, BM 2001932 KRAS Mutation Detection with Reflex to BRAF Codon 600 Mutation Detection 2013921 BRAF V600E Mutation Detection in Circulating Tumor DNA by Digital Droplet CR 2008894 Lung Cancer anel 2008895 Lung Cancer anel with KRAS 2011616 Colon Cancer Gene anel, Somatic 0051104 Cytochrome 450 2C19 (CY2C19) 9 Mutations 0055655 Methylenetetrahydrofolate Reductase (MTHFR) 2 Mutations 0051103 Cytochrome 450 2C9 (CY2C9) 2 Mutations 2003123 NRAS Mutation Detection by yrosequencing 2014547 Cytochrome 450 2D6 (CY2D6) 15 Variants and Gene DGFRA by FISH, BM DGFRB by FISH, BM 2002440 EGFR Mutation Detection by yrosequencing, FNA 2002363 ML-RARA Translocation by FISH, BM 2012868 EGFR T790M Mutation Detection in Circulating Tumor DNA by Digital Droplet CR 2002871 ML-RARA Translocation, t(15;17) by RT-CR,, BM 2008603 ERBB2 (HER-2/neu) Gene Amplification by FISH 2007991 Solid Tumor Mutation anel by Next-Generation, FNA 2014683 LeukoStrat CDx FLT3 Mutation Detection by CR, BM 2002674 Gastrointestinal Stromal Tumor Mutation 0051332 UD-Glucuronosyltransferase 1A1 (UGT1A1) Genotyping rognostic Markers 2012710 Aggressive B-Cell Lymphoma FISH Reflex, Tissue BCR-ABL1 Fusion, t(9;22)(q34;q11.2) by FISH, BM 2012032 Cancer anel, Hereditary, and, 47 Genes 2008420 BCR-ABL1 Mutation Analysis by Next-Generation, BM CBFB Rearrangement inv(16)(p13.3q22) by FISH, BM 2011114 CBFB-MYH11 inv(16) Detection,, BM 2005017 BCR-ABL1 Major (p210),, BM 2005016 BCR-ABL1 Minor (p190),, BM 2004247 CEBA Mutation Detection, BM 2002295 Chronic Lymphocytic Leukemia (CLL) anel by FISH, BM 2005010 BCR-ABL1 Qualitative with Reflex to BCR-ABL1, BM 2008605 EGFR Gene Amplification by FISH 2002440 EGFR Mutation Detection by yrosequencing, FNA 2011954 2011949 Breast and Ovarian Hereditary Cancer Syndrome (BRCA1 and BRCA2) Breast and Ovarian Hereditary Cancer Syndrome (BRCA1 and BRCA2) and Deletion/ 2002378 Eosinophilia anel by FISH, BM 2004863 ETV6-RUNX1 (TEL-AML1) Fusion, t(12;21)(p13;q22) by FISH Familial Adenomatous olyposis (AC), BM 2012026 Breast and Ovarian Hereditary Cancer anel, and, 20 Genes 2010673 CALR (Calreticulin) Exon 9 Mutation Analysis by CR, BM 2004915 Familial Adenomatous olyposis anel: (AC) and, (MUTYH) 2 Mutations + Fresh tissue, unfixed specimen. Use test code to order and specify probe. BM bone marrow FF fresh frozen tissue For more on ARU Molecular Oncology, please visit
TEST CATEGORIES rognostic Markers, continued 2001961 Familial Mutation, Targeted (HNCC/ Lynch Syndrome) 2006307 MUTYH-Associated olyposis (MUTYH) 2 Mutations with Reflex to 2007167 Hereditary araganglioma-heochromocytoma (SDHB, SDHC, and SDHD) and Deletion/ anel 2006191 MUTYH-Associated olyposis (MUTYH) 2004911 MUTYH-Associated olyposis (MUTYH) 2 Mutations 2002709 Myelodysplastic Syndrome (MDS) anel by FISH BM, 2007108 2007117 Hereditary araganglioma-heochromocytoma (SDHB) and Hereditary araganglioma-heochromocytoma (SDHC) and 3000066 NM1 Mutation Detection by RT-CR,, BM, 2010102 CA3 rostate Cancer Biomarker by Transcription-Mediated Amplification 2002363 ML-RARα FISH, BM UR 2007122 Hereditary araganglioma-heochromocytoma (SDHD) and 2002871 ML-RARA Translocation, t(15;17) by RT-CR,, BM 0051650 HNCC/Lynch Syndrome (MLH1) and RUNX1-RUNX1T1 (AML1-ETO) Fusion, t(8;21) (q22;q22) by FISH, BM 0051654 HNCC/Lynch Syndrome (MSH2) and 2010138 RUNX1-RUNX1T1 (AML1-ETO) t(8;21) Detection,, BM 0051656 HNCC/Lynch Syndrome (MSH6) and TCF3 (E2A) Rearrangement, BM 2005766 WT1 Mutations by, BM 0051737 HNCC/Lynch Syndrome (MS2) and 2006444 IDH1 and IDH2 Mutation Analysis, Exon 4, BM 2014188 IDH1 and IDH2 Mutation Analysis, Exon 4, Formalin-Fixed, araffin-embedded (FFE) Tissue 0040227 IGHV Mutation Analysis by, BM 2002437 KIT Mutations in AML by Fragment Analysis and, BM 2014683 LeukoStrat CDx FLT3 Mutation Detection by CR, BM 2009302 Li-Fraumeni (T53) 2009313 Li-Fraumeni (T53) and Deletion/ 2013082 MET Gene Amplification by FISH 0051740 Microsatellite Instability (MSI), HNCC/Lynch Syndrome by CR MLL Rearrangement 11q23 by FISH, BM 2005359 Multiple Endocrine Neoplasia (MEN1) 2005360 0051390 Multiple Endocrine Neoplasia (MEN1) and Multiple Endocrine Neoplasia 2 (MEN2), RET Gene Mutations by 2002294 Multiple Myeloma anel by FISH, BM FNA FNA smear paraffinized tissue L plasma T touch prep whole blood UR urine www.aruplab.com/oncology
Alveolar Rhabdomyosarcoma FKHR (FOX01) 13q13 by FISH + 2001497 FOXO1 (FKHR) (13q14) Gene Rearrangement by FISH Bladder Cancer (Urothelial Carcinoma) 2001181 UroVysion FISH UR Breast Cancer (Breast Carcinoma) 2011954 2011949 Breast and Ovarian Hereditary Cancer Syndrome (BRCA1 and BRCA2) Breast and Ovarian Hereditary Cancer Syndrome (BRCA1 and BRCA2) and Deletion/ DIAGNOSTIC CATEGORIES/TUMOR TYE 0051650 0051654 0051656 0051737 2001728 HNCC/Lynch Syndrome (MLH1) and HNCC/Lynch Syndrome (MSH2) and HNCC/Lynch Syndrome (MSH6) and HNCC/Lynch Syndrome (MS2) and HNCC/Lynch Syndrome MLH1, MSH2, MSH6, or MS2 0051510 Juvenile olyposis (SMAD4) 2012026 Breast and Ovarian Hereditary Cancer anel, and, 20 Genes 2001971 Juvenile olyposis (SMAD4) and 2008603 ERBB2 (HER-2/neu) Gene Amplification by FISH 2002722 TEN-Related Disorders (TEN) 2002470 TEN-Related Disorders (TEN) and 2009302 Li-Fraumeni (T53) 2009313 Li-Fraumeni (T53) and Deletion/ 2008394 eutz-jeghers Syndrome (STK11) 2008398 2007228 2002498 2013921 0051750 2010757 2012032 eutz-jeghers Syndrome (STK11) and Colon Cancer (Colonic Adenocarcinoma) 5-Fluorouracil (5-FU) Toxicity and Chemotherapeutic Response, 7 Mutations BRAF Codon 600 Mutation Detection by yrosequencing BRAF V600E Mutation Detection in Circulating Tumor DNA by Digital Droplet CR BRAF Codon 600 Mutation Detection with Reflex to MLH1 romoter Methylation Cancer anel, Hereditary,, 46 Genes Cancer anel, Hereditary, and, 47 Genes 2011616 Colon Cancer Gene anel, Somatic 2013906 Epi procolon 2004863 Familial Adenomatous olyposis (AC) 2004915 2001961 2013449 Familial Adenomatous olyposis anel: (AC) and, (MUTYH) 2 Mutations Familial Mutation, Targeted (HNCC/ Lynch Syndrome) Gastrointestinal Hereditary Cancer anel, and, 16 genes 2004988 Juvenile olyposis Syndrome (BMR1A) 2004992 Juvenile olyposis Syndrome (BMR1A) and 0040248 KRAS Mutation Detection 2001932 KRAS Mutation Detection with Reflex to BRAF Codon 600 Mutation Detection 2009302 Li-Fraumeni (T53) 2009313 0051740 2002327 Li-Fraumeni (T53) and Deletion/ Microsatellite Instability (MSI), HNCC/Lynch Syndrome by CR Mismatch Repair by IHC with Reflex to BRAF Codon 600 Mutation and MLH1 romoter Methylation 2002499 MLH1 romoter Methylation, araffin 2006307 MUTYH-Associated olyposis (MUTYH) 2 Mutations with Reflex to 2006191 MUTYH-Associated olyposis (MUTYH) 2004911 MUTYH-Associated olyposis (MUTYH) 2 Mutations 2003123 NRAS Mutation Detection by yrosequencing 2008394 eutz-jeghers Syndrome (STK11) 2008398 2007991 0051332 2010188 eutz-jeghers Syndrome (STK11) and Solid Tumor Mutation anel by Next-Generation UD-Glucuronosyltransferase 1A1 (UGT1A1) Genotyping, FNA CNS/ Renal Cell Carcinoma/ heochromocytoma Central Nervous System Hereditary Cancer anel, and, 15 Genes 2002970 von Hippel-Lindau (VHL) 2002965 von Hippel-Lindau (VHL) and Deletion/ + Fresh tissue, unfixed specimen. Use test code to order and specify probe. BM bone marrow FF fresh frozen tissue For more on ARU Molecular Oncology, please visit
2005270 Endometrial Carcinoma Mismatch Repair by IHC with Reflex to MLH1 romoter Methylation Ewing Sarcoma 2007225 EWSR1 (22q12) Gene Rearrangement by FISH EWSR1 Rearrangement by FISH + Gastrointestinal Stromal Tumor (GIST) 2002674 Gastrointestinal Stromal Tumor Mutation DIAGNOSTIC CATEGORIES/TUMOR TYE Neuroblastoma 2007227 MYCN (N-Myc) Gene Amplification by FISH Oligodendroglioma 2008604 1p/19q Deletion by FISH araganglioma/heochromocytoma 2007167 Hereditary araganglioma-heochromocytoma (SDHB, SDHC, and SDHD) and Deletion/ anel 2007991 Solid Tumor Mutation anel by Next-Generation Glioblastoma 2008605 EGFR Gene Amplification by FISH 2002440 EGFR Mutation Detection by yrosequencing, FNA 2014188 IDH1 and IDH2 Mutation Analysis, Exon 4 2009310 MGMT Methylation Detection by CR Lung Carcinoma 2006102 ALK Gene Rearrangements by FISH, Lung 2002498 BRAF Codon 600 Mutation Detection by yrosequencing 2007108 2007117 2007122 Hereditary araganglioma-heochromocytoma (SDHB) and Hereditary araganglioma-heochromocytoma (SDHC) and Hereditary araganglioma-heochromocytoma (SDHD) and arathyroid/ituitary/ancreatic 2005359 Multiple Endocrine Neoplasia (MEN1) 2005360 Multiple Endocrine Neoplasia (MEN1) and Round Cell/Myxoid Liposarcoma 2013921 BRAF V600E Mutation Detection in Circulating Tumor DNA by Digital Droplet CR DDIT3 (CHO) (12q13) Gene Rearrangement by FISH TOUCH RE, + 2002440 EGFR Mutation Detection by yrosequencing, FNA 2012868 EGFR T790M Mutation Detection in Circulating Tumor DNA by Digital Droplet CR 0040248 KRAS Mutation Detection 2008894 Lung Cancer anel 2008895 Lung Cancer anel with KRAS 2013082 MET Gene Amplification by FISH 2012654 RET Gene Rearrangements by FISH 2008418 ROS1 by FISH 2007991 Solid Tumor Mutation anel by Next-Generation Melanoma, FNA 2007223 DDIT3 (CHO) (12q13) Gene Rearrangement by FISH 2003016 MDM2 Gene Amplification by FISH Synovial Sarcoma 2007222 SS18 (SYT) (18q11) Gene Rearrangement by FISH Systemic Mastocytosis 0040137 KIT (D816V) Mutation by CR 2002498 2013921 Thyroid Carcinoma BRAF Codon 600 Mutation Detection by yrosequencing BRAF V600E Mutation Detection in Circulating Tumor DNA by Digital Droplet CR, BM, FF, 2002498 BRAF Codon 600 Mutation Detection by yrosequencing 0051390 Multiple Endocrine Neoplasia 2 (MEN2), RET Gene Mutations by 2013921 2010757 BRAF V600E Mutation Detection in Circulating Tumor DNA by Digital Droplet CR Cancer anel, Hereditary,, 46 Genes 2012654 RET Gene Rearrangements by FISH 2007991 Solid Tumor Mutation anel by Next-Generation, FNA 2002695 KIT Mutations, Melanoma 2010209 Melanoma Hereditary Cancer anel, and, 6 Genes 2003123 NRAS Mutation Detection by yrosequencing 2007991 Solid Tumor Mutation anel by Next-Generation, FNA FNA FNA smear paraffinized tissue L plasma T touch prep whole blood UR urine www.aruplab.com/oncology
Acute Lymphoblastic Leukemia (ALL) 2002647 2002719 Acute Lymphocytic Leukemia (ALL) anel by FISH, Adult Acute Lymphocytic Leukemia (ALL) anel by FISH, ediatric LEUKEMIA/LYMHOMA BM, BM, BCR-ABL1 Fusion, t(9;22)(q34;q11.2) by FISH, BM 2005010 BCR-ABL1 Qualitative with Reflex to BCR-ABL1, BM 2005016 BCR-ABL1 Minor (p190),, BM 3000066 NM1 Mutation Detection by RT-CR, 2010138 RUNX1-RUNX1T1 (AML1-ETO) t(8;21) Detection, RUNX1-RUNX1T1 (AML1-ETO) Fusion, t(8;21) (q22;q22) by FISH, BM, FF,, BM, BM 2005766 WT1 Mutations by, BM Acute romyelocytic Leukemia (AL) 2002363 ML-RARA Translocation by FISH, BM 2008420 BCR-ABL1 Mutation Analysis by Next-Generation, BM CDKN2 p16 Deletion 9p21 by FISH, BM ML-RARA Translocation, t(15;17) by RT-CR, 2002871 B- and T-Cell Markers Lymphoma, BM 2007130 Chromosome Analysis, Bone Marrow with Reflex to Genomic Microarray BM 2006193 B-Cell Clonality Screening (IgH and IgK) by CR, BM, FF 2007131 Chromosome Analysis, Leukemic Blood with Reflex to Genomic Microarray 2009318 MYD88 L265 Mutation Detection by CR,, BM, 2006325 Cytogenomic SN Microarray Oncology BM, ETV6-RUNX1 (TEL-AML1) Fusion, t(12;21)(p13;q22) by FISH, BM Hyperdiploidy with Trisomy 4 and 10, BM IGH Rearrangement 14q32 by FISH, BM 0055655 Methylenetetrahydrofolate Reductase (MTHFR) 2 Mutations MLL Rearrangement 11q23 by FISH, BM TCF3 (E2A) Rearrangement 19p13 by FISH, BM Acute Myelogenous Leukemia (AML) 2011132 Acute Myeloid Leukemia anel by FISH, BM 2002653 Acute Myelogenous Leukemia (AML) with Myelodysplastic Syndrome (MDS) or Therapy- Related AML by FISH 2012222 Bone Marrow Failure, 35 Genes, BM CBFB Rearrangement inv(16)(p13.3q22) by FISH, BM 2011114 CBFB-MYH11 inv(16) Detection,, BM 2004247 CEBA Mutation Detection, BM 2007130 Chromosome Analysis, Bone Marrow with Reflex to Genomic Microarray 2006325 Cytogenomic SN Microarray Oncology BM, 2006444 IDH1 and IDH2 Mutation Analysis, Exon 4, BM 2002437 KIT Mutations in AML by Fragment Analysis and BM, BM 2014683 LeukoStrat CDx FLT3 Mutation Detection by CR, BM MLL Rearrangement 11q23 by FISH, BM 0055567 T-Cell Clonality Screening by CR Burkitt Lymphoma 2012710 Aggressive B-Cell Lymphoma FISH Reflex, Tissue 2010107 BCL6 (3q27) Gene Rearrangement by FISH 2001538 IGH-MYC Fusion t(8;14) by FISH 2002345 MYC (8q24) Gene Rearrangement by FISH, BM, FF, MYC Rearrangement 8q24 by FISH, BM Chronic Lymphocytic Leukemia (CLL) 2002295 Chronic Lymphocytic Leukemia (CLL) anel by FISH, BM 0040227 IGHV Mutation Analysis by, BM Chronic Myelogenous Leukemia (CML) BCR-ABL1 Fusion, t(9;22)(q34;q11.2) by FISH, BM 2008420 BCR-ABL1 Mutation Analysis by Next-Generation, BM 2005017 BCR-ABL1 Major (p210),, BM 2005016 BCR-ABL1 Minor (p190),, BM 2005010 0055655 BCR-ABL1 Qualitative with Reflex to BCR-ABL1 Methylenetetrahydrofolate Reductase (MTHFR) 2 Mutations Follicular Lymphoma/Diffuse Large-Cell Lymphoma 2012710 Aggressive B-Cell Lymphoma FISH Reflex, Tissue, BM BCL6 Rearrangement (3q27) by FISH, BM 2011117 2012182 Myeloid Malignancies anel by Next-Generation Myeloid Malignancies Somatic Mutation and Copy Number Analysis anel, BM, BM 2010107 BCL6 (3q27) Gene Rearrangement by FISH IGH-BCL2 Fusion, t(14;18)(q32;q21) by FISH, BM 2001536 IGH-BCL2 Fusion, t(14;18) by FISH + Fresh tissue, unfixed specimen. Use test code to order and specify probe. BM bone marrow FF fresh frozen tissue For more on ARU Molecular Oncology, please visit
Hairy Cell Leukemia LEUKEMIA/LYMHOMA Myeloproliferative Neoplasms (MN) BRAF V600E Mutation Detection in Hairy Cell 2007132 Leukemia by Real-Time CR, Lymphoproliferative Disorders (LD), BM 2002650 Lymphoma (Aggressive) anel by FISH BM, Trisomy 12 by FISH, BM Mantle Cell Non-Hodgkins Lymphoma IGH Rearrangement by FISH, BM 2007226 IGH-CCND1 Fusion, t(11;14) by FISH IGH-CCND1 Fusion, t(11;14)(q13;q32) by FISH, BM Marginal Zone B-Cell Lymphoma MALT1 (18q21) gene rearrangement by FISH BM, Multiple Myeloma 2002294 Multiple Myeloma anel by FISH BM, Myelodysplastic Syndrome (MDS) 20q Deletion (D20S108) del(20)(q12) by FISH, BM 5q Deletion (EGR1)/Monosomy 5 del(5)(q31)/-5 by FISH 7q Deletion (D7S486)/Monosomy 7 del(7)(q31)/-7 by FISH 2012222 Bone Marrow Failure, 35 Genes 2010229 Cytogenomic Molecular Inversion robe Array, FFE Tissue Oncology, BM, BM 2002709 Myelodysplastic Syndrome (MDS) anel by FISH BM, 2011117 2012182 Myeloid Malignancies anel by Next-Generation Myeloid Malignancies Somatic Mutation and Copy Number Analysis anel, BM, BM Trisomy 8 by FISH, BM 2010673 CALR (Calreticulin) Exon 9 Mutation Analysis by CR, BM 2002378 Eosinophilia anel by FISH, BM 2002357 JAK2 Exon 12 Mutation Analysis by CR BM, 0051245 JAK2 Gene, V617F Mutation, Qualitative BM, 0040168 JAK2 Gene, V617F Mutation, 2012085 2012084 2005545 2011117 2012182 JAK2 Gene, V617F Mutation, Qualitative with Reflex to JAK2 Exon 12 Mutation Analysis by CR JAK2 Gene, V617F Mutation, Qualitative with Reflex to CALR (Calreticulin) Exon 9 Mutation Analysis by CR with Reflex to ML codon 515 Mutation Detection by yrosequencing, ML Codon 515 Mutation Detection by yrosequencing, Myeloid Malignancies Mutation anel by Next Generation Myeloid Malignancies Somatic Mutation and Copy Number Analysis anel, BM, BM, BM, BM 2002360 Myeloproliferative Disorders anel by FISH BM, DGFRA-FI1L1 Fusion by FISH (CHIC2 Deletion), BM DGFRB Rearrangement 5q33.1 by FISH, BM Trisomy 8 by FISH, BM Trisomy 9 by FISH, BM rimary Effusion Lymphoma 2002902 Epstein-Barr Virus (EBV) by in situ Hybridization, araffin FNA FNA smear paraffinized tissue L plasma T touch prep whole blood UR urine www.aruplab.com/oncology
www.aruplab.com www.arupconsult.com ARU LABORATORIES 500 Chipeta Way Salt Lake City, UT 84108-1221 hone: (800) 522-2787 Fax: (801) 583-2712 www.aruplab.com ARU is a nonprofit enterprise of the University of Utah and its Department of athology. 2018 ARU Laboratories BD-TS-026, Rev 8, March 2018