Multiple Choice Questions - Paper 1 Instructions for candidates The examination consists of 30 multiple choice questions, each divided into 5 different parts. Each part contains a statement which could be true or false. Each question will have at least one part which is true. For each part, you should indicate whether you think it is true (T), false (F), or don t know (DN). You must fill in the relevant square with a black pen. One mark will be given for each correct answer and one mark deducted for each incorrect answer. You will not be marked for those questions for which you have indicated "don t know". 1. Viruses Contain both DNA and RNA May have an envelope Have their own metabolism May contain enzymes for replication Cell wall 2. The following are DNA viruses Herpesviruses Orthomyxoviruses Enteroviruses Hepadnaviruses Parvoviruses 3. The following are RNA viruses Picornaviruses Adenoviruses Papillomaviruses Rhabdoviruses Rotaviruses
4. Live attenuated vaccines are available against the following viruses Influenza A Virus Hepatitis B Virus Rubella Virus Yellow Fever Virus Varicella-Zoster Virus 5. The following antiviral agents is active against the following virus Lamivudine and HIV Lamivudine and HBV Amantidine and Influenza B virus Ribavirin and RSV Acyclovir and HSV 6. Herpes Simplex Encephalitis Commonly affect the temporal lobe Is usually diagnosed by culture of the CSF May be diagnosed by PCR of the CSF Should be treated with IV ganciclovir May be diagnosed by the finding of specific antibody in the CSF 7. The following statements are true of Varicella-Zoster Virus Causes a maculopapular rash Respond to AZT therapy Remains latent in sensory ganglia following primary infection
Recurrent episodes of Shingles usually occur Patients with shingles are not infectious 8. Cytomegalovirus (CMV) Primary infection is usually symptomatic An infectious mononucleosis-like syndrome may occur during primary infection. May cause severe infection in immunocompromised individuals Is teratogenic Causes Kawasaki's Disease 9. Epstein-Barr Virus (EBV) is associated with Infectious Mononucleosis Hepatitis Burkitt's lymphoma Nasopharyngeal carcinoma Oral leukoplakia 10. HHV-6 is associated with Fifth disease Roseala Infantum Kaposi's Sarcoma Infectious Mononucleosis-like illness Oral leukoplakia 11. Adenoviruses Are associated with genital cancers May cause gastroenteritis
May cause conjunctivitis May cause pneumonia May cause warts 12. Papillomaviruses HPV-6 and HPV-11 are associated with genital cancers HPV-16 and HPV-18 are associated with genital cancers Warts caused by papillomaviruses may respond to interferon therapy Papillomavirus infection is commonly diagnosed by viral culture Are associated with progressive multifocal leucoencephalopathy (PML) 13. Coxsackie B Virus is associated with the following Paralytic illness Myocarditis Bornholm's disease Severe congenital infection Meningitis 14. Influenza A Virus May undergo antigenic shift and antigenic drift May cause pandemics Respond to rimantidine Respond to neuraminidase inhibitors Vaccination confers lifelong protection 15. Paramyxoviruses may cause Croup
Maculopapular rash Pneumonia Bronchiolitis Diarrhoea 16. Respiratory Syncytial Virus (RSV) Respond to Amantidine May cause bronchiolitis May cause croup May cause pneumonia May be prevented by vaccination 17. Parvoviruses Causes Roseola Infantum Causes Erythema Infectiousum Is teratogenic May cause abortion May cause aplastic crisis in persons with haemolytic anaemias 18. Measles Virus Infection Causes a vesicular rash May cause encephalitis May respond to acyclovir May be prevented by HNIG May be prevented by vaccination
19. Rubella Virus The rash of rubella is similar to that caused by parvo and enteroviruses Is teratogenic Congenital rubella is charaterised by eye, ear and heart defects Congenital rubella is diagnosed by the finding of rubella-specific antibody in the cord blood of infants Infants with congenital rubella poses a great infectious risk. 20. Human T-lymphotropic virus 1 (HTLV-1) is associated with Burkitt's lymphoma Adult T-cell lymphoma Tropical Spastic Paraparesis Multiple Sclerosis Hodgkin's lymphoma 21. HIV Infection may lead to Dementia Chronic Diarrhoea CMV retinitis Oesophageal candidiasis Non-Hodgkin's lymphoma 22. The following may be useful for prognostic purposes in HIV-infected individuals HIV envelope antibody HIV-p24 antigen CD4 count
HIV pro-viral DNA in leucocytes HIV plasma RNA 23. A chronic carrier state may occur in the following: Hantavirus Infection Hepatitis A Hepatitis B Hepatitis C Smallpox Infection 24. The following markers are usually present in a hepatitis B carrier with chronic active h HbeAg Anti-HBc IgG Anti-HBc IgM HBV-DNA HbsAg 25. The following statements are true Chronic HBV infection may respond to interferon therapy Chronic HCV infection may respond to interferon therapy Chronic HCV infection may respond to ribavirin therapy Hepatitis Delta infection may be prevented by vaccination against HBV Hepatitis E Infection may be prevented by vaccination 26. The following viruses can be transmitted by blood Hepatitis A HIV
HTLV-1 HBV HCV 27. Regarding viral infection of the central nervous system (CNS) Meningitis may occur together with encephalitis Enteroviruses are one of the commonest causes of CNS infections in childhood HSV encephalitis is a postinfectious encephalomyelitis Measles encephalitis is a postinfectious encephalomyelitis The detection of antibody in the CSF is a useful diagnostic marker 28. The following viruses are associated with gastroenteritis Astroviruses Norwalk-like viruses Caliviruses Adenoviruses Rotaviruses 29. The following viruses are transmitted from animals to humans Rabies Virus Polioviruses CMV Hantaviruses Lassa Fever Virus 30. The following is true of rabies virus The majority of cases worldwide result from bat bites Infection may be prevented by active and passive immunisation
Rabies vaccine is a live attenuated vaccine The animal reservoir differ from country to country May be diagnosed by serology ال تنسونا من صاحل دعائكم