George F. Heinrich, M.D. SYMPOSIUM. Diabetes 2010: From Public Policy to Target Organs

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George F. Heinrich, M.D. SYMPOSIUM Diabetes 2010: From Public Policy to Target Organs Tuesday, November 30, 2010 8:00 a.m. to 11:30 a.m. The Lang Auditorium Presented by the Theresa and Eugene M. Lang Center for Research and Education CME credits offered For information call 718-670-2914

PREVIEW The annual George F. Heinrich, M.D., Symposium presents cutting-edge medical knowledge consistent with the mission of the Lang Research Center. The center promotes research in a community hospital setting to improve daily medical practice at the community level. This year s topic diabetes affects every physician because it affects so many people across all ages and ethnicities: 23.6 million children and adults in the United States have diabetes, almost 25% of whom are undiagnosed.* An additional 57 million have pre-diabetes. In 2007, there were 180,000 pregnancies in which gestational diabetes was diagnosed. Diabetes accounts for more than 25% of medical expenditures, more than $218 billion in 2007. Diabetes is significantly more prevalent in Asian-Americans, African-Americans, and Hispanic-Americans, ethnic groups represented in large numbers in the community. In this educational forum you will learn: How government policy is impacting diabetes research and treatment choices. Our keynote speaker is a physician with a national perspective on the development of health care policy and reform, and a special interest in translating controlled trials into community-based practice. New developments in the diagnosis and treatment of diabetes. specialists will bring you up to date on the impact of diabetes in four areas of special interest: brain function, pregnancy, vision, and obesity. The symposium provides up to 4.0 AMA PRA Category I credits (see page 4).There is no fee for attendance. * Centers for Disease Control and Prevention

KEYNOTE SPEAKER Robert E. Ratner, M.D., F.A.C.P., is Senior Research Scientist at the MedStar Health Research Institute, Hyattsville, Md. MedStar is a not-for-profit regional health care system serving the Baltimore- Washington area, with a network of nine hospitals and 20 other health-related businesses. In addition, Dr. Ratner is Professor of Medicine at Georgetown University School of Medicine, Washington, DC. He has also recently completed a sabbatical as a Robert Wood Johnson Foundation Fellow in Health Policy, having served as the study director for the Comparative Effectiveness Research Priorities Committee of the Institute of Medicine, and a program examiner for health reform in the Health Division of the U.S. Office of Management and Budget. He has extensive national-level experience with both the government and the American Diabetes Association. Most recently, he completed six years of service on the Steering Committee of the National Diabetes Education Program, a partnership of the National Institutes of Health, the Centers for Disease Control and Prevention, and more than 200 public and private organizations. Dr. Ratner earned his M.D. and served an internal medicine residency at Baylor College of Medicine in Houston. He also served a fellowship in endocrinology and metabolism at Harvard Medical School. He has received numerous grants and served as principal investigator for numerous national and international studies in diabetes. His research interests include diabetes therapeutics and complications with an emphasis on translational efforts from controlled trials into community-based practice. He is an associate editor of the Journal of Clinical Endocrinology & Metabolism and the author of more than 110 scientific articles and 20 book chapters.

PROGRAM 7:45 a.m.-8:15 a.m. Continental Breakfast 8:15 a.m.-8:30 a.m. Welcoming Remarks Stephen S. Mills, F.A.C.H.E. President and Chief Executive Officer Phyllis August, M.D., M.P.H. Theresa Lang Director Theresa and Eugene M. Lang Center for Research and Education George F. Heinrich, M.D. Chairman, Board of Trustees, Moderator Daniel Lorber, M.D., F.A.C.P., C.D.E. Associate Director Theresa and Eugene M. Lang Center for Research and Education Director of Endocrinology Department of Medicine Clinical Associate Professor of Medicine Weill Cornell Medical College 8:30 a.m.-9:15 a.m. Keynote National Health Reform: Its Impact on Diabetes and Public Health Policy Robert E. Ratner, M.D., F.A.C.P. Senior Research Scientist MedStar Research Institute Professor of Medicine Georgetown University Medical School This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Medical Society of the State of New York (MSSNY) through the joint sponsorship of New York Hospital Queens and the Theresa and Eugene M. Lang Center for Research and Education. New York Hospital Queens is accredited by the MSSNY to provide continuing medical education for physicians. New York Hospital Queens designates this educational activity for a maximum 4.0 AMA PRA Category 1 Credits. Physicians should claim credit commensurate with the extent of their participation in the activity.

Scientific Program 9:15 a.m.-9:45 a.m. TARGET: Brain Function Neuropsychiatric Manifestations of Diabetes Edward Chai, M.D. Director of Neurology and Director of Stroke Services Department of Medicine Clinical Associate Professor of Neurology Weill Cornell Medical College 9:45 a.m.-10:15 a.m. TARGET: Pregnancy Management of Diabetes in Pregnancy: State of the Art 2010 Daniel Skupski, M.D., F.A.C.O.G. Associate Chairman and Director of Maternal-Fetal Medicine Department of Obstetrics and Gynecology Professor of Obstetrics and Gynecology Weill Cornell Medical College 10:15 a.m.-10:45 a.m. TARGET:Vision Diabetic Retinopathy 2010: Latest Trends and Treatments Sangwoo Lee, M.D. Director of Ophthalmology Vitreoretinal Diseases and Surgery Department of Surgery Assistant Professor of Clinical Ophthalmology Weill Cornell Medical College 10:45 a.m.-11:15 a.m. TARGET: Obesity The Effect of Gastric Bypass on Glucose Metabolism Stephen Merola, M.D., F.A.C.S. Associate Chairman and Director of Minimally Invasive and Obesity Surgery Department of Surgery Assistant Professor of Clinical Surgery Weill Cornell Medical College 11:15 a.m. Wrap-up and Lunch

The Theresa and Eugene M. Lang Center for Research and Education Promoting Research in a Community Hospital Setting has taken a leadership position among community hospitals nationally by establishing a significant research capability in addition to its residency and fellowship programs. I think we are on the cutting edge of a new emphasis in research, says Phyllis August, M.D., Theresa Lang Director of the Lang Research Center, and that is conducting research in the community setting. Research activity has traditionally been centered in major academic centers, Dr. August notes, where the clinical problems are often rare and highly complex. They are frequently not generalizable to the majority of people suffering from common but serious illnesses. The community hospital is better suited to addressing the more common diseases such as diabetes, cancer, heart attack, stroke, kidney failure and hypertension, Dr. August continues. It makes sense to study these diseases where most patients will be treated. And studies performed in community hospitals are more likely to be applicable to the general population. The Lang Research Center offers a major program of consultation and support services for physicians and others who want to do research: Identifying research opportunities. Conducting statistical analyses. Assisting in the writing of grant applications. Securing research funding from outside sources, including government, industry and foundations. Preparing IRB protocols. Creating databases. We want to inspire and support our investigators to produce meaningful research at the highest level of quality, says Board Chairman George F. Heinrich, M.D., and to contribute to knowledge that results in better health.

Community hospitals are not typically perceived as environments conductive to scholarly pursuits, notes Dr. Heinrich, a long-term champion of having a research program at NewYork Hospital Queens. But what better location for research than the community in which the patients live and the hospital in which they are cared for? The Lang Research Center currently has 193 studies under way in a broad range of clinical areas including diabetes. Recent major studies in diabetes have included the following national trials sponsored by the National Institutes of Health: Action to Control Cardiovascular Risk in Diabetes (ACCORD). The research center was one of 77 participants in a landmark national study of the treatment of patients with Type 2 diabetes. This high-profile study examined the optimal strategies for preventing heart disease in individuals with Type 2 diabetes. More than 10,000 participants were recruited, including 62 from. Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Study. The research center was one of 49 participants in a multinational study of more than 2,000 patients that examined how to treat coronary artery disease in patients with Type 2 diabetes. Targeting Inflammation Using Salsalate for Type 2 Diabetes TINSAL-T2D. is participating in a multicenter clinical trial to test a new use for an old drug. Subjects will be randomly assigned to receive either salsalate (an anti-inflammatory agent related to aspirin) or placebo, in addition to their usual diabetes medication, to determine whether the addition of salsalate reduces inflammation and improves control of Type 2 diabetes. Subjects will be followed for two years and will receive expert diabetes management during the study. In addition to supporting investigations,the Lang Research Center also provides training programs for residents and fellows. Physicians-in-training learn research essentials, are mentored in conducting a project, and present their results at an annual Research Day judged by the center s Scientific Advisory Board.

GEORGE F. HEINRICH, M.D. Introduced by the Lang Research Center in 2009, the Heinrich Symposium honors Dr. George F. Heinrich for his extraordinary vision and leadership at every major turning point in the life of NewYork Hospital Queens. He has been a member of the Board of Trustees since 1986 and Chairman since 1994. In 1991, Dr. Heinrich negotiated the transfer of ownership of Booth Memorial Medical Center to The Society of The NewYork Hospital. Subsequently, he guided the medical center s academic and clinical affiliation with Weill Medical College of Cornell University, thereby strengthening and reconfiguring the center s medical education program as a model for community teaching hospitals across the country. In 1998, he provided the leadership for consolidating all existing clinical research activities and programs within the newly established Theresa and Eugene M. Lang Center for Research and Education. His vision and support have been vital to the success of the center, which has significantly expanded and enhanced the research efforts. Dr. Heinrich also plays an active role in the governance of the NewYork-Presbyterian Healthcare System and the Silvercrest Extended Care Facility. In addition, he and his wife, Debra, are members of the Advisory Board of Rockefeller University. Dr. Heinrich is the Associate Dean for Admissions and Adjunct Associate Professor in the Department of Preventive Medicine and Community Health at the New Jersey Medical School. In addition, he is a member of the board of the Foundation of the University of Medicine and Dentistry of New Jersey. He is also President of the Eye Institute of New Jersey.

The Theresa and Eugene M. Lang Center for Research and Education Promoting research in a commuity health setting PHYLLIS AUGUST, M.D., M.P.H. DIRECTOR KAREN HULTBERG ADMINISTRATOR DANIEL LORBER, M.D. ASSOCIATE DIRECTOR SCIENTIFIC ADVISORY BOARD OLAKUNLE O. AKINBOBOYE, M.D., F.A.C.C. ATTENDING, CARDIOLOGY DIVISION PHYLLIS AUGUST, M.D., M.P.H. THERESA LANG DIRECTOR, LANG RESEARCH CENTER TERENCE M. BRADY, M.D. F.C.C.P. ASSOCIATE DIRECTOR, CRITICAL CARE CHAIM CHARYTAN, M.D., F.A.C.P. CHIEF, RENAL DIVISION AND MEDICAL DIRECTOR, DIALYSIS UNITS GARY S. EGLINTON, M.D., F.A.C.O.G. CHAIRMAN, OBSTETRICS AND GYNECOLOGY KAREN S. KARSIF, M.D., F.A.C.S. DIRECTOR, THE BREAST CENTER DANIEL LORBER, M.D., F.A.C.P. ASSOCIATE DIRECTOR, LANG RESEARCH CENTER ISAAC P. LOWENWIRT, M.D. ASSOCIATE CHAIRMAN, ANESTHESIOLOGY DATTATREYUDU NORI, M.D., F.A.C.R., F.A.C.R.O. CHAIRMAN, RADIATION ONCOLOGY JAMES J. RAHAL, M.D. DIRECTOR, INFECTIOUS DISEASE DIVISION STEPHEN RIMAR, M.D. SENIORVICE PRESIDENT FOR MEDICAL AFFAIRS AND CHJIEF MEDICAL OFFICER JAMES G. RYAN, M.D., F.A.C.E.P. ASSOCIATE CHAIRMAN, EMERGENCY MEDICINE JAMES W.TURNER, M.D., F.A.C.S. CHAIRMAN, SURGERY

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