Timothy Malins, MD, FACC Governor, New York Chapter, American College of Cardiology President, New York Cardiological Society

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New York Cardiovascular Symposium December 8-10, 2017 New York Hilton Midtown Thursday, December 7 2:30 p.m. - Registration Rhinelander (2 nd Floor) 6:30 p.m Friday, December 8 6:00 a.m. Registration Rhinelander (2 nd Floor) Continental Breakfast America s Hall Introductions 7:15 a.m. Shalom Jacobovitz Chief Executive Officer American College of Cardiology Mary Norine Walsh, MD, FACC President American College of Cardiology Timothy Malins, MD, FACC Governor, New York Chapter, American College of Cardiology President, New York Cardiological Society Cardiovascular and Coronary Artery Disease Challenges in 2017 Session I: New Frontiers Dr. Bhatt, Presiding 7:30 a.m. Vascular 3D-Ultrasound in Subclinical Systemic Disease: 12,000 Subjects Feasible, Predictable, Preventable, Futurable 8:00 a.m. Intravascular Optical Coherence Tomography in Clinical CAD: 1,400 Patients Feasibility, Predictability, Preventability, Futurability Dr. Jang 8:25 a.m. Genomics in Myocardial and Structural Heart Disease From Generic to a Personalized Cardiovascular Approach Dr. Seidman 8:50 a.m. Panel Discussion Drs. Fuster, Jang and Seidman 9:20 a.m. Coffee Break America s Hall

Session II: Acute Coronary Syndromes Dr. Levine, Presiding 9:40 a.m. STEMI 1: Timing, Mechanical Type and Pharmacology of Reperfusion The Three Main Challenges to Decrease Infarct Size and Increase Viability Dr. Ibáñez 10:05 a.m. STEMI 2: PCI of Culprit Lesion Alone vs. FFR Guided Complete Revascularization Effects on Hard End Points, MACE and Cost Effectiveness Dr. Bhatt 10:30 a.m. STEMI vs. NSTEMI vs. STABLE CAD: Post PCI Optimal DAPT Duration Scoring the Complexity of Stenting and Disease Dr. Yeh 10:55 a.m. STEMI vs. NSTEMI vs. STABLE CAD: Five Challenging Cases Five Challenging Antithrombotic Approaches Dr. Levine 11:20 a.m. Panel Discussion Drs. Bhatt, Ibanez, Levine and Yeh 12:00 p.m. Lunch America s Hall Session III: Systemic Arterial Disease Chronic Coronary Disease, Stroke and Pulmonary Embolism Dr. Douglas, Presiding 1:00 p.m. Chest Pain Evaluation: Possible vs. Probable CAD No Test, Stress Test or CT Angio? Dr. Douglas 1:20 p.m. Complex Stable CAD: Evolving Evaluation and Management Strategies Evaluate: Anatomy (SYNTAX), Ischemia (IFR), Microcirculation (CT, MRI) Manage: Optimal Medical Therapy (OMT), PCI (Stents), CABG (IMA) 1:45 p.m. Acute Ischemic Stroke and Chronic Carotid Artery Stenosis Two Entities with Novel Approaches Dr. Brott 2:05 p.m. Pulmonary Emboli: Diagnosis Based on Suspicion and Management in 2017 Based on the Acute Severity and Degree of Chronic PH Dr. Piazza 2:25 p.m. Panel Discussion Drs. Brott, Douglas, Fuster and Piazza 2:55 p.m. Coffee Break America s Hall

Session IV: Trends and Challenges of Approaching Prevention Dr. Rader, Presiding 3:15 p.m. Aspirin in Primary and Secondary Cardiovascular Disease Prevention: Still Four Questions About Enteric Coated, Indicated Doses, Use in Diabetes, Use in PVD Dr. Patrono 3:35 p.m. Lipid Evaluation and Management: Four Evolving Advances Familial LDL-C, ApoB, HDL Efflux Capacity and PCSK9 Inhibitors Dr. Rader 4:00 p.m. Hypertension (HBP) Evaluation and Management: Three Challenges Identify Those with HBP, Reduce Salt (Amount?) and Personalize BP Target Dr. Spatz 4:25 p.m. Diabetes and Obesity: The Four Hot Spots Mechanisms of Diabetes, New Agents for Macrovascular Diabetes Weight vs. Obesity in AF, Bariatric Surgery 4:50 p.m. Panel Discussion Drs. Fuster, Patrono, Rader and Spatz 5:30 p.m. Adjournment Saturday, December 9 6:15 a.m. Registration Rhinelander (2 nd Floor) Continental Breakfast America s Hall Cardio-Pulmonary and Electrical Failure 2017 Session V: Systolic Heart Failure and Basis for Management Dr. Mann, Presiding 7:00 a.m. Imaging (Echo, MRI, PET) as Diagnostic and Prognostic Tools For Seven Cardiomyopathies: Myocarditis, Dilated CM, Hypertrophic CM, Noncompaction LV, Amyloid CM, Sarcoid and Takotsubo Dr. Bonow 7:25 a.m. Therapeutic Approaches to Three Specific Cardiomyopathies Acute/Subacute Myocarditis, AL/TTR Amyloid, Non-compaction LV Dr. Dec 7:50 a.m. Systolic and Diastolic Dysfunction: Three Upcoming Challenges Promoting Early Detection HFrEF: Beyond Neprilysin/Enalapril HFmrEF: What Is It and How Does One Manage It? HFpEF: Etiopathogenetic Role and Impact of Comorbidities Dr. Mann

8:20 a.m. Advanced Heart Failure The Three Upcoming Challenges Acute Heart Failure: Is It a Disease that Can Be Treated? Comorbidities in Heart Failure: Emerging Positive Signals End Stage Heart Failure: Are We Doing Better? Dr. O Connor 8:45 a.m. State-of-the-Art Management of Pulmonary Hypertension Monitoring and Approach of the Three Main Etiopathogenesis L-Sided Failure, Pulmonary Arterial Hypertension, Thromboembolic Dr. Gomberg-Maitland 9:10 a.m. Panel Discussion Drs. Bonow, Dec, Gomberg-Maitland, Mann and O Connor 9:40 a.m. Coffee Break America s Hall Session VI: Rhythm Disorders, Contemporary and Future Topics of Focus Dr. Reddy, Presiding 10:00 a.m. Innovations in Device Therapies: Three Approaches CRTs, the Right Indications, Subcutaneous ICDs, Leadless Pacemakers Dr. Wilber 10:25 a.m. Ventricular Tachycardia: Catheter Ablation Four Questions Who? When? How? Results? Dr. Reddy 10:50 a.m. Atrial Fibrillation: Catheter Ablation Four Questions Who? When? How? Results? Dr. Marchlinski 11:15 a.m. Left Atrial Appendage Closure: Four Questions Who? When? How? Results? Dr. Holmes 11:40 a.m. Atrial Fibrillation 2017: The Fourteen Non-ablation Clinical Challenges Quality of Life and Preventing Stroke 12:00 p.m. Panel Discussion Drs. Fuster, Holmes, Marchlinski, Reddy and Wilber 12:30 p.m. Lunch America s Hall Session VII: Valvular Heart Disease and Aorta Challenges in 2017 Management of Aortic Valve Disease and Aorta Dr. O Gara, Presiding 1:30 p.m. Aortic Valvular Stenosis: How to Assess the Four Variables for Management

Low Flow / Low Gradient / Normal EF / Low EF Dr. O Gara 1:50 p.m. Severe Aortic Valvular Disease: TAVR in Four Ages and Four Etiologies Age 25 y/o Congenital, 50 y/o Bicuspid, 75 y/o Rheumatic, 100 y/o Degenerative Drs. Adams, Nishimura and Sharma 2:20 p.m. The Dilated Thoracic and Abdominal Aorta and Complicating Dissection Evolving Understanding of the Basic Biology and Management 2:45 p.m. Panel Discussion Drs. Adams, Fuster, O Gara, Nishimura and Sharma 3:15 p.m. Coffee Break America s Hall Session VIII: Management of Mitral Regurgitation and Hypertrophic Cardiomyopathy Dr. Adams, Presiding 3:35 p.m. Significant Mitral Regurgitation (EF, LVEdD, PH or AF): Five Challenges Two Etiologies (Primary, Secondary), Three Approaches (Medical, Clipping, Surgical) Drs. Adams, Bonow and Sharma 4:05 p.m. Transcatheter Replacement for Mitral and Tricuspid Regurgitation Evolving Approaches Under Investigation Dr. Rodés-Cabau 4:30 p.m. Hypertrophic Cardiomyopathy: Four Challenging Questions Genetics/Acquired, Myectomy/Three Types, Natural Hx/ICD, Apical/Aneurysm Dr. Nishimura 4:55 p.m. Panel Discussion Drs. Adams, Bonow, Nishimura, Rodes-Cabau and Sharma 5:30 p.m. Adjournment Sunday, December 10 6:45 a.m. Registration Rhinelander (2 nd Floor) Continental Breakfast America s Hall Year in Review: The Nine Highlights of Progress in 2017, Presiding Session IX: Novelties on Genetics, Molecular Signaling and Cell Regeneration 7:30 a.m. Part 1: Progress in Genetic Medicine Genome Editing A New Understanding of Cardiovascular Physiology, Pathology and Future Therapies Dr. Musunuru

7:55 a.m. Part 2: Progress in Molecular Cardiovascular Medicine MicroRNAs, Proteomics and Metabolomics A New Understanding of Cardiovascular Physiology, Pathology and Future Therapies Dr. Mayr 8:20 a.m. Part 3: Progress in Myocardial Regeneration Exosomes and ipcs A New Understanding of Cardiovascular Physiology, Pathology and Future Therapies Dr. Janssens Section X: Novelties on Diagnostic and Therapeutic Strategies 8:45 a.m. Part 1: Evolving Progress of Cardiovascular Imaging Redefining Its Role in Biomedical Research and Clinical Practice Dr. Di Carli 9:10 a.m. Part 2: Evolving Progress of Coronary Interventional Stents Bioresorbable Scaffolds Moving Forward or Backwards? Dr. Dangas 9:35 a.m. HENRY RUSSEK LECTURE 2017 Part 3: The Known and Unknown of Transcatheter Aortic Valve Thrombosis Dr. Bax 10:00 a.m. Coffee Break America s Hall Section XI: Aiming at the Future of Medicine 10:20 a.m. Part 1: The Future of Promoting Health Should Children s Education Be the Priority Focus? 10:45 a.m. Part 2: Evolving Progress of Atherothrombotic Therapies Reducing Inflammation to Reduce Cardiovascular Risk: The CANTOS Trial Dr. Ridker 11:15 a.m. PAUL DUDLEY WHITE LECTURE 2017 Part 3: The Future of Personalized Cardiovascular Medicine A Practical Reality or a Dream Not Economical Feasible? Dr. Califf 11:45 a.m. Course Adjournment