Material Safety Data Sheet Diisononyl Phthalate MSDS 1. Supplier and Substance Identification Product: Diisononyl Phthalate CAS-No: 28553-12-0 Synonym: Use of Substance: DINP Plasticizer for Polymers Phlegmatiser (to dilute organic peroxides) Construction Chemicals Manufacture of Coatings Preparation of Lubricants Preparation of adhesives Supplier: The Chemical Company 19 Narragansett Avenue Jamestown, RI 02835 USA Phone : 401.423.3100 Fax : 401.423.3102 Email : info@thechemco.com Web : For Chemical Emergency Spill, Leak, Fire, Exposure, or Accident Call CHEMTREC Day or Night Within USA and Canada: 1-800-424-9300 Outside USA and Canada: +1 703-527-3887 (collect calls accepted) 2. Composition /Information on ingredients Chemical Name: Di-isononyl Phthalate CAS-No: 28553-12-0 EC-No: 249-079-5 Page 1 of 7
3. Hazard Identification Appearance/Odor: Colorless liquid; mild odor. Potential Health Effects Skin Contact: Repeated or prolonged skin contact may cause mild skin irritation. Eye Contact: May cause mild eye irritation of susceptible persons. Ingestion: May cause nausea, vomiting and diarrhea. Inhalation: Prolonged or excessive inhalation may cause respiratory tract irritation. 4. First Aid Measures Skin Contact: Wash affected skin with soap and water. Seek medical attention if symptoms persist. Eye Contact: Flush eyes with large amounts of water for at least 15 minutes. If irritation persists, consult a physician. Ingestion: Seek medical advice. Inhalation: Person should be moved to a fresh air environment. 5. Fire Fighting Measures Flash Point (COC): 470 F Autoignition Temperature: 500 F Extinguishing Media: CO2, Dry Chemical, Water Fog, or Foam Special Fire-Fighting Procedures: A MSHA/NIOSH approved self-contained breathing apparatus should be worn. Use water spray to cool fire-exposed containers. Unusual Fire and Explosion Hazards: Water or foam may cause frothing. 6. Accidental Release Measures Steps to be Taken in Case Material is Released or Spilled: Dike and contain the spill with inert material (i.e., sand, earth, sawdust) and transfer liquid and solid diking material to separate containers for recovery or disposal. Wash floor area with hot water solution. Remove contaminated clothing and wash before reuse. Wash affected skin areas with soap and water. Keep spills out of all sewers and bodies of water. 7. Handling and Storage Any use of this product in an elevated temperature process should be evaluated to establish and maintain safe operating procedures. Keep away from heat, sparks, and flame. Containers should be kept tightly closed and stored in a dry well-ventilated place Page 2 of 7
8. Exposure Controls/Personal Protection OSHA Permissible Exposure Limit (PEL): Not established Hand Protection: Neoprene or Nitrile Gloves Respiratory Protection: Use a NIOSH approved respirator when exposure to mists or vapors is anticipated. Eye Protection: Safety glasses Engineering Measures: For normal operation, local exhaust ventilation should suffice. Direct exhaust may be necessary when material becomes heated and vapors are given off. Other: Eyewash facility in vicinity. 9. Physical and Chemical Properties Boiling Point: 485 F Specific Gravity: 0.973 Flash Point (COC): 470 F Freezing Point: N/A Vapor Density(Air=1): >10 Solubility in Water: Insoluble Vapor Pressure (psia): Negligible Viscosity (25 C): N/A Appearance/Odor: Colorless liquid; mild odor 10. Stability and Reactivity Stability: This product is stable under normal conditions. Will hydrolyze under acidic & basic conditions. Conditions to Avoid: Oxidizers Hazardous Decomposition Products: Combustion may produce carbon monoxide, carbon dioxide and other asphyxiants. Organic acids. Hazardous Polymerization: Will not occur under normal circumstances. 11. Toxicological Information Acute oral toxicity LD50 rat(male/female): > 10000 mg/kg Method: OECD Guide-line 401 Labelling not required by GHS regulation. Page 3 of 7
Acute inhalation toxicity LC50 Rat(male/female): > 4.4 mg/l / 4 h / Aerosol Method: US-EPA-method (limit test) Labelling not required by GHS regulation. Acute dermal toxicity LD50 Rabbit(male/female): > 3160 mg/kg Labelling not required by GHS regulation. Skin irritation Rabbit / 4 h not irritating Method: OECD Test Guideline 404 Eye irritation Rabbit not irritating Method: OECD Test Guideline 405 Sensitization Buehler Test guinea pig: not sensitizing to the skin Method: Directive 67/548/EEC, Annex V, B.6. sensitizing to the respiratory tract No sensizitation expected. Repeated dose toxicity Oral Rat(male) / 2 years Number of exposures: 7 days a week NOAEL: ca. 88.3 mg/kg target organ/effect: Liver, Kidney Method: OECD method Oral Rat(female) / 2 years Number of exposures: 7 days a week NOAEL: ca. 108.6 mg/kg target organ/effect: Liver, Kidney Method: OECD method dermal Rabbit(male/female) / 6 weeks NOAEL: ca. 500 mg/kg inhalative Rat(male) / 2 weeks Number of exposures: 6 hours/day NOAEL: > 0.5 mg/l Only one dosage was tested. The available data do not suffice for classification. This information is derived from evaluation of or a test result for a similar compound (conclusion based on analogy). Risk of aspiration toxicity No Aspiration toxicity classification Gentoxicity in vitro Ames test Salmonella typhimurium negative Metabolic activation: with or without Method: OECD TG 471 S-9 rat liver mix Page 4 of 7
Chromosome aberration test in vitro Chinese hamster negative Metabolic activation: with or without Method: OECD TG 473 CHO-cells Genetic mutation in mammal cells TK +/- mouse lymphoma cell (L5178Y) negative Metabolic activation: with or without Method: OECD TG 476 S-9 rat liver mix Gentoxicity in vivo no evidence of mutagenic effects literature Carcinogenicity Peroxisome proliferation The mechanism of action is not relevant for humans. Toxicity to reproduction Two-generation study Oral Rat(male/female) Number of exposures: daily NOAEL (No Observed Adverse Effect Level) of parents: ca. 500 mg/kg NOAEL F1: 200-260 mg/kg Method: Directive 67/548/EEC, Annex V, B.35. Reduced bodyweight gain. Two-generation study Oral Rat(male/female) Number of exposures: daily NOAEL (No Observed Adverse Effect Level) of parents: 1000 mg/kg Method: Directive 67/548/EEC, Annex V, B.35. no evidence of reproductiontoxic properties Teratogenicity Oral Rat(female) Number of exposures: daily NOEL maternal (No Observed Effect Level): 200 mg/kg NOAEL (No Observed Adverse Effect Level) teratogenesis: 1000 mg/kg Method: OECD TG 414 Toxicology Assessment Acute effects Non-toxic in case of one-time contact with skin. Not toxic after single exposure (oral, inhalative). Does not irritate skin / eyes. Sensitization Does not cause skin sensitization in humans. CMR assessment Carcinogenicity Indication of carcinogenic effect in animal tests. Not relevant for humans due to animalspecific mechanisms of action. Mutagenicity No mutagenic effects were determined in various investigations of microorganisms, cell cultures and in vivo data. Page 5 of 7
Toxicity to reproduction Animal experiment studies revealed no evidence of an embryotoxic effect at dosage / concentration levels that are not toxic in the parent animals. 12. Ecological Information Acute aquatic toxicity The substance does not show acute toxicity in aquatic organisms. Chronic aquatic toxicity The substance does not have any chronic effects on water solubility. Toxicity Data on Soil This substance does not show acute toxicity in sediment organisms. Other Environmental Relevant Organisms The substance does not show any effects on terrestrial organisms. Impact on Sewage Treatment The substance does not show acute toxicity in waste treatment plant organisms. Results of PBT assessment Not a PBT, vpvb substance according to the criteria of the REACH Ordinance. 13. Disposal Consideration Waste Disposal Methods: Material should be disposed of in accordance to current local, state, and federal regulations. Contacting a waste disposal service is recommended. 14. Transport Information No regulated as hazardous by the Department of Transportation. 15. Regulatory Information Toxic Substances Control Act (TSCA): This product is in compliance with the TSCA regulation of the United States. Domestic Substance List (DSL): This product is listed on the DSL inventory of Canada. China Inventory of Existing Chemical Substances (IECSC): This product is listed on the IECSC Inventory of China. European Inventory of Existing Chemical Substances (EINECS): This product is listed on the EINECS inventory of Europe. ECL (Korean Toxic Substances Control Act): This product is listed on the Korean Inventory or otherwise complies with the Korean Toxic Substances Control Act. Superfund Amendments and Reauthorization Act (SARA): This product has the following hazards as defined in Section 311/312 of 40 CFR Part 372: Hazards Acute Health Hazard Page 6 of 7
This product contains the following chemicals subject to the reporting requirements of Section 313 or Title III of SARA and 40 CFR Part 372: Ingredients None California Proposition 65: This product does not contain substances known to the State of California to cause cancer, birth defects, or other reproductive harm per the Safe Drinking Water and Toxic Enforcement Act of 1986: 16. Other Information Disclaimer: The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall The Chemical Company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if The Chemical Company has been advised of the possibility of such damages. Page 7 of 7