We will be announcing this year s award winner of the Yang K. Chen Fellowship Program.

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Welcome to Dear Colleague, ICCU 2011 will be focused on how to improve and adapt diagnosis and therapeutic interventions with pcle. The program has been designed to build on the knowledge we have obtained from current clinical practice, as well as new major study results. The program will allow us to explore avenues in tissue characterization, disease detection and treatment options. Despite the flow of new findings, many clinical questions still need attention and best practice shared. This scientific symposium aims to offer insight into the current questions we have regarding improving disease detection, treatment and how pcle contributes to patient management. Our distinguished speakers are drawn from a variety of specialties including digestive and pulmonary endoscopy, urology, pathology and image processing. This year, additional time has been allotted to pulmonology, a new field of application. Poster sessions, which will allow each one of you to present your latest findings with pcle, have also been included. We would like to thank Mauna Kea Technologies for their commitment to this forum, which continues to push the boundaries of endomicroscopy forward. Thanks to this continued support, we would like to extend our invitation to a world wide audience to join us in Nice, France to discuss the best options for improving the way we manage our patients now and in the future. Pr. Jean-Paul Galmiche CHU Nantes, France Pr. Prateek Sharma University of Kansas, Kansas City, USA Dear ICCU Guest, It is my pleasure, on behalf of Mauna Kea Technologies, to welcome you to the third edition of ICCU, hosted this year in Nice, France. Our objective is to keep developing innovative diagnostic solutions for the improvement of patient management and therapeutic interventions. Our commitment to clinical and product development is demonstrated by this year s ICCU curriculum/agenda. ICCU remains your meeting, a truly physician-led symposium. Outstanding faculty members have once again designed a very attractive scientific program to enrich the knowledge and clinical skills in managing and treating patients. Aligned with Mauna Kea Technologies vision, ICCU is aimed at highlighting the future developments of pcle and the advantages of accurate disease characterization. We hope that the strong scientific content of this event, friendly atmosphere and international representation will all favor open and inspiring communication. I offer a sincere welcome and wish everyone an insightful experience at ICCU 2011. Sacha Loiseau, PhD President, CEO & Founder, Mauna Kea Technologies Yang K. Chen Fellowship Program The Yang K. Chen Fellowship Program has been established to commemorate his contribution in improving medical practice, notably in the diagnosis and treatment of ERCP patients. The objective of the program is to support young physicians and researchers dedicated to improving the quality of patient care and the management of ERCP patients. Pr. Chen was one of the pioneers of ERCP and a world-known leader in this field. He was the principal investigator of the pcle ERCP registry and was present at ICCU in 2009 and 2010, where he unveiled the game-changing results for pcle in biliary indications. We will be announcing this year s award winner of the Yang K. Chen Fellowship Program.

Saturday April 9 th 7:00 AM 7:45 AM Breakfast LUNG SESSION / 8:00 AM TO 12:30 PM Lung endomicroscopy: building the foundations Chairman: Michael Wallace 8:00 AM 8:15 AM Introduction - Michael Wallace 8:15 AM 9:45 AM Clinical results 8:15 AM 8:30 AM Peripheral nodules - David Wilson 8:30 AM 8:45 AM Interstitial lung diseases - Luc Thiberville 8:45 AM 9:00 AM Lung transplantation - Cesar Keller 9:00 AM 9:15 AM Patient monitoring in the ICU - Kev Dhaliwal 9:15 AM 9:45 AM Discussions 9:45 AM 10:15 AM Alveoscopy procedure standardization - Bill Krimsky 10:15 AM 10:45 AM Coffee break & poster session, group picture 10:45 AM 12:00PM Image interpretation in alveoscopy 12:00 PM 12:30 PM Recap & concluding statements - Michael Wallace 12:30 PM 1:30 PM Opening buffet for all participants PLENARY SESSION / ALL / 2:00 PM TO 6:00 PM ICCU 2011: the future of endoscopy, now Chairmen: Jean-Paul Galmiche, Prateek Sharma 2:00 PM 2:15 PM Introduction - Jean-Paul Galmiche & Prateek Sharma 2:15 PM 2:45 PM Keynote address - Nicholas Ayache 2:45 PM 3:10 PM GI update: what have we achieved since ICCU 2010? - David Carr-Locke & Guido Costamagna 3:10 PM 3:30 PM Lung update - David Wilson 3:30 PM 4:00 PM Coffee break 4:00 PM 4:30 PM Interactive survey on pcle usage 4:30 PM 4:50 PM Urology update - Joseph Liao 4:50 PM 5:05 PM Translating pre-clinical research into patient care: pcle in the liver - Michael Nathanson 5:05 PM 5:20 PM The role of pathologists in pcle adoption - Michael Vieth 5:20 PM 5:45 PM What s next in pcle - Sacha Loiseau 5:45 PM 6:30 PM Celebratory cocktail around future pcle developments, group picture 7:00 PM 11:00 PM Offsite dinner in Nice, transfer departure, meet in the lobby at 7:00 PM

Sunday April 10 th 7:30 AM 8:15 AM Breakfast GI SESSION / 8:30 AM TO 6:00 PM GI endomicroscopy: making it common practice Chairmen: Jean-Paul Galmiche, Prateek Sharma 8:30 AM 10:00 AM Improving management of patients with pancreatico-biliary strictures Moderator : Kenneth Chang Results - Adam Slivka Case study - Marc Giovannini Objections - Michel Kahaleh 10:00 AM 10:45 AM Coffee break & poster session 10:45 PM 12:30 PM Detection of neoplastic tissue: is endoscopy enough? 10:45 AM 11:30 AM Impact of pcle on random biopsies and the detection yield in BE surveillance Moderator : Kenneth Wang Results - Prateek Sharma Case study - Helga Bertani Objections - Herbert Wolfsen 11:30 AM 12:15 PM Colorectal polyps: should we «diagnose and discard»? Should we «leave polyps behind»? Moderator : Michael Wallace Results - Michael Wallace Case study - Rémy Dumas Objections - Emmanuel Coron 12:15 PM 12:30 PM Inflammatory Bowel Diseases - Helmut Neumann 12:30 PM 1:30 PM Lunch break, group picture 1:30 PM 3:15 PM Real-time decision making in patient treatment and follow-up 1:30 PM 2:15 PM What is the impact of pcle on Barrett s esophagus treatment and follow-up? Moderator : Paul Tarnasky Results - Vani Konda Case study - Uzma Siddiqui Objections - Lawrence Ho 2:15 PM 3:15 PM Can we avoid empiric re-treatment of colorectal lesions? Moderator : Michael Wallace Results - Emanuele Dabizzi Case study - Firas Al Kawas Objections - Satish Singh 3:15 PM 4:00 PM Coffee break & poster session 4:00 PM 5:30 PM Going beyond the GI tract: in vivo characterization of pancreatic cysts during EUSFNA Moderator : Harry Aslanian Results - Alexander Meining Case study - Kenneth Chang Objections - Simon Lo and Laith Jamil 5:30 PM 6:00 PM Recap & concluding statements - Jean-Paul Galmiche & Prateek Sharma 6:30 PM 11:00 PM Offsite dinner in Saint Paul de Vence, transfer departure, meet in the lobby at 6:30 PM

PRACTICAL INFORMATION HOUSING Radisson Blu 223 Promenade des Anglais 06200 Nice - France Tel : +33 (0)4 97 17 71 77 www.radissonblu.com/hotel-nice The conference will be held at Hotel Radisson Blu, Nice. The hotel is located on the waterfront between the airport and the city center of Nice. Average temperatures in April 10-17 C (50-63 F ) TRANSFERS All transfers to and from the airport will be organized by Mauna Kea Technologies: Friday and Saturday arrival Sunday and Monday morning departure CONFERENCE HALL The conference will be held in the Salon «La Baie des Anges» COMPLIANCE The conference hall, coffee breaks and lunch areas are dedicated to the scientific conference MEALS Breakfasts and lunches will take place in the Salon Riviera (ground floor). Dinners will be organized offsite OFFICIAL LANGUAGE English DRESS CODE Business casual Comfortable shoes are recommended for Saturday night event CURRENCY The French currency, as part of the European Community, is the euro ( ) CONTACT Scientific: Anne Osdoit anne@maunakeatech.com +33 (0) 6 60 42 28 31 Organizational: Laetitia Montfort laetitia@maunakeatech.com +33 (0) 6 61 64 82 52

www.maunakeatech.com cellvizio@maunakeatech.com EUROPE Mauna Kea Technologies SAS 9 rue d Enghien 75010 Paris, France Ph: + 33 1 48 24 03 45 Fax: + 33 1 48 24 12 18 USA Mauna Kea Technologies, Inc. 660 Newtown-Yardley Road, Suite 107 Newtown, PA 18940 Ph: + 1 215 478 6288 Fax: + 1 215 279 8463 Toll free: + 1 888 590 1798