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Nonprofit Org. U.S. Postage PAID Pittsburgh, PA Permit No. 2110 D E P A R T M E N T O F C A R D I O T H O R A C I C S U R G E R Y : Surgical Treatment of End-Stage Cardiopulmonary Diseases October 1 and 2, 2010 UPMC Presbyterian Biomedical Science Tower, Room S120 Pittsburgh, Pennsylvania 200 Lothrop Street PUH C-800 Pittsburgh, PA 15213 D E P A R T M E N T O F C A R D I O T H O R A C I C S U R G E R Y : Surgical Treatment of End-Stage Cardiopulmonary Diseases October 1 and 2, 2010 UPMC Presbyterian Biomedical Science Tower, Room S120 Pittsburgh, Pennsylvania For additional information, contact: Wendy Kalocay - Director of Operations email: kalocayw@upmc.edu Online registration is available at: https://ccehs.upmc.com/formalcourses.jsp#2541 Sponsored by: University of Pittsburgh School of Medicine Center for Continuing Education in the Health Sciences and Invited Guest Speakers Margarita T. Camacho, MD Newark Beth Israel Medical Center Newark, NJ Si Mai Pham, MD, FACS, FAHA University of Miami Miami, FL Course Director Head, Section of Cardiothoracic Transplantation Associate Professor of Surgery Cardiothoracic Surgery Course Co-Directors James D. Luketich, MD, FACS Henry T. Bahnson Professor of Cardiothoracic Surgery Chair, Chief, Division of Thoracic and Foregut Surgery Robert Kormos, MD, FAHA, FRCS(C) Professor of Surgery Director, Artificial Heart Program Co-Director, Heart Transplant Program Medical Director, Biotronics

Intent and Objectives The two-day program will consist of a series of lectures by UPMC faculty and experts on the subject from outside facilities. Topics will include the technical aspects, risks, benefits and outcomes of heart and lung transplantation, heart failure surgery and the use of ventricular assist devices. Who Should Attend This course is designed for transplant surgeons, cardiologists, pulmonologists, general surgeons and thoracic surgeons; minimally invasive team members (MD, RN, PA, NP); allied health care professionals. Continuing Education Credit The University of Pittsburgh School of Medicine is accredited by the ACCME to provide continuing medical education for physicians. The University of Pittsburgh School of Medicine designates this educational activity for a maximum of 14.5 AMA PRA Category 1 Credits. Physicians should only claim credit commensurate with the extent of their participation in the activity. Other health care professional are awarded 1.4 continuing education units (CEU s) which are equal to 14.5 contact hours. Conference Location UPMC Presbyterian Biomedical Science Tower 215 Lothrop Street. Room S120 Pittsburgh, PA 15213 Accommodations For hotel reservations, contact the Wyndham Garden Hotel and ask for the Surgical Treatment of End-Stage Cardiopulmonary Diseases room block. Wyndham Garden Hotel University Place 3454 Forbes Avenue Pittsburgh, PA 15213 (412) 683-2040 Schedule ~ Friday, October 1, 2010 7:30 am Registration and Breakfast 7:55 am Welcome James D. Luketich, MD, FACS Heart Transplantation 8:00 am Innovations in Patient Selection and Management: Who, When and How Dennis McNamara, MD 8:30 am How I Do It Recipient Surgery 9:00 am How to Increase Donor Pool, and How I Do It Donor Surgery Pramod Bonde, MD 9:30 am Mechanical Circulatory Support following Heart Transplantation Jay Bhama, MD 10:00 am BREAK 10:15 am Pulmonary Vascular Disease in Heart Failure: Assessment and Impact on Heart Transplantation Hunter Champion, MD 10:45 am Rejection Surveillance After Cardiac Transplantation in 2010: Is the Biopsy Still the Gold Standard? Jeffrey Teuteberg, MD 11:15 am Detection, Characterization and Clinical Significance of Allo-antibodies in Thoracic Transplantation Adriana Zeevi, PhD 11:45 am LUNCH 12:30 pm CASE PRESENTATIONS Highly Sensitized Patient with Complex Congenital Heart Disease Complex Congenital Heart Disease with Child B Liver Cirrhosis ~ 2 ~ ~ 3 ~ continued on page 4

1:00 pm Future of Cardiothoracic Xenotransplantation David Cooper, MD, PhD Ventricular Assist Device and Heart Failure Surgery 1:30 pm Traditional Cardiac Surgery in Advanced Heart Failure. Is It Still an Option? Christian Bermudez, MD 2:00 pm LVAD: Bridge to Transplantation Current Indications and Results Pramod Bonde, MD 2:30 pm LVAD: Destination Therapy: What Is It and When Is It Indicated? Jeffrey Teuteberg, MD 3:00 pm BREAK 3:15 pm What Is the Future of Ventricular Assist Devices for Heart Failure? Building on History Robert Kormos, MD, FAHA, FRCS(C) INVITED LECTURE 1 4:15 pm Understanding Circulatory Support in 2010: Tailoring the Device to the Patient Margarita Camacho, MD 5:00 pm Friday Adjournment 6:30 pm Technology Displays and Course Dinner at the University Club (included with registration fee; please RSVP when registering online) Schedule ~ Saturday, October 2, 2010 7:30 am Registration and Breakfast Lung Transplantation 8:00 am Recipient Selection of Lung and Heart-Lung Transplantation Jnanesh Thacker, MD 8:30 am How I Do It Recipient Surgery; Minimally Invasive Lung Transplantation 9:00 am Expanding the Donor Pool: How I Do It Donor Surgery Norihisa Shigemura, MD 9:30 am Role of ECMO as a Bridge to Lung Transplant and in Primary Graft Dysfunction Christian Bermudez, MD 10:00 am BREAK 10:15 am Early Post-transplant Complications and Prevention with T Cell Depletion and Steroid Minimization Joseph Pilewski, MD 10:45 am Airway Complications after Lung Transplantation Maria Crespo, MD 11:15 am Prevention of Chronic Rejection: Inhaled Cyclosporine Bruce Johnson, MD 11:45 am Lung Transplantation for Pulmonary Hypertension Patricia George, MD 12:15 pm LUNCH ~ 4 ~ ~ 5 ~ continued on page 6

INVITED LECTURE 2 1:00 pm Alemtuzumab Induction in Cardiothoracic Transplantation Si Pham, MD 1:45 pm Critical Care in Cardiothoracic Transplantation Penny Sappington, MD 2:15 pm Cardiac Anesthesia in Cardiothoracic Transplantation Cynthia M.Q. Wells, MD 2:45 pm BREAK 3:00 pm Impact of Antifungal and Antiviral Prophylaxis after Lung Transplantation Minh-Hong Nguyen, MD 3:30 pm CASE PRESENTATION Cystic Fibrosis with Active Cenocepacia Pneumonia Minimally Invasive Single Left Lung Transplant with Two-vessel Off-pump Coronary Artery Bypass Grafting Course Director Head, Section of Cardiothoracic Transplantation Associate Professor of Surgery Cardiothoracic Surgery Course Co-Directors James D. Luketich, MD, FACS Henry T. Bahnson Professor of Cardiothoracic Surgery Chair, Chief, Division of Thoracic and Foregut Surgery Robert Kormos, MD, FAHA, FRCS(C) Professor of Surgery Director, Artificial Heart Program Medical Director, Biotronics Co-Director, Heart Transplant Program Invited Guest Speakers Margarita T. Camacho, MD Surgical Director, Cardiac Transplant and Mechanical Assist Device Program Saint Barnabas Heart Center at Newark Beth Israel Medical Center Chair, Workforce on Surgical Treatment of End-Stage Cardiopulmonary Disease The Society of Thoracic Surgeons Newark, NJ Si Pham, MD, FACS, FAHA Professor of Surgery Director, Cardiopulmonary Transplantation Co-Director, Artificial Heart Program University of Miami Miami, FL 4:00 pm Conference Adjournment 6:00 pm Please join us for Patient Day and the 30th Anniversary Celebration of the UPMC Heart/Lung Transplant Program at the Westin Convention Center Pittsburgh (optional; not included with registration fee) Please see page 11 for more information. Faculty are affiliated with the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, unless noted otherwise. In accordance with Accreditation Council for Continuing Medical Education requirements on disclosure, information about relationships of presenters with commercial interests (if any) will be included in materials distributed at the time of the conference. ~ 6 ~ ~ 7 ~ continued on page 8

UPMC Faculty Christian Bermudez, MD Jay Bhama, MD Pramod Bonde, MD Hunter Champion, MD Associate Professor of Medicine David Cooper, MD, PhD Professor of Medicine Maria Crespo, MD Patricia George, MD Bruce Johnson, MD Dennis McNamara, MD Professor of Medicine Minh-Hon Nguyen, MD Professor of Medicine Joseph Pilewski, MD Associate Professor of Medicine, Cell Biology, Physiology and Pediatrics Penny Sappington, MD Norihisa Shigemura, MD Jeffrey Teuteberg, MD Jnanesh Thacker, MD Cynthia M.Q. Wells, MD Assistant Professor of Anesthesiology Adriana Zeevi, PhD Professor of Pathology Faculty are affiliated with the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, unless noted otherwise. Registration Information Registration for this course will be accepted as long as space is available; however, all pre-registrations are due by September 8, 2010. Pre-registration (due by September 8, 2010) Registering online is the quickest and easiest way to reserve your space at CCEHS conferences. 1. Visit our online registration site at https://ccehs.upmc.com/formalcourses.jsp#2541 2. Click the Registration button and enter all the requested information (including an email address) and follow the prompts to submit your registration after entering your payment information. 3. Print the automatic electronic registration confirmation email sent to the email address you provided us when you registered. If you do not receive this confirmation, please contact us at (412) 647-2845. You must bring this confirmation letter with you to the conference. Paper Registrations by Fax or Mail (see contact information below) If you are unable to register online please submit a request for paper form. For a paper registration form, please contact us at (412) 647-4735. A confirmation letter will be faxed or mailed if registration is completed through the mail or fax by the pre-registration deadline. If you register online, you will receive an immediate e-mail confirmation message. All paper registrations by fax or mail are due by September 15, 2010. Please note: Registration is not complete until you receive this confirmation. If you do not receive this letter within 5-7 days of registration, please contact us at (412) 647-4735. You must bring this confirmation letter with you to the conference. Cancellation All cancellations must be in writing and sent to us via U.S. mail, e-mail or fax. Tuition for cancellations postmarked or date stamped before September 20, 2010 will be refunded in full. After September 20, 2010 a $35 administrative fee will be assessed. No refunds will be made after September 22, 2010. Conference Contact for cancellation requests: Wendy Kalocay 200 Lothrop Street PUH C-800 Pittsburgh, PA 15213 Email: kalocayw@upmc.edu Phone: (412) 647-4735 Fax: (412) 647-4710 ~ 8 ~ ~ 9 ~ continued on page 10

Registration Information continued from page 8 The UPMC Center for Continuing Education in the Health Sciences reserves the right to cancel this program if sufficient registrations are not received. In the case of cancellation, the department will fully refund registration fees. However, other costs incurred by the registrant, such as airline or hotel penalties, are the responsibility of the registrant. For Additional Information, Contact: Wendy Kalocay 200 Lothrop Street PUH C-800 Pittsburgh, PA 15213 Email: kalocayw@upmc.edu Phone: (412) 647-4735 Fax: (412) 647-4710 Registration Fees Early Registration before September 8, 2010 $150 Physicians $ 75 Fellows, residents, nurses, and other health care professionals (Fee Waived for UPMC Employees) After September 8, 2010 $200 Physicians $100 Fellows, residents, nurses, and other health care professionals (Fee Waived for UPMC Employees) Registration fee includes: Continuing education credit Registration and course materials Continental breakfast, refreshments, lunch and Friday night course dinner Special Needs X Technology Displays and Course Dinner 6:30 pm Friday, October 1, 2010 University Club, 123 University Place, Pittsburgh, PA 15213 Please RSVP when registering online. Participation by all individuals is encouraged. Advance notification of any special needs will help us provide better service. Please notify us of your needs at least two weeks in advance of the program by calling Wendy Kalocay at (412) 647-4735. Patient Day and 30th Anniversary Celebration of the UPMC Heart/Lung Transplant Program 6:00 pm Saturday, October 2, 2010 Westin Convention Center Pittsburgh 1000 Penn Avenue Pittsburgh, PA 15222 (Optional; not included in registration fee) For tickets, please contact Michelle Houser at (412) 647-4241 or housermk@upmc.edu. The University of Pittsburgh, as an educational institution and as an employer, values equality of opportunity, human dignity, and racial/ethnic and cultural diversity. Accordingly, the University prohibits and will not engage in discrimination or harassment on the basis of race, color, religion, national origin, ancestry, sex, age, marital status, familial status, sexual orientation, disability, or status as a disabled veteran or a veteran of the Vietnam era. Further, the University will continue to take affirmative steps to support and advance these values consistent with the University s mission. This policy applies to admissions, employment, access to and treatment in University programs and activities. This is a commitment made by the University and is in accordance with federal, state, and/ or local laws and regulations. For information on University equal opportunity and affirmative action programs and complaint/grievance procedures, please contact: William A. Savage, Assistant to the Chancellor and Director of Affirmative Action (and Title IX and 504 Coordinator), Office of Affirmative Action, 901 William Pitt Union, University of Pittsburgh, Pittsburgh, PA 15260, (412) 648-7860. ~ 10 ~