Curriculum Vita Date updated: November 4th, 2013

Curriculum Vita Date updated: November 4th, 2013 Part 1: General Information: Name: Mostafa Abdel- Salam Ahmad Kabiel Office Address: Ophthalmic Center, Mansoura University, ElGomhouria Street, Mansoura City 35516, Egypt. University ID: 159942 E- Mail: mostafakabiel@gmail.com Place of Birth: Mansoura, Egypt Education: Year Degree Institution 1994-2000 M.B. B.CH (Medicine and Surgery) Mansoura University, Egypt. 2003-2006 Masters Degree (Ophthalmology) Mansoura University, Egypt. 2007-2012 Doctoral degree (PhD Ophthalmology) Mansoura University, Egypt & Harvard University, USA. Post- doctoral training: Year Title Specialty/Discipline Place of training 2001-2002 Intern Emergency care programs Mansoura University Hospitals 2002-2006 Resident Ophthalmology/Pediatric lens abnormalities Mansoura Ophthalmic Center. An Affiliate of Mansoura Medical School

2006-2009 Assistant Lecturer Ophthalmology/Stem Cell Regeneration of Retinal Degeneration Mansoura Ophthalmic Center An Affiliate of Mansoura Medical School 2009-2011 Research Fellow Ocular Regeneration Schepens Eye Research Institute/ Harvard Medical School 2010-2011 Clinical Trainee Cornea & Refractive Surgery Services Massachusetts Eye and Ear Infirmary/ Harvard Medical School 2011 Visiting Physician Glaucoma Service New York Eye and Ear Infirmary/ New York Medical College Academic appointments: Year Academic Title Institution 2006 Clinical Demonstrator in Ophthalmology Department Mansoura School of Medicine 2006-2012 Assistant Lecturer of Ophthalmology Mansoura School of Medicine 2009-2011 Post- doctoral Research Fellow Harvard Medical School 2012 Lecturer of Ophthalmology Mansoura School of Medicine Hospital or Affiliated Institution Appointments: Year Title Hospital/Affiliated Institution 2001-2002 Intern Mansoura university Hospitals 2002 General Practitioner Mansoura General Hospital 2002-2006 Resident Mansoura Ophthalmic Center

2006 to date Attending Ophthalmic Surgeon Mansoura ophthalmic Center 2010-2011 Visiting physician, Cornea & Refractive Surgery Service 2011 Visiting Physician and Lecturer, Glaucoma Service Mass Eye and Ear, Harvard Medical School New York Eye and Ear Infirmary, New york Medical College 2013 Consultant Ophthalmic Surgeon Mansoura Ophthalmic Center, Mansoura University Professional Societies Membership: Year Society Role 2002 Egyptian Medical Syndicate (EMS) Member 2003 Egyptian Ophthalmological Society (EOS) Member 2003 Delta Ophthalmological Society of Egypt (DOSE) Member 2003 Egyptian Society of Ocular Implants and Refractive Surgery (ESOIRS) Member 2008 Egyptian Society for the Glaucomas (ESG) Member 2010 American Academy of Ophthalmology (AAO) Member- in training 2010 International Society of Refractive Surgery (ISRS) Member- in training 2011 American Society of Cataract and Refractive Surgery (ASCRS) 2011 Association of Research in Vision and Ophthalmology (ARVO) Member Member 2012 American Academy of Ophthalmology (AAO) International Member

Community Service Related to Professional Work: Year Position/Title Role Institution 2006 Assistant Lecturer Screening of rural population 2008 Assistant Lecturer Screening of Sinai Bedwins Mansoura of Medicine Mansoura of Medicine School School Part 2: Research, Teaching and Clinical Contributions: Master degree research project: Risk Factors for Secondary Membrane Formation after Removal of Pediatric Cataract: Pediatric cataract is a challenging ophthalmic problem; it may lead to a varying degree of visual and developmental disability. Surgery for pediatric cataract differs from the adult onset or senile cataract in many aspects, preoperative, intraoperative and postoperative, the problem under investigation was the development of posterior capsule opacification and secondary membrane formation which eventually occurs in most operated eyes. The research studied different items that may contribute to this problem. The items studied were: age, sex, type of cataract, posterior capsule management, biomaterial of intraocular lens implanted and anterior vitreous management. The study concluded that intact posterior capsule left is still the main risk factor for occurrence of secondary opacification. Biochemical study of Acute Inflammatory Proteins in Diabetic Retinopathy: The aim of the study was to investigate the relationship between diabetic retinopathy and Monocyte Chemotactic Protein- 1 (MCP- 1) in the aqueous humor and serum of diabetic patients, also to assess the levels of serum nitrite and C- reactive protein (CRP) in the disease. The study reached a conclusion that there is a strong relation between MCP- 1 and pathogenesis of the disease, its level in aqueous could be used as a marker for the disease rather than its severity. Nitric oxide serves as a useful marker for the diagnosis of the disease as well as its progression.

Ph.D. research project: Neuroretinal Cell Replacement by Stem Cell Transplantation: A study that was accomplished at the Schepens Eye Research Institute, Massachusetts Eye and Ear infirmary/ Harvard Medical School. The main objective is to study the role of Human Retinal Progenitor Cells in repairing the damaged or dystrophic retinal elements. We achieved promising results in terms of ERG response after transplanting human retinal progenitors in an animal model of retinal degeneration. hrpcs showed ability to integrate into retinal layers and differentiate into photoreceptors and were considered relatively safe in terms of tumorogenesis. Ongoing Research Projects: Study of the effect of some antioxidants on diabetic retinopathy. Effect of ranibizumab on diabetic macular edema. Management of cystoid macular edema after cataract surgery. Effect of Multiple Sclerosis on the retinal ganglion cell layer. Genetic and biochemical studies for keratoconic corneas. Report of Teaching: Year Position Institution 2006- to date Clinical demonstrator / assistant lecturer. Teaching for the Undergraduates. Supervision of Residents and fellows during the outpatient and operative practice. Mansoura School of Medicine 2012-2013 Lecturer of Ophthalmology. Teaching for the Undergraduates. Supervision of Residents and Fellows. Clinical Tutor in Mansoura- Manchester program for the undergraduates (PBL). Mansoura School of Medicine

Report of Clinical Activities: Setting: Mansoura ophthalmic Center (an Affiliate of Mansoura School of Medicine). Activities: Outpatient examination and treatment of patients with external eye disorders. Corneal collagen crosslinking. Keratoplasty techniques (PK& DALK). Laser vision correction (LVC). Performing Argon laser photocoagulation for diabetic retinopathy cases. Treatment of diabetic macular edema via laser and intravitreal injection. YAG laser for opacified capsule and YAG iridotomy. Major surgical procedures: Cataract surgery, either open techniques or phacoemulsification with implantation of various types of IOLs (Hard, Soft, Sclera fixed). Special interest in pediatric cataract surgery, treatment of subluxated lenses and management of opacified posterior capsules. Glaucoma surgery (SST). Part 3: Bibliography 1. Adel El- layeh, Aiman Gamil, Mostafa Kabiel. Risk Factors for Visual Axis Opacification after Pediatric Cataract Surgery. Bulleteins of Egyptian Ophthalmic Society 2005; 98 (6): 915-920. 2. Lamiaa Elabbasy, Mostafa Kabiel, Amany Atwa. Biochemical study of Acute Inflammatory Proteins in Diabetic Retinopathy. Egyptian Journal of Biochemistry & Molecular Biology 2007; 26: 1-18.

3. Jian Ma, Mostafa Kabiel, Budd A Tucker, Jian Ge, Michael J Young. Combining Chondroitinase ABC and Growth Factors Promotes Integration of Murine Retinal Progenitor Cells Transplanted into Rh - /- Mice. Molecular Vision 2011; 17:1759-1770. 4. Mostafa Kabiel, Mohamed Emarah, Hesham Elserogy, Michael Young and Robert Ritch. Neuroretinal Cell Replacement by Stem Cell Transplantation. Free Paper presented at the World Ophthalmology Congress, February 2012. Abu Dhabi, UAE. Part 4: Sharing in Scientific Activities: Sharing in Conferences & Symposia: 1. Annual meeting of Egyptian Ophthalmology Society (EOS), Cairo. 2. Annual summer meeting of Egyptian Ophthalmology Society (EOS), Alexandria. 3. Circular meetings of Delta Clinical Ophthalmological Society of Egypt. 4. Annual Scientific meetings of ophthalmic departments in Egyptian Universities. 5. Annual meetings of Egyptian society of Ocular Implants and Refractive surgery ESOIRS (Alexandria). 6. Annual meeting of Egyptian Group of Pediatric Ophthalmology (EGPO) (Cairo). 7. Annual Scientific meetings of Faculty of Medicine, Mansoura University. 8. Annual Joint meeting of Ukraine & Egypt, Mansoura. 9. Meeting on "Role of Stem Cells in Medical Fields", Menoufiya University, April 2009. 10. 26th Biennial Cornea Research Conference, Boston, MA, October 2009. 11. Meeting of The New England Ophthalmologic Society, Boston, MA, April 2010. 12. AMD Symposium, Harvard Medical School, Boston, MA, October 2010.

13. Fifth annual meeting f New York stem Cell Foundation (NYSCF), Rockefeller University, NY, October 2010. 14. Meeting of the American Academy of Ophthalmology, Chicago, IL, October 2010. 15. International Congress of Ophthalmology, Mansoura, Egypt, November 2010. 16. Meeting of the American Society of Cataract and Refractive Surgery, March 2011, San Diego, CA. 17. ARVO Annual Meeting, Fort Lauderdale, FL, May 2011. 18. World Ophthalmology Congress, Abu Dhabi, UAE, February 2012. Presentations, Posters and Courses: 1. Oral Presentation (Risk Factors for Visual Axis Opacification after Pediatric Cataract Surgery): Egyptian Ophthalmological Society (EOS) Annual meeting, Alexandria, Egypt 2005. 2. Discussion of the Master thesis, Mansoura, Egypt, 2005. 3. Poster (Biochemical Study of Acute Inflammatory Proteins in Diabetic Retinopathy), Annual Scientific meeting of Medical Biochemistry department, Mansoura- Egypt, 2008. 4. Oral Presentation (Thyroid Ophthalmopathy). Annual Joint meeting of Ukrainian and Egyptian Ophthalmological Societies, Mansoura 2004. 5. Poster presentation (ERG Evaluation of Retinal Function after Stem Cell Transplantation) at the meeting of International Society of Stem Cell Research (ISSCR), Toronto, Canada, June 15th - 18th 2011. 6. Poster presentation at the Annual Poster Session, Schepens Eye Research Institute/Massachusetts Eye and Ear Infirmary, June 14th 2011. Boston, MA, USA. 7. Visiting Lecturer at the New York Eye and Ear Infirmary. Attempting Photoreceptor Regeneration by Stem Cell transplantation. July 2011. New York, NY, USA.

8. Free Paper Presentation (Neuroretinal Cell Replacement by Stem Cell Transplantation) at the World Ophthalmology Congress, February 2012, Abu Dhabi, UAE. 9. Ph.D. Thesis presentation, Mansoura Ophthalmic Center. October 2012. 10. Participation in Mansoura first Annual Regenerative Medicine Conference. Role of Stem Cells in Ocular Regeneration - December 2012, Alexandria, Egypt. 11. Instruction course (Modern Extracapsular Cataract surgery). Annual Meeting of the Egyptian Ophthalmological Society (EOS), Cairo, March 2013. Training Courses and Workshops in Ophthalmology: 1. Workshop on Ultrasound Phacoemulsification, Mansoura, Egypt 2005, 2008. 2. Workshop on ocular trauma. Mansoura, Egypt, 2007. 3. Training course in: Diagnostic Tools in Glaucoma. Mansoura, Egypt, 2007 4. Training course in: Glaucoma Recent Therapies. Cairo, Egypt, 2004. 5. Training course in: Pediatric cataract surgery. Cairo, Egypt, 2005. 6. Training course in: LASIK surgery. Mansoura, Egypt, 2006. 7. Training course in: Glaucoma Investigations (OCT, HRT, Visual Field), Mansoura, Egypt, 2007. 8. Hands on training course on "Basic Techniques in Cell Culture, Medical Technology Center, Alexandria University, Egypt, May 2009. 9. Workshop on Responsible Conduct of Research. Brigham and Woman Hospital, Harvard Medical School, October 2009. Boston, MA, USA. 10. Workshop on implantable sustained release steroid Ozurdex. October 2011, Chicago, IL, USA. 11. Molecular Bases of Eye Diseases, Winter 2010, Harvard Medical School, Boston, MA. 12. Faculty and Leadership Development Program (FLDP Courses), 2011-2012, Mansoura University.

Academic Distinctions & Awards: 1. Prize of Ministry of Education, Egypt (for 7 th rank in upper secondary education on the Egyptian state level, 1994). 2. Faculty of Medicine, Mansoura University, Egypt (Scientific Distinction, 2000).