Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Jha V, Garcia-Garcia G, Iseki K, et al. Chronic kidney disease: global dimension and perspectives. Lancet 2013; published online May 31. http://dx.doi. org/10.1016/s0140-6736(13)60687-x.
1 Table : Prevalence of indicators of chronic kidney disease around the world Reference Year of study Number of subjects Population Screening tools Prevalence of reduced GFR and proteinuria Australia Chadban 1 1999-2000 11,247 Adults 7, 11 egfr<60 : 11.2% Proteinuria: 2.4% Hematuria: 4.6% Bangladesh Cravedi 2 2005-10 1,518 High-risk rural adults 1,10 egfr<60 : 8.6% Albuminuria: 45.4% Bolivia Cravedi 2 2005-10 3,436 Urban adults 1,11 egfr<60 : 3.2% Proteinuria: 4.5% Brazil Passos 3 1997 2,560 Urban adults 1742 > 60 y 81818-59 y 9 Serum creatinine (>1.3 mg/dl males, >1.2 females) 5.1% >60 y 0.5% 18-59 y Cipullo 4 2007 1,717 Urban adults 8 Creatinine clearance <60 23.4% China Zhang 5 2009-10 47,204 Urban and rural adults 5,10 Albuminuria 9.4% egfr<60 1.7% Zhang 6 2005-06 13,925 Urban and 5,10 Albuminuria 9.2% CKD stages Stage 3: 2.5% Stage 4: 0.4% Stage 5: 0.4% Stage 3: 7.4% Stage 4: 1.4% Stage 5: 0.1% Stage 1: 5.7% Stage 2: 3.4% Stage 3: 1.6% Stage 4/5: 0.1%
2 rural adults Hematuria 3.5% egfr<60 1.7% Zhang 7 2,353 Adults >40 y 5,10 Albuminuria 6.2% Hematuria 0.8% egfr<60 5.2% Chen 8 2006-07 6,311 Urban adults 3 egfr<60 :3.2% Albuminuria :6.6% Chen 9 2000-01 15,540 Urban and rural adults 35-74 y Hematuria:3.8% 5,10 All CKD (agestandardized): 41.9% Liu 10 2006-07 1,214 Rural adults Albuminuria 7.1% Hematuria 4.6% egfr<60 2.6% Congo Sumaili 11 2006 503 Urban adults 1,7,11 egfr<60 MDRD: 8% C-G: 15.3% Proteinuria 18% India Varma 12 2008-09 2,850 Urban adults 1,2,10 Albuminuria 10% egfr<60 15% by MDRD 13.1% by CKD-EPI Stage 1: 1.9% Stage 2: 4.3% Stage 3: 5.2% Stage 2:39.4% Stage 3:2.4% Stage 4/5:0.14% MDRD and CG Stage 1: 2% and 1.4% Stage 2: 2.4% and 2.2% Stage 3: 7.8% and 15.0% Stage 4/5: 0.2% MDRD and CKD-EPI Stage 1: 6.6% and 6.7% Stage 2: 5.4% and 4.3% Stage 3: 3% and 2.1% Singh 13 2005-07 5,252 1,7 MDRD egfr<60 :4.2% CG egfr<60 :13.3% Proteinuria : 2.3% Iran Hosseinpanah 1997-2000 10,063 Urban adults 1 egfr<60 Stage 3: 99.2%
3 14 18.9% Italy Ravera 14 2005 39,525 Adult 1 egfr<60 hypertensive 3.3% Minutolo 15 2003 77,630 Adults 1 egfr<60 Crude 16.2% Age-adjusted 9.3% Japan Horio 16 2010 574,024 Adults 4,6 egfr< 60 By J-MDRD 7.7% By J-CKD-Epi 5.4% Stage 4: 0.7% Stage 5: 0.2% Stage 2: 5.8% Stage 3: 2.2% Stage 4/5: 1.1% Break-up of stages J-MDRD and J-CKDEpi Stage 1: 31.9% and 34.1% Stage 2: 60.1% and 60.5% Stage 3: 7.5% and 5.2% Stage 4/5: 0.2% each Imai 17 2000-04 527,594 Adults 4 All CKD 12.9% Stage 1:0.6% Stage 2:1.7% Stage 3:10.4% Stage 4/5:0.2% Iseki 18 2009 154,019 Adults 4 egfr<60 15.1% Korea Kim 19 2006 2,356 Urban adults 1 All CKD :13.7% Stage 1:2.0% Stage 2: 6.7% Stage 3:4.8% Stage 4:0.2% Chang 20 2001-07 60,921 Urban adults 1,11 All CKD: 7.3% Proteinuria: 5.7% Mexico
4 Obrador 21 2008 3,539 High risk adults, 90% urban Amato 22 Not mentioned Mongolia Sharma 23 2005-08 997 High risk 1,10,11 egfr<60 6.2% proteinuria 16.8% 3,564 Urban adults 7 egfr<60 : 35.8% 1,10,11 egfr<60 8% Proteinuria 6.2% urban adults Nepal Cravedi 23 2006-2009 20,811 Rural adults 1,11 egfr<60 : 19% Proteinuria: 3.5% Stage 1: 14% Stage 2: 9% Stage 3: 3.5% Stage 4/5: 1% Stage 3: 4.2% Stage 4: 0.2% Stage 5: 0.2% Stage 3: 7% Stage 4/5: 1% Stage 3: 18.6% Stage 4/5: 0.4% Norway Hallan 24 1995-97 92,939 Adults > 20 y 1 All CKD: 10.2% Stage 1: 2.7% Stage 2: 3.2% Stage 3: 4.2% Stage 4 :0.2% Spain Buitrago 24 1990-1994 845 35-74 yr old urban 1,7 egfr<60 MDRD: 8.3% C-G: 11.6% Stage 1: 12.8% Stage 2 : 75.6% Stage 3: 11.6% Singapore Teo 25 2000-05 3,979 Multi ethnic adults 1,3 egfr<60 MDRD: 3.7% All subjects: Normal or stage 1: 45.7%, Stage 2: 50.6%, Stage 3: 3.3% Stage 4: 0.3% Stage 5: 0.08% Chinese, MDRD v C-MDRD
5 Stage1:15.2% and 29.3% Stage 2: 56.8% and 19.7% Stage 3: 3% and 0.8% Stage 4: 0.2% each Taiwan Wen 26 1994-2006 46,293 1 Total CKD:11.9% Stage 1:1.0% Stage 2 : 3.8% Stage 3: 6.8% Stage 4 : 0.2% Stage 5:0.1% Hsu 27 2002 5,409 Adults 1 egfr<60 6.9% Kuo 28 1997-2003 176,365 Adults ICD-9 All CKD: 9.8% Thailand Chittinandana 28 2002-03 15,612 Urban adults (Air Force forces) Perkovic 29 2000 5,146 Urban and rural adults > 35 y Ong-Ajyooth 29 2004 3,117 Urban and rural adults>15y codes 1,11 Proteinuria 1.9% egfr<60 7.4% C-G 3.1% MDRD 1,7 All CKD: 4.5% Urban: 4.8% Rural: 5.8% In >40 y old, stage 3 25.5% (CG) and 16.3# Progressive increase in prevalence from urban to rural and more to less developed (MDRD) 3 All CKD: 8.5% stage 3: 8.1% stage 4: 0.2% stage 5: 0.2% Kitiyakara 30 1997-98 6,152 Urban adults 1,2,3,6, egfr<60 CKD-EPI: 12.2% MDRD: 20.2% Stage 1: 29.2% Stage 2: 65.5% Stage 3: 5.4% Stage 4/5: 0.1%
6 J-CKD-Epi: 37.9% C-MDRD: 5.5% T-GFR: 5.4% USA Coresh 31 1999-2004 13,233 Adults 1 Stage 1: 1.8% Stage 2: 3.2% Stage 3:7.7% Stage 4:0.35% 1MDRD egfr, 2 CKD-EPI egfr, 3 Chinese and 4 Japanese modifications of MDRD equation, 5 Chinese and 6 Japanese modifications of CKD-EPI equation, 7 Cockroft and Gault equation, 8 24-h urinary creatinine clearance, 9 Serum creatinine, 10 microalbuminuria, 11dipstick proteinuria, 12 Serum creatinine, 13 Thai GFR equation
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