ADNI-related initiatives in Europe E-ADNI neugrid/outgrid EADC/ADNI harmonization of hippo manual segmentation
Pharma-Cog AIM: To develop new markers homologous in animal and humans sensitive to symptomatic effects and disease modification Development of markers in ANIMALS Development of markers in HUMANS
neugrid and outgrid: THE CONCEPT
FP7 outgrid A Worldwide e-infrastructure for Computational Neuroscientists Access to large image datasets Image analysis algorithms Grid-based high performance computing Image analysis algorithms Grid-based high performance computing Home to world largest image dataset on Alzheimer s Image analysis algorithms Friendly Pipeline Interface Centralized high performance computing
neugrid/outgrid Agreement w/ A Toga and A Evans to progress towards integration of the three infrastructures. A proof-of-concept challenge will be done by the end of 2010 (any source-any sink)
CSF total tau Alzheimer THE CONCEPT Hippocampal volume as a diagnostic marker Structure: MR hippo volumetry Function: FDG PET Amyloid deposits: PET Biochemistry: CSF tau/abeta Normal CSF Abeta42 Dubois, Feldman et al., Lancet Neurol 2007
THE CONCEPT The effect of segmentation protocols on hippocampal volume Ref. Med border Lat border Watson et al. Zipursk y et al. Mesial edge of temporal lobe Regional outline at choroidal fissure Temp horn of lat ventr Not mentioned Inf border Incl subicular complex & uncal cleft w/ border separating subicular complex from parahippo gyrus The interface of hippocampal tissue and parahippocampal gyrus white matter Norm. hippo vol (cm 3 ) Left Right 4.903 5.264 1.990 2.070 Geuze et al., Mol Psychiatry 2005;10:147-59
THE CONCEPT Hippocampal volume as an outcome measure in trials of disease modifiers Drug Study Effect Segment. method Ref Tramiprosate Alphase 68% (100 mg) 120% (150 mg) Atorvastatin ADCLT CHV* mm³ -134 174 vs -583 354 p>.05 Not mentioned Manual protocol Insausti et al., 1998 AJNR; Machulda et al., 2001, Neuroimage Gauthier et al., JNHA 2009 Sparks et.a,l CCJM,2008 LEADe significant at p<.05 MIDAS (semiautomated) Jones et al., Alz&Dem 2008 Feldman et al., Neurology 2010 AN1792 CHV* % 3.78 2.63 vs 2.86 3.19 p = 0.124 Manual protocol Watson et al., 1992, Neurology Fox N et al., Neurology, 2005 Xaliproden Sanofi- Aventis Trials significant atrophy Not mentioned From Vellas B et al. (Review), Lancet Neurol.,2008 Donepezil CHV* % -6.14 3.49vs - 4.50 2.28 p= 0.07 ε4 carriers only Manual protocol Jack et al., 1989;Radiology Jack et al., 2004; Neurology Jack CR et al., Neurobiol. Aging, 2008
BACKGROUND Hippocampal volume (manual segmentation) gold standard for automated segmentation algorithm Morey et al., NeuroImage 2009
AIMS To Harmonize Available Protocols for Manual Hippocampal Segmentation To Test the Validity of the Harmonized Protocol
AUTHORS OF HIPPO PROTOCOLS Bartzokis G, et al. Psychiatry Res 1998;82:11-24 Convit A, et al. Neurobiol Aging 1997;18:131-8 Haller JW, et al. Radiology 1997;202:504-10 Jack CR Jr. Epilepsia 1994;35 - Suppl 6:S21-9 Killiany RJ, et al. Arch Neurol 1993;50:949-54 Lehéricy S, et al. Am J Neuroradiol 1994;15:929-37 Malykhin NV, et al. Psychiatry Res 2007;155:155-65 Pantel J, et al. Hippocampus 2000;10:752-8 Pruessner JC, et al. Cereb Cortex 2000;10:433-42 Soininen HS, et al. Neurology 1994;44:1660-8
THE WORKGROUP EADC F Barkhof/P Scheltens B Dubois/S Leherici N Fox/J Barnes GB Frisoni H Hampel/J Pantel A Simmons H Soininen S Teipel LO Wahlund Amsterdam Paris London Brescia Frankfurt London Kuopio Rostock Stockholm
THE WORKGROUP ADNI CR Jack Jr Rochester, MN G Barzokis UCLA, CA D Bennet Chicago, IL J Csernansky NorthW U, WA C DeCarli UC Davis, CA M De Leon New York, NY J Kaye Portland, OR R Killiany Boston USM, MA PM Thompson LoNI, UCLA, CA M Weiner/S Mueller UCSF/VAMC
THE WORKGROUP other relevant hippo experts R Camicioli J O Brien J Pruessner Univ Alberta, Canada NewCastle, UK McGill, QC, Canada
THE WORKGROUP Boards EADC-ADNI P.I.s B Vellas B Winblad M Weiner Toulouse, France Stockholm, Sweden UCSF, US Population-based studies M Breteler / T Den Heijer P Sachdev/ JJ Maller L Launer W Jagust Rotterdam Scan Study PATH through life NIA Bethesda Berkeley
THE WORKGROUP Boards Statistical Board S Duchesne L Collins P Pasqualetti Clinical Advisor PJ Visser Netherlands Laval Univ, Canada MNI, McGill, Montreal AFaR, Rome Maastricht, The Dissemination/Education G Waldemar Copenhagen, Denmark
THE WORKGROUP Personnel in Brescia Marina Boccardi Rossana Ganzola Enrica Cavedo Michela Pievani Anna Caroli Alberto Redolfi psychologist, PhD psychologist psychologist mathematician mathematician bioinformaticist
PRELIMINARY RESULTS
EADC-ADNI Harmonization of Hippocampal Volumetry A meeting has been hold in Toronto yesterday (co-chair Cliff jack) to update. Oral communication will be given at Imaging preconference at ICAD 2010. Featured Research Symposium of the AIC will take place at ICAD 2010 www.hippocampal-protocol.net