BioVin Collagen Membrane

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BioVin Collagen Membrane Resorbable cross-linked collagen membrane BioVin Bovine Bone Bovine Bone Substitute OToss Synthetic Bone Synthetic Resorbable Biphasic Calcium Phosphate OToss Synthetic Bone Inject Microporous Resorbable Biphasic Calcium Phosphate

BioVin Collagen Membrane BIORESORBABLE Collagen membrane Controlled resorption BioVin Collagen Membrane is a cross-linked collagen membrane which is indicated for controlled tissue regeneration in periodontal defects. The resorbable membrane provides reliable protection against the adverse effects of bone regeneration and provides support to the healing process of soft tissue through its natural structure. Easy to use The biocompatible BioVin Collagen Membrane is characterized by an easy and safe handling procedure: It can be cut and shaped, it is flexible and also stabile and adapts perfectly to defects. Biocompatible and safe The membrane is made of porcine collagen type I and type III with standardized purification process. BioVin Collagen Membrane is obtained by controlled manufacturing processes and international recognized standards for excellent biocompatibility. The collagen is extracted from veterinary certified pigs skin. SEM of membrane SEM of membrane 2 Biomaterial

BioVin Collagen Membrane PROPERTIES Suppleness and flexibility Easy to use (cut to size and moldable) High stability and tear resistance by cross-linking Cell occlusive Excellent adhesion Long-lasting barrier function INDICATIONS The BioVin Collagen Membrane can be used in a variety of indications: Implantology, periodontology, oral surgery, maxilla-facial surgery Sinus lift Horizontal augmentation Ridge augmentation Alveolar ridge reconstruction Fenestration defects Dehiscence Product information The BioVin Collagen Membrane is available in following sizes: Art.-No. Size Content 05-9159252010 15 x 25 mm 1 Membrane 05-9209302010 20 x 30 mm 1 Membrane 05-9309402010 30 x 40 mm 1 Membrane Manufacturer: Biomatlante, ZA Les Quatre Nations, 5 Rue Edouard Belin, 44360 Vigneux de Bretagne, France Biomaterial 3

BioVin Bovine Bone Bovine Bone Substitute material BioVin Bovine Bone is an inorganic bone substitute material of hydroxyapatite, origin of bovine bone (Australian bovine bone, BSE-free). Due to its natural origin, BioVin Bovine Bone is chemically as well as structurally comparable to the mineralized human bone. This ensures a positive acceptance and high efficiency. After insertion into bone cavities or interstices BioVin Bovine Bone builds an osteoconductive matrix, allowing growth into the adjacent functional bone. BioVin Bovine Bone is slowly absorbed during the healing process and replaced by bone. The micro- and macro-porosity work together with the interconnecting pore system providing rapid revascularization. SEM Mesopore SEM Micropore 4 Biomaterial

BioVin Bovine Bone PROPERTIES Safe and Biocompatible Interconnecting pore system ensures fast revascularization Long-Term Volume Stability Micro & Macro Porosity Highly Purified Processing INDICATIONS BioVin Bovine BONE can be used in a variety of indications: Implantology, periodontology, oral surgery, maxilla-facial surgery Alveolar ridge reconstruction Extraction sockets Peri-Implant defects Periodontal regeneration Intra-oral bone defects Root tip resections ProduCt information The bone substitution material BioVin Bovine Bone is available in the following sizes and volumes: Art.-No. Granule size Volume 05-9059051010 0.25-1.0 mm 0.25 g ( 0.54 ml) 05-9059101010 0.25-1.0 mm 0.50 g ( 1.08 ml) 05-9109101010 1.0-2.0 mm 0.50 g ( 2.00 ml) Manufacturer: SigmaGraft, Inc., 335 N. Puente St., Unit A, Brea, CA 92821, USA Biomaterial 5

OToss Synthetic Bone SYNTHETIC BONE SUBSTITUTE OToss Synthetic Bone synthetic bone substitute material consisting of 80% beta-tricalcium Phosphate (ß-TCP) and 20% Hydroxylapatite (HA). The optimal balance of a stable component (HA) and a more bioactive and resorbable component (β- TCP) in connection to porosity, provides a controlled process for ceramic resorption and bone substitution. The unique manufacturing process of OToss Synthetic Bone offers an interconnecting porous structure which builds the basis for optimal angiogenesis and osteoconduction. PROPERTIES 80% ß-TCP, 20% HA Interconnected porosity Micro- & macro pores Osteoconduction Controlled resorption 30 years of clinical experience INDICATIONS OToss Synthetic Bone can be used in variety of indications: Periodontal/Bone defects Sinus lift Extraction sockets Alveolar ridge augmentations Filling of cystic cavities ProduCt information The bone substitution material OToss Synthetic Bone is available in following sizes and volumes: Art.-No. Granule size Volume 05-9059051020 0.5-1.0 mm 0.5 ml 05-9059101020 0.5-1.0 mm 1.0 ml Manufacturer: Biomatlante, ZA Les Quatre Nations, 5 Rue Edouard Belin, 44360 Vigneux de Bretagne, France 6 Biomaterial

OToss Synthetic Bone Inject SYNTHETIC BONE SUBSTITUTE OToss Synthetic Bone Inject is a new, synthetic bone substitute material. The micro-pores, moldable Calcium Phosphate paste consists of 60% Hydroxylapatite (HA) and 40% beta-tricalcium Phosphate (ß-TCP) as well as a hydrogel which acts as the soluble carrier. The resorbable bone graft substitute is supplied sterile in a syringe and can be applied directly into the bone defect, where it fits perfectly into the defect geometry. The material remains stable in volume and ensures a controlled process of ceramic resorption and bone substitution. PROPERTIES 40% ß-TCP, 60% HA Moldable High volume stability Interconnected porosity Osteoconduction Controlled resorption INDICATIONS OToss Synthetic Bone Inject can be used in varies indications: Sinus lift Extraction sockets Periodontal/Bone defects Ridge augmentation Filling of cystic cavities Product information The bone substitution material OToss Synthetic Bone Inject is available in following sizes and volumes Art.-No. Granule size Volume 05-9059053010 0.5-1.0 mm 0.5 ml Manufacturer: Biomatlante, ZA Les Quatre Nations, 5 Rue Edouard Belin, 44360 Vigneux de Bretagne, France Biomaterial 7

09-751200010 01-2015/2 Vertrieb durch OT medical GmbH Konsul-Smidt-Straße 8b, 28217 Bremen, Germany Tel. +49 421 557161-0, Fax +49 421 557161-95 info@ot-medical.de, www.ot-medical.de 14-080