ORAN S. AARONSON. Nashville, Tennessee. August 1999-July 2004 Neurosurgery Department of Neurosurgery. Nashville, Tennessee

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ORAN S. AARONSON Assistant Professor of Neurological Surgery Residency Program Director T-4224 Medical Center North 37232-2380 Office: (615) 322-1883 Fax: (615) 343-8104 EDUCATION 1989-1992 B.S. First Class Honors University of London, Kings College Department of Biomedical Sciences 1992-1997 M.B., B.S. (M.D.) University of London The Medical College of St. Bartholomew s Hospital & The Royal London Hospital August 1997-July 1998 House Officer Barts and The London Hospitals London, England August 1998-July 1999 General Surgery Department of Surgery Intern August 1999-July 2004 Neurosurgery Resident I

MEDICAL LICENSURE 2004-Present State of Tennessee Medical License 2007-Present State of Florida Medical License BOARD CERTIFICATION 2007-Present Board Certified: American Board of Neurosurgery ACADEMIC APPOINTMENTS August 2004-Present Assistant Professor August 2004 Associate Residency Program Director August 2010-Present Residency Program Director HOSPITAL APPOINTMENTS August 2004-Present Chief, Neurosurgery Veterans Administration Hospital August 2007-Present Attending Surgeon Williamson Medical Center PROFESSIONAL ORGANIZATION MEMBERSHIP 1999-Present American Medical Association 1999-Present American Association of Neurological Surgeons 1999-Present Congress of Neurological Surgeons 2004-Present North American Spine Society 2004-Present Tennessee Neurosurgical Society II

PROFESSIONAL ACTIVITIES 2001 Chair, House Staff Advisory Council 2001 Tennessee Resident Representative American Medical Association RESEARCH 1991-1994 Neural Growth and Regeneration Department of Physiology, University of London London, England 2001 Robot-Assisted In-Utero Endoscopic Repair of Myelomeningocele 2002 Microendoscopic Discectomy Percutaneous Placement of Pedicle Screws Chicago Institute of Neurosurgery and Neuroresearch Chicago, Illinois 2002 Image Guidance for Placement of Instrumentation in the Spine 2006 Development of Recovery Methods for Artificial Lumbar Discs 2008-Present Comparative effectiveness and cost-utility of various surgical interventions for spinal pathology via prospective web-based registries. III

2009-Present Does continuous preoperative dexmedetomidine infusion reduce time to discharge in patients undergoing major lumbar fusion? A multi center observational study of patients undergoing minimally invasive TLIF surgical approach compared to open TLIF approach. PUBLICATIONS AND PRESENTATIONS Peer-reviewed Papers: 1. Golding J.P., Aaronson O.S., Tonge D.A. Axonal regeneration and changes in protein secretion from lesioned peripheral nerves in the axolotl, Ambystoma Mexicanum. Proceedings of the Journal of physiology, 475: 5P, 1994. 2. Aaronson O.S., Golding J.P., Tonge D.A. Oriented growth of regenerating axons in Axolotl forelimbs is consistent with guidance by diffusible factors from distal nerve stumps. Neuroscience 66: 201-213, 1995. 3. Tonge, D.A., Aaronson, O.S., Golding, J.P., Jaggers, D. Cellular migration and axonal outgrowth from adult mammalian peripheral nerves in vitro. Journal of Neurobiology 29: 151-164, 1996. 4. Aaronson, O.S., Tulipan, N.B., Cywes, R., Sundell, H.W., Davis, G.H., Bruner, J.P., Richards, W.O. Robot-assisted endoscopic intrauterine myelomeningocele repair: a feasibility study. Pediatric Neurosurgery 36:85-89, 2002. 5. Aaronson, O.S., Hernanz-Schulman, M., Bruner, J.P., Reed, G.W., Tulipan, N.B. Prenatal evaluation of myelomeningocele: a comparison between transabdominal ultrasonography and magnetic resonance imaging. Radiology 227:839-843, 2003. 6. Isaacs R.E., Podichetty V.K., Sandhu, F.A., Santiago P., Spears J.D., Aaronson O.S., Kelly K., Hrubes M., Fessler R.G: Thoracic Microendoscopic Discectomy: A Human Cadaver Study. Spine 30(10):1226-31, 2005. 7. Oberer, D.M., Aaronson, O.S., Cheng, J.S: Development of Quadraparesis from the Delayed Formation of a Compressive Epidural CSF Collection after Suboccipital Craniectomy and Duraplasty for Chiari 1 Malformation: Case Report and Technical Note. Journal of Neurosurgery: Spine, October 2007. IV

8. Mukherjee R, Chaichana K, Gokaslan Z, Aaronson O, Cheng J, McGirt MJ. Survival of patients with primary osseous spinal neoplasms from the surveillance, epidemiology, and end results (SEER) database: Histology specific analysis from 1973-2005. Journal of Neurosurgery: Spine. In Press 9. Parker S.L., Adogwa O., Witham T., Aaronson O.S., Cheng J.S., McGirt M.J: Postoperative infection after minimally invasive versus open transforaminal lumbar interbody fusion (TLIF): Literature review and cost analysis. Journal of Minimally Invasive Neurosurgery. In Press 10. Adogwa O, Parker S, Davis B, Aaronson O, Cheng J, Devin C, McGirt MJ. Cost effectiveness of transforaminal lumbar inter-body fusion (TLIF) for grade I degenerative spondylolithesis. Journal of Neurosurgery: Spine. In Press 11. Chaichana K, Mukherjee R, Gokaslan Z, Aaronson O, Cheng J, McGirt MJ. Association of surgical resection and survival in patients with primary osseous spinal neoplasms: A 30-year population-based study. Spine. Submitted 12. Adogwa O, Parker S, Aaronson O, Cheng J, McGirt MJ. Minimally invasive versus open transforaminal lumbar interbody fusion (TLIF) for the treatment of spondylolithesis and degenerative disc disease: an evidenced-based review of the literature. Journal of Neurosurgery: Spine. Submitted 13. Mukherjee R, Chaichana K, Gokaslan Z, Aaronson O, Cheng J, McGirt MJ. Association of extent of invasion and survival in patients with primary osseous spinal neoplasms: A 30-year population-based study. European Spine Journal. Submitted 14. Davis B, Adogwa O, Fulchiero E, Aaronson O, Cheng J, Devin C, McGirt MJ. Comparative effectiveness of minimally invasive versus open multi-level decompression for lumbar stenosis. Journal of Neurosurgery: Spine. Submitted 15. Adogwa O, Davis B, Fulchiero E, Aaronson O, Cheng J, Devin C, McGirt MJ. Cost effectiveness of minimally invasive versus open multi-level decompression for lumbar stenosis. Journal of Neurosurgery: Spine. Submitted 16. Mukherjee R, Adogwa O, Gokaslan Z, Aaronson O, Cheng J, McGirt MJ. Association of extent of local tumor invasion and survival in patients with malignant primary osseous spinal neoplasms from the surveillance, epidemiology, and end results (SEER) database. Journal of Neurosurgery: Spine. Submitted V

Manuscripts in preparation: 1. Parker S, Adogwa O, Davis B, Aaronson O, Cheng J, Devin C, McGirt MJ. Determination of the minimum improvement in pain, disability, and health state associated with cost-effectiveness: Introduction of the concept of Minimum Cost Effective Difference (MCED). Journal of Neurosurgery: Spine. 2. Adogwa O, Davis B, Fulchiero E, Aaronson O, Cheng J, Devin C, McGirt MJ. Cost effectiveness of revision lumbar decompression and fusion for failed back surgery syndrome (FBSS). Journal of Neurosurgery: Spine. 3. Adogwa O, Davis B, Fulchiero E, Aaronson O, Cheng J, Devin C, McGirt MJ. Costutility analysis of minimally invasive versus open multilevel laminectomy for lumbar stenosis. The Spine Journal. Book Chapters: 1. Mendel, E., Guiot, B.H., Isaacs, R.E., Rhines, L.D., Fessler, R.G., Aaronson, O.S. Diagnosis and management of thoracic disc herniation and the transpedicular decompression for thoracic disc herniation. Atlas of Neurosurgical Techniques: Spine and Peripheral Nerves. Thieme, New York, NY 2006 Peer-reviewed Abstracts and Presentations: 1. Golding J.P., Aaronson O.S., Tonge D.A. Axonal regeneration and changes in protein secretion from lesioned peripheral nerves in the axolotl, Ambystoma Mexicanum. Physiological Society Meeting, London, England. December 1993. Abstract 2. Aaronson O.S. Robotic Endoscopic Repair of Spina Bifida: Sheep Model. Society for Maternal and Fetal Medicine Annual Meeting, New Orelans, LA. January 2002. Podium Presentation 3. Isaacs R.E., Aaronson O.S., Sandu F.A., Santiago P., Fessler R.G. Thoracic Microendoscopic Discectomy, Spine Science Management, New Orleans, LA. November 2002. Abstract 4. Sandu F.A., Isaacs R.E., Aaronson O.S., Santiago P., Fessler R.G. Percutaneous Thoracic Pedicle Screws, Spine Science Management, New Orleans, LA. November 2002. Abstract VI

5. Isaacs R.E., Aaronson O.S., Sandu F.A., Santiago P., Fessler R.G. Percutaneous Thoracic Pedicle Screws, Joint Section on Disorders of the Spine and Peripheral Nerves, Tampa, FL. March 2003. Abstract 6. Isaacs R.E., Aaronson O.S., Sandu F.A., Santiago P., Fessler R.G. Thoracic Microendoscopic Discectomy, Joint Section on Disorders of the Spine and Peripheral Nerves, Tampa, FL. March 2003. Abstract 7. Isaacs R.E., Aaronson O.S., Sandu F.A., Santiago P., Fessler R.G. Thoracic Microendoscopic Discectomy, Annual Meeting of the American Association of Neurological Surgeons, San Diego, CA. April 2003. Abstract 8. Isaacs R, Aaronson O.S., Santiago P, Sandhu F, Fessler, RG: Percutaneous thoracic pedicel screw placement. Annual Meeting of the American Association of Neurological Surgeons, San Diego, 2003. Abstract 9. Isaacs R.E., Aaronson O.S., Fessler R.G. Microendoscopic Posterolateral Thoracic Discectomy, World Spine II, Chicago, IL. August 2003. Abstract 10. Spooner J., Yu H., Sun D.A., Carpenter R.O., Segebarth P.B., Aaronson O.S., Cheng J. S. Retroperitoneal transpsoas approach for retrieval of lumbar artificial disc: a cadaveric feasibility study. Congress of Neurological Surgeons, 2006. Abstract 11. Chaichana K.L., Parker S., Adogwa O., Mukherjee D., Aaronson O.S., Cheng J.S., Gokaslan Z.L., McGirt M. Survival of Patients with Malignant Primary Osseous Spinal Neoplasms from the Surveillance, Epidemiology, and End Results (SEER) Database from 1973-2005. AANS/CNS Spine section. Accepted March 2011. Podium Presentation 12. Parker S., Lebow R.L., Adogwa O., Sharma A., Aaronson O.S., Cheng J.S., Gokaslan Z.L., McGirt M. Radiographic Same-level Recurrent Disc Herniation After Lumbar Discectomy: Prospective Longitudinal Study with Two-year Follow-up. AANS/CNS Spine section. Accepted March 2011. Podium Presentation 13. Adogwa O, Parker S, Aaronson O, Cheng J, McGirt MJ. Comparative effectiveness of minimally invasive versus open transforaminal lumbar interbody fusion: Two year assessment of narcotic use, return to work, disability, and quality of life. AANS/CNS Spine section. Accepted March 2011. Podium Presentation 14. Fulchiero E., Davis B.J, Adogwa O., Aaronson O.S., Cheng J.S., Devin C., McGirt M. Cost Effectiveness of Multilevel Hemilaminectomy for Lumbar Stenosis VII

Associated Radiculopathy. AANS/CNS Spine section. Accepted March 2011. Podium Presentation 15. Parker S., Kaisom C.L., Aaronson O.S., Cheng J.S., Gokaslan Z.L., McGirt M. Preoperative Grading Scale to Predict Survival in Patients Undergoing Resection of Malignant Primary Osseous Spinal Neoplasms. AANS/CNS Spine section. Accepted March 2011. Podium Presentation 16. Owoicho, A., Parker S., Aaronson O.S., Cheng J.S., McGirt M. Comparative Effectiveness of Minimally Invasive versus Open Transforaminal Lumbar Interbody Fusion: Two-year Assessment of Narcotic Use, Return to Work, Disability, and Quality of Life. AANS/CNS Spine section. Accepted March 2011. Podium Presentation 17. Parker S., Owoicho, A., Paul A., Anderson B., Aaronson O.S., Cheng J.S., McGirt M. Determination of Minimum Clinically Important Difference (MCID) in Pain, Disability, and Health State Utility After Transforaminal Lumbar Interbody Fusion (TLIF) for Degenerative Lumbar Spondylolithesis. AANS/CNS Spine section. Accepted March 2011. Podium Presentation 18. Owoicho, A., Davis B, Fulchiero E., Aaronson O.S., Cheng J.S., Devin C., McGirt M. Cost-utility Analysis of Minimally Invasive Versus Open Multilevel Decompression for Lumbar Stenosis. AANS/CNS Spine section. Accepted March 2011. Podium Presentation Invited Abstracts, Presentations and Teaching conferences: 1. Aaronson O.S. Robot-assisted endoscopic intrauterine myelomeningocele repair: an animal model. Lecture at the Meacham Neurosurgery Meeting, Nashville, TN. November 2001. 2. Aaronson, O.S., Tulipan, N.B., Cywes, R., Sundell, H.W., Davis, G.H., Bruner, J.P., Richards, W.O. Robot-assisted endoscopic intrauterine myelomeningocele repair: a feasibility study. Poster presentation 20 th Annual Research Forum, Vanderbilt University Medical Center, Nashville, TN. April 2002. 3. Aaronson O.S. Minimally Invasive Spine Procedures: Technique and Application Scenarios. Lecture at the Meacham Neurosurgery Meeting, Nashville, TN. November 2004. VIII

4. Aaronson O.S. Faculty Transition Into Practice Resident Fellow Course. Sponsored by Medtronic Sofamor Danek. Memphis, TN 2004, 2005, 2006. 5. Aaronson O.S. Faculty Kyphoplasty Resident Course. Sponsored by Medtronic Sofamor Danek. Nashville, TN 2005, 2009. 6. Aaronson O.S. Management of Thoracic Disc Herniations. Neurosurgery Grand Rounds, Vanderbilt University, Nashville, TN. March 2005. 7. Aaronson O.S. A Surgeon s Perspective on Acute Spinal Problems. Neurology Teaching Conference, Vanderbilt University, Nashville, TN. February 2006, August 2009, July 2010. 8. Aaronson O.S. Overview of Peripheral Nerve Surgery. Neurosurgery Journal Club, Vanderbilt University, Nashville, TN. May 2007, October 2008. 9. Aaronson O.S. Management of Benign Compression Fractures. Lecture to Internal Medicine Department, Vanderbilt University, Nashville, TN. 2007. 10. Aaronson O.S. X-STOP Interspinous Process Decompression System. Lecture at the Meacham Neurosurgery Meeting, Nashville, TN. October 2007. 11. Aaronson O.S. Management of Pathological Compression Fractures. Lecture to Hematology Oncology Department, Vanderbilt University, Nashville, TN. 2008. 12. Aaronson O.S. Peripheral Nerve Surgery for the Boards. Neurosurgery Teaching Conference, Vanderbilt University, Nashville, TN. October 2008. 13. Aaronson O.S. Pitfalls of Spinal Diagnoses. Neurosurgery Teaching Conference, Vanderbilt University, Nashville, TN. February 2009. 14. Aaronson O.S. Peripheral Nerve Biopsy. Combined Neurology, Neurosurgery, Neuropathology Grand Rounds Conference, Vanderbilt University, Nahsville, TN. March 2009. IX