MEDICINES FOR SMOKING CESSATION: GLOBAL MARKETS PHM154A September 2013 Anand Gijare Project Analyst ISBN: 1-56965-544-8 BCC Research 49 Walnut Park, Building 2 Wellesley, MA 02481 866-285-7215, 781-489-7301 www.bccresearch.com Custom Reports: carol.laverty@bccresearch.com
TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 2 STUDY GOALS AND OBJECTIVES 2 REASONS FOR DOING THE STUDY 2 SCOPE OF REPORT 2 INTENDED AUDIENCE 2 INFORMATION SOURCES 3 ANALYST CREDENTIALS 3 RELATED REPORTS 3 BCC ONLINE SERVICES 4 DISCLAIMER 4 CHAPTER 2 SUMMARY 6 SUMMARY TABLE SIZE OF GLOBAL SMOKING CESSATION MEDICINE MARKET BY REGION, THROUGH 2018 ($ SUMMARY FIGURE SIZE OF GLOBAL SMOKING CESSATION MEDICINE MARKET BY REGION, 2011-2018 ($ 8 8 CHAPTER 3 OVERVIEW 12 SMOKING AND HEALTH HAZARDS 12 CURRENT TRENDS IN THE TOBACCO INDUSTRY 13 HEALTH HAZARDS OF SMOKING 14 METHODS OF SMOKING CESSATION 16 SMOKING CESSATION WITHOUT ASSISTANCE 16 SMOKING CESSATION WITH EXPERT INTERVENTIONS 18 SMOKING CESSATION WITH MEDICATION 18 HEALTH BENEFITS OF SMOKING CESSATION 18 TABLE 1 BENEFITS OF SMOKING CESSATION 19 TRENDS IN SMOKING CESSATION 20 ROLE OF NICOTINE 21 FIGURE 1 NICOTINE MOLECULE: 3-[(2S)-1-METHYLPYRROLIDINE-2-YL]PYRIDINE 21 UNDERSTANDING NICOTINE ADDICTION 22 TABLE 2 GENERAL CRITERIA FOR DRUG DEPENDENCE 23 UNDERSTANDING NICOTINE ABSORPTION MECHANISM 24 UNDERSTANDING WITHDRAWAL SYMPTOMS OF NICOTINE 25 CHAPTER 4 SMOKING CESSATION MEDICINES 28 TABLE 3 CLASSIFICATION OF SMOKING CESSATION MEDICINES BASED ON MODE OF ACTION NICOTINE REPLACEMENT THERAPY 29 TABLE 4 CLASSIFICATION OF NICOTINE REPLACEMENT THERAPY BASED ON DRUG DELIVERY SYSTEM NICOTINE REPLACEMENT THERAPY: ORAL MUCOSA DELIVERY SYSTEM 30 Nicotine Gum 30 TABLE 5 NICOTINE GUM DOSAGES AND SCHEDULES 30 Key Brands 31 TABLE 6 KEY BRANDS AND MARKETERS OF NICOTINE GUMS 32 29 29
Nicotine Lozenges 32 TABLE 7 NICOTINE LOZENGE DOSAGE AND SCHEDULE 32 TABLE 8 KEY BRANDS AND MARKETERS OF NICOTINE LOZENGES 33 Nicotine Tablets 33 TABLE 9 KEY BRANDS AND MARKETERS OF NICOTINE TABLETS 34 Nicotine Inhalers 34 TABLE 10 KEY BRANDS AND MARKETERS OF NICOTINE INHALERS 34 Nicotine Mouth Sprays 35 TABLE 11 KEY BRANDS AND MARKETERS OF NICOTINE MOUTH SPRAYS 35 NICOTINE REPLACEMENT THERAPY: TRANSDERMAL DELIVERY SYSTEM 35 Nicotine Patches 35 TABLE 12 NICOTINE PATCH DOSAGE AND SCHEDULE 36 TABLE 13 KEY BRANDS AND MARKETERS OF NICOTINE PATCHES 37 NICOTINE REPLACEMENT THERAPY: NASAL DELIVERY SYSTEM 37 Nicotine Nasal Sprays 37 TABLE 14 KEY BRANDS AND MARKETERS OF NICOTINE NASAL SPRAYS 37 NON-NICOTINE THERAPIES 38 CHANTIX/CHAMPIX (VARENICLINE TARTRATE) 38 Mechanism of Action 38 Marketing 38 TABLE 15 CHANTIX/CHAMPIX SALES REVENUE, 2007-2012 ($ 39 Zyban (bupropion HCl) 39 R&D IN SMOKING CESSATION MEDICINES 40 DEVELOPMENTS IN THE PIPELINE (NICOTINE REPLACEMENT THERAPY) 40 NICOTINE VACCINES 40 TABLE 16 NICOTINE VACCINES IN DEVELOPMENT PHASE AS OF JANUARY 2013 41 NICOTINE ORALLY DISSOLVABLE FILMS 41 VERY LOW NICOTINE CIGARETTES 42 CYTISINE (TABEX) 42 DEVELOPMENTS IN THE PIPELINE (NON-NICOTINE THERAPY) 43 TABLE 17 DEVELOPMENTS IN THE PIPELINE (NON-NICOTINE) 43 GSK598809 SELECTIVE D3 RECEPTOR ANTAGONIST 44 D-CYCLOSERINE 44 TABLE 18 CLINICAL TRIALS OF D-CYCLOSERINE 44 EVT 302 44 SELEGILINE 45 NALMEFENE 45 CHAPTER 5 THE GLOBAL SMOKING CESSATION MEDICINE MARKET 47 SMOKING CESSATION MARKET REVENUE, 2012 47 SMOKING CESSATION MEDICINE MARKET FORECAST, 47 TABLE 19 SMOKING CESSATION MEDICINE GLOBAL MARKET FORECAST, THROUGH 2018 ($ FIGURE 2 SMOKING CESSATION MEDICINE GLOBAL MARKET FORECAST, 2011-2018 ($ GLOBAL MARKET FORECAST BY CLASSIFICATION OF SMOKING CESSATION MEDICINES, 48 48 49
TABLE 20 SMOKING CESSATION MEDICINE GLOBAL MARKET FORECAST BY CLASSIFICATION, THROUGH 2018 ($ FIGURE 3 SMOKING CESSATION MEDICINE GLOBAL MARKET FORECAST BY CLASSIFICATION, 2011-2018 ($ GLOBAL MARKET FORECAST BY TYPE OF SALES, 50 TABLE 21 GLOBAL SMOKING CESSATION MEDICINES BY TYPE OF SALES 50 TABLE 22 SMOKING CESSATION MEDICINES FORECAST BY TYPE OF SALES, THROUGH 2018 ($ FIGURE 4 SMOKING CESSATION MEDICINE GLOBAL MARKET FORECAST BY TYPE OF SALES, 2011-2018 ($ GLOBAL SMOKING CESSATION MEDICINE MARKET FORECAST BY CATEGORY, TABLE 23 SIZE OF GLOBAL SMOKING CESSATION MEDICINE MARKET BY CATEGORY, THROUGH 2018 ($ FIGURE 5 SIZE OF GLOBAL SMOKING CESSATION MEDICINE MARKET BY CATEGORY, 2011-2018 ($ GLOBAL NICOTINE REPLACEMENT THERAPY MARKET FORECAST BY CATEGORY, TABLE 24 GLOBAL NICOTINE REPLACEMENT THERAPY MARKET FORECAST BY CATEGORY, THROUGH 2018 ($ FIGURE 6 GLOBAL NICOTINE REPLACEMENT THERAPY MARKET FORECAST BY CATEGORY, 2011-2018 ($ 49 50 51 51 52 53 53 55 56 56 CHAPTER 6 LEADING MARKETS FOR SMOKING CESSATION MEDICINES 59 GLOBAL MARKET FORECAST BY REGION FOR SMOKING CESSATION MEDICINES, EMERGING MARKETS ARE NEW TARGET MARKETS FOR SMOKING CESSATION, THROUGH 2018 Quit Rates are High in Developed Countries 59 Decrease in Smoking Rates Have Reached Saturation Point in Developed Markets Smoking Rates are Increasing in Developing Markets 60 STRATEGIC INITIATIVES TO INCREASE SMOKING CESSATION IN DEVELOPING COUNTRIES Developing and Poor Countries Sign WHO FCTC Treaty 61 WHO FCTC Progress Report 2012 61 TABLE 25 ARTICLES REPORTING HIGHEST IMPLEMENTATION RATES: 2012 WHO FCTC PROGRESS REPORT (%) TABLE 26 ARTICLES REPORTING MODERATE IMPLEMENTATION RATES: 2012 WHO FCTC PROGRESS REPORT (%) TABLE 27 ARTICLES REPORTING LOWEST IMPLEMENTATION RATES: 2012 WHO FCTC PROGRESS REPORT (%) FIGURE 7 GLOBAL IMPLEMENTATION OF ARTICLES: 2012 FCTC REPORT (%) 63 TABLE 28 GLOBAL IMPLEMENTATION OF FCTC ARTICLES: 2012 REPORT 64 Implementation of Article 14 in 2012 66 TABLE 29 GLOBAL IMPLEMENTATION OF ARTICLE 14 OF FCTC, 2012 67 TABLE 30 SIZE OF GLOBAL SMOKING CESSATION MEDICINE MARKET BY REGION, THROUGH 2018 ($ FIGURE 8 SIZE OF GLOBAL SMOKING CESSATION MEDICINE MARKET BY REGION, 2011-2018 ($ THE U.S.: SMOKING CESSATION MARKET 70 59 59 60 60 62 62 63 69 69
CIGARETTE SMOKING DECLINES IN THE U.S. 71 THE U.S. SMOKING CESSATION MEDICINE MARKET 71 TABLE 31 SMOKING CESSATION BRANDS IN THE U.S. MARKET, 2012 72 NEW ENTRANTS EYE THE U.S. MARKET 72 THE U.S.: SMOKING CESSATION MARKET REVENUE, 2012 73 THE U.S.: MARKET FORECAST FOR SMOKING CESSATION MEDICINES, TABLE 32 SMOKING CESSATION MEDICINE MARKET IN THE U.S., THROUGH 2018 ($ FIGURE 9 SMOKING CESSATION MEDICINE MARKET IN THE U.S., 2011-2018 ($ CANADA: SMOKING CESSATION MARKET 74 CANADA SMOKING CESSATION MEDICINE MARKET 75 TABLE 33 SMOKING CESSATION BRANDS IN CANADA MARKET: 2012 76 NEW ENTRANTS IN CANADIAN MARKET 76 CANADA: SMOKING CESSATION MARKET REVENUE 2012 76 CANADA: MARKET FORECAST FOR SMOKING CESSATION MEDICINES, TABLE 34 SMOKING CESSATION MEDICINE MARKET IN CANADA, THROUGH 2018 ($ EUROPE: SMOKING CESSATION MEDICINE MARKET 77 TABLE 35 SMOKING CESSATION BRANDS IN EUROPEAN MARKET: 2012 78 EUROPE: SMOKING CESSATION MARKET REVENUE, 2012 78 EUROPE: MARKET FORECAST FOR SMOKING CESSATION MEDICINES, 79 TABLE 36 SMOKING CESSATION MEDICINE MARKET IN EUROPE, THROUGH 2018 ($ FIGURE 10 SMOKING CESSATION MEDICINE MARKET IN EUROPE, 2011-2018 ($ THE U.K.: SMOKING CESSATION MEDICINE MARKET 80 TOBACCO INDUSTRY IN THE U.K. 80 SMOKING BANS AND REGULATING NICOTINE PRODUCTS 80 THE U.K.: SMOKING CESSATION MARKET REVENUE, 2012 81 TABLE 37 SMOKING CESSATION BRANDS IN THE U.K. MARKET: 2012 81 THE U.K.: MARKET FORECAST FOR SMOKING CESSATION MEDICINES, TABLE 38 SMOKING CESSATION MEDICINE MARKET IN THE U.K., THROUGH 2018 ($ FIGURE 11 SMOKING CESSATION MEDICINE MARKET IN THE U.K., 2011-2018 ($ FRANCE: SMOKING CESSATION MEDICINE MARKET 83 FRANCE: MARKET FORECAST FOR SMOKING CESSATION MEDICINES, 84 TABLE 39 SMOKING CESSATION MEDICINE MARKET IN FRANCE, THROUGH 2018 ($ FIGURE 12 SMOKING CESSATION MEDICINE MARKET IN FRANCE, 2011-2018 ($ OTHER PROMISING EUROPEAN MARKETS 85 GERMANY HAS LOW POTENTIAL FOR SMOKING CESSATION MEDICATION 85 ASIA PACIFIC: SMOKING CESSATION MEDICINE MARKET 85 TABLE 40 SMOKING CESSATION MEDICINE MARKET IN ASIA PACIFIC, THROUGH 2018 ($ 73 73 73 77 77 79 79 82 82 82 84 84 86
AUSTRALIA: SMOKING CESSATION MEDICINE MARKET 87 TABLE 41 SMOKING CESSATION BRANDS IN AUSTRALIA MARKET: 2012 88 AUSTRALIA: MARKET FORECAST FOR SMOKING CESSATION MEDICINES, TABLE 42 SMOKING CESSATION MEDICINE MARKET IN AUSTRALIA, THROUGH 2018 ($ NEW ZEALAND: SMOKING CESSATION MEDICINE MARKET 89 TABLE 43 SMOKING CESSATION BRANDS IN NEW ZEALAND MARKET: 2012 90 JAPAN: SMOKING CESSATION MEDICINE MARKET 91 JAPAN: MARKET FORECAST FOR SMOKING CESSATION MEDICINES, 92 EMERGING MARKETS FOR SMOKING CESSATION MEDICINES 92 TABLE 44 SMOKING CESSATION MEDICINE MARKET IN EMERGING MARKETS, THROUGH 2018 ($ EMERGING MARKETS: MARKET FORECAST FOR SMOKING CESSATION MEDICINES, CHINA: SMOKING CESSATION MEDICINE MARKET 93 SMOKING PREVALENCE AND TOBACCO CONTROL INITIATIVES 93 SMOKING CESSATION MEDICINE MARKET IN CHINA 95 CHINA: MARKET FORECAST FOR SMOKING CESSATION MEDICINES, 95 CHINA: MARKET POTENTIAL COULD BE TAPPED THROUGH COPD TREATMENT INDIA: SMOKING CESSATION MEDICINE MARKET 96 TOBACCO CONTROL INITIATIVES IN INDIA 96 SMOKING CESSATION MEDICINE MARKET IN INDIA 97 TABLE 45 SMOKING CESSATION BRANDS IN INDIAN MARKET: 2012 98 GENERIC BUPROPION HCL LEADS INDIAN MARKET FOR SMOKING CESSATION INDIA: MARKET FORECAST FOR SMOKING CESSATION MEDICINES, 99 TABLE 46 SMOKING CESSATION MEDICINE MARKET IN INDIA, THROUGH 2018 ($ BRAZIL: SMOKING CESSATION MEDICINE MARKET 99 SMOKING CESSATION MEDICINE MARKET IN BRAZIL 100 TABLE 47 SMOKING CESSATION BRANDS IN BRAZILIAN MARKET, 2012 100 BRAZIL: MARKET FORECAST FOR SMOKING CESSATION MEDICINES, 101 TABLE 48 SMOKING CESSATION MEDICINE MARKET IN BRAZIL, THROUGH 2018 ($ 88 88 93 93 95 98 99 101 CHAPTER 7 SMOKING CESSATION INDUSTRY AND MARKET ANALYSES 103 GLOBAL MARKET FOR SMOKING CESSATION MEDICINES 104 PESTLE ANALYSIS 104 Political and Legal Interventions Influence Markets 104 TABLE 49 INITIATIVES IMPLEMENTED BY PARTIES TO FCTC TREATY (%) 106 Socioeconomic Factors 106 TABLE 50 PROJECTED GLOBAL CAUSE OF DEATH (%) 108 TABLE 51 PUBLIC HEALTH BURDEN DUE TO SMOKING-RELATED DISEASES ($ BILLIONS) Technology Developments 108 FIGURE 13 GLOBAL STUDIES ON TOBACCO DEPENDENCE AND SMOKING CESSATION, BY REGION (NO. OF ONGOING STUDIES) 108 109
TABLE 52 SWOT ANALYSIS OF SMOKING CESSATION MEDICINES 110 COMPETITIVE ANALYSIS AND BENCHMARKING 111 TOBACCO TRANSFORMATION STRATEGY 111 DIFFERENTIATION BETWEEN SMOKING CESSATION MEDICINES AND ALTERNATIVES TO CIGARETTES TABLE 53 COMPARING SMOKING CESSATION MEDICINES AND OTHER NICOTINE DELIVERY SYSTEMS COLLABORATIONS AND COMBINATIONS 112 INDUSTRY OPINION ON FUTURE OF THE SMOKING CESSATION MEDICINE INDUSTRY UNTAPPED POTENTIAL OF SMOKING CESSATION MARKET COULD BE $60 BILLION 112 112 113 114 CHAPTER 8 COMPANY PROFILES 116 22ND CENTURY GROUP INC. 116 ACTAVIS, INC. 116 ALKALON A/S 117 BIOTA PHARMACEUTICALS, INC. 117 BIOTIE THERAPIES CORP. 117 BOEHRINGER INGELHEIM GMBH 118 CELTIC PHARMA MANAGEMENT L.P. 118 CIPLA LTD. 118 CYTOS BIOTECHNOLOGY AG 119 EVOTEC AG 119 FERTIN PHARMA A/S 119 GENTECH HEALTHCARE 120 GLAXOSMITHKLINE PLC 120 JOHNSON & JOHNSON 121 MCNEIL CONSUMER HEALTHCARE 121 NICONOVUM AB 121 NOVARTIS INTERNATIONAL AG 122 PERRIGO CO. 122 PFIZER INC. 122 PIERRE FABRE PHARMACEUTICALS INC. 123 LABORATOIRES PIERRE FABRE 123 PSYCOREMEDIES 123 REVOLYMER (U.K.) LTD. 124 SANOFI 124 SOMAXON PHARMACEUTICALS INC. 124 SOPHARMA AD 125 SUN PHARMACEUTICAL INDUSTRIES LTD. 125 TAISHO PHARMACEUTICAL HOLDINGS 125 TAKEDA PHARMACEUTICALS LTD. 126 TARGACEPT, INC. 126 WALGREENS 126 ZENARA PHARMACEUTICALS 127
LIST OF TABLES TABLE HEADING SUMMARY TABLE SIZE OF GLOBAL SMOKING CESSATION MEDICINE MARKET BY REGION, THROUGH 2018 ($ TABLE 1 BENEFITS OF SMOKING CESSATION 19 TABLE 2 GENERAL CRITERIA FOR DRUG DEPENDENCE 23 TABLE 3 CLASSIFICATION OF SMOKING CESSATION MEDICINES BASED ON MODE OF ACTION TABLE 4 CLASSIFICATION OF NICOTINE REPLACEMENT THERAPY BASED ON DRUG DELIVERY SYSTEM TABLE 5 NICOTINE GUM DOSAGES AND SCHEDULES 30 TABLE 6 KEY BRANDS AND MARKETERS OF NICOTINE GUMS 32 TABLE 7 NICOTINE LOZENGE DOSAGE AND SCHEDULE 32 TABLE 8 KEY BRANDS AND MARKETERS OF NICOTINE LOZENGES 33 TABLE 9 KEY BRANDS AND MARKETERS OF NICOTINE TABLETS 34 TABLE 10 KEY BRANDS AND MARKETERS OF NICOTINE INHALERS 34 TABLE 11 KEY BRANDS AND MARKETERS OF NICOTINE MOUTH SPRAYS 35 TABLE 12 NICOTINE PATCH DOSAGE AND SCHEDULE 36 TABLE 13 KEY BRANDS AND MARKETERS OF NICOTINE PATCHES 37 TABLE 14 KEY BRANDS AND MARKETERS OF NICOTINE NASAL SPRAYS 37 TABLE 15 CHANTIX/CHAMPIX SALES REVENUE, 2007-2012 ($ 39 TABLE 16 NICOTINE VACCINES IN DEVELOPMENT PHASE AS OF JANUARY 2013 41 TABLE 17 DEVELOPMENTS IN THE PIPELINE (NON-NICOTINE) 43 TABLE 18 CLINICAL TRIALS OF D-CYCLOSERINE 44 TABLE 19 SMOKING CESSATION MEDICINE GLOBAL MARKET FORECAST, THROUGH 2018 ($ TABLE 20 SMOKING CESSATION MEDICINE GLOBAL MARKET FORECAST BY CLASSIFICATION, THROUGH 2018 ($ TABLE 21 GLOBAL SMOKING CESSATION MEDICINES BY TYPE OF SALES 50 TABLE 22 SMOKING CESSATION MEDICINES FORECAST BY TYPE OF SALES, THROUGH 2018 ($ TABLE 23 SIZE OF GLOBAL SMOKING CESSATION MEDICINE MARKET BY CATEGORY, THROUGH 2018 ($ TABLE 24 GLOBAL NICOTINE REPLACEMENT THERAPY MARKET FORECAST BY CATEGORY, THROUGH 2018 ($ TABLE 25 ARTICLES REPORTING HIGHEST IMPLEMENTATION RATES: 2012 WHO FCTC PROGRESS REPORT (%) TABLE 26 ARTICLES REPORTING MODERATE IMPLEMENTATION RATES: 2012 WHO FCTC PROGRESS REPORT (%) TABLE 27 ARTICLES REPORTING LOWEST IMPLEMENTATION RATES: 2012 WHO FCTC PROGRESS REPORT (%) TABLE 28 GLOBAL IMPLEMENTATION OF FCTC ARTICLES: 2012 REPORT 64 TABLE 29 GLOBAL IMPLEMENTATION OF ARTICLE 14 OF FCTC, 2012 67 TABLE 30 SIZE OF GLOBAL SMOKING CESSATION MEDICINE MARKET BY REGION, THROUGH 2018 ($ TABLE 31 SMOKING CESSATION BRANDS IN THE U.S. MARKET, 2012 72 TABLE 32 SMOKING CESSATION MEDICINE MARKET IN THE U.S., THROUGH 2018 ($ TABLE 33 SMOKING CESSATION BRANDS IN CANADA MARKET: 2012 76 TABLE 34 SMOKING CESSATION MEDICINE MARKET IN CANADA, THROUGH 2018 ($ 8 29 29 48 49 51 53 56 62 62 63 69 73 77
TABLE HEADING TABLE 35 SMOKING CESSATION BRANDS IN EUROPEAN MARKET: 2012 78 TABLE 36 SMOKING CESSATION MEDICINE MARKET IN EUROPE, THROUGH 2018 ($ TABLE 37 SMOKING CESSATION BRANDS IN THE U.K. MARKET: 2012 81 TABLE 38 SMOKING CESSATION MEDICINE MARKET IN THE U.K., THROUGH 2018 ($ TABLE 39 SMOKING CESSATION MEDICINE MARKET IN FRANCE, THROUGH 2018 ($ TABLE 40 SMOKING CESSATION MEDICINE MARKET IN ASIA PACIFIC, THROUGH 2018 ($ TABLE 41 SMOKING CESSATION BRANDS IN AUSTRALIA MARKET: 2012 88 TABLE 42 SMOKING CESSATION MEDICINE MARKET IN AUSTRALIA, THROUGH 2018 ($ TABLE 43 SMOKING CESSATION BRANDS IN NEW ZEALAND MARKET: 2012 90 TABLE 44 SMOKING CESSATION MEDICINE MARKET IN EMERGING MARKETS, THROUGH 2018 ($ TABLE 45 SMOKING CESSATION BRANDS IN INDIAN MARKET: 2012 98 TABLE 46 SMOKING CESSATION MEDICINE MARKET IN INDIA, THROUGH 2018 ($ TABLE 47 SMOKING CESSATION BRANDS IN BRAZILIAN MARKET, 2012 100 TABLE 48 SMOKING CESSATION MEDICINE MARKET IN BRAZIL, THROUGH 2018 ($ TABLE 49 INITIATIVES IMPLEMENTED BY PARTIES TO FCTC TREATY (%) 106 TABLE 50 PROJECTED GLOBAL CAUSE OF DEATH (%) 108 TABLE 51 PUBLIC HEALTH BURDEN DUE TO SMOKING-RELATED DISEASES ($ BILLIONS) TABLE 52 SWOT ANALYSIS OF SMOKING CESSATION MEDICINES 110 TABLE 53 COMPARING SMOKING CESSATION MEDICINES AND OTHER NICOTINE DELIVERY SYSTEMS 79 82 84 86 88 93 99 101 108 112
LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE SIZE OF GLOBAL SMOKING CESSATION MEDICINE MARKET BY REGION, 2011-2018 ($ FIGURE 1 NICOTINE MOLECULE: 3-[(2S)-1-METHYLPYRROLIDINE-2-YL]PYRIDINE 21 FIGURE 2 SMOKING CESSATION MEDICINE GLOBAL MARKET FORECAST, 2011-2018 ($ FIGURE 3 SMOKING CESSATION MEDICINE GLOBAL MARKET FORECAST BY CLASSIFICATION, 2011-2018 ($ FIGURE 4 SMOKING CESSATION MEDICINE GLOBAL MARKET FORECAST BY TYPE OF SALES, 2011-2018 ($ FIGURE 5 SIZE OF GLOBAL SMOKING CESSATION MEDICINE MARKET BY CATEGORY, 2011-2018 ($ FIGURE 6 GLOBAL NICOTINE REPLACEMENT THERAPY MARKET FORECAST BY CATEGORY, 2011-2018 ($ FIGURE 7 GLOBAL IMPLEMENTATION OF ARTICLES: 2012 FCTC REPORT (%) 63 FIGURE 8 SIZE OF GLOBAL SMOKING CESSATION MEDICINE MARKET BY REGION, 2011-2018 ($ FIGURE 9 SMOKING CESSATION MEDICINE MARKET IN THE U.S., 2011-2018 ($ FIGURE 10 SMOKING CESSATION MEDICINE MARKET IN EUROPE, 2011-2018 ($ FIGURE 11 SMOKING CESSATION MEDICINE MARKET IN THE U.K., 2011-2018 ($ FIGURE 12 SMOKING CESSATION MEDICINE MARKET IN FRANCE, 2011-2018 ($ FIGURE 13 GLOBAL STUDIES ON TOBACCO DEPENDENCE AND SMOKING CESSATION, BY REGION (NO. OF ONGOING STUDIES) 8 48 50 51 53 56 69 73 79 82 84 109