Formulary Drug Removals

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July 2017 Below is a list of medicines by drug class that have been removed from your plan s formulary. If you continue using one of the drugs listed below and identified as a Removal, you may be required to pay the full cost. If you are currently using one of the formulary drug removals, ask your doctor to choose one of the generic or brand formulary options listed below. Category Allergic Reaction (Anaphylaxis) Treatment Allergies Nasal Steroids / Combinations Allergies Ophthalmic ADRENACLICK BECONASE AQ OMNARIS QNASL RHINOCORT AQUA ZETONNA LASTACAFT epinephrine auto-injector, EPIPEN, EPIPEN JR flunisolide spray, fluticasone spray, mometasone spray, triamcinolone spray, DYMISTA azelastine, cromolyn sodium, olopatadine, PATADAY, PAZEO Anticonvulsants ZONEGRAN zonisamide Anti-infectives, Antibacterials Erythromycins / Macrolides Anti-infectives, Antibacterials Miscellaneous Anti-infectives, Antibacterials Tetracyclines Anti-infectives, Antivirals Cytomegalovirus * E.E.S. GRANULES ERYPED MACRODANTIN MINOCIN VALCYTE erythromycins nitrofurantoin minocycline valganciclovir Anti-infectives, Antivirals Hepatitis C * DAKLINZA EPCLUSA (genotypes 2, 3), HARVONI (genotypes 1, 4, 5, 6) OLYSIO TECHNIVIE VIEKIRA PAK ZEPATIER HARVONI (genotypes 1, 4, 5, 6) Anti-infectives, Antivirals Herpes * Anti-inflammatory Steroidal, Ophthalmic VALTREX FML PRED FORTE PRED MILD acyclovir, valacyclovir dexamethasone, prednisolone acetate 1%, DUREZOL, LOTEMAX Antiobesity QSYMIA BELVIQ, BELVIQ XR, CONTRAVE, SAXENDA Asthma * Beta Agonists, Short-Acting Asthma * Steroid Inhalants Asthma * or Chronic Obstructive Pulmonary Disease (COPD) * Steroid / Beta Agonist Combinations PROVENTIL HFA VENTOLIN HFA XOPENEX HFA AEROSPAN ALVESCO SYMBICORT PROAIR HFA, PROAIR RESPICLICK ASMANEX, FLOVENT, PULMICORT FLEXHALER, QVAR ADVAIR, BREO ELLIPTA, DULERA

Attention Deficit Hyperactivity Disorder * Cancer Chronic Myelogenous Leukemia * Cancer Prostate * Hormonal Agents, Antiandrogens Antiarrhythmics Antilipemics Fibrates Antilipemics HMG-CoA Reductase Inhibitors (HMGs or Statins) / Combinations Digitalis Glycosides Diuretics Pulmonary Arterial Hypertension * Endothelin Receptor Antagonists Carnitine Deficiency Chronic Obstructive Pulmonary Disease (COPD) * Anticholinergics Cystic Fibrosis * Inhaled Antibiotics Depression * Antidepressants, Selective Norepinephrine Reuptake Inhibitors (SNRIs) Depression * Antidepressants, Miscellaneous Agents Depression and/or Schizophrenia * Antipsychotics, Atypicals Acne * Actinic Keratosis * ADDERALL XR INTUNIV GLEEVEC TASIGNA NILANDRON XTANDI BETAPACE BETAPACE AF TRICOR ALTOPREV CRESTOR LESCOL XL LIPITOR LIVALO LANOXIN TABLET (125 MCG and 250 MCG only) DYRENIUM OPSUMIT CARNITOR CARNITOR SF INCRUSE ELLIPTA TUDORZA TOBI TOBI PODHALER venlafaxine ext-rel tablet (except 225 MG) CYMBALTA VENLAFAXINE EXT-REL TABLET (except 225 MG) OLEPTRO ABILIFY FANAPT VANOXIDE-HC fluorouracil cream 0.5% CARAC amphetamine-dextroamphetamine mixed salts, amphetamine-dextroamphetamine mixed salts ext-rel, guanfacine ext-rel, methylphenidate, methylphenidate ext-rel, APTENSIO XR, QUILLIVANT XR, STRATTERA, VYVANSE imatinib mesylate, BOSULIF, SPRYCEL bicalutamide, ZYTIGA sotalol fenofibrate, fenofibric acid atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, simvastatin, VYTORIN digoxin amiloride LETAIRIS, TRACLEER levocarnitine SPIRIVA tobramycin inhalation solution, BETHKIS duloxetine, venlafaxine, venlafaxine ext-rel capsule, PRISTIQ trazodone aripiprazole, clozapine, olanzapine, quetiapine, risperidone, ziprasidone, LATUDA, SEROQUEL XR benzoyl peroxide fluorouracil cream 5%, fluorouracil solution, imiquimod, PICATO, ZYCLARA

Rosacea * Skin Inflammation and Hives * Corticosteroids Miscellaneous Skin Conditions Biguanides Dipeptidyl Peptidase-4 (DPP-4) Inhibitors Dipeptidyl Peptidase-4 (DPP-4) Inhibitor Combinations Injectable Incretin Mimetics NORITATE clobetasol spray CLOBEX SPRAY OLUX-E APEXICON E ALCORTIN A ALOQUIN NOVACORT BENSAL HP FORTAMET GLUMETZA RIOMET NESINA ONGLYZA KAZANO KOMBIGLYZE XR OSENI BYDUREON BYETTA metronidazole, FINACEA, SOOLANTRA clobetasol foam desoximetasone, fluocinonide hydrocortisone desonide, hydrocortisone metformin, metformin ext-rel JANUVIA, TRADJENTA JANUMET, JANUMET XR, JENTADUETO, JENTADUETO XR TRULICITY, VICTOZA Insulins APIDRA HUMALOG NOVOLOG HUMALOG MIX 50/50 NOVOLOG MIX 70/30 HUMALOG MIX 75/25 NOVOLOG MIX 70/30 HUMULIN 70/30 1 NOVOLIN 70/30 1 HUMULIN N 1 NOVOLIN N 1 HUMULIN R 1 NOVOLIN R 1 NOTE: Humulin R U-500 concentrate will not be subject to removal and will continue to be covered. Long Acting Insulins Insulin Sensitizers Sodium-Glucose Co-transporter 2 (SGLT2) Inhibitors Sodium-Glucose Co-transporter 2 (SGLT2) Inhibitor / Biguanide Combinations Supplies, Needles 2 LANTUS TOUJEO ACTOS INVOKANA INVOKAMET NOVO NORDISK NEEDLES OWEN MUMFORD NEEDLES PERRIGO NEEDLES ULTIMED NEEDLES All other insulin needles that are not BD ULTRAFINE brand BASAGLAR, LEVEMIR, TRESIBA pioglitazone FARXIGA, JARDIANCE XIGDUO XR BD ULTRAFINE NEEDLES

Supplies, Syringes 2 Supplies, Test Strips and Kits 3, 4 Erectile Dysfunction * Phosphodiesterase Inhibitors Gastrointestinal Opioid-induced Constipation Gastrointestinal Proton Pump Inhibitors (PPIs) Genitourinary Interstitial Cystitis Glaucoma * Prostaglandin Analogs Growth Hormones Hematologic Anticoagulants (oral) Hematologic Hemophilia Hematologic Neutropenia Colony Stimulating Factors Hematologic Platelet Aggregation Inhibitors Angiotensin II Receptor Antagonists Angiotensin II Receptor Antagonist / Diuretic Combinations Angiotensin II Receptor Antagonist / Calcium Channel Blocker Combinations ALLISON MEDICAL INSULIN SYRINGES TRIVIDIA INSULIN SYRINGES ULTIMED INSULIN SYRINGES All other insulin syringes that are not BD ULTRAFINE brand ACCU-CHEK STRIPS AND KITS BREEZE 2 STRIPS AND KITS CONTOUR NEXT STRIPS AND KITS CONTOUR STRIPS AND KITS FREESTYLE STRIPS AND KITS All other test strips that are not ONETOUCH brand LEVITRA VIAGRA RELISTOR NEXIUM PREVACID PROTONIX ZEGERID RIMSO-50 LUMIGAN GENOTROPIN NUTROPIN AQ OMNITROPE SAIZEN PRADAXA HELIXATE FS NEUPOGEN PLAVIX ATACAND DIOVAN EDARBI ATACAND HCT DIOVAN HCT EDARBYCLOR EXFORGE BD ULTRAFINE INSULIN SYRINGES ONETOUCH ULTRA STRIPS AND KITS 3, ONETOUCH VERIO STRIPS AND KITS 3 CIALIS MOVANTIK esomeprazole, lansoprazole, omeprazole, pantoprazole, DEXILANT Consult doctor latanoprost, TRAVATAN Z, ZIOPTAN HUMATROPE, NORDITROPIN warfarin, ELIQUIS, XARELTO KOGENATE FS, KOVALTRY, NOVOEIGHT, NUWIQ ZARXIO clopidogrel, BRILINTA, EFFIENT candesartan, eprosartan, irbesartan, losartan, telmisartan, valsartan, BENICAR candesartan-hydrochlorothiazide, irbesartan-hydrochlorothiazide, losartan-hydrochlorothiazide, telmisartan-hydrochlorothiazide, valsartan-hydrochlorothiazide, BENICAR HCT amlodipine-telmisartan, amlodipine-valsartan, AZOR

Angiotensin II Receptor Antagonist / Calcium Channel Blocker / Diuretic Combinations Beta-blocker Combinations Calcium Channel Blockers EXFORGE HCT DUTOPROL NORVASC CARDIZEM CARDIZEM CD CARDIZEM LA (and its generics) Matzim LA amlodipine-valsartan-hydrochlorothiazide, TRIBENZOR metoprolol succinate ext-rel WITH hydrochlorothiazide amlodipine diltiazem ext-rel (except generic of CARDIZEM LA) Huntington's Disease XENAZINE tetrabenazine Inflammatory Bowel Disease (IBD) Ulcerative Colitis * Aminosalicylates Kidney Disease * Phosphate Binders Multiple Sclerosis ASACOL HD DELZICOL COLAZAL FOSRENOL AVONEX EXTAVIA PLEGRIDY balsalazide, sulfasalazine, sulfasalazine delayed-rel, APRISO, LIALDA, PENTASA balsalazide calcium acetate, PHOSLYRA, RENVELA, VELPHORO glatiramer, AUBAGIO, BETASERON, COPAXONE 40 MG, GILENYA, REBIF, TECFIDERA Musculoskeletal AMRIX cyclobenzaprine Nutritional / Supplements Electrolytes KLOR-CON/25 potassium chloride liquid Opioid Dependence ZUBSOLV buprenorphine-naloxone sublingual tablet, SUBOXONE FILM Opioid Reversal EVZIO naloxone injection, NARCAN NASAL SPRAY Osteoarthritis * Viscosupplements EUFLEXXA MONOVISC ORTHOVISC GEL-ONE, HYALGAN, SUPARTZ FX Osteoporosis * MIACALCIN INJECTION alendronate, calcitonin-salmon, ibandronate, risedronate, ATELVIA, FORTEO Overactive Bladder / Incontinence * Urinary Antispasmodics Pain Headache * Pain * Transmucosal Immediate-release Fentanyl Pain and Inflammation * Corticosteroids MIACALCIN NASAL SPRAY DETROL LA ENABLEX GELNIQUE OXYTROL butalbital-acetaminophen-caffeine capsule CAFERGOT FIORICET CAPSULE ABSTRAL DEXPAK MILLIPRED RAYOS calcitonin-salmon darifenacin ext-rel, oxybutynin ext-rel, tolterodine, tolterodine ext-rel, trospium, trospium ext-rel, MYRBETRIQ, TOVIAZ, VESICARE naratriptan, rizatriptan, sumatriptan, zolmitriptan, ONZETRA XSAIL, RELPAX, ZEMBRACE SYMTOUCH, ZOMIG NASAL SPRAY fentanyl transmucosal lozenge, FENTORA, SUBSYS dexamethasone, methylprednisolone, prednisone

Pain and Inflammation * Nonsteroidal Anti-inflammatory Drugs (NSAIDs) / Combinations Prostate Condition Benign Prostatic Hyperplasia * Sleep Disorder Hypnotics, Non-benzodiazepines Testosterone Replacement * Androgens ARTHROTEC PENNSAID NAPRELAN JALYN UROXATRAL INTERMEZZO LUNESTA ROZEREM testosterone gel 1% 5 ANDROGEL FORTESTA NATESTO TESTIM VOGELXO celecoxib or diclofenac sodium, meloxicam or naproxen WITH esomeprazole, lansoprazole, omeprazole, pantoprazole or DEXILANT diclofenac sodium, diclofenac sodium solution, meloxicam, naproxen, VOLTAREN GEL celecoxib, diclofenac sodium, meloxicam, naproxen dutasteride-tamsulosin alfuzosin ext-rel, tamsulosin eszopiclone, zolpidem, zolpidem ext-rel, zolpidem sublingual, BELSOMRA, SILENOR testosterone gel 2%, ANDRODERM, AXIRON Category Autoimmune and Hepatitis C * Generics Hyperinflation New-to-Market Agents 6 Specialty For some clients, an Indication Based Formulary will be utilized for products in these classes and may result in additional exclusions. Limited source generics may be evaluated when appropriate and potentially removed from the formulary. On a quarterly basis, products with significant cost inflation that have clinically-appropriate and more cost-effective alternatives may be evaluated and potentially removed from the formulary. New-to-market products and new variations of products already in the marketplace will not be added to the formulary immediately. Each product will be evaluated for clinical appropriateness and cost-effectiveness. Recommended additions to the formulary will be presented to the CVS Caremark National Pharmacy and Therapeutics Committee (or other appropriate reviewing body) for review and approval. As new specialty products launch, all existing products in the class will be re-evaluated to determine appropriate formulary placement and potentially excluded, added back to formulary or not listed. The listed formulary options are subject to change.

ABILIFY ABSTRAL ACCU-CHEK STRIPS AND KITS 4 ACTOS ADDERALL XR ADRENACLICK AEROSPAN ALCORTIN A ALLISON MEDICAL INSULIN SYRINGES 2 ALOQUIN ALTOPREV ALVESCO AMRIX ANDROGEL APEXICON E APIDRA ARTHROTEC ASACOL HD ATACAND ATACAND HCT AVONEX BECONASE AQ BENSAL HP BETAPACE BETAPACE AF BREEZE 2 STRIPS AND KITS 4 butalbital-acetaminophen-caffeine capsule BYDUREON BYETTA CAFERGOT CARAC CARDIZEM CARDIZEM CD CARDIZEM LA (and its generics) CARNITOR CARNITOR SF clobetasol spray CLOBEX SPRAY COLAZAL CONTOUR NEXT STRIPS AND KITS 4 CONTOUR STRIPS AND KITS 4 CRESTOR CYMBALTA DAKLINZA DELZICOL DETROL LA DEXPAK DIOVAN DIOVAN HCT DUTOPROL DYRENIUM EDARBI EDARBYCLOR E.E.S. GRANULES ENABLEX ERYPED EUFLEXXA EVZIO List of EXFORGE EXFORGE HCT EXTAVIA FANAPT FIORICET CAPSULE fluorouracil cream 0.5% FML FORTAMET FORTESTA FOSRENOL FREESTYLE STRIPS AND KITS 4 GELNIQUE GENOTROPIN GLEEVEC GLUMETZA HELIXATE FS HUMALOG HUMALOG MIX 50/50 HUMALOG MIX 75/25 HUMULIN 70/30 1 HUMULIN N 1 HUMULIN R 1 INCRUSE ELLIPTA INTERMEZZO INTUNIV INVOKAMET INVOKANA JALYN KAZANO KLOR-CON/25 KOMBIGLYZE XR LANOXIN TABLET (125 MCG and 250 MCG only) LANTUS LASTACAFT LESCOL XL LEVITRA LIPITOR LIVALO LUMIGAN LUNESTA MACRODANTIN Matzim LA MIACALCIN INJECTION MIACALCIN NASAL SPRAY MILLIPRED MINOCIN MONOVISC NAPRELAN NATESTO NESINA NEUPOGEN NEXIUM NILANDRON NORITATE NORVASC NOVACORT NOVO NORDISK NEEDLES 2 NUTROPIN AQ OLEPTRO OLUX-E OLYSIO OMNARIS OMNITROPE ONGLYZA OPSUMIT ORTHOVISC OSENI OWEN MUMFORD NEEDLES 2 OXYTROL PENNSAID PERRIGO NEEDLES 2 PLAVIX PLEGRIDY PRADAXA PRED FORTE PRED MILD PREVACID PROTONIX PROVENTIL HFA QNASL QSYMIA RAYOS RELISTOR RHINOCORT AQUA RIMSO-50 RIOMET ROZEREM SAIZEN SYMBICORT TASIGNA TECHNIVIE TESTIM testosterone gel 1% 5 TOBI TOBI PODHALER TOUJEO TRICOR TRIVIDIA INSULIN SYRINGES 2 TUDORZA ULTIMED INSULIN SYRINGES 2 ULTIMED NEEDLES 2 UROXATRAL VALCYTE VALTREX VANOXIDE-HC venlafaxine ext-rel tablet (except 225 MG) VENLAFAXINE EXT-REL TABLET (except 225 MG) VENTOLIN HFA VIAGRA VIEKIRA PAK VOGELXO XENAZINE XOPENEX HFA XTANDI ZEGERID ZEPATIER ZETONNA ZONEGRAN ZUBSOLV

This list represents brand products in CAPS, branded generics in upper- and lowercase Italics, and generic products in lowercase italics. This is not an all-inclusive list of available drug options. Log in to www.caremark.com to check coverage and copay information for a specific drug. Discuss this information with your doctor or health care provider. This information is not a substitute for medical advice or treatment. Talk to your doctor or health care provider about this information and any health-related questions you have. CVS Caremark assumes no liability whatsoever for the information provided or for any diagnosis or treatment made as a result of this information. This list is subject to change. There may be additional plan restrictions. Please consult your plan for further information. Subject to applicable laws and regulations. * This list indicates the common uses for which the drug is prescribed. Some drugs are prescribed for more than one condition. 1 Rebranded or private label formulations are not covered (i.e., RELION). 2 BD ULTRAFINE syringes and needles are the only preferred options. 3 A ONETOUCH blood glucose meter may be provided at no charge by the manufacturer to those individuals currently using a meter other than ONETOUCH. For more information on how to obtain a blood glucose meter, call: 1-800-588-4456. 4 ONETOUCH brand test strips are the only preferred options. 5 Listing reflects the authorized generics for TESTIM and VOGELXO. 6 An exception process may exist for specific clinical or regulatory circumstances that require coverage of an excluded medication. Your privacy is important to us. Our employees are trained regarding the appropriate way to handle your private health information. This document contains confidential and proprietary information of CVS Caremark and cannot be reproduced, distributed or printed without written permission from CVS Caremark. CVS Caremark may receive rebates, discounts and service fees from pharmaceutical manufacturers for certain listed products. This document contains references to brand-name prescription drugs that are trademarks or registered trademarks of pharmaceutical manufacturers not affiliated with CVS Caremark. Listed products are for informational purposes only and are not intended to replace the clinical judgment of the doctor. 2017 CVS Caremark. All rights reserved. 106-25923A 070117 www.caremark.com