Infectious disease
Advantages OF TESTING INFECTIOUS DISEASE We are in the middle of a paradigm shift in infectious disease diagnostic testing. As we move from targeted infectious disease testing to a syndromic approach, laboratories are able to provide clinically relevant diagnostic results in a time frame that was not previously possible. Advanta has incorporated FilmArray into our clinical laboratory. Our technology is impacting users and allowing physicians to make better clinical decisions. Many infections present with similar signs and symptoms. But today s targeted infectious disease diagnostics limit testing to only the most common pathogens associated with a clinical syndrome. This leaves most infections undiagnosed and leads to additional downstream testing, patient dissatisfaction and compromised patient care. By using a molecular syndromic approach and a broad test menu, the FilmArray can better detect and identify the infectious agent with just one easy diagnostic test. Advanta s infectious disease testing increases the probability of identifying a pathogen in patients with symptoms of an infectious disease and increases capability of detection of co-infections. Page 2
ENCEPHALITIS/MENINGITIS PatHOGENS bacteria Escherichia coli K1 Haemophilus influenzae Listeria monocytogenes Neisseria meningitidis Streptococcus agalactiae Streptococcus pneumoniae viruses Cytomegalovirus (CMV) Enterovirus Herpes simplex virus 1 (HSV-1) Herpes simplex virus 2 (HSV-2) Human herpes virus 6 (HHV-6) Human parechovirus Varicella zoster virus (VZV) yeast Cryptococcus neoformans/gattii RESPIRATORY PatHOGENS bacteria Bordetella pertussis Chlamydophila pneumoniae Mycoplasma pneumoniae viruses Adenovirus Coronavirus HKU1 Coronavirus NL63 Coronavirus 229E Coronavirus OC43 Human Metapneumovirus Human Rhinovirus/Enterovirus Influenza A/H1 Influenza A/H3 Influenza A/H1-2009 Influenza B Parainfluenza Virus 1 Parainfluenza Virus 2 Parainfluenza Virus 3 Parainfluenza Virus 4 Respiratory Syncytial Virus Page 3
BLOOD CULTURE IDENTIFICATION PANEL gram + bacteria Enterococcus Listeria monocytogenes Staphylococcus Staphylococcus aureus Streptococcus Streptococcus agalactiae Streptococcus pyogenes Streptococcus pneumoniae gram - bacteria Acinetobacter baumannii Haemophilus influenzae Neisseria meningitidis Pseudomonas aeruginosa Enterobacteriaceae Enterobacter cloacae complex Escherichia coli Klebsiella oxytoca Klebsiella pneumoniae Proteus Serratia marcescens yeast Candida albicans Candida glabrata Candida krusei Candida parapsilosis Candida tropicalis antibiotic resistance meca - methicillin resistant vana/b - vancomycin resistant KPC - carbapenem resistant Page 4
GASTROINTESTINAL DISEASE PatHOGENS bacteria Campylobacter ( jejuni, coli, and upsaliensis) Clostridium difficile (toxin A/B) Plesiomonas shigelloides Salmonella Yersinia enterocolitica Vibrio (parahaemolyticus, vulnificus and cholerae) diarrheagenic e. coli/shigella Enteroaggregative E. coli (EAEC) Enteropathogenic E. coli (EPEC) Enterotoxigenic E. coli (ETEC) lt/st Shiga-like toxin-producing E. coli (STEC) stx1/stx2 E. coli O157 Shigella/Enteroinvasive E. coli (EIEC) parasites Cryptosporidium Cyclospora cayetanensis Entamoeba histolytica Giardia lamblia viruses Adenovirus F40/41 Astrovirus Norovirus GI/GII Rotavirus A Sapovirus (I, II, IV & V) Page 5
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