University of Groningen Pulmonary arterial hypertension van Albada, Mirjam Ellen IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2007 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): van Albada, M. E. (2007). Pulmonary arterial hypertension: cardiovascular effects of pharmacological intervention s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 04-05-2018
Pulmonary arterial hypertension Cardiovascular effects of pharmacological intervention Mirjam E. van Albada
Financial support by the Groningen University Institute for Drug Exploration (GUIDE) and the University of Groningen for the publication of this thesis is gratefully acknowledged. Cip-gegevens koninklijke bibliotheek, Den Haag Van Albada, Mirjam E. Pulmonary arterial hypertension; cardiovascular effects of pharmacological intervention Proefschrift Groningen Met literatuuropgave en samenvatting in het Nederlands ISBN 978-90-367-3077-8 Mirjam E. van Albada, 2007 All rights reserved. No part of this thesis may be reproduced, or transmitted in any form or by any means, without permission of the author. Tekening cover: Jannie van Oort (www.jannievanoort.nl) Layout: Helga de Graaf, Studio Eye Candy Groningen (proefschrift.info) Printed by Ipskamp PrintPartners, Enschede
RIJKSUNIVERSITEIT GRONINGEN Pulmonary arterial hypertension Cardiovascular effects of pharmacological intervention Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op woensdag 4 juli 2007 om 14.45 uur door Mirjam Ellen van Albada geboren op 17 oktober 1977 te Eindhoven
Promotor: Prof. dr. R.M.F. Berger Copromotor: Dr. R.G. Schoemaker Beoordelingscommissie: Prof. dr. R. Naeije Prof. dr. P.J.J. Sauer Prof. dr. W.H. van Gilst
Paranimfen: Willemijn Windt Marieke van der Werf-Eldering The publication of this thesis van financially supported by: Actelion Pharmaceuticals Nederland BV, Arie Blok Diervoeding, Astellas Pharma BV, Bristol Meyers Squibb BV, Harlan Netherlands BV, Pfizer BV, Roche Diagnostics Nederland BV, Servier Nederland Farma BV, Therabel Pharma, United Therapeutics.
Contents Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9 Chapter 10 Introduction and scope of this thesis Pulmonary arterial hypertension in congenital heart disease: the need for refinement of the Evian-Venice classification Submitted Biological serum markers in the management of pediatric pulmonary arterial hypertension Submitted The role of increased pulmonary blood flow in pulmonary arterial hypertension Eur Respir J. 2005 Sep;26(3):487-93. Gene expression profiling in a rat model of flow-associated pulmonary hypertension: effects of pulmonary blood flow and prostacyclin treatment Manuscript in preparation Prostacyclin therapy increases right ventricular capillarisation in a model for flow-associated pulmonary hypertension Eur J Pharmacol. 2006 Nov 7;549(1-3):107-16. Treprostinil in pulmonary hypertension: beneficial outcome without reversed vascular remodeling J Cardiovasc Pharmacol. 2006 Nov;48(5):249-54. Dual endothelin receptor antagonism improves both pulmonary vascular and cardiac remodeling in experimental flow-associated pulmonary hypertension Manuscript in preparation Erythropoietin improves advanced pulmonary vascular remodeling in a rat model Submitted General discussion and summary 9 27 45 63 79 101 125 141 163 181 Nederlandse samenvatting Dankwoord Bibliography 193 203 209