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QOPI REPTING REGISTRY (QCDR) 2018 QOPI5 Title Chemotherapy administered to patients with metastatic solid tumor with performance status of 3, 4, or undocumented (Lower Score - Better) Description Percentage of adult patients with metastatic solid tumors and performance status of 3, 4, or undocumented who receive chemotherapy (Lower score - Better) Diagnosis of malignant neoplasm of placenta/trophoblastic neoplasm, testicular carcinoma, leukemia, Hodgkin and non- Hodgkin s lymphoma Solid tumor ((Intent not documented Stage IV at initial diagnosis or development of distant metastases = Yes) Intent = non-curative) Patient received chemotherapy for stage IV or distant metastatic disease (Performance status documented within 2 weeks of most recent chemotherapy administration for distant metastatic disease = 3 or 4 Not documented) (Patient received chemotherapy for metastatic disease as part of IRB approved protocol = No Patient received chemotherapy for metastatic disease as part of IRB approved protocol = Unknown) QOPI11 Combination chemotherapy received within 4 months of diagnosis by women under 70 with AJCC stage IA (T1c) to III ER/PR negative breast cancer Percentage of adult women under 70 with a diagnosis of AJCC stage IA (T1c) to III ER/PR negative breast cancer, who receive combination chemotherapy within 4 months of diagnosis Transfer-in Status Reporting practice has/had primary responsibility for the initial course of the patient's medical oncology care M-Stage at breast cancer diagnosis = M1 Diagnosis of malignant phyllodes, cystosarcoma phyllodes, tubular carcinoma, mucinous carcinoma ((Multi-agent Breast Chemotherapy administered = Chemotherapy NOT administered Patients 18-69 at diagnosis Breast cancer diagnosis ((AJCC stage at breast cancer diagnosis = IIA - IIIC) (AJCC stage at breast cancer diagnosis = (IA and T-Stage at breast cancer diagnosis=t1c) or IB) (T-Stage at breast cancer diagnosis = T1c, T2-T4d and N-Stage at breast cancer diagnosis = N0) (N-Stage at breast cancer diagnosis = N1-N3c) Chemotherapy administered during initial treatment course (Breast cancer) = Multi-agent chemotherapy administered Date the chemotherapy was initiated (multi-agent) - Date of Diagnosis 124 days Alternative treatment according to clinical trial protocol information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 1

QOPI REPTING REGISTRY (QCDR) 2018 Title Description (Abstraction date diagnosis date < 124 days Deceased date diagnosis date < 124 days Date of first visit diagnosis date > 124 days) (Reason Multi-Agent Chemotherapy NOT Administered = Patient declined or Patient died or transferred or Contraindication or other clinical exclusion or Null)) (T1c and N1mi)) (ER status = ER negative and PR status = PR negative) QOPI15 GCSF administered to patients who received chemotherapy for metastatic cancer (Lower Score - Better) Percentage of adult patients with metastatic cancer who are administered chemotherapy and who receive a colony stimulating factor (Lower score - Better) Diagnosis of malignant neoplasm of placenta/trophoblastic neoplasm, testicular carcinoma, leukemia, Hodgkin and non- Hodgkin s lymphoma Patients 18 at cancer diagnosis ((Metastatic/advanced disease Chemotherapy administered) Palliative intent chemotherapy administered) GCSF received = Yes information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 2

QOPI REPTING REGISTRY (QCDR) 2018 QOPI16 Title Oncology: Treatment Summary Communication Radiation Oncology Description Percentage of patients, regardless of age, with a diagnosis of cancer who have undergone brachytherapy or external beam radiation therapy who have a treatment summary report in the chart that was communicated to the physician(s) providing continuing care and to the patient within one month of completing treatment Documentation of a patient reason(s) for not communicating the treatment summary report to the physician(s) providing continuing care (e.g., patient requests that report not be sent) and to the patient within one month of completing treatment Documentation of a system reason(s) for not communicating the treatment summary report to the physician(s) providing continuing care (e.g., patient does not have any physician responsible for providing continuing care) and to the patient within one month of completing treatment All patients, regardless of age, with a diagnosis of cancer who have undergone brachytherapy or external beam radiation therapy Patients who have a treatment summary report in the chart that was communicated to the physician(s) providing continuing care and to the patient within one month of completing treatment QOPI17 External Beam Radiotherapy for Bone Metastases Percentage of patients, regardless of age, with a diagnosis of painful bone metastases and no history of previous radiation who receive external beam radiation therapy (EBRT) with an acceptable fractionation scheme as defined by the guideline. The medical reasons for denominator exclusions are: 1) Previous radiation treatment to the same anatomic site; 2) Patients with femoral axis cortical involvement greater than 3 cm in length; 3) Patients who have undergone a surgical stabilization procedure; and 4) Patients with spinal cord compression, cauda equina compression or radicular pain All patients with painful bone metastases and no previous radiation to the same anatomic site who receive EBRT All patients, regardless of age, with painful bone metastases, and no previous radiation to the same anatomic site who receive EBRT with any of the following recommended fractionation schemes: 30Gy/10fxns, 24Gy/6fxns, 20Gy/5fxns, 8Gy/1fxn. information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 3

QOPI REPTING REGISTRY (QCDR) 2018 Title Description QPP 47 Care Plan Percentage of patients aged 65 years and older who have an advance care plan or surrogate decision maker documented in the medical record or documentation in the medical record that an advance care plan was discussed but the patient did not wish or was not able to name a surrogate decision maker or provide an advance care plan Hospice services received by patient any time during the measurement period: G9692 Patients aged 65 years on date of performance period (CPT or HCPCS): 99201, 99202, 99203, 99204, 99205, 99212, 99213, 99214, 99215, 99218, 99219, 99220, 99221, 99222, 99223, 99231, 99232, 99233, 99234, 99235, 99236, 99291, 99304, 99305, 99306, 99307, 99308, 99309, 99310, 99324, 99325, 99326, 99327, 99328, 99334, 99335, 99336, 99337, 99341, 99342, 99343, 99344, 99345, 99347, 99348, 99349, 99350, G0402, G0438, G0439 Advance Care Planning discussed and documented; advance care plan or surrogate decision maker documented in the medical record (1123F) Advance Care Planning discussed and documented in the medical record; patient did not wish or was not able to name a surrogate decision maker or provide an advance care plan (1124F) QPP 67 Hematology: Myelodysplastic Syndrome (MDS) and Acute Leukemias: Baseline Cytogenetic Testing Performed on Bone Marrow Percentage of patients aged 18 years and older with a diagnosis of myelodysplastic syndrome (MDS) or an acute leukemia who had baseline cytogenetic testing performed on bone marrow Exceptions: Documentation of medical reason(s) for not performing baseline cytogenetic testing on bone marrow (e.g., no liquid bone marrow or fibrotic marrow) (3155F with 1P) Documentation of patient reason(s) for not performing baseline cytogenetic testing on bone marrow (e.g., at time of diagnosis receiving palliative care or not receiving treatment as defined above) (3155F with 2P) Documentation of system reason(s) for not performing Patients aged 18 years on date of Diagnosis for MDS or acute leukemia not in remission (ICD-10-CM) performance period (CPT) Cytogenetic testing performed on bone marrow at time of diagnosis or prior to initiating treatment (3155F) information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 4

QOPI REPTING REGISTRY (QCDR) 2018 Title Description baseline cytogenetic testing on bone marrow (e.g., patient previously treated by another physician at the time cytogenetic testing performed) (3155F with 3P) QPP 69 Hematology: Multiple Myeloma: Treatment with Bisphosphonates Percentage of patients aged 18 years and older with a diagnosis of multiple myeloma, not in remission, who were prescribed or received intravenous bisphosphonate therapy within the 12 month reporting period. Exception: Documentation of medical reason(s) for not prescribing bisphosphonates (e.g., patients who do not have bone disease, patients with dental disease, patients with renal insufficiency) (4100F with 1P) Documentation of patient reason(s) for not prescribing bisphosphonates (4100F with 2P) Patients aged 18 years on date of Diagnosis for multiple myeloma not in remission (ICD-10-CM): C90.00, C90.02 performance period (CPT): 99201, 99202, 99203, 99204, 99205, 99212, 99213, 99214, 99215 Bisphosphonate therapy, intravenous, ordered or received (4100F) QPP 70 Hematology: Chronic Lymphocytic Leukemia (CLL): Baseline Flow Cytometry Percentage of patients aged 18 years and older, seen within a 12 month reporting period, with a diagnosis of chronic lymphocytic leukemia (CLL) made at any time during or prior to the reporting period who had baseline flow cytometry studies performed and documented in the chart Exceptions: Documentation of medical reason(s) for not performing baseline flow cytometry studies (3170F with 1P) Documentation of patient reason(s) for not performing baseline flow cytometry studies (e.g., receiving palliative care or not receiving treatment as defined above) (3170F with 2P) Documentation of system reason(s) for not performing Patients aged 18 years on date of Diagnosis for CLL not in remission (ICD-10-CM): C91.10, C91.12 performance period (CPT): 99201, 99202, 99203, 99204, 99205, 99212, 99213, 99214, 99215 Flow cytometry studies performed at time of diagnosis or prior to initiating treatment (3170F) information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 5

QOPI REPTING REGISTRY (QCDR) 2018 Title Description baseline flow cytometry studies (e.g., patient previously treated by another physician at the time baseline flow cytometry studies were performed) (3170F with 3P) QPP 102 Prostate Cancer: Avoidance of Overuse of Bone Scan for Staging Low Risk Prostate Cancer Patients Percentage of patients, regardless of age, with a diagnosis of prostate cancer at low (or very low) risk of recurrence receiving interstitial prostate brachytherapy, external beam radiotherapy to the prostate, radical prostatectomy, cryotherapy who did not have a bone scan performed at any time since diagnosis of prostate cancer Exceptions: Documentation of medical reason(s) for performing a bone scan (including documented pain, salvage therapy, other medical reasons) (3269F with 1P) Documentation of system reason(s) for performing a bone scan (including bone scan ordered by someone other than the reporting physician) (3269F with 3P) Diagnosis for prostate cancer (ICD- 10-CM): C61 performance period Low (very low) risk of recurrence = Yes Receiving interstitial prostate brachytherapy = Yes Receiving external beam radiotherapy to the prostate = Yes Receiving radical prostatectomy = Yes Receiving cryotherapy = Yes Bone scan not performed prior to initiation of treatment nor at any time since diagnosis of prostate cancer information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 6

QOPI REPTING REGISTRY (QCDR) 2018 QPP 104 Title Prostate Cancer: Adjuvant Hormonal Therapy for High Risk or Very High Risk Prostate Cancer Description Percentage of patients, regardless of age, with a diagnosis of prostate cancer at high or very high risk of recurrence receiving external beam radiotherapy to the prostate who were prescribed adjuvant hormonal therapy (GnRH [gonadotropin-releasing hormone] agonist or antagonist) Diagnosis for metastatic cancer Exception: Documentation of medical reason(s) for not prescribing/administering adjuvant hormonal therapy (e.g., salvage therapy) Documentation of patient reason(s) for not prescribing/administering adjuvant hormonal therapy Diagnosis for prostate cancer (ICD- 10-CM): C61 performance period (CPT): 77427, 77435 High or very high risk of recurrence = Yes Receiving external beam radiotherapy to the prostate = Yes Adjuvant (i.e., in combination with external beam radiotherapy to the prostate for prostate cancer) hormonal therapy (gonadotropin-releasing hormone[gnrh] agonist or antagonist) prescribed/administered (4164F) QPP 130 Documentation of Current Medications in the Medical Record Percentage of visits for patients aged 18 years and older for which the eligible professional attests to documenting a list of current medications using all immediate resources available on the date of the. This list must include ALL known prescriptions, over-thecounters, herbals, and vitamin/mineral/dietary (nutritional) supplements must contain the medications' name, dosage, frequency and route of administration Exception: Patient Not Eligible: Eligible clinician attests to documenting in the medical record the patient is not eligible for a current list of medications being obtained, updated, or reviewed by the eligible clinician. Diagnosis of cancer Patients aged 18 years on date of performance period Eligible clinician attests to documenting in the medical record they obtained, updated, or reviewed the patient s current medications (G8427) information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 7

QOPI REPTING REGISTRY (QCDR) 2018 QPP 134 Title Preventive Care and Screening: Screening for Clinical Depression and Follow-Up Plan Description Percentage of patients aged 12 years and older screened for depression on the date of the using an age appropriate standardized depression screening tool if positive, a follow-up plan is documented on the date of the positive screen Documentation stating the patient has an active diagnosis of depression or has a diagnosed bipolar disorder, therefore screening or follow-up not required: G9717 Exception: Screening for depression not completed, documented reason (G8433) Patients aged 12 years on date of performance period (CPT or HCPCS): 90791, 90792, 90832, 90834, 90837, 92625, 96116, 96118, 96150, 96151, 97165, 97166, 97167, 99201, 99202, 99203, 99204, 99205, 99212, 99213, 99214, 99215, G0101, G0402, G0438, G0439, G0444 Screening for depression is documented as being positive a follow-up plan is documented (G8431) Screening for depression is documented as negative, a follow-up plan is not required (G8510) QPP 143 Oncology: Medical and Radiation - Pain Intensity Quantified Percentage of patient visits, regardless of patient age, with a diagnosis of cancer currently receiving chemotherapy or radiation therapy in which pain intensity is quantified Diagnosis of cancer Each office visit during the performance period (Receiving chemotherapy = Yes Receiving radiation therapy = Yes) Pain severity quantified; pain present (1125F) Pain severity quantified; no pain present (1126F) QPP 226 Preventive Care and Screening: Tobacco Use: Screening and Cessation Intervention Percentage of patients aged 18 years and older who were screened for tobacco use one or more times within 24 months who received cessation counseling intervention if identified as a tobacco user Exception: Documentation of medical reason(s) for not screening for tobacco use (e.g., limited life expectancy, other medical reason) Patients 18 on date of (Patient s during performance period 2 Preventive during performance period 1) Patient screened for tobacco use received tobacco cessation intervention (counseling, pharmacotherapy, or both), if identified as a tobacco user (4004F) Current tobacco non-user (1036F) information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 8

QOPI REPTING REGISTRY (QCDR) 2018 QPP 317 Title Preventive Care and Screening: Screening for High Blood Pressure and Follow-Up Documented Description Percentage of patients aged 18 years and older seen during the reporting period who were screened for high blood pressure a recommended follow-up plan is documented based on the current blood pressure (BP) reading as indicated Active diagnosis of hypertension Exception: Documented reason for not screening or recommending a follow-up for high blood pressure. Patient refuses to participate (either BP measurement or follow-up) Patient is in an urgent or emergent situation where time is of the essence and to delay treatment would jeopardize the patient s health status. This may include but is not limited to severely elevated BP when immediate medical treatment is indicated Patients 18 performance period Normal blood pressure reading documented, follow-up not required (G8783) Pre-Hypertensive or Hypertensive blood pressure reading documented, the indicated follow-up is documented (G8950) information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 9

QOPI REPTING REGISTRY (QCDR) 2018 QPP 408 Title Opioid Therapy Followup Evaluation Description All patients 18 and older prescribed opiates for longer than six weeks duration who had a follow-up evaluation conducted at least every three months during Opioid Therapy documented in the medical record Patients aged 18 years on date of performance period (CPT): 99201, 99202, 99203, 99204, 99205, 99212, 99213, 99214, 99215, 99304, 99305, 99306, 99307, 99308, 99309, 99310, 99324, 99325, 99326, 99327, 99328, 99334, 99335, 99336, 99337, 99341, 99342, 99343, 99344, 99345, 99347, 99348, 99349, 99350 Patients prescribed opiates for longer than six weeks: G9561 Patients who had a follow-up evaluation conducted at least every three months during opioid therapy (G9562) QPP 449 HER2 Negative or Undocumented Breast Cancer Patients Spared Treatment with HER2- Targeted Therapies Proportion of female patients (aged 18 years and older) with breast cancer who are human epidermal growth factor receptor 2 (HER2)/neu negative who are not administered HER2-targeted therapies Patient transferred to practice after initiation of chemotherapy Female Patients 18 years on date of Diagnosis of Breast Cancer Two or more s at the reporting site HER-2/neu = Negative HER-2/neu = Undocumented HER-2/neu =Unknown HER2-targeted therapies not administered during the initial course of treatment (G9827) information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 10

QOPI REPTING REGISTRY (QCDR) 2018 QPP 450 Title Trastuzumab Received By Patients With AJCC Stage I (T1c) - III And HER2 Positive Breast Cancer Receiving Adjuvant Chemotherapy Description Proportion of female patients (aged 18 years and older) with AJCC stage I (T1c) III, human epidermal growth factor receptor 2 (HER2) positive breast cancer receiving adjuvant chemotherapy who are also receiving trastuzumab Reason for not administering Trastuzumab documented (e.g. patient declined, patient died, patient transferred, contraindication or other clinical exclusion, neoadjuvant chemotherapy or radiation NOT complete) (G9836) Exception: Reason for not administering Trastuzumab documented (e.g. patient declined, patient died, patient transferred, contraindication or other clinical exclusion, neoadjuvant chemotherapy or radiation NOT complete) (G9836) Female Patients aged 18 years on date of Diagnosis of breast cancer Patient during performance period (CPT): 99201, 99202, 99203, 99204, 99205, 99212, 99213, 99214, 99215 Two or more s at the reporting site Breast Adjuvant Chemotherapy administered= Yes HER-2/neu = Positive AJCC stage at breast cancer diagnosis = II or III AJCC stage at breast cancer diagnosis = I (IA or IB) and T-Stage at breast cancer diagnosis does NOT equal = T1, T1a, T1b Trastuzumab administered within 12 months of diagnosis (G9835) information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 11

QOPI REPTING REGISTRY (QCDR) 2018 QPP 451 QPP 452 Title KRAS Gene Mutation Testing Performed for Patients with Metastatic Colorectal Cancer who receive Anti-epidermal Growth Factor Receptor (EGFR) Monoclonal Antibody Therapy Patients with Metastatic Colorectal Cancer and KRAS Gene Mutation Spared Treatment with Antiepidermal Growth Factor Receptor (EGFR) Monoclonal Antibodies Description Percentage of adult patients (aged 18 or over) with metastatic colorectal cancer who receive anti-epidermal growth factor receptor monoclonal antibody therapy for whom KRAS gene mutation testing was performed Percentage of adult patients (aged 18 or over) with metastatic colorectal cancer and KRAS gene mutation spared treatment with anti- EGFR monoclonal antibodies Patients aged 18 years on date of Diagnosis of Initial colon or rectal cancer diagnosis Two or more s at the reporting site Patient has metastatic disease at diagnosis Anti-EGFR monoclonal antibody therapy Patients aged 18 years on date of Diagnosis of colon or rectal cancer (ICD-10 CM): C18.0, C18.2, C18.3, C18.4, C18.5, C18.6, C18.7, C18.8, C18.9, C19, C20 performance period: 99201, 99202, 99203, 99204, 99205, 99212, 99213, 99214, 99215 Two or more s at the reporting site Patient has metastatic disease at diagnosis: G9842 KRAS gene mutation: G9843 KRAS gene mutation testing performed before initiation of anti-egfr MoAb (G9840) Patient did not receive anti-egfr monoclonal antibody therapy ((Anti-EGFR monoclonal antibodycetuximab or panitumumab) G9844) information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 12

QOPI REPTING REGISTRY (QCDR) 2018 QPP 453 QPP 456 QPP 457 Title Proportion Receiving Chemotherapy in the Last 14 Days of Life (Lower score - Better) Proportion Not Admitted To Hospice Proportion Admitted to Hospice for less than 3 days (Lower score - Better) Description Proportion of patients who died from cancer receiving chemotherapy in the last 14 days of life (Lower score - Better) Proportion of patients who died from cancer not admitted to hospice Proportion of patients who died from cancer, and admitted to hospice and spent less than 3 days there (Lower score - Better) Diagnosis of cancer Two or more s at the reporting site Patients who died from cancer: G9846 Diagnosis of cancer performance period (CPT): 99201, 99202, 99203, 99204, 99205, 99212, 99213, 99214, 99215 Two or more s at the reporting site Patients who died from cancer: G9855 Diagnosis of cancer Two or more s at the reporting site Patient enrolled in hospice: G9858 Patients who died from cancer: G9859 Patient received chemotherapy in the last 14 days of life (G9847) Patient was not admitted to hospice (G9856) Patient spent less than three days in hospice care (G9860) information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 13

QOPI REPTING REGISTRY (QCDR) 2018 QPP 462 Title Bone Density Evaluation for Patients with Prostate Cancer and Receiving Androgen Therapy Description Patients determined as having prostate cancer who are currently starting or undergoing androgen deprivation therapy )ADT), for an anticipated period of 12 months or greater and who receive an annual bone density evaluation. The bone density evaluation must be prior to the start of ADT or within 3 months of the start of ADT. Patients determined as having prostate cancer who are currently starting or undergoing androgen deprivation therapy (ADT), for an anticipated period of 12 months or greater Patients with a bone density evaluation within the two years prior to the start of or less than three months after the start of ADT Treament information storage and retrieval system, without written permission by the Society. Updated: 01/02/2017 14