Important Information Regarding Platelets Apheresis, LR Product Update

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1800 Alta Vista Ottawa, ON K1G 4J5 T 613.739.2300 F 613.731.1411 www.blood.ca www.sang.ca Important Information Regarding Platelets Apheresis, LR Product Update Customer Letter #2007-34 Dear Colleague: This letter pertains to: 2007-11-23 Platelets Apheresis, LR Transfusion Instructions Label Canadian Blood Services (CBS) is implementing new automated technology for collecting Platelets Apheresis, LR. Platelets Apheresis, LR will be supplied in either one container, or where the product volume exceeds 400mL and/or the platelet yield is greater than 5x10 11 /unit, in two connected containers. The provision of Platelets Apheresis, LR in two containers improves platelet viability during storage by permitting more surface area for gas exchange. From a licensing perspective, Canadian Blood Services considers platelets stored in two bags as one product/unit. For transfusion of the entire unit, the platelets stored in two containers should be pooled into the primary container immediately prior to transfusion, as indicated on the transfusion instruction label that is adhered to the secondary container. Canadian Blood Services sites will apply this label (as shown) with instructions for the product to be pooled prior to transfusion. However, should the transfusion facility decide to issue the product in each container separately, internal procedures that include instructions to allow for identification of the separated containers should be followed.

Canadian Blood Services - 2-2007-11-23 Actual Size If you have any questions regarding this matter, please do not hesitate to contact your local Canadian Blood Services. Attachments: 1. List of Regional s and Hospital Liaison Specialists 2. Site Implementation Schedule Sincerely, Dana V. Devine, Ph.D. Vice-President, Medical, Scientific and Research Affairs

Canadian Blood Services - 3-2007-11-23 Attachment 1 CANADIAN BLOOD SERVICES MEDICAL CONSULTANT/DIRECTORS LISTED BY SITE BC & Yukon C.-B. et Yukon Edmonton Calgary Saskatchewan Winnipeg Site Localité North/Eastern Ontario & Nunavut Nord et Est de l Ontario et Nunavut London Central Ontario Centre de l Ontario Halifax New Brunswick Newfoundland & Labrador/ Nouveau-Brunswick et Terre-Neuve-et-Labrador Medical Consultant/Director Directeurs et conseillers médicaux Medical Consultant Conseiller médical Dr./D r Gershon Growe Directrice médicale Dr./D re Judy Hannon Dr./D r Dale Towns Dr./D r Edward C. Alport Directrice médicale Dr./D re Debra Lane Dr./D r Peter Lesley Dr./D r Robert Barr Dr./D r Morris Blajchman Dr./D r Ben Saxon Medical Consultant Conseillère médicale Dr./D re Irene Sadek Dr./D r Karl Misik SOCIÉTÉ CANADIENNE DU SANG DIRECTEURS ET CONSEILLERS MÉDICAUX LISTE PAR LOCALITÉ Phone Téléphone Email Courriel 604-707-3449 gershon.growe@blood.ca 780-702-8634 judy.hannon@blood.ca 403-410-2676 dale.towns@blood.ca 306-347-1652 ted.alport@blood.ca 204-789-1079 debra.lane@blood.ca 613-560-7209 peter.lesley@blood.ca 519-690-3944 bob.barr@blood.ca 905-645-6390 blajchman@mcmaster.ca 416-313-4431 ben.saxon@blood.ca 902-474-8298 irene.sadek@blood.ca 709-758-8037 karl.misik@blood.ca

Canadian Blood Services - 4-2007-11-23 CANADIAN BLOOD SERVICES HOSPITAL LIAISON SPECIALIST LISTED BY REGION Regions Région Hospital Liaison Specialist Spécialiste de la liaison avec les hôpitaux SOCIÉTÉ CANADIENNE DU SANG SPÉCIALISTES DE LA LIAISON AVEC LES HÔPITAUX LISTE PAR RÉGION Phone Téléphone Email Courriel BC & Yukon C.-B. et Yukon Janet Unrau 604-707-3516 janet.unrau@blood.ca Alberta Colleen Young 780-431-8738 colleen.young@blood.ca Prairies Valerie Paulson 306-347-1633 valerie.paulson@blood.ca Northern & Eastern Ontario Denyse Tremblay 613-560-7259 denyse.tremblay@blood.ca Nord et Est de l Ontario Southern Ontario Sud de l Ontario Jon Fawcett 905-645-6568 jon.fawcett@blood.ca Central Ontario Centre de l Ontario Ahmed Coovadia 416-313-4452 ahmed.coovadia@blood.ca Atlantic (NS & NL) Atlantique (N.-É. et T.- Cheryl Doncaster 902-474-8291 cheryl.doncaster@blood.ca N.-L.) Atlantic (NB & PEI) Atlantique (N.-B. et Î.- P.-É.) Dorothy Harris 506-648-5054 dorothy.harris@blood.ca

Canadian Blood Services - 5-2007-11-23 Attachment 2 As this will be staggered implementation with equipment from two vendors, you may see a mixed inventory of current and new product bags issued for a period of time. Site Implementation Schedule Date (Week of) 2007-12-03 2008-01-07 2008-01-21 Site - MCS+ Newfoundland Saskatchewan Toronto Ottawa BC/Y Calgary Winnipeg London Edmonton Sudbury Date (Week of) 2007-12-03 2008-02-04 Halifax Feb-Mar 2008 Site - Trima New Brunswick Toronto Ottawa BC/Y