Atrial Fibrillation Version 2 11/4/15 This order set must be used with an admission order set if patient not already admitted.

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Patient Name: Diagnosis: Allergies with reaction type: Atrial Fibrillation Version 2 11/4/15 This order set must be used with an admission order set if patient not already admitted. Telemetry Medical Telemetry: Patient may be off telemetry for showering or transport for diagnostic tests [ ] Yes [ ] No Nursing Orders Notify provider IF Heart Rate remains greater than 130 bpm IF Systolic BP is less than 90 mmhg Diet Diet, cardiac (HEART HEALTHY) Caffeine free NPO at, cancel if converts to normal sinus rhythm Medications Anticoagulants For patients without contraindications who have atrial fibrillation of > 48 hours' duration or of unknown duration adequate anticoagulation should be used for 3 weeks prior to elective electrical cardioversion to prevent thromboembolism. For patients without contraindications who have atrial fibrillation of < 48 hours' duration consider adequate anticoagulation prior to electrical cardioversion to prevent thromboembolism. enoxaparin (LOVENOX) 1 milligram/kilogram subcutaneously every 12 hours 1 milligram/kilogram subcutaneously every 24 hours (Select if GFR < 30 ml/min) rivaroxaban (XARELTO) 20 milligram orally once a day, with evening meal 15 milligram orally once a day, with evening meal. Select for patients with GFR 15-50 ml/min [Inappropriate for patients with GFR < 15] apixaban (ELIQUIS) 5 orally 2 times a day 2.5 orally 2 times a day Select if patient has any 2 of the following: age > 80, weight < 60 kg, serum creatine > 1.5 mg/dl Low Dose Heparin Weight Based Drip Weight-based Heparin Infusion with loading dose (Select both) 60 unit/kilogram intravenously once loading dose (MAX 10,000 units) and initiate Low Dose Heparin Weight Based Protocol; (Pharmacy to adjust dosing weight 12 unit/kilogram per hour continuous intravenous infusion maintenance dose (MAX Infusion Rate 2,300 units per hour); titrate per low dose heparin weight based protocol (Pharmacy to adjust dosing weight Weight-based Heparin Infusion NO loading dose 12 unit/kilogram per hour continuous intravenous infusion maintenance dose (MAX Infusion Rate 2,300 units per hour); titrate per low dose heparin weight based protocol (Pharmacy to adjust dosing weight * Page 1 of 5

High Dose Heparin Weight Based Drip Weight-based Heparin Infusion Protocol WITH loading dose (Select both) 80 unit/kilogram intravenously once loading dose (MAX 10,000 units) and initiate High Dose Heparin Weight Based Protocol; (Pharmacy to adjust dosing weight 18 unit/kilogram per hour continuous intravenous infusion maintenance dose (MAX Infusion Rate 2,300 units per hour); titrate per High Dose Heparin Weight Based Protocol(Pharmacy to adjust dosing weight Weight-based Heparin Infusion Protocol WITHOUT loading dose 18 unit/kilogram per hour continuous intravenous infusion maintenance dose and titrate per High Dose Heparin Weight Based Protocol(Pharmacy to adjust dosing weight warfarin (COUMADIN) with loading dose SELECT BOTH warfarin (COUMADIN) 10 milligram orally once start on Loading dose 5 milligram orally once a day start on maintenance dose start day after loading dose warfarin (COUMADIN) without loading dose warfarin (COUMADIN) 5 milligram orally once a day start on 10 milligram orally once a day start on Platelet Inhibitors Concomitant use of ticagrelor(brilinta) with aspirin maintenance doses greater than 100 mg should be avoided aspirin 81 milligram orally once a day 325 milligram orally once a day clopidogrel (PLAVIX) 300 milligram orally once ; loading dose 75 milligram orally once a day (Begin day after loading dose if ordered) ticagrelor (BRILINTA)- Select both 180 milligram orally once now 90 orally 2 times a day maintenance dose (Begin day after loading dose) Amiodarone and Diltiazem Infusions amiodarone intravenous drip 1.8 milligram per milliliter (NEXTERONE) SELECT BOTH 150 milligram bolus over 10 minutes intravenously once followed by continuous infusion 1 milligram/minute continuous intravenous infusion for x 6 hours (begin after bolus) then decrease infusion rate to 0.5 milligram/minute; Do not start if Heart Rate is less than 100 bpm or Systolic BP is less than 100 mmhg; If patient converts to normal sinus rhythm discontinue and notify provieder diltiazem in normal saline 125 milligram/125 milliliter (CARDIZEM) SELECT BOTH 20 milligram bolus over 10 minutes intravenously once followed by continuous infusion 5 milligram/hour continuous infusion Titrate by 5 milligrams per hour [MAX infusion rate: 15 milligram/hour, MAX infusion time: 24 hours] to goal Heart Rate of 90-100 bpm as long as Systolic PB remains greater than 100 mmhg; HOLD and CALL provider for Heart Rate less than 50 bpm and/or SPB less than 90 mmhg; If patient converts to normal sinus rhythm discontinue and notify provider Page 2 of 5

Angiotensin-Converting Enzyme Inhibitors lisinopril (PRINIVIL) 10 milligram orally once a day -Hold for Systolic BP less than 90 mmhg 20 milligram orally once a day -Hold for Systolic BP less than 90 mmhg ramipril (ALTACE) 2.5 milligram orally once a day -Hold for Systolic BP less than 90 mmhg 5 milligram orally once a day Hold for Systolic BP less than 90 mmhg Angiotensin Receptor Blockers losartan (COZAAR) 50 milligram orally once a day -Hold for Systolic BP less than 90 mmhg 100 milligram orally once a day -Hold for Systolic BP less than 90 mmhg Antiarrhythmics: Class III Agents amiodarone (CORDARONE) 400 milligram orally 2 times a day 400 milligram orally once a day 200 milligram orally once a day Antiarrhythmics: Class II/III Agents Do not use sotalol for pharmacologic cardioversion sotalol (BETAPACE) 40 milligram orally 2 times a day 80 milligram orally 2 times a day Beta-Blockers carvedilol (COREG) 6.25 milligram orally 2 times a day -Hold for Systolic BP less than 90 mmhg or Heart rate less than 50 bpm 12.5 milligram orally 2 times a day -Hold for Systolic BP less than 90 mmhg or Heart rate less than 50 bpm metoprolol tartrate (LOPRESSOR) 25 milligram orally 2 times a day -Hold for Systolic BP less than 90 mmhg or Heart rate less than 50 bpm 50 milligram orally 2 times a day -Hold for Systolic BP less than 90 mmhg or Heart rate less than 50 bpm Calcium Channel Blockers diltiazem (CARDIZEM) 60 milligram orally 3 times a day verapamil (ISOPTIN) 40 milligram orally 3 times a day Cardiac Glycosides digoxin (LANOXIN) loading dose SELECT BOTH 0.5 milligram intravenously once 0.25 milligram intravenously every 6 hours for 2 doses Start 6 hours after 0.5 mg dose digoxin (LANOXIN) maintenance SELECT ONE 0.125 milligram orally once a day maintenance dose (Begin day after loading dose if ordered) 0.25 milligram orally once a day maintenance dose (Begin day after loading dose if ordered) Page 3 of 5

Statin Therapy ACC/AHA guideline Expert Panel recommendations for the treatment of blood cholesterol levels to reduce atherosclerotic cardiovascular disease (ASCVD) - includes coronary heart disease (CHD), stroke, and peripheral arterial disease, all of presumed atherosclerotic origin. High-Intensity SELECT ONE: High-intensity statin therapy should be initiated for adults < /=75 years of age with clinical ASCVD who are not receiving statin therapy or the intensity should be increased in those receiving a low- or moderateintensity statin, unless they have a history of intolerance to high-intensity statin therapy or other characteristics that may influence safety atorvastatin (LIPITOR) 40 milligram orally once a day, in the evening 80 milligram orally once a day, in the evening rosuvastatin (CRESTOR) 20 milligram orally once a day, in the evening [Potentially inappropriate for patients of Asian descent] 40 milligram orally once a day, in the evening [Potentially inappropriate for patients of Asian descent] Moderate-Intensity SELECT ONE: Moderate-intensity statin therapy should be used in individuals in whom high-intensity statin therapy would otherwise be recommended when characteristics predisposing them to statin-associated adverse effects are present. ( > 75 years of age, multiple or serious comorbidities, history of statin intolerance atorvastatin (LIPITOR) 10 milligram orally once a day, in the evening 20 milligram orally once a day, in the evening rosuvastatin (CRESTOR) 5 milligram orally once a day, in the evening 10 milligram orally once a day, in the evening [Potentially inappropriate for patients of Asian descent] Laboratory Admission Labs: CBC/AUTO DIFF Comprehensive metabolic panel Magnesium level, plasma Phosphorus level, plasma Troponin-I PT (PROTIME AND INR) PTT Digoxin level Morning Labs: CBC/AUTO DIFF Basic metabolic panel Lipid panel, fasting Radiology and Diagnostic Tests XR Chest Single routine Reason for exam: line or tube placement verification XR Chest PA and Lateral now Reason for exam: ECG stat Reason for exam: Atrial Fib routine Reason for exam: Atrial Fib Page 4 of 5

ECHO, Transthoracic Complete stat ICD 9 Indications: Contrast? [ ] Yes [ ] No Agitated Saline (Bubble Study) [ ] Yes [ ] No Additional Instructions: routine ICD 9 Indications: Contrast? [ ] Yes [ ] No Agitated Saline (Bubble Study) [ ] Yes [ ] No Additional Instructions: ECHO, Transesophageal routine **Cardiology Consult required** Reason for exam: Additional Instructions: Consult Provider Provider to provider notification preferred. Consult Cardiologist: Consult other provider regarding Does nursing need to contact consulted provider? [ ] Yes [ ] No * Provider_Signature: Date: Time: Page 5 of 5