CLINICAL CANCER UPDATE

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Presented by Department of Surgery University of California, San Francisco School of Medicine University of California San Francisco 7th Annual CLINICAL CANCER UPDATE FRIDAY - SUNDAY January 25-27, 2008 North Lake Tahoe California PROGRAM CHAIR David M. Jablons, MD Professor of Surgery Chief, Section of General Thoracic Surgery Ada Distinguished Professor and Program Leader Thoracic Oncology Program UCSF Comprehensive Cancer Center CO-CHAIR Alan Venook, MD Professor of Clinical Medicine UCSF Comprehensive Cancer Center SESSION CHAIRS Allan Balmain, PhD, FRSE David W. Eisele, MD Thierry M. Jahan, MD Richard J. O'Donnell, MD C. Bethann Powell, MD Hope S. Rugo, MD Eric J. Small, MD

7th Annual CLINICAL CANCER UPDATE This annual conference is designed as a threeday course, with morning and evening sessions on Friday, Saturday and Sunday. This year's sessions will include a review new advances in the treatment, early detection and prevention of breast, genitourinary, gynecologic, head and neck, sarcoma, and lung cancers. It will also include a session on translational science related to hematologic cancers. The program is focused on clinical management and issues facing the busy practicing community internist, oncologist, radiation oncologist, and surgeon. Each session will have one invited guest faculty, two UCSF Faculty, and two case presentations by community physicians, highlighting diagnostic and treatment dilemmas faced in daily practice. Full CME credit is being offered through the University of California, San Francisco. TARGET AUDIENCE The intended audience is practicing physicians and nurses in the areas of internal medicine, medical, surgical, and radiation oncology, pulmonology, and family practice. Since we are limited on space, we will be mainly targeting the Western United States and select Eastern states as well as previous attendees. EDUCATIONAL OBJECTIVES An attendee completing this course should be able to: Identify the latest clinical management of patients with breast, genitourinary, gynecologic, head and neck, sarcoma and lung cancers. Identify the chemotherapeutic and radiation therapy options for patients with breast, genitourinary, gynecologic, head and neck, sarcoma and lung cancers. Understand the indications for surgical intervention in patients with breast, genitourinary, gynecologic, head and neck, sarcoma and lung cancers. Identify early detection methods for breast, genitourinary, gynecologic, head and neck, sarcoma and lung cancers. Verbalize a general understanding of the latest discoveries in the translational science related to hematologic cancers Identify emerging therapies available to patients with breast, genitourinary, gynecologic, head and neck, sarcoma and lung cancers. North Lake Tahoe, California January 25-27, 2008 ACCREDITATION The University of California, San Francisco School of Medicine (UCSF) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. UCSF designates this educational activity for a maximum of 14.75 AMA PRA Category 1 Credit(s) TM. Physicians should only claim credit commensurate with the extent of their participation in the activity. This CME activity meets the requirements under California Assembly Bill 1195, continuing education and cultural and linguistic competency. For the purpose of recertification, the American Nurses Credentialing Center accepts AMA PRA Category 1 Credit TM issued by organizations accredited by the ACCME. The California Board of Pharmacy accepts as continuing professional education those courses that meet the standard of relevance to pharmacy practice and have been approved for AMA PRA Category 1 Credit TM.

0569 University of California, San Francisco Office of Continuing Medical Education UCSF Box 0742 San Francisco, CA 94143-0742 Upcoming CME Courses 9th Annual UCSF/UC Davis Thoracic Oncology Conference November 17, 2007 The Nikko Hotel, Union Square San Francisco, California Anyone who attended the November Thoracic Oncology conference receives a $50 discount on this course. For more information or to register online visit our website at www.cme.ucsf.edu. You may also reach us by calling the Office of CME at (415) 476-4251 or email info@ocme.ucsf.edu. COURSE CHAIR David M. Jablons, MD Professor of Surgery Chief, Section of General Thoracic Surgery; Ada Distinguished Professor and Program Leader Thoracic Oncology Program UCSF Comprehensive Cancer Center COURSE CO-CHAIR Alan Venook, MD Professor of Clinical Medicine Associate Chief, Division of Medical Oncology; UCSF Comprehensive Cancer Center UCSF SESSION CHAIRS Allan Balmain, PhD, FRSE Professor in Residence Barbara Bass Bakar Endowed Chair in Cancer Genetics David W. Eisele, MD Professor and Chairman Director, Division of Head and Neck Surgery; Department of Otolaryngology - Head and Neck Surgery Thierry M. Jahan, MD Associate Clinical Professor of Medicine Richard J. O Donnell, MD Associate Professor of Clinical Orthopedic Surgery; Chief, Orthopaedic Oncology Service C. Bethan Powell, MD Assistant Professor, Obstetrics, Gynecology, and Reproductive Sciences; Co-Leader, Gynecologic Oncology Program Co-Leader, Gynecologic Oncology Program Hope Rugo, MD Clinical Professor of Medicine Director, Breast Oncology Clinical Trials Program Eric Small, MD Professor of Medicine and Urology Interim Chief, Division of Hematology-Oncology; Stanford W. and Norman R. Ascherman Endowed Chair UCSF Comprehensive Cancer Center INVITED GUEST FACULTY Jay Boyle, MD Memorial Sloan Kettering Cancer Center, New York, NY Warren A. Chow, MD Associate Professor, Medical Oncology, City Of Hope, Duarte, CA Michael F. Clarke, MD Associate Director of the Stanford Institute for Stem Cell and Regenerative Medicine Stanford University Palo Alto, CA Julie R. Gralow, MD Medical Oncology Division, Associate Professor, Fred Hutchinson Cancer Research Center; Seattle, WA James D. Luketich, MD Sampson Family Endowed Professor of Surgery Chief, The Heart, Lung, and Esophageal Surgery Institute University of Pittsburgh Medical Center, Pittsburgh, PA UCSF FACULTY (University of California, San Francisco unless indicated) Lee-May Chen, MD Assistant Clinical Professor, Obstetrics, Gynecology, and Reproductive Sciences Sarita Dubey, MD Assistant Professor of Medicine Alexander R. Gottschalk, MD,PhD Assistant Professor, Department of Radiation Oncology Andrew Horvai, MD PhD Assistant Professor of Pathology Jasleen Kukreja, MD Assistant Professor of Surgery Michelle Melisko, MD Assistant Clinical Professor Mark Moasser, MD Associate Clinical Professor of Medicine UCSF FACULTY (CONT.) Lisa Orloff, MD Professor, Department of Otolaryngology - Head and Neck Surgery Emmanuelle Passegue, PhD Assistant Professor of Medicine, Developmental and Stem Cell Biology Program Jonathan Rosenberg, MD Assistant Clinical Professor, Department of Hematology/Oncology Charles Ryan, MD Assistant Clinical Professor Neil Shah, MD, PhD Assistant Professor, Division of Hematology/Oncology Karen Smith McCune, MD, PhD John A. Kerner Chair in Gynecologic Oncology, Associate Professor, Cancer Research Institute and Obstetrics, Gynecology, & Reproductive Sciences Pierre Theodore, MD Assistant Professor of Surgery Steven J. Wang, MD Assistant Professor Chief of Otolaryngology - Head and Neck Surgery, San Francisco Veterans Administration Medical Center Sue S. Yom, MD, PhD Assistant Professor, Radiation Oncology faculty

7th Annual CLINICAL CANCER UPDAT Janu FRIDAY, JANUARY 25, 2008 7:00-7:30 am Continental Breakfast SESSION 1: LUNG CANCER/MESOTHELIOMA MODERATOR: THIERRY M. JAHAN, MD 7:30 am CT-Guided RFA and Stereotactic Radiosurgery James Luketich, MD for Lung Cancer 7:55 State of the Art Multi-Modality Treatment of Sue S. Yom, MD, PhD Locally Advanced NSCLC 8:15 Questions 8:25 Case Presentation / Panel Discussion 8:45 Break 9:00 Advanced NSCLC-Recent Advances, Sarita Dubey, MD Future Trends 9:20 Case Presentation / Panel Discussion 9:40 Questions SESSION 2: SARCOMA MODERATOR: RICHARD J. O DONNELL, MD 10:00 am Case Presentation / Panel Discussion 10:15 Case Presentation / Panel Discussion 10:30 Current Issues in Diagnosis of Soft Tissue Andrew E. Horvai, MD Sarcomas 11:00 Soft Tissue Sarcoma and Radiation Therapy Alexander R. Gottschalk, MD, PhD 11:30 Soft Tissue Sarcoma Chemotherapy: Warren A. Chow, MD Past, Present, Future 12:15 pm Case Review, Discussion, and Questions SESSION 3: GYNECOLOGIC CANCERS MODERATOR: C. BETHAN POWELL, MD 5:00 pm TBA Invited Guest Faculty Talk 5:25 A Practical Approach to Intraperitoneal Lee-may Chen, MD Chemotherapy for Ovarian Carcinoma 5:45 Questions 6:00 Case Presentation / Panel Discussion 6:20 Break 6:35 HPV Vaccination: What We Hope Versus Karen Smith McCune, MD, PhD What We Know 6:55 Case Presentation / Panel Discussion 7:15 Questions SATURDAY, JANUARY 26, 2008 7:00-7:30 am Continental Breakfast SESSION 4: GENITOURINARY CANCER MODERATOR: ERIC SMALL, MD 7:30 TBA Invited Guest Faculty Talk 7:55 New Approaches for Kidney Cancer: Jonathan Rosenberg, MD Too Many Choices? 8:15 Questions 8:25 Case Presentation / Panel Discussion GENERAL INFORMATION Pre-registration is preferred to ensure that registrants receive a syllabus and CME Certificate at the course. REGISTRATION INFORMATION Tuition*: $375 Practicing Physicians $275 Nurses/ Pharmacists/Allied Health Professionals/ Residents/Fellows * Attendees who register for both Thoracic Oncology and Clinical Cancer will receive a $50.00 discount off of the registration for the Clinical Cancer Update course. Payment may be made by Visa, MasterCard, AmEx or check. REGISTER VIA: Online: www.cme.ucsf.edu Mail: Complete course registration form and send with payment to: UCSF Office of CME P.O. Box 45368 San Francisco, CA 94145-0368 Fax: Fax completed registration form to: (415) 502-1795 (be sure to include your credit card number) program On-Site Registration: Generally we are able to accommodate on-site registration at our courses. To register by phone or to inquire about registration status, please call UCSF s CME Registration Office at (415) 476-5808. Please check our website for up-to-date information on the course: www.cme.ucsf.edu REFUND POLICY Cancellations received in writing before the first day of the course will be refunded, less a $75 administrative fee. No refunds will be made on cancellations received after that date. CONFERENCE LOCATION Nestled at the base of Squaw Valley USA, site of the 1960 winter Olympics and minutes from world renowned Lake Tahoe, the is the premier all season mountain resort in California. Its 405 resort rooms, and suites complete with residential style kitchens, fireplaces and LCD flat screen TVs, offer guests a mountain home experience with four diamond luxury and full service amenities. general With services to accommodate info most any visitor, this all season mountain resort offers its own shopping promenade, four restaurants, extensive meeting and

E ary 25-27, 2008 North Lake Tahoe, California SATURDAY, JANUARY 26, 2008 (CONT.) 8:45 Break 9:00 Neither White nor Black: What to Do After Charles Ryan, MD Hormones, and Before Chemotherapy in Prostate Cancer Patients 9:20 Case Presentation / Panel Discussion 9:40-9:50 am Questions SESSION 5: HEAD AND NECK CANCER MODERATOR: DAVID EISELE, MD 3:45 pm Oral Cavity Carcinoma Jay Boyle, MD 4:15 Management of the Neck Following Steven J. Wang, MD Chemoradiation for Oropharyngeal Carcinoma 4:35 Questions 4:45 Case Presentation / Panel Discussion 5:05 Break 5:15 Transoral Laser Resection of Laryngeal Lisa Orloff, MD Carcinoma 5:35 Case Presentation / Panel Discussion 5:55 Questions SESSION 6: TRANSLATIONAL SCIENCE MODERATOR: ALLAN BALMAIN, PHD, FRSE 6:05 pm Regulation of Self Renewal in Normal and Michael F. Clarke, MD Malignant Stem Cells 6:35 Hematopoietic Stem Cells, Leukemic Stem Emmanuelle Passegue, PhD Cells and Leukemia 6:55 Break 7:05 Activity and Limitations of Kinase Inhibitor Neil Shah, MD PhD Therapy for the Treatment of Chronic Myeloid Leukemia 7:25 Questions 7:30 Dinner Reception (included in tuition, registration required) SUNDAY, JANUARY 27, 2008 6:30-7:00 am Continental Breakfast SESSION 7: BREAST CANCER MODERATOR: HOPE RUGO, MD 7:00 am TBA Julie R. Gralow, MD 7:25 TBA Mark Moasser, MD 7:45 Questions 8:00 Case Presentation / Panel Discussion 8:20 Break 8:35 San Antonio Update: What s New Michelle Melisko, MD and in Breast Cancer Hope Rugo, MD 8:55 Case Presentation / Panel Discussion 9:20-9:30 am Questions CONFERENCE LOCATION (CONT.) special event facilities, a full-service spa, a complete health and fitness center, and Mountain Buddies, a comprehensive children's program. Recreation enthusiasts will love the resort's ski-in/ski-out access to Squaw Valley USA, on-site Cross-Country Ski Center, ice-skating rink, and heated swimming pools. A block of guestrooms has been reserved at the special UCSF conference rate of $299**. The cut off date is December 24, 2007, or until the group room block is filled. After this date, rooms will be provided on a space-available basis only. If you prefer to phone in your reservation, please identify yourself as a member of this conference to receive the special rate. To make hotel reservations please call 800-403-4434, please identify yourself as a member of this UCSF conference to receive the special rate. ** Hotel Policies: Reservations must be cancelled at least 14 days prior to arrival date to avoid penalty of one night's room charge (and applicable taxes). A credit card number and deposit of one night's room charge is required to confirm your reservation. Check-in 4:00 pm; check-out 11:00 am. Reservation requests made after 12/24/07 will be honored at the conference room-rates on a space-available basis. Room rates are subject to all occupancy, state and local taxes (currently 10% and 7.25%, subject to change without notice). Rates do not include daily $15 Resort Fee. By staying at the host hotel, you help UCSF meet its contractual obligations and keep registration fees reasonable. Please take this into consideration when making your accommodation decisions. RENTAL CAR Hertz is offering special rates for participants of this conference; simply call (800) 654-2240 and refer to identification number # 03BW0127, or call your travel agent. You may also make reservations at www.hertz.com. Advance reservations are recommended. AIR TRANSPORTATION Special arrangements have been made with Montgomery Travel. Simply call (800) 391-2287 or complete the form on the UCSF web page at www.montgomerytravel.com. In addition to offering lower rates than published airfares, ticketed passengers may take advantage of the 24 hour emergency service. There is a $35 service fee. UCSF has negotiated special fares with American and United Airlines for our course attendees. You may use the following tour codes to book on your own: American (800) 433-1790 code: 15273 Secondary code: A0628SS United (800) 521-4041 code: 510CF Secondary code: 577LN.

Course Registration Form www.cme.ucsf.edu 7TH ANNUAL UCSF CLINICAL CANCER UPDATE Friday, January 25 - Sunday, January 27, 2008 North Lake Tahoe, California Mail to : Dr. Mr. Mrs. Ms. Last Name First M.I. Degree Specialty Address City State Zip Daytime Phone Fax Email Address Label Code Letter (see address label: example, A, B, C, D, etc.) Would you like to be on our priority email list? Yes No Would you like to be on our priority fax list? Yes No Date of birth to be used as OCME registrant number: / / X X Month Day Please indicate if you have any special needs: Registration Fees (receipt/confirmation will be mailed within two to four weeks): $375 $275 Reception UCSF Office of CME P.O. Box 45368 San Francisco, CA 94145-0368 Fax: (415) 502-1795 Physicians or Practicing Physicians Nurses/Pharmacist/Allied Health Professionals /Residents/Fellows Please confirm below so we may plan for the appropriate number of people I will attend the reception (included in tuition) I will not attend # of adults # of children under 12 Make checks payable to UC Regents Please charge my credit card: Visa MasterCard AmEx for $ / Card # Expiration date Name on Card (Please Print) Authorized Signature Refund Policy: Cancellations received in writing before the first day of the course will be refunded, less a $75 administrative fee. No refunds will be made on cancellations received after that date. Please check our website for up-to-date information on the course: www.cme.ucsf.edu 400 Squaw Creek Road Olympic Valley, CA 96146 Phone: 530-583-6300 Guest Fax: 530-581-6632 Toll free: 800-3CREEK3 www.squawcreek.com MSU08006 Registration Information: (415) 476-5808 Course Information: (415) 476-4251 Online registration: www.cme.ucsf.edu