Drug Testing Index A comprehensive analysis of workplace drug use trends

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Employer Solutions Semi-Annual Report Fall 2013 Drug Testing Index A comprehensive analysis of workplace drug use trends Anniversary DTI

The Quest Diagnostics Drug Testing Index is published as a public service for government, media and industry and has been considered a benchmark for national trends since its inception in 1988. It examines positivity rates the proportion of positive results for each drug to all such drug tests performed among three major testing populations: federally-mandated, safety-sensitive workers; the general U.S. workforce; and the combined U.S. workforce. Table of Contents 25 Years of the Drug Testing Index 1 Drug Use Among American Workers Declined 74% Over Past 25 Years 4 Urine Drug Tests Positivity by Combined U.S. Workforce 8 Positivity by Testing Category 9 Positivity by Testing Reason 10 Positivity by Drug Category 12 Non-Negativity by SVT Category 15 About Quest Diagnostics 20

The Drug Testing Index is arguably the industry s longest standing, most consistent and most frequently relied upon resource indicating the drug use patterns among American workers. Anniversary DTI This fall, we are excited to share our 25th anniversary timeline which tracks the evolution of our industry, notes milestones in drug testing and illustrates our steadfast commitment towards helping to keep workplaces safe and drug-free. We believe in the benefits that drug testing delivers. We also believe in the value and insights that the Drug Testing Index provides. Drug Testing Index Fall 2013 1

25 Years of the Drug Testing Index 1988 The first Drug Testing Index is published April Congress passes the Drug-Free Workplace Act November Anti-Drug Abuse Act is passed 13.6% 1990 National Collegiate Athletic Association adopts year-round drug testing policy April Congress passes the Anabolic Steroids Control Act 11.0% 1992 Drug Testing Index showed 1 of every 6 transportation workers who were tested for reasonable suspicion tested positive 8.8% 1994 Quest Diagnostics offers Hair Drug Testing September Marijuana metabolite screening cut-off is lowered from 100 to 50 ng/ml December Breath Alcohol Testing added to obtain a commercial driver s license 7.5% 1996 September Drug Importer Death Penalty Act is established November California legalizes the growing and use of marijuana for medical purposes 5.8% 1998 Drug Enforcement Administration focuses on drug eradication December Opiate cut-off raised from 300 to 2,000 ng/ml for greater drug detection 4.8% 2000 October Drug Addiction Treatment Act is introduced December Transportation workers get greater drug test protection 4.7% 1989 12.7% March Skinner vs. Railway Labor Executives Association upholds the constitutionality of drug testing railroad employees October Drug testing policies implemented at major corporations December Department of Transportation issues first urine drug testing rules 1991 8.8% Congress passes the Omnibus Employee Drug Testing Act 1993 8.4% June MedWatch is introduced November Drug-Free Schools and Communities Act Amendment is passed 1995 6.7% June Vernonia School District 47J vs. Acton upholds random testing of student athletes 1997 5.0% Drug Testing Index enhanced its reporting, allowing for specimen type and regional trends 1999 4.6% November Michigan begins random drug testing welfare recipients November World Anti-Doping Agency is established 2 Fall 2013 Drug Testing Index Year Positivity rate for the year

Mexican government cracks down on drug trafficking June Supreme Court reapproves high school drug testing March White House encourages more drug tests in schools Worldwide use of illegal drug increases 2002 July Drug testing begins on the Professional Golfers Association Tour March Combat Methamphetamine Epidemic Act is established 4.4% August Department of Transportation publishes final rules on specimen validity testing, making it harder to cheat a urine drug test 2006 3.8% 2004 4.5% Drug Testing Index data shows post-accident tests find opiates up to four times more than pre-employment tests October Cocaine and amphetamine cutoff changes added to federally mandated drug testing panel 2010 Substance Abuse and Mental Health Services Administration accepts Drug Testing Advisory Board recommendations to add oral fluid and expanded opiate testing to federally regulated drug testing November Colorado and Washington are the first U.S. states to legalize the recreational use of marijuana 3.5% 2012 2008 3.5% 3.6% 2003 2001 2009 4.1% 2007 4.5% 3.5% 3.6% 2013 3.8% 4.6% Health and Human Services provides regulatory guidance for specimen validity testing 2011 2005 Drug Testing Index finds the incidence of amphetamine positivity has grown by 70% over the past five years May President Bush moves to shut down National Drug Intelligence Center August Drug Testing Index finds cocaine use at 10-year low among U.S. workers October First large-scale study of same-donor hair and urine results presented by Dr. Barry Sample at The Society of Forensic Toxicologists meeting Quest Diagnostics creates Drug Testing ROI Calculator October Quest Diagnostics introduces Oral-Eze oral fluid drug testing device October Drug Testing Index reports that hydrocodone and oxycodones lead U.S. general workforce positives Anniversary DTI Quest Diagnostics Drug Testing Index celebrates its 25th anniversary Drug Testing Index Fall 2013 3

Drug Use Among American Workers Declined 74% Over Past 25 Years Landmark Drug Testing Index analysis from Quest Diagnostics coincides with passage of the Drug-Free Workplace Act 25 years ago today. Drug use among American workers declined dramatically over the past 25 years, although the rate of positive test results for certain drugs, including amphetamine and opiates, continues to climb, according to a landmark analysis of workplace drug test results by Quest Diagnostics. The special 25th anniversary Drug Testing Index (DTI) coincides with the passage of the Drug-Free Workplace Act in 1988, which was a catalyst for greater awareness of the problem of workplace drug use and the implementation of workplace drug education and monitoring programs, including drug testing, by federal agencies and private employers in the United States. Today s Quest Diagnostics Drug Testing Index provides the best evidence to date that the Drug-Free Workplace Act and the public and private initiatives it helped to spur have led to steep declines in drug use among much of the American workforce, said Laura Shelton, Executive Director, Drug and Alcohol Testing Industry Association (DATIA). While more needs to be done to reduce illicit drug use by workers, we should take heart from the tremendous progress employers have made to create safer workplaces for millions of Americans. The DTI analysis examined more than 125 million urine drug tests performed by Quest Diagnostics forensic toxicology laboratories across the United States as a service for government and private employers between 1988 and 2012. The analysis examined the annual positivity rate for employees in positions subject to certain federal safety regulations, such as truck drivers, train operators, airline and nuclear power plant workers (federally-mandated safety-sensitive workers); workers primarily from private companies (U.S. general workforce); and the results of both groups together (combined U.S. workforce). The index reports the percentage of results that tested positive for the presence of a drug or its metabolite, an adulterant or that involved a specimen that was deemed to be unacceptable for testing ( positivity ). The company s testing services identify approximately 20 commonly abused drugs, including marijuana, opiates and cocaine. 4 Fall 2013 Drug Testing Index

Despite the declines in overall drug use, the DTI analysis also found that the positivity rate for certain segments of drugs has increased. Positivity rates for amphetamines, including amphetamine and methamphetamine, has nearly tripled (196% higher) in the combined U.S. workforce and, in 2012, were at the highest level since 1997. The positivity rate for amphetamine itself, including prescription medications such as Adderall, has more than doubled in the last 10 years. DTI analysis examined more than 125 million urine drug tests performed by Quest Diagnostics laboratories across the United States. Key findings from the analysis The positivity rate for the combined U.S. workforce declined 74%, from 13.6% in 1988 to 3.5% in 2012. The positivity rate for the federally-mandated safety sensitive workforce declined by 38%, from 2.6% in 1992 to 1.6% in 2012. The positivity rate for the U.S. general workforce declined by 60%, from 10.3% in 1992 to 4.1% in 2012. Positivity rates for prescription opiates, which include the drugs hydrocodone, hydromorphone, oxycodone and oxymorphone, have also increased steadily over the last decade more than doubling for hydrocodone and hydromorphone and up 71% for oxycodone reflective of national prescribing trends. These data are consistent with other studies, including a 2012 Quest Diagnostics Health Trends analysis of more than 75,000 test results from patients tested for compliance through the company s prescription drug monitoring services. This report found that the majority of Americans misused their prescription medications, including opioids and amphetamine medications. Drug Testing Index Fall 2013 5

An increasing number of workers are testing positive for certain prescription drugs, such as opiates and stimulants. The DTI report also found that changing positivity rates often mirrored larger developments in drug use in the U.S. For instance, a decline in drug positives for methamphetamine observed in 2005 roughly coincided with federal and state efforts to crackdown on so-called meth labs and put over-the-counter medicines such as ephedrine and pseudoephedrine behind the pharmacy counter. While this Silver Anniversary Drug Testing Index underscores the nation s progress in reducing the prevalence of drug use in our country s work environments, there is a danger in becoming complacent in response to this good news, said Dr. Barry Sample, Director of Science and Technology for Quest Diagnostics Employer Solutions. Our data shows that an increasing number of workers are testing positive for certain prescription drugs, such as opiates and stimulants, reflecting the increased use, and potentially abuse, of prescription medications in the U.S. We also know from other research that the steep declines in our data s overall drug positivity rates would likely not be observed in workplaces that do not have workplace drug testing programs. Some industries such as the restaurant industry have adopted an attitude that drug use in their industry is something they cannot control. The fact remains that drugs in the workforce contribute to industrial and other accidents, not to mention employer costs and liability, said Mary Brown-Ybos, Director of Compliance for DISA Global Solutions, Inc., and President of Substance Abuse Program Administrators Association (SAPAA). The Drug-Free Workplace Act was an important step in fostering safer workplaces, but we have more work ahead of us to foster truly drug-free work environments. 6 Fall 2013 Drug Testing Index

The Drug Testing Index is more than an established barometer of workplace drug use trends. Quest s DTI demonstrates the power of diagnostic insights to reveal opportunities to create a healthier and safer world, said Harvey Kaufman, MD, Senior Medical Director, Quest Diagnostics. Our goal for this seminal DTI report is to reveal both the huge progress made to date to deter the use of drugs by workers, but also to show that vigilance is required by employers seeking to create safe, healthy environments for their employees. Changing positivity rates often mirrored larger developments in drug use in the U.S. The Drug-Free Workplace Act of 1988 requires federal contractors and all federal grantees to agree to provide drug-free workplaces as a precondition of receiving a contract or grant from a federal agency. Although the Act did not mandate mandatory drug testing, federal agencies subsequently promulgated drug testing regulations affecting safety-sensitive employees and other federal employees. Many private employers also created policies consistent with the federal requirements in order to minimize the hazards of drug use in the workplace. The strengths of the DTI analysis include its unprecedented sample size, the longitudinal nature of the monitoring, a testing population that is generally reflective of the U.S. workforce, and the quality of the company s drug testing services to confirm positive results. Limitations include the selection of the testing population, which is reflective only of results from employers that perform drug testing, and a lack of exact cross-specimen comparisons due to variations in substances for which employers test. DTI reports involve analysis of de-identified results from urine, oral fluid and hair drug tests. Drug Testing Index Fall 2013 7

Annual Positivity Rates Urine Drug Tests For Combined U.S. Workforce 15% 12% 9% 6% 3% 0% 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 2008 2010 2012 More than 6.7 million tests from to December 2012 Year Drug Positivity Rate 1988 13.6% 1989 12.7% 1990 11.0% 1991 8.8% 1992 8.8% 1993 8.4% 1994 7.5% 1995 6.7% Year Drug Positivity Rate 1996 5.8% 1997 5.0% 1998 4.8% 1999 4.6% 2000 4.7% 2001 4.6% 2002 4.4% 2003 4.5% Year Drug Positivity Rate 2004 4.5% 2005 4.1% 2006 3.8% 2007 3.8% 2008 3.6% 2009 3.6% 2010 3.5% 2011 3.5% 2012 3.5% 8 Fall 2013 Drug Testing Index

Positivity Rates by Testing Category Urine Drug Tests 5% 4% 3% Federally-Mandated, Safety-Sensitive Workforce General U.S. Combined Workforce U.S. Workforce Combined U.S. Workforce General U.S. Workforce Federally Mandated, Safety 2% 1% 0% 2008 2009 2010 2011 2012 Testing Category 2008 2009 2010 2011 2012 Federally-Mandated, Safety-Sensitive Workforce 1.6% 1.5% 1.5% 1.7% 1.6% General U.S. Workforce 4.2% 4.2% 4.2% 4.1% 4.1% Combined U.S. Workforce 3.6% 3.6% 3.5% 3.5% 3.5% Drug Testing Index Fall 2013 9

Positivity Rates by Testing Reason Urine Drug Tests For Federally-Mandated, Safety-Sensitive Workforce 12% 10% 8% 6% Follow-Up For Cause Periodic Post-Accident Pre-Employment Random Returned to Duty 4% 2% 0% 2008 2009 2010 2011 2012 More than 1.7 million tests from to December 2012 Testing Reason 2008 2009 2010 2011 2012 Follow-Up 2.2% 2.5% 2.4% 2.8% 2.8% For Cause 9.9% 11.1% 9.7% 7.5% 8.5% Periodic 0.71% 0.82% 1.0% 1.6% 1.5% Post-Accident 2.3% 2.2% 2.2% 2.3% 2.4% Pre-Employment 1.7% 1.5% 1.6% 1.8% 1.7% Random 1.4% 1.4% 1.4% 1.5% 1.4% Returned to Duty 3.1% 3.0% 3.3% 2.5% 2.7% 10 Fall 2013 Drug Testing Index

Positivity Rates by Testing Reason Urine Drug Tests For General U.S. Workforce 30% 25% 20% 15% Follow-Up For Cause Periodic Post-Accident Pre-Employment Random Returned to Duty 10% 5% 0% 2008 2009 2010 2011 2012 More than 5 million tests from to December 2012 Testing Reason 2008 2009 2010 2011 2012 Follow-Up 7.6% 7.5% 6.5% 6.6% 6.4% For Cause 22.0% 26.8% 26.9% 26.8% 26.3% Periodic 1.4% 1.5% 1.3% 1.3% 1.3% Post-Accident 5.6% 5.3% 5.3% 5.3% 5.5% Pre-Employment 3.6% 3.4% 3.6% 3.5% 3.7% Random 5.3% 5.4% 5.3% 5.2% 4.9% Returned to Duty 5.3% 4.6% 5.2% 5.2% 5.4% Drug Testing Index Fall 2013 11

Positivity Rates by Drug Category Urine Drug Tests For Federally-Mandated, Safety-Sensitive Workforce, as a Percentage of All Such Tests 0.8% 0.7% 0.6% 6-AM PCP Amphetamines Cocaine Opiates Marijuana 0.5% 0.4% MDMA Opiates PCP MDMA Marijuana 0.3% Cocaine 0.2% 0.1% 0.0% 2008 2009 2010 2011 2012 Amphetamines 6-Acetylmorphine More than 1.7 million tests from to December 2012 Drug Category 2008 2009 2010 2011 2012 6-AM 0.011% 1 0.012% 0.014% Amphetamines 0.26% 0.29% 0.35% 0.44% 0.48% Cocaine 0.32% 0.24% 0.24% 0.32% 0.27% Marijuana 0.77% 0.69% 0.69% 0.64% 0.63% MDMA 0.005% 1 0.003% 0.003% Opiates 0.20% 0.21% 0.17% 0.18% 0.18% PCP 0.04% 0.04% 0.04% 0.04% 0.03% 12 Fall 2013 Drug Testing Index

Positivity Rates by Drug Category Urine Drug Tests For General U.S. Workforce, as a Percentage of All Such Tests 2.5% 6-AM Propoxyphene Amphetamines 2.0% Barbiturates PCP Benzodiazepines 1.5% Cocaine Marijuana Methadone Oxycodones Opiates 1.0% MDMA Opiates MDMA 0.5% Oxycodones Methadone PCP 0.0% 2008 2009 2010 2011 2012 PropoxypheneMarijuana Cocaine More than 5 million tests from to December 2012 Drug Category 2008 2009 2010 2011 2012 6-AM 0.013% 1 0.015% 0.022% Amphetamines 0.48% 0.57% 0.66% 0.77% 0.87% Barbiturates 0.25% 0.26% 0.25% 0.26% 0.25% Benzodiazepines 0.76% 0.84% 0.79% 0.78% 0.73% Cocaine 0.40% 0.29% 0.25% 0.27% 0.21% Marijuana 2.1% 2.0% 2.0% 2.0% 2.0% Drug Category 2008 2009 2010 2011 2012 Methadone 0.22% 0.23% 0.22% 0.20% 0.19% MDMA 0.015% 0.015% 0.009% 0.003% 0.001% Opiates 0.38% 0.45% 0.39% 0.42% 0.44% Oxycodones 0.83% 1.00% 1.02% 1.10% 0.96% PCP 0.02% 0.02% 0.01% 0.01% 0.01% Propoxyphene 0.56% 0.48% 0.38% 0.06% 0.02% Drug Testing Index Fall 2013 13

Positivity Rates by Drug Category Urine Drug Tests For Combined U.S. Workforce, as a Percentage of All Such Tests 2.0% 6-AM Propoxyphene Amphetamines 1.5% Barbiturates PCP Benzodiazepines Cocaine Oxycodones Marijuana 1.0% Methadone Opiates 0.5% MDMA MDMA Opiates Oxycodones Methadone PCP 0.0% 2008 2009 2010 2011 2012 PropoxypheneMarijuana Cocaine More than 6.7 million tests from to December 2012 Drug Category 2008 2009 2010 2011 2012 6-AM 0.013% 0.017% Amphetamines 0.43% 0.50% 0.58% 0.69% 0.77% Barbiturates 0.25% 0.26% 0.25% 0.26% 0.25% Benzodiazepines 0.76% 0.84% 0.79% 0.78% 0.73% Cocaine 0.39% 0.28% 0.25% 0.28% 0.23% Marijuana 1.8% 1.7% 1.7% 1.6% 1.6% Drug Category 2008 2009 2010 2011 2012 Methadone 0.22% 0.23% 0.22% 0.20% 0.19% MDMA 0.015% 0.015% 0.007% 0.003% 0.002% Opiates 0.34% 0.39% 0.34% 0.36% 0.37% Oxycodones 0.83% 1.00% 1.02% 1.10% 0.96% PCP 0.02% 0.02% 0.02% 0.02% 0.02% Propoxyphene 0.56% 0.48% 0.38% 0.06% 0.02% 14 Fall 2013 Drug Testing Index

Non-Negative Rates by Specimen Validity Test (SVT) 2 Category Urine Drug Tests For Federally-Mandated, Safety-Sensitive Workforce, as a Percentage of All Such Tests 0.12% 0.10% 0.08% 0.06% 0.04% Acid-Base Invalid Oxidizing Adulterants Substitution Substitution Oxidizing Adulterants Invalid Acid-Base 0.02% 0.00% 2008 2009 2010 2011 2012 More than 1.7 million tests from to December 2012 SVT Category 2008 2009 2010 2011 2012 Acid-Base 0.02% 0.03% 0.03% 0.03% 0.03% Invalid 0.11% 0.09% 0.09% 0.09% 0.11% Oxidizing Adulterants 0.00% 0.00% 0.00% 0.00% 0.00% Substitution 0.05% 0.06% 0.06% 0.06% 0.05% Drug Testing Index Fall 2013 15

Non-Negative Rates by Drug/SVT Category Urine Drug Tests For General U.S. Workforce, as a Percentage of All Non-Negatives 0.15% 0.12% 0.09% Acid-Base Invalid Oxidizing Adulterants Substitution Substitution Oxidizing Adulterants Invalid 0.06% Acid-Base 0.03% 0.00% 2008 2009 2010 2011 2012 More than 5 million test results from to December 2012 SVT Category 2008 2009 2010 2011 2012 Acid-Base 0.002% 0.001% 0.001% 0.001% 0.001% Invalid 0.12% 0.12% 0.13% 0.14% 0.15% Oxidizing Adulterants 0.000% 0.000% 0.000% 0.000% 0.000% Substitution 0.01% 0.02% 0.02% 0.01% 0.01% 16 Fall 2013 Drug Testing Index

Non-Negative Rates by Drug/SVT Category Urine Drug Tests For Federally-Mandated, Safety-Sensitive Workforce, as a Percentage of All Non-Negatives 50% 6-AM Acid/Base PCP 40% Amphetamines Oxycodones Cocaine 30% Invalid Marijuana MDMA Opiates MDMA 20% Opiates Marijuana Oxidizing Adulterants 10% PCP Invalid 0% 2008 2009 2010 2011 2012 Cocaine Amphetamines More than 30 thousand non-negative test results from to December 2012 Drug Category 2008 2009 2010 2011 2012 6-AM 0.62% 0.75% Acid/Base 0.86% 1.70% 1.70% 1.60% 1.44% Amphetamines 14.40% 17.40% 21.30% 24.60% 26.53% Cocaine 17.70% 14.80% 14.40% 17.50% 14.87% Invalid 6.40% 5.50% 5.30% 4.90% 6.36% Drug Category 2008 2009 2010 2011 2012 Marijuana 44.30% 41.70% 41.20% 35.60% 35.24% MDMA 0.14% 0.17% Opiates 11.00% 12.60% 10.50% 9.70% 9.90% Oxidizing Adulterants 0.00% 0.01% 0.00% 0.00% 0.00% PCP 2.30% 2.50% 2.20% 2.10% 1.79% Drug Testing Index Fall 2013 17

Non-Negative Rates by Drug/SVT Category Urine Drug Tests For General U.S. Workforce, as a Percentage of All Non-Negatives 50% 6-AM Acid/Base Substituted Methadone Methaqualone 40% Amphetamines Opiates Propoxyphene Barbiturates Oxidizing Adulterants 30% 20% Benzodiazepines PCP Oxycodones Cocaine PCP Invalid Oxycodones Propoxyphene Marijuana Substituted Oxidizing Adulterants MDMA 10% Opiates 0% 2008 2009 2010 2011 2012 Methaqualone MDMA More than 225 thousand non-negative test results from to December 2012 Drug Category 2008 2009 2010 2011 2012 6-AM 0.06% 0.09% Acid/Base 0.04% 0.02% 0.03% 0.03% 0.03% Amphetamines 10.70% 12.60% 14.70% 17.50% 19.30% Barbiturates 3.30% 3.50% 3.50% 3.70% 3.52% Benzodiazepines 8.20% 9.00% 8.50% 8.70% 9.63% Cocaine 9.20% 6.40% 5.60% 6.10% 4.75% Invalid 2.60% 2.70% 2.90% 3.20% 3.34% Marijuana 46.30% 44.00% 45.40% 44.30% 43.36% MDMA 0.01% 0.01% Drug Category 2008 2009 2010 2011 2012 Methadone 2.50% 2.70% 2.70% 2.60% 2.32% Methaqualone 0.00% 0.00% 0.00% 0.00% 0.00% Opiates 8.40% 10.00% 8.80% 9.50% 9.81% Oxidizing Adulterants 0.00% 0.00% 0.00% 0.00% 0.00% Oxycodones 1.80% 2.70% 2.70% 3.10% 2.99% PCP 0.38% 0.34% 0.33% 0.32% 0.30% Propoxyphene 6.30% 5.60% 4.50% 0.71% 0.23% Substituted 0.26% 0.40% 0.40% 0.26% 0.31% 18 Fall 2013 Drug Testing Index

Non-Negative Rates by Drug/SVT Category Urine Drug Tests For Combined U.S. Workforce, as a Percentage of All Non-Negatives 50% 6-AM Acid/Base Substituted Methadone Methaqualone 40% Amphetamines Opiates Propoxyphene Barbiturates Oxidizing Adulterants 30% 20% Benzodiazepines PCP Oxycodones Cocaine PCP Invalid Oxycodones Propoxyphene Marijuana Substituted Oxidizing Adulterants MDMA 10% Opiates 0% 2008 2009 2010 2011 2012 Methaqualone Methadone More than 256 thousand non-negative test results from to December 2012 Drug Category 2008 2009 2010 2011 2012 6-AM 0.12% 0.17% Acid/Base 0.12% 0.20% 0.22% 0.23% 0.20% Amphetamines 11.10% 13.10% 15.40% 18.40% 20.17% Barbiturates 2.90% 3.20% 3.10% 3.20% 3.09% Benzodiazepines 7.40% 8.00% 7.60% 7.60% 8.47% Cocaine 10.00% 7.30% 6.60% 7.50% 5.97% Invalid 3.00% 3.00% 3.20% 3.40% 3.71% Marijuana 46.10% 43.70% 44.90% 43.30% 42.38% MDMA 0.03% 0.03% Drug Category 2008 2009 2010 2011 2012 Methadone 2.30% 2.40% 2.40% 2.30% 2.04% Methaqualone 0.00% 0.00% 0.00% 0.00% 0.00% Opiates 8.70% 10.30% 9.00% 9.50% 9.82% Oxidizing Adulterants 0.00% 0.00% 0.00% 0.00% 0.00% Oxycodones 1.60% 2.40% 2.40% 2.70% 2.63% PCP 0.57% 0.56% 0.54% 0.54% 0.48% Propoxyphene 5.70% 5.00% 4.00% 0.62% 0.20% Substituted 0.54% 0.76% 0.76% 0.62% 0.63% Drug Testing Index Fall 2013 19

About Quest Diagnostics Quest Diagnostics is the world s leading provider of diagnostic testing, information and services that patients and doctors need to make better healthcare decisions. The company offers the broadest access to diagnostic testing services through its network of laboratories and patient service centers, and provides interpretive consultation through its extensive medical and scientific staff. Quest Diagnostics is a pioneer in developing innovative new diagnostic tests and advanced healthcare information technology solutions that help improve patient care. Additional company information is available at: QuestDiagnostics.com. Notes 1. October December 2010 2. Specimen validity testing is the evaluation of a specimen to determine if it is consistent with a normal human specimen. Tests for specimen validity include tests to determine whether a specimen is adulterated or substituted. 20 Fall 2013 Drug Testing Index

Employer Solutions Semi-Annual Report Fall 2013 25 Years of the Drug Testing Index Snap to view the Drug Testing Index online QuestDiagnostics.com Quest, Quest Diagnostics, any associated logos, medmatch, and all associated Quest Diagnostics registered or unregistered trademarks are the property of Quest Diagnostics. All third party marks and are the property of their respective owners. 2013 Quest Diagnostics Incorporated. All rights reserved. SB3563 12/2013