Jack S. Remington, M.D.

Jack S. Remington, M.D. Professor of Medicine, Emeritus Bio ACADEMIC APPOINTMENTS Emeritus Faculty, Acad Council, Medicine HONORS AND AWARDS Distinguished Career Achievement Award, International Immunocompromised Host Society (ICHS) (2002) Kenneth L. Vosti, M.D., Infectious Diseases Teaching Award, Stanford University School of Medicine (2002) Albion Walter Hewlett Award, Stanford University (2002) Infectious Diseases Divisional Teaching Award, Stanford University Department of Medicine (2002) Fellow, American Academy of Microbiology (2000) Fellow, American Association for the Advancement of Science (2000) Ludwig Heilmeyer Society honorary membership, Ludwig Heilmeyer Society, Cologne, Germany (1998) Bristol Award, Infectious Diseases Society of America (IDSA) (1996) Diplomé de Docteur de L Université Paul Sabatier de Toulouse DOCTEUR HONORIS CAUSA, l Université Paul Sabatier, Toulouse, France (1992) Harry A. Feldman Presidential Award, Infectious Diseases Society of America (IDSA) (1987-1988) Alexander von Humboldt Scientific Award, Germany (1988) MERIT Award, National Institutes of Health (1987) James W. McLaughlin, MD Award, University of Texas (1985) Maxwell Finland Award, Infectious Diseases Society of America (IDSA) (1982) Osler Oration and Gold Medal, Royal College of Physicians, London, England (1999) Award/Gold Medal, Dr.-Friedrich-Sasse-Foundation, Berlin, Germany (1999) Fellowship, Royal College of Physicians, London, England (1999) "Achievement in Medicine" Award, Santa Clara County Medical Association (1993) Fellows Award for Clinical Excellence, Stanford University School of Medicine (1973) PROFESSIONAL EDUCATION Board Certif., ID, Amer. Brd. of Internal Med. Fellowship, Harvard Medical School, Infectious Diseases (1962) Resident, UCSF Medical Center, SF, Internal Medicine/ID (1960) MD, Univers. of IL Coll. of Medicine, Internal Medicine (1956) Page 1 of 6

Jack S. Remington, M.D. LINKS Toxoplasma Serology Laboratory: http://www.pamf.org/serology Research & Scholarship CURRENT RESEARCH AND SCHOLARLY INTERESTS Studies on the diagnosis, epidemiology, clinical features and prevention of toxoplasmosis in the pregnant woman, the fetus and newborn, in eye disease and in the immunocompromised patient. Teaching GRADUATE AND FELLOWSHIP PROGRAM AFFILIATIONS Immunology (Phd Program) Infectious Diseases (Fellowship Program) Publications PUBLICATIONS Polymerase chain reaction in cerebrospinal fluid for the diagnosis of congenital toxoplasmosis. Pediatric infectious disease journal Olariu, T. R.,, Montoya, J. G. 2014; 33 (6): 566-570 Severe Congenital Toxoplasmosis in the United States Clinical and Serologic Findings in Untreated Infants PEDIATRIC INFECTIOUS DISEASE JOURNAL Olariu, T. R.,, McLeod, R., Alam, A., Montoya, J. G. 2011; 30 (12): 1056-1061 Risk Factors for Toxoplasma gondii Infection in the United States CLINICAL INFECTIOUS DISEASES Jones, J. L., Dargelas, V., Roberts, J., Press, C.,, Montoya, J. G. 2009; 49 (6): 878-884 Management of Toxoplasma gondii infection during pregnancy CLINICAL INFECTIOUS DISEASES Montoya, J. G., 2008; 47 (4): 554-566 Prevalence of infection with Toxoplasma gondii among pregnant women in Cali, Colombia, South America AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Rosso, F., Les, J. T., Agudelo, A., Villalobos, C., Chaves, J. A., Tunubala, G. A., Messa, A.,, Montoya, J. G. 2008; 78 (3): 504-508 The differential agglutination test as a diagnostic aid in cases of toxoplasmic lymphadenitis JOURNAL OF CLINICAL MICROBIOLOGY Montoya, J. G., Berry, A., Rosso, F., 2007; 45 (5): 1463-1468 Use of a single serum sample for diagnosis of acute toxoplasmosis in pregnant women and other adults JOURNAL OF CLINICAL MICROBIOLOGY Press, C., Montoya, J. G., 2005; 43 (7): 3481-3483 Evaluation of the immunoglobulin G avidity test for diagnosis of toxoplasmic lymphadenopathy JOURNAL OF CLINICAL MICROBIOLOGY Montoya, J. G., Huffman, H. B., 2004; 42 (10): 4627-4631 Management of community-acquired respiratory tract infections CLINICAL INFECTIOUS DISEASES 2004; 39: S141-S141 Page 2 of 6

Recent developments for diagnosis of toxoplasmosis JOURNAL OF CLINICAL MICROBIOLOGY, Thulliez, P., Montoya, J. G. 2004; 42 (3): 941-945 Jack S. Remington, M.D. TCR V beta 8(+) T cells prevent development of toxoplasmic encephalitis in BALB/c mice genetically resistant to the disease JOURNAL OF IMMUNOLOGY Kang, H., Liesenfeld, O.,, Claflin, J., Wang, X. S., Suzuki, Y. 2003; 170 (8): 4254-4259 VIDAS test for avidity of Toxoplasma-specific immunoglobulin G for confirmatory testing of pregnant women JOURNAL OF CLINICAL MICROBIOLOGY Montoya, J. G., Liesenfeld, O., Kinney, S., Press, C., 2002; 40 (7): 2504-2508 Infectious complications among 620 consecutive heart transplant patients at Stanford University Medical Center 10th International Symposium on Infections in the Immunocompromised Montoya, J. G., Giraldo, L. F., Efron, B., Stinson, E. B., Gamberg, P., Hung, S., Giannetti, N., Miller, J., OXFORD UNIV PRESS INC.2001: 629 40 Infectious complications among 620 consecutive heart transplant patients at Stanford University Medical Center 10th International Symposium on Infection in the Immunocompromised Host Montoya, J. G., Giraldo, L. F., Efron, B., Stinson, E. B., Gamberg, P., Hunt, S., Giannetti, N., Miller, J., CELL PRESS.2001: 629 U6 Simple and efficient method for measuring anti-toxoplasma immunoglobulin antibodies in human sera using complement-mediated lysis of transgenic tachyzoites expressing beta-galactosidase JOURNAL OF CLINICAL MICROBIOLOGY Dando, C., Gabriel, K. E.,, Parmley, S. F. 2001; 39 (6): 2122-2125 Detection of immunoglobulin m antibodies to p35 antigen of Toxoplasma gondii for serodiagnosis of recently acquired infection in pregnant women JOURNAL OF CLINICAL MICROBIOLOGY Suzuki, Y., Ramirez, R., Press, C., Li, S. L., Parmley, S., Thulliez, P., 2000; 38 (11): 3967-3970 Protection against lipopolysaccharide-induced death by fluoroquinolones ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Khan, A. A., Slifer, T. R., Araujo, F. G., Suzuki, Y., 2000; 44 (11): 3169-3173 Ketolide ABT-773 is active against Toxoplasma gondii JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY Khan, A. A., Araujo, F. G., Craft, J. C., 2000; 46 (3): 489-492 Serodiagnosis of recently acquired Toxoplasma gondii infection using an enzyme-linked immunosorbent assay with a combination of recombinant antigens CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY Li, S. L., Galvan, G., Araujo, F. G., Suzuki, Y.,, Parmley, S. 2000; 7 (5): 781-787 Strategies for the successful treatment of gram-positive bacterial infections CLINICAL INFECTIOUS DISEASES 2000; 31: S150-S151 Effect of quinupristin/dalfopristin on production of cytokines by human monocytes JOURNAL OF INFECTIOUS DISEASES Khan, A. A., Slifer, T. R., Araujo, F. G., 2000; 182 (1): 356-358 Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma, TNF-alpha, and inducible nitric oxide synthase JOURNAL OF IMMUNOLOGY Kang, H.,, Suzuki, Y. 2000; 164 (5): 2629-2634 Introduction Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Page 3 of 6

2000; 31 Suppl 4: S123 Jack S. Remington, M.D. Use of ketolides in combination with other drugs to treat experimental toxoplasmosis JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY Araujo, F. G., Khan, A. A., Bryskier, A., 1998; 42 (5): 665-667 Scedosporium apiospermum (Pseudallescheria boydii) infection in a heart transplant recipient: A case of mistaken identity JOURNAL OF HEART AND LUNG TRANSPLANTATION Lopez, F. A., Crowley, R. S., Wastila, L., Valantine, H. A., 1998; 17 (3): 321-324 Impaired resistance to the development of toxoplasmic encephalitis in interleukin-6-deficient mice INFECTION AND IMMUNITY Suzuki, Y., Rani, S., Liesenfeld, O., Kojima, T., Lim, S., Nguyen, T. A., Dalrymple, S. A., Murray, R., 1997; 65 (6): 2339-2345 Treatment with interleukin 12 in combination with atovaquone or clindamycin significantly increases survival of mice with acute toxoplasmosis ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Araujo, F. G., Hunter, C. A., 1997; 41 (1): 188-190 Macrolides, azalides, and streptogramins in treatment of opportunistic infections in immunocompromised patients 3rd International Conference on the Macrolides, Azalides, and Streptogramins MARCEL DEKKER.1997: 189 204 Tularemia presenting as community-acquired pneumonia - Implications in the era of managed care ARCHIVES OF INTERNAL MEDICINE Fredricks, D. N., 1996; 156 (18): 2137-2140 Rifapentine is active in vitro and in vivo against Toxoplasma gondii ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Araujo, F. G., Khan, A. A., 1996; 40 (6): 1335-1337 Human CD4(+) and CD8(+) T lymphocytes are both cytotoxic to Toxoplasma gondii-infected cells INFECTION AND IMMUNITY Montoya, J. G., Lowe, K. E., CLAYBERGER, C., Moody, D., Do, D.,, Talib, S., Subauste, C. S. 1996; 64 (1): 176-181 Cells and cytokines in resistance to Toxoplasma gondii TOXOPLASMA GONDII Hunter, C. A., Suzuki, Y., Subauste, C. S., 1996; 219: 113-125 The role of IL12 in toxoplasmosis RESEARCH IN IMMUNOLOGY Hunter, C. A., 1995; 146 (7-8): 546-551 DEFINITIVE IDENTIFICATION OF A GENE THAT CONFERS RESISTANCE AGAINST TOXOPLASMA CYST BURDEN AND ENCEPHALITIS IMMUNOLOGY Brown, C. R., Hunter, C. A., Estes, R. G., Beckmann, E., Forman, J., David, C.,, McLeod, R. 1995; 85 (3): 419-428 PREFERENTIAL ACTIVATION AND EXPANSION OF HUMAN PERIPHERAL-BLOOD GAMMA-DELTA T-CELLS IN RESPONSE TO TOXOPLASMA GONDII IN VITRO AND THEIR CYTOKINE PRODUCTION AND CYTOTOXIC ACTIVITY AGAINST T-GONDII-INFECTED CELLS JOURNAL OF CLINICAL INVESTIGATION Subauste, C. S., Chung, J. Y., Do, D., Koniaris, A. H., Hunter, C. A., Montoya, J. G., Porcelli, S., 1995; 96 (1): 610-619 IL-1b is required for IL-12 to induce production of IFN-j by NK cells. J. Immun. Remington J.S., Hunter C.A., Chizzonite R. 1995: 4347-4354 Transforming growth factor-b inhibits interleukin-12 induced production of interferon-g by natural killer cells: a role for transforming growth factor-b in the regulation of T cell-independent resistance to Toxoplasma gondii. Eur. J. Immun. Page 4 of 6

Remington J.S., Hunter C.A., Bermudez L.E., Beernink H., Waegell W. 1995: 994-1000 Jack S. Remington, M.D. IMMUNOCYTOCHEMICAL DETECTION OF CYTOKINES IN THE LYMPH-NODES AND BRAINS OF MICE RESISTANT OR SUSCEPTIBLE TO TOXOPLASMIC ENCEPHALITIS JOURNAL OF INFECTIOUS DISEASES Hunter, C. A., Litton, M. J.,, Abrams, J. S. 1994; 170 (4): 939-945 TOXOPLASMOSIS IN PREGNANCY CLINICAL INFECTIOUS DISEASES Wong, S. Y., 1994; 18 (6): 853-861 Toxoplasma-macrophage interactions. Immunology series Beaman, M. H., Subauste, C. S., Wong, S. Y., 1994; 60: 475-493 THE ROLE OF CYTOKINES IN TOXOPLASMOSIS BIOTHERAPY Hunter, C. A., Subauste, C. S., 1994; 7 (3-4): 237-247 TOXOPLASMOSIS IN PATIENTS WITH CANCER CLINICAL INFECTIOUS DISEASES Israelski, D. M., 1993; 17: S423-S435 CYTOKINE MESSENGER-RNA IN THE CENTRAL-NERVOUS-SYSTEM OF SCID MICE INFECTED WITH TOXOPLASMA-GONDII - IMPORTANCE OF T-CELL-INDEPENDENT REGULATION OF RESISTANCE TO TOXOPLASMA-GONDII INFECTION AND IMMUNITY Hunter, C. A., Abrams, J. S., Beaman, M. H., 1993; 61 (10): 4038-4044 IMMUNITY TO TOXOPLASMA-GONDII CURRENT OPINION IN IMMUNOLOGY Subauste, C. S., 1993; 5 (4): 532-537 PREVALENCE OF TOXOPLASMA INFECTION IN A COHORT OF HOMOSEXUAL MEN AT RISK OF AIDS AND TOXOPLASMIC ENCEPHALITIS JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES Israelski, D. M., Chmiel, J. S., POGGENSEE, L., Phair, J. P., 1993; 6 (4): 414-418 VACCINATION OF MICE WITH THE PROTECTIVE F3G3 ANTIGEN OF TOXOPLASMA-GONDII ACTIVATES CD4+ BUT NOT CD8+ T-CELLS AND INDUCES TOXOPLASMA SPECIFIC IGG ANTIBODY MOLECULAR IMMUNOLOGY Brinkmann, V.,, Sharma, S. D. 1993; 30 (4): 353-358 THE ACTIVITY OF ATOVAQUONE-(566C80) IN MURINE TOXOPLASMOSIS IS MARKEDLY AUGMENTED WHEN USED IN COMBINATION WITH PYRIMETHAMINE OR SULFADIAZINE JOURNAL OF INFECTIOUS DISEASES Araujo, F. G., Lin, T., 1993; 167 (2): 494-497 Toxoplasmosis in the non-aids immunocompromised host. Current clinical topics in infectious diseases Israelski, D. M., 1993; 13: 322-356 CYTOKINES, TOXOPLASMA AND INTRACELLULAR PARASITISM IMMUNOLOGICAL REVIEWS Beaman, M. H., Wong, S. Y., 1992; 127: 97-117 MURINE CD8+ CYTOTOXIC LYMPHOCYTES-T LYSE TOXOPLASMA-GONDII-INFECTED CELLS JOURNAL OF IMMUNOLOGY Subauste, C. S., Koniaris, A. H., 1991; 147 (11): 3955-3959 Page 5 of 6

Jack S. Remington, M.D. RAPID PRENATAL-DIAGNOSIS OF CONGENITAL TOXOPLASMA INFECTION BY USING POLYMERASE CHAIN-REACTION AND AMNIOTIC-FLUID JOURNAL OF CLINICAL MICROBIOLOGY GROVER, C. M., Thulliez, P.,, Boothroyd, J. C. 1990; 28 (10): 2297-2301 THE TRAGEDY OF TOXOPLASMOSIS SYMP ON PERINATAL INFECTIOUS DISEASES : UPDATE 1990 LIPPINCOTT WILLIAMS & WILKINS.1990: 762 63 TOXOPLASMIC ENCEPHALITIS IN AIDS HOSPITAL PRACTICE DANNEMANN, B. R., 1989; 24 (3): 139-? TREATMENT OF TOXOPLASMIC ENCEPHALITIS WITH INTRAVENOUS CLINDAMYCIN ARCHIVES OF INTERNAL MEDICINE DANNEMANN, B. R., Israelski, D. M., 1988; 148 (11): 2477-2482 Page 6 of 6