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New Cases Total Patients diagnosed with eye tumors 184 Eye tumor related surgeries 146 Examination under anesthesia 95 Children received chemotherapy 53 Ocular prosthesis dispensed 9 Tumor related pathology specimens studied 155 Follow Up Cases n=40 New Cases n=144 6

Non Paying n=74 Paying n=110 Male n=89 Female n=95 Above 16 years n=69 Below 16 years n=115 7

Akhil s Life and Vision Saved Akhil Lal, 13, hailing from Kerala, was diagnosed with bilateral retinoblastoma, a type of eye cancer in very young children, when he was barely three months old. The cancer had taken its toll on the right eye and to save his life, it was necessary to remove the eye. But fortunately in the left eye, it was at an early stage and there was still hope to restore some amount of vision. For further management of the condition, on the advice of the local doctors, the worried parents brought Akhil to The Operational Eyesight Institute of Eye Cancer at LVPEI,. He was immediately started on chemotherapy to save his left eye and the vision. A prosthetic eye was also implanted in his right eye. Later in January 2016 during a follow up, tumor recurrence was noticed and he was put on high dose chemotherapy cycle. He received his last chemo cycle last month and now the tumor is regressed. Even though his vision is not perfect, we are still happy that he has functional vision and there is no threat to his life, says the delighted father, Krishnan Lal. Akhil is currently studying in his 9 th grade. We asked him what he loves doing the most and prompt came the reply, I love studying and one day want to become a successful engineer. The family is grateful for the guidance and treatment given by Dr Swathi Kaliki that has saved Akhil s life, eye, and vision. Akhil s condition needs to be closely monitored and regular follow up has been recommended. 8

Bhavani s Life Changing Story A happy Bhavani and her husband - after the surgery Bhavani, 20, residing in Jakkamcherla village, Krishna district, AP had developed a severe protrusion and inferolateral displacement of the right eye. As a result not only had her eye protruded, spoiling the cosmetic appeal of her face, but it also resulted in progressive vision loss since. After suffering from this for two years and being disappointed with the treatment received locally, she and her husband - a farmer by profession - visited LVPEI s Kode Venkatadri Chowdary Campus, Vijayawada. Detailed examinations revealed the presence of a right superior orbital mass extending till the orbital apex. Dr Anasua Ganguly Kapoor performed an orbitotomy and the schwanomma the entire mass was removed. Bhavani is extremely thankful to her treating doctor and the staff at LVPEI for not only restoring her vision but also restoring the cosmetic appeal of her face. Bhavani, before the surgery 9

Presentations Dr Swathi Kaliki Invited speaker at MEACO (Middle-East African Council of Ophthalmology) 2016 at Bahrain on 6 th May 2016; Recent advances in Ocular Oncology: LVPEI experience Keynote speaker in the retinoblastoma session at MEACO (Middle-East African Council of Ophthalmology) 2016 at Bahrain on 7 th May 2016; Update on retinoblastoma Grants Dr Mamatha Reddy Innovative Young Biotechnologist Award (IYBA) grant to study dysregulated pathways in Retinoblastoma. Funding agency: Department of Biotechnology, Govt. of India Left to right: Mustafa Mehyar (Ocular Oncologist, Jordan), Swathi Kaliki (Ocular Oncologist, LVPEI, India), Sana Al-Zuhaibi (Consultant in Pediatric Ophthalmology and Ocular Genitics, Oman), Arif Khan (Consultant in Pediatric Ophthalmology and Ocular Genitics, Abu Dhabi), Anuradha Ganesh (Consultant in Pediatric Ophthalmology and Ocular Genitics, Oman), Cristina Skrypnk (Geneticist, Oman) 10

Services Provided at The Operation Eyesight Universal Institute for Eye Cancer Special Investigative Diagnostics A and B-scan ultrasonography Ultrasound biomicroscopy Digital fundus and slit-lamp camera Wide-angle fundus photography (RetCam) Digital fluorescein angiography, and Indocyaning green angiography Optical coherence tomography Computed tomography (CT), Magnetic resonance imaging (MRI), Positron emission tomography (PET-CT), Radionucleotide studies (in collaboration) Ophthalmic oncopathology with Rapid intraoperative diagnostic facility including frozen section Ophthalmic Genetics and Molecular Biology Cutting-edge Treatment Integrated multi-speciality approach Integrated cancer surgery and cosmetic reconstruction Semiconductor diode laser Transpupillary thermotherapy Photodynamic therapy Frequency-doubled Nd:YAG laser photocoagulation Cryotherapy Bloodless radiofrequency-assisted surgery Navigation-guided orbital surgery External beam radiotherapy - IMRT, IGRT, Rapid Arc and Stereotactic Radiosurgery (in collaboration) Ruthenium 106 plaque brachytherapy Systemic chemotherapy for ophthalmic/intraocular tumors Intra vitreal chemotherapy Intra arterial chemotherapy (in collaboration) Neurosurgical, ENT and head and neck oncosurgical support Custom made ocular prosthesis Education & Training Cutting-edge Eye Cancer Research 11

Clinicians Swathi Kaliki Head, The Operation Eyesight Universal Institute for Eye Cancer Consultant, Oncology services, P Vijay Anand Reddy Medical and Radiation Oncologist Director, Apollo Cancer Hospital, Visiting consultant, L V Prasad Eye Institute, Mohammad Javed Ali Consultant Oculoplasty, Oncology, and Dacryology services, Tarjani Dave Consultant Oculoplasty, Oncology, and Dacryology services, OUR TEAM Anasua Ganguly Consultant Oculoplasty, Oncology, and Dacryology services, Vijayawada Samir Mohapatra Consultant Oculoplasty, Oncology, and Dacryology services, Vishakhapatnam Milind N Naik Head of the Oculoplasty Service Consultant, Oculoplasty, Oncology, and Dacryology services, Suryasnath Rath Consultant Oculoplasty, Oncology, and Dacryology services, Bhubaneswar Pathologist Vishal R Raval Consultant Retina and intraocular tumors Vijayawada Devjyoti Tripathy Consultant Oculoplasty, Oncology, and Dacryology services, Bhubaneswar Ruchi Mittal Consultant Ophthalmic pathology laboratory, Bhubaneswar, Vishakhapatnam, Vijayawada 12

Basic Research Scientists Chitra Kannabiran Scientist, Kallam Anji Reddy Molecular Genetics Laboratory, Indumati Mariappan Research Scientist, Sudhakar & Sreekanth Ravi Stem Cell Biology Laboratory, Mamatha Reddy Research Scientist, Bhubaneswar Genetic Counsellors Ocular Prosthesis Consultants Annie Hassan Consultant genetic counsellor, Akhilesh Pujar Consultant genetic counsellor, Ravi Shankar Chaudhary Consultant optometrist, Ocular prosthesis clinic, Arunima Mishra Consultant optometrist, Ocular prosthesis clinic, Bhubaneswar Consultant Optometrists Yashwanth Goud Consultant optometrist, Sadiya Iram Consultant optometrist, Dharani Tripuraneni Consultant optometrist, 13

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Unique Features of The Operation Eyesight Universal Institute for Eye Cancer : An exclusive institute for eye cancer that is one of its kind in the world The oncology services at LVPEI can claim to have more than a decade s experience in offering plaque radiation therapy and treatment to all types of ophthalmic/ ocular tumors. We continue to provide this service at The Operation Eyesight Universal Institute for Eye Cancer Entire value chain of services for eye cancer offered under one roof - patient care, research, education and rehabilitation Equipped with in-house chemotherapy unit for children The first and the only institute in India to perform Navigation-assisted surgery for complex orbital tumors Based on the socio-economic criteria, more than 50% patients are offered the same quality treatment entirely free-of-cost Copyright June 2016 Kallam Anji Reddy Campus L V Prasad Marg, Banjara Hills - 500 034 Telangana, India Bhubaneshwar Patia Bhubaneshwar - 751 024 Odisha, India Visakhapatnam GMR Varalakshmi Campus 11-113/1, Hanumanthawaka Junction Visakhapatnam - 530 040 Andhra Pradesh, India Vijaywada Kode Venkatadri Chowdary Campus Tadigadapa Vijayawada - 521 137 Andhra Pradesh, India Follow us on To book an appointment, reach us at: T: +91 91 7032700389; 40 39892020 F: +91 40 2354 8339 E: oncology@lvpei.org, www.lvpei.org