Sleep, Anxiety. &Stress SUPPLEMENTS TO SUPPORT SLEEP, ANXIETY & STRESS

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Sleep, Anxiety &Stress SUPPLEMENTS TO SUPPORT SLEEP, ANXIETY & STRESS

Chronic stress and insomnia have been linked to a number of life-threatening health conditions, including cancer, heart disease, diabetes and, also, mood disorders. Not only is stress the underlying cause of more than 75% of patient visits, it may also be the key contributing factor for sleep problems suffered by approximately 1/3 of all Americans. Neurotransmitters, chemical messengers of the nervous system, such as GABA, serotonin, dopamine and acetylcholine, are required for everything from signaling the heart and lungs to function, to enabling the body to relax and sleep. They are key players in overall physical and mental health. The balance and the proper response of both the calming (inhibitory) and stimulating (excitatory) neurotransmitters provide neuroprotective effects, and also help support cognitive ability, mood health and sleep quality. Biotics Research Corporation provides a number of nutritional formulas specifically targeting the balance and proper response of neurotransmitters, which may help promote an overall relaxation response and improve mood. Some products, such as the PheniTropic formulas, are designed to support sleep onset, quality and duration.

Sleep, Anxiety & Stress Support From Biotics Research PheniTropic Ultra PM Product Number: 7896 (30C) Each capsule of PheniTropic Ultra PM contains a potent blend of Phenibut (beta-phenyl-gamma-aminobutyric acid, a derivative of GABA), melatonin, 5-HTP, and passionflower. These nutrients are specifically formulated to promote a calming effect, assist with occasional sleeplessness and improve the overall quality of sleep. Vitamin B6 (as pyridoxal-5-phosphate), proprietary blend of Phenibut (4-amino-3- phenylbutyric acid HCl), 5-HTP (L-5-Hydroxy-Tryptophan), Passionflower (Passiflora incarnata) (aerial part) PheniTropic PM Product Number: 7894 (60C) PheniTropic PM supplies a proprietary blend of Phenibut (beta-phenylgamma-aminobutyric acid, a derivative of GABA), vitamin B6 and taurine, ingredients clinically shown to support the overall relaxation response and circadian rhythms as they relate to sleep. Vitamin B6 (as pyridoxal-5-phosphate), proprietary blend of Phenibut (4-amino-3- phenylbutyric acid HCl) and Taurine Size: 1 Capsule Vitamin B6 (as pyridoxal-5-phosphate) 5 mg 294% Melatonin 3 mg * Proprietary Blend 650 mg Phenibut (4-amino-3-phenylbutyric acid HCl)*, 5-HTP (L-5-Hydroxy-Tryptophan)*, Passionflower (Passiflora incarnata) (aerial part)* * Daily not established Other ingredients: Vegetarian capsule shell, microcrystalline cellulose, medium chain triglycerides and magnesium stearate. This product is gluten, dairy and GMO free. Size: 2 Capsules s Per Container: 30 Vitamin B6 (as pyridoxal-5-phosphate) 3.4 mg 200% Proprietary Blend 1,000 mg Phenibut (4-amino-3-phenylbutyric acid HCl)*, Taurine* * Daily not established Other ingredients: Vegetarian capsule shell, microcrystalline cellulose, medium chain triglycerides and magnesium stearate. This product is gluten, dairy and GMO free. PheniTropic Product Number: 7892 (60C) or 7893 (120C) PheniTropic contains beta-phenyl-gamma-aminobutyric acid, which is a derivative of GABA, a naturally occurring inhibitory neurotransmitter. Phenibut has been shown to have a calming effect and may assist in instances of stress, anxiety and occasional sleeplessness. Phenibut (4-amino-3-phenylbutyric acid HCl) Size: 1 Capsule Phenibut (4-amino-3-phenylbutyric acid HCl) 300 mg * * Daily not established Other ingredients: Capsule shell (gelatin and water), microcrystalline cellulose and magnesium stearate (vegetable source). For more information, visit www.bioticsresearch.com or call 800-231-5777

De-Stress Product Number: 7707 (30C) De-Stress supplies a patented, all natural, bio-active peptide (derived from milk), which has anxiolytic (inhibits anxiety) activity. De-Stress is clinically proven to be effective. De-Stress hydrolysate (as hydrolyzed casein concentrate) Size: 1 Capsule De-Stress hydrolysate (as hydrolyzed casein concentrate) 150 mg * * Daily not established Other ingredients: Capsule shell (gelatin and water). Contains ingredients derived from milk. De-Stress supplies a decapeptide, as determined by its amino acid sequence, having anxiolytic activity. This statement has not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Patent # 5,846,939 This product is gluten free. RECOMMENDATION: One (1) capsule each day as a dietary supplement or DopaTropic Powder Product Number: 7890 (132g) DopaTropic Powder contains a naturally occurring source of L-Dopa from the seed of the Mucuna pruriens plant. Dopamine functions to trigger numerous nerve impulses that affect muscle movement. Dopamine is also largely responsible for regulating physical movement, and emotion, and also effects the pleasure and motivation centers of the brain. Dopamine also assists neuronal transmission between neurons in the brain. Thus, the less dopamine there is, the less communication there is between the cells in the substantia nigra (midbrain). This area of the brain plays an important role in reward, addiction, and movement. Size: 1 rounded teaspoon (approx. 4.4 g) s Per Container: 30 Calories 0 Total Carbohydrates 3 g 1%* Sugar Alcohols 3 g Sugars 0 g Mucuna pruriens (seed) (extract) 1.6 g * Percent Daily s based on a 2,000 calorie diet Daily not established Other ingredients: Erythritol (a natural, zero glycemic carbohydrate). Mucuna pruriens (seed) (extract) Li-Zyme & Li-Zyme Forte Product Numbers: 1706 (100T) & 1724 (100T) Li-Zyme supplies lithium as a whole food, phytochemically bound vegetable culture. Typical dietary intakes of lithium range from 200 to 600 mcg per day, however certain population groups consume levels that are significantly higher. While not considered an essential trace mineral, animal studies have documented detrimental effects of lithium deficiency. Li-Zyme supplies 1/3 the amount of lithium (50mcg) as does the product Li-Zyme Forte. Lithium (from vegetable culture ) Size: 1 Tablet Lithium (from vegetable culture ) * Daily not established 50 mcg* Other ingredients: Cellulose, stearic acid (vegetable source), food glaze and magnesium stearate (vegetable source). Specially grown, biologically active vegetable culture containing Phytochemically Bound Lithium and other phytochemicals including polyphenolic compounds with SOD and catalase, dehydrated at low temperature to preserve associated enzyme factors. This product is gluten, dairy and GMO free.

Other Sleep, Anxiety & Stress Support Formulas Melatonin-B6/Mg Product Number: 7750 (60T) Melatonin supports a normal circadian rhythm for healthy sleep patterns, and provides support for GI health via its antioxidant effect. B6 (as P-5-P) and magnesium support protein synthesis, GABA production, dopa to dopamine conversion, and structural and dynamic functions including modulation of enzyme activities. Vitamin B6 (as pyridoxal-5-phosphate), Magnesium (as magnesium glycinate), Melatonin Mood Enhancer Product Number: 8100 (60C) Mood Enhancer addresses serotonin need and supplies important nutritional synergists to support healthy brain function. Thiamin (as thiamin HCl), Niacin (as niacinamide), Folate (as calcium folinate), Vitamin B12 (as methylcobalamin), Pantothenic Acid (as calcium pantothenate), St. John s Wort (0.3% hypericin), 5-Hydroxytryptophan NeuPerzine Product Number: 7891 (90C) NeuPerzine is a natural sesquiterpene alkaloid compound extracted from the plant Huperzia serrata, and is a compound that is utilized in neurology for memory support. Huperzia serrata (aerial part) (extract), Huperzine A Size: 1 Capsule Thiamin (as thiamin HCI) 15 mg 1,000% Niacin (as niacinamide) 25 mg 125% Folate (as calcium folinate) 300 mcg 75% Vitamin B12 (as methylcobalamin) 250 mcg 4,167% Pantothenic Acid (as calcium pantothenate) 25 mg 250% St. John s Wort (0.3% hypericin) 300 mg * 5-Hydroxytryptophan 100 mg * *Daily not established Other ingredients: Vegetarian capsule shell (modified cellulose) and magnesium stearate (vegetable source). RECOMMENDATION: Take one (1) to two (2) capsules before meals, or at les Size: One-half (½) Tablet s Per Container: 120 Size: 1 Capsule Vitamin B6 (as pyridoxal-5-phosphate) 5 mg 250% Magnesium (as magnesium glycinate) 25 mg 7% Melatonin 1.5 mg * * Daily not established Other Ingredients: Stearic acid (vegetable source), modified cellulose gum, magnesium stearate (vegetable source), and food glaze. This product is gluten free. Huperzia serrata (aerial part) (extract) 10 mg * Huperzine A 100 mcg * * Daily not established Other ingredients: Microcrystalline cellulose, capsule shell (gelatin and water) and magnesium stearate (vegetable source). RECOMMENDATION: Neuro-5-HTP Plus Product Number: 6349 (90C) Neuro-5-HTP Plus supplies 5-HTP (L-5-Hydroxy Tryptophan) with L-Theanine and B-vitamin synergists with SOD and catalase. 5-HTP (derived from L-Tryptophan) is converted to serotonin, a key neurotransmitter. L-theanine (from green tea), a derivative of L-glutamic acid, may possess mood-modulating activity as a result of increased production of alpha-brain wave activity. Niacin (as niacinamide), Vitamin B6 (as pyridoxal-5-phosphate), L-5- Hydroxytryptophan, L-Theanine, Superoxide Dismutase (from vegetable culture ), Catalase (from vegetable culture ) Specially grown, biologically active vegetable culture containing naturally associated phytochemicals including polyphenolic compounds with SOD and catalase, dehydrated at low temperature to preserve associated enzyme factors. Size: 1 Capsule Niacin (as niacinamide) 50 mg 313% Vitamin B6 (as pyridoxal-5-phosphate) 10 mg 500% L-5-Hydroxytryptophan 50 mg * L-Theanine 50 mg * Superoxide Dismutase (from vegetable culture ) 50 mcg * Catalase (from vegetable culture ) 50 mcg * * Daily not established Other ingredients: Capsule shell (gelatin and water). Specially grown, biologically active vegetable culture containing naturally associated phytochemicals including polyphenolic compounds with SOD and catalase, dehydrated at low temperature to preserve associated enzyme factors.

SAMethylate Plus Product Number: 8010 (60C) SAMe (S-adenosyl-L-methionine), found in every living human cell, is the principal methyl group donor in a great many reactions in the body with the ability to cross the blood-brain barrier where it impacts the synthesis and activation of various brain chemicals, including neurotransmitters. SAMethylate Plus supplies a stable source of SAMe with important synergists and building blocks, including B6, Folate, B12, L-Methionine, Choline bitartrate, trimethylglycine, SOD and Catalase. Vitamin B6 (as pyridoxal-5-phospate), Folate (as 5-MTHF glucosamine salt), Vitamin B12 Size: 1 Capsule (as methylcobalamin), SAMe (S-Adenosyl-L-Methionine disulfate p-toluensulfonate), L-Methionine, Choline bitartrate, Trimethylglycine, Superoxide Dismutase (from vegetable culture ), Catalase (from vegetable culture ) Specially grown, biologically active vegetable culture containing naturally associated and/or organically bound phytochemicals including polyphenolic compounds with SOD and catalase, dehydrated at low temperature to preserve associated enzyme factors. Vitamin B6 (as pyridoxal-5-phospate) 5 mg 250% Folate (as 5-MTHF glucosamine salt) 100 mcg 25% Vitamin B12 (as methylcobalamin) 20 mcg 333% SAMe (S-Adenosyl-L-Methionine disulfate p-toluensulfonate) 200 mg * L-Methionine 50 mg * Choline bitartrate 50 mg * Trimethylglycine 25 mg * Superoxide Dismutase (from vegetable culture ) 12.5 mcg * Catalase (from vegetable culture ) 12.5 mcg * *Daily not established Other ingredients: Acid resistant vegetarian capsule shell (cellulose and water), silica and magnesium stearate (vegetable source). Specially grown, biologically active vegetable culture containing naturally associated and/or organically bound phytochemicals including polyphenolic compounds with SOD and catalase, dehydrated at low temperature to preserve associated enzyme factors. V.H.P. Product Number: 5105 (90C) V.H.P. supplies a combination of Valerian, Hops and Passionflower, herbs that provide a calming effect. Consider it as a supplemental relief for occasional sleeplessness due to nervousness or irritability. Valerian (Valeriana officinalis) (root) (extract), Hops (Humulus lupulus) (flower), Passionflower (Passiflora incarnata) (aerial part) Size: 1 Capsule Valerian (Valeriana officinalis) (root) (extract) 200 mg * Hops (Humulus lupulus) (flower) 100 mg * Passionflower (Passiflora incarnata) (aerial part) 100 mg * * Daily not established Other ingredients: Capsule shell (gelatin and water) and magnesium stearate (vegetable source). CAUTION: Not This recommended product is gluten, for pregnant dairy or and lactating GMO free. women. Adjunct Products: 5-HTP, Pregnenolone 25, St. John s Forte For more information, visit www.bioticsresearch.com or call 800-231-5777 LIT-246 Copyright 2018 Rev. 03/18