Jaime L. Hook, MD 622 W. 168 th Street, PH-14 Room 104 New York, NY

Jaime L. Hook, C.V., p. 1 Preparation Date: 7/20/2017 Jaime L. Hook, MD 622 W. 168 th Street, PH-14 Room 104 New York, NY 10032 212-305-7771 jh3036@cumc.columbia.edu Birthplace: Milwaukee, WI Citizenship: United States of America Academic Appointments 7/2017 - present Columbia University Medical Center New York, NY Assistant Professor of Medicine 7/2015-6/2017 Columbia University Medical Center New York, NY Instructor in Medicine at CUMC Hospital Appointments 7/2015 - present New York-Presbyterian/Columbia University Medical Center New York, NY Assistant Attending Physician Education 8/2004-5/2008 University of Wisconsin School of Medicine and Public Health Madison, WI MD, May 2008 Alpha Omega Alpha Gold Humanism Honor Society Member 8/2000-5/2004 University of Wisconsin Madison, WI BS in Molecular Biology, May 2004 Phi Beta Kappa Graduation with Distinction (top 20% of graduating class) Beta Beta Beta Biological Honor Society Member Medical Scholar (pre-admitted to medical school based on high school performance) Training 7/2013-6/2015 Columbia University Medical Center New York, NY T32 Research Fellow, Lung Biology Laboratory 7/2011-6/2014 Columbia University Medical Center New York, NY Clinical Fellow, Division of Pulmonary, Allergy, and Critical Care Medicine 7/2009-6/2011 Columbia University Medical Center New York, NY Resident, Department of Medicine 6/2008-6/2009 New York University Medical Center New York, NY Intern, Internal Medicine 5/2005-8/2005 University of Wisconsin School of Medicine and Public Health Madison, WI Medical Student Research Fellow, Institute for Clinical and Translational Research

Jaime L. Hook, C.V., p. 2 Gaps There are no gaps in my work, training, or education. Licensure and Certifications (all active) 2014 Critical Care Medicine, American Board of Internal Medicine 2013 Pulmonary Medicine, American Board of Internal Medicine 2011 Internal Medicine, American Board of Internal Medicine 2009 Physician License, New York State (#255534) 2008 American Heart Association Basic and Advanced Cardiac Life Support Honors and Awards Post-graduate: 2016 Abstract Scholarship, Respiratory Cell & Molecular Biology Assembly of the American Thoracic Society (ATS) 2015 Travel Award, Allergy, Immunology, and Inflammation Assembly of the ATS 2014 Abstract Award, Respiratory Cell & Molecular Biology Assembly of the ATS 2014 Travel Award, Federation of American Societies for Experimental Biology 2012 Travel Award, Clinical Problems Assembly of the ATS 2010 Arnold P. Gold Foundation Award for Humanism and Excellence in Clinical Teaching Medical school: 2008 University of Wisconsin Department of OB/GYN Award for Academic Excellence 2007 Wisconsin Medical Society Foundation Presidential Scholar Award for Leadership 2007 University League Endowed Scholarship for Leadership 2006 Wisconsin Medical Society Foundation General Medical Education Scholarship 2006 Wisconsin Medical Alumni Association Scholarship for Leadership 2006 Eugene M. Polo Scholarship for Dedication to Education 2005 Wisconsin Medical Society Charity Roast Scholarship 2005 Lora L. Marshall Scholarship for Academic Achievement Academic Service at Columbia University Medical Center 2016 - present Division of Pulmonary, Allergy, and Critical Care Medicine Fellowship Selection Committee Member and Applicant Interviewer 2016 Department of Medicine, Junior Faculty Panelist at the Academic and Research Career Guidance Seminar for Fellows Professional Organizations and Societies Conference organizing roles: 2018 Gordon Research Seminar on the Biology of Acute Respiratory Infection Co-Chair 2018 Gordon Research Conference on the Biology of Acute Respiratory Infection Chair of a Symposium that addresses challenges faced by women in science American Thoracic Society: 2017 - present Respiratory Cell & Molecular Biology Assembly Program Committee Member 2017 - present Respiratory Cell & Molecular Biology Assembly Early Career Professionals Working Group Member 2009 - present Society Member Wisconsin Medical Society: 2006-2007 Council on the Health of the Public Member 2005-2006 Board of Directors Member 2005-2008 Society Member

Jaime L. Hook, C.V., p. 3 University of Wisconsin School of Medicine and Public Health Medical Student Association: 2005-2006 President (elected to serve as the primary representative of the 700-student body and lead organizer of medical student events and fundraisers) 2004-2008 Association Member Other professional memberships and positions: 2017 - present Columbia University Virginia Kneeland Frantz Society for Women Faculty Member 2015 - present American Heart Association Member 2008 - present Wisconsin Medical Alumni Association Class of 2008 Representative 2004-2008 American Medical Association Medical Student Representative Fellowship and Grant Support Present: AHA Fellow-to-Faculty Transition Award (scored in the 0.1 percentile) 7/1/16-6/30/21 Pulmonary microvascular responses to methicillin-resistant Staphylococcus aureus lung infection This career development award critically supports the transition from trainee to independent investigator. Role: PI ($526,000) Past: Competitive renewal, Stony Wold-Herbert Fund Research Training Fellowship 7/1/16-6/30/17 The goal of this Fellowship was to receive training in the investigation of respiratory diseases. This Fellowship was relinquished due to overlapping support with the AHA Award. Role: PI ($25,000) Stony Wold-Herbert Fund Research Training Fellowship 7/1/15-6/30/16 The goal of this Fellowship was to receive training in the investigation of respiratory diseases. Role: PI ($25,000) NHLBI T32 HL105323, Columbia Training Program in Lung Science 7/1/13-6/30/15 The goal of this Fellowship was to receive training in basic and translational lung biology. Role: Fellow ($103,032); PI: J. Bhattacharya Research Fellowship, UW Institute for Clinical and Translational Research 5/15/05-8/15/05 Self-rated health as a predictor of future functioning in older adults after a diagnosis of cancer The goal of this project was to receive training in clinical epidemiology research. Role: PI ($4,000) Pending: None Educational Contributions 2015 - present Columbia University Medical Center Inpatient Lung Transplant Service Teaching and Supervising Attending for rotating clinical fellows (6 weeks/year) 2003 University of Wisconsin Department of Zoology Teaching Assistant for undergraduate Comparative Anatomy (course 430, 431) Clinical and Public Health Activities 2004-2005 Volunteer for MEDiC, a medical student-run free community clinic in Madison, WI 2003-2004 University of Wisconsin Relay for Life Planning Committee Co-Chair (organized an annual fundraiser to support cancer research) 2003-2004 University of Wisconsin Relay for Life Planning Committee Logistics Chair Patents and Inventions None

Jaime L. Hook, C.V., p. 4 Publications Peer-Reviewed Research Publications: Hook JL, Arcasoy SM, Zemmel D, Bartels MN, Kawut SM, Lederer DJ. Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis. Eur Respir J. 2012;39(2):359-65. PMID 21885386 Hook JL, Lederer DJ. Socioeconomic barriers to lung transplantation: balancing access and equity. Am J Respir Crit Care Med. 2012;186(10): 937-9. PMID 23155209 Hook JL, Lederer DJ. Selecting lung transplant candidates: where do current guidelines fall short? Expert Rev Respir Med. 2012;6(1):51-61. PMID 22283579 Manuscripts Under Review: Hook JL, Islam MN, Parker D, Prince AS, Bhattacharya S, Bhattacharya J. Disruption of Staphylococcal aggregation protects against lethal lung injury. In external peer review. Published Abstracts: Hook JL, Islam MN, Gusarova G, Parker D, Prince A, Bhattacharya J. Localized alveolar-bacterial interactions determine global lung injury by Staphylococcus aureus. In: American Thoracic Society International Conference Abstracts, Section B80: Mechanisms and Models of Acute Lung Injury. May 20-24, 2017; Washington, D.C. Abstract A4398. Hook JL and Bhattacharya J. Staphylococcus aureus causes mitochondrial injury in live alveoli. In: American Thoracic Society International Conference Abstracts, Section B97: Mitochondrial Dysfunction in the Development of Lung Disease. May 14-18, 2016; San Francisco, CA. Abstract A4597. Hook JL, Islam MN, Westphalen K, Parker D, Prince A, Bhattacharya J. Alveolar curvatures determine Staphylococcus aureus-induced lung injury. In: American Thoracic Society International Conference Abstracts, Section B101: Acute Lung Injury and Inflammation. May 15-20, 2015; Denver, CO. Abstract A3687. Hook JL, Islam MN, Westphalen K, Cohen T, Prince A, Bhattacharya J. Alveolar retention of Staphylococcus aureus. Presented at: Federation of American Societies for Experimental Biology (FASEB) Conference, The Lung Epithelium in Health and Disease. July 27 August 1, 2014; Saxtons River, VT. Abstract. Hook JL, Islam MN, Westphalen K, Cohen TS, Prince AS, Bhattacharya J. Optical imaging of bacterial clearance in live alveoli. In: American Thoracic Society International Conference Abstracts, Section C18: Not Just A Job, But An Adventure: Molecular Underpinnings of Acute Lung Injury. May 17-21, 2014; San Diego, CA. Abstract A3963. Hook JL and Smith MA. A longitudinal model for progressive decline leading to frailty in cancer patients. Abstract. Medical Student Summer Research Fall Forum, UWSMPH. November 17, 2005; Madison, WI. Invited and Peer-Selected Oral Presentations at Scientific Meetings National and International Presentations: Hook JL. Lung infection by Staphylococcus aureus novel mechanisms. Invited Presentation at the Gordon Research Conference on the Biology of Acute Respiratory Infection. February 22, 2016; Galveston, TX.

Jaime L. Hook, C.V., p. 5 Hook JL. Lung infection by Staphylococcus aureus novel mechanisms. Gordon Research Seminar on the Biology of Acute Respiratory Infection. February 20, 2016; Galveston, TX. Hook JL. Staphylococcus aureus causes localized lung alveolar injury. Mini-Symposium, Mitochondrial Dysfunction in Development of Lung Disease, American Thoracic Society Conference. May 23, 2016; San Francisco, CA. Hook JL. Mechanisms of alveolar retention and injury in Staphylococcus aureus lung infection. Poster Discussion, Session on Acute Lung Injury and Inflammation, American Thoracic Society Conference. May 18, 2015; Denver, CO. Hook JL. Alveolar retention of Staphylococcus aureus. Conference on the Lung Epithelium in Health and Disease, Federation of American Societies for Experimental Biology. July 28, 2014; Saxtons River, VT. Hook JL. Alveolar retention of Staphylococcus aureus. Mini-Symposium, Molecular Underpinnings of Acute Lung Injury, American Thoracic Society Conference. May 19, 2014; San Diego, CA. Hook JL. The frail phenotype in lung transplantation: preliminary results. Mini-Symposium, Scientific and Clinical Innovations in Lung Transplantation, American Thoracic Society Conference. May 23, 2012; San Francisco, CA. Regional Presentations: Hook JL. Alveolar retention and injury in Staphylococcus aureus lung infection. William A. Briscoe Lung Club, New York City Divisions of Pulmonary and Critical Care Medicine. October 16, 2014; Weill Cornell Medical Center, New York, NY. Local Presentations: Hook JL. Host-pathogen interactions promote antibiotic failure in Staphylococcus aureus lung infection. T32 Retreat, Department of Medicine, Columbia University Medical Center. May 10, 2017; New York, NY. Hook JL. Novel mechanisms of pulmonary edema formation in Staphylococcus aureus lung infection. Research in Progress Seminar, Department of Medicine, Columbia University Medical Center. December 12, 2016; New York, NY. Hook JL. Staphylococcus aureus exploits alveolar niches in acute lung injury. Research Conference, Division of Pulmonary and Critical Care Medicine, Columbia University Medical Center. December 9, 2015; New York, NY. Hook JL. Staphylococcus aureus exploits host properties in lung infection. Multi-Departmental Conference for the Program for Microbial Pathogenesis, Columbia University Medical Center. November 16, 2015; New York, NY. Hook JL. Gap junctions amplify lung injury in Staphylococcus aureus pneumonia. Research in Progress Seminar, Department of Medicine, Columbia University Medical Center. November 9, 2015; New York, NY. Hook JL. Mechanisms of lung injury in Staphylococcus aureus pneumonia. Research Conference, Division of Pulmonary and Critical Care Medicine, Columbia University Medical Center. March 25, 2015; New York, NY. Hook JL. Mechanisms of Staphylococcus aureus-induced acute lung injury. Research in Progress Seminar, Department of Medicine, Columbia University Medical Center. January 26, 2015; New York, NY.

Jaime L. Hook, C.V., p. 6 Hook JL. Alveolar retention and injury in Staphyloccus aureus lung infection. T32 Executive Committee Meeting, Division of Pulmonary and Critical Care Medicine, Columbia University Medical Center. July 8, 2014; New York, NY. Hook JL. Alveolar retention and injury in Staphylococcus aureus lung infection. Research Conference, Division of Pulmonary and Critical Care Medicine, Columbia University Medical Center. June 11, 2014; New York, NY. Hook JL. Alveolar epithelial interactions with Staphylococcus aureus. Research Conference, Division of Pulmonary and Critical Care Medicine, Columbia University Medical Center. September 25, 2013; New York, NY. Hook JL. A novel point-of-care oxygen titration study in interstitial lung disease. Grand Rounds, Department of Medicine, Columbia University Medical Center. March 3, 2010; New York, NY. Poster Presentations at Scientific Meetings National and International Meetings: Hook JL, Islam MN, Gusarova G, Parker D, Prince A, Bhattacharya J. Novel mechanisms of antibiotic failure in Staphylococcus aureus USA300 lung infection. American Thoracic Society International Conference. May 22, 2017; Washington, D.C. Hook JL, Islam MN, Gusarova G, Parker D, Prince A, Bhattacharya J. Novel mechanisms of alveolar injury in Staphylococcus aureus lung infection. Gordon Research Conference and Seminar on the Biology of Acute Respiratory Infection. February 20-26, 2016; Galveston, TX. Hook JL, Islam MN, Gusarova G, Westphalen K, Parker D, Prince A, Bhattacharya J. Alveolar retention of Staphylococcus aureus. Federation of American Societies for Experimental Biology Conference, The Lung Epithelium in Health and Disease. July 27 August 1, 2014; Saxtons River, VT. Hook JL and Chong DH. Influenza A (H1N1) causing severe adult croup and complicated by bacterial tracheitis. American Thoracic Society International Conference. May 16, 2011; Denver, CO. Hook JL, Arcasoy SM, Zemmel D, Bartels MN, Kawut SM, Lederer DJ. Gas exchange and outcome prediction in idiopathic pulmonary fibrosis. American Thoracic Society International Conference. May 15, 2011; Denver, CO. Hook JL, Arcasoy SM, Zemmel D, Bartels MN, Kawut SM, Lederer DJ. A novel point-of-care oxygen titration study in interstitial lung disease. American Thoracic Society International Conference. May 17, 2010; New Orleans, LA. Local Meetings: Hook JL and Bhattacharya J. Localized alveolar-toxin interactions determine lung injury by Staphylococcus aureus. Research Day for Clinical and Postdoctoral Fellows and Scientists, Department of Medicine, Columbia University Medical Center. March 1, 2017; New York, NY. Hook JL, Islam MN, Westphalen K, Parker D, Prince A, Bhattacharya J. Mechanisms of alveolar retention and injury in Staphylococcus aureus lung infection. Research Day for Clinical and Postdoctoral Fellows and Scientists, Department of Medicine, Columbia University Medical Center. March 11, 2015; New York, NY.

Jaime L. Hook, C.V., p. 7 Hook JL, Arcasoy SM, Zemmel D, Bartels MN, Kawut SM, Lederer DJ. Gas exchange and outcome prediction in idiopathic pulmonary fibrosis. House Staff Research Day, Department of Medicine, Columbia University Medical Center. March 9, 2011; New York, NY. Hook JL and Smith MA. A longitudinal model for progressive decline leading to frailty in cancer patients. Medical Student Summer Research Fall Forum, University of Wisconsin School of Medicine and Public Health. November 17, 2005; Madison, WI.