Tobacco Cessation, E- Cigarettes and Hookahs

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Objectives Tobacco Cessation, E- Cigarettes and Hookahs Discuss evidence-based tobacco cessation interventions including pharmacologic options. Review e-cigarette and hookah facts and safety considerations. AMY V. LUKOWSKI, PSY.D. CLINICAL DIRECTOR, ASSOCIATE PROFESSOR NATIONAL JEWISH HEALTH PUBLIC HEALTH SERVICE (PHS) 2008 Guidelines 2014 CDC Best Practices for Cessation Interventions Tobacco dependence is a chronic disease that requires multiple interventions and attempts to overcome Clinicians should consistently attempt to identify, document and treat every tobacco user Counseling and medications are effective and should be recommended by clinicians Individual, group and telephonic counseling are effective and enhanced by medications Promote health systems change Expanding insurance coverage and utilization of proven cessation treatments Supporting state quitline capacity If an individual in unwilling to quit at the present time, use motivational treatment to encourage future attempts U.S. Health Service Clinical Practice Guideline on Treating Tobacco Use and Dependence: 2008 (DHHS, 2008) and Recommendation Statement (Annals of Internal Medicine, Oct 2015) Centers for Disease Control and Prevention. Best Practices for Comprehensive Tobacco Control Programs 2014. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014.

What Works: Multi-Disciplinary Approach What Can Multi-Disciplinary Teams Do? Establish staff roles (front desk staff, R.N., M.D., N.P., social worker) to implement smoking cessation in the clinic: assessment of smoking status brief interventions (based on stage of change) Motivational Interviewing Cognitive-behavioral strategies Relapse prevention addiction education referral to quitline or other counseling prescription of medication follow-up Ask tobacco questions at every visit Document responses as a vital sign Provider reminders to ask about tobacco use: electronic prompt, stamp, or vital sign checkbox Advise all tobacco users to quit smoking Use clear, strong and personalized message Provide a brief intervention brief (3-4 minutes) Refer individuals to an appropriate program Individual counseling Group counseling Quitline Follow-up with all patients on tobacco status and quit process at every visit U.S. Health Service Clinical Practice Guideline on Treating Tobacco Use and Dependence: 2008 (DHHS, 2008) and Recommendation Statement (Annals of Internal Medicine, Oct 2015) U.S. Health Service Clinical Practice Guideline on Treating Tobacco Use and Dependence: 2008 (DHHS, 2008) and Recommendation Statement (Annals of Internal Medicine, Oct 2015) Impact of Multi-Disciplinary Team Approach Next Step: Where Do you Focus the intervention? Patients expect that health team will address tobacco use, even if they are ambivalent Patient perspective Tobacco cessation intervention = quality care Different types of providers are effective at significantly increasing quit rates Multiple types of providers can enhance abstinence rates. Assess Stage of Change 1 Pre-Contemplation & Contemplation = Motivational Interviewing Intervention Preparation, Action, Maintenance, Slip/Relapse = Tobacco Cessation Intervention or Referral Assess Readiness 2 Importance How important is it to you to quit using tobacco? Confidence How confident are you in your ability to quit using tobacco? U.S. Health Service Clinical Practice Guideline on Treating Tobacco Use and Dependence: 2008 (DHHS, 2008) and Recommendation Statement (Annals of Internal Medicine, Oct 2015) 1. Transtheoretical Model of Change: Stages of Change (Prochaska & Velicer, 1997) R., Rollnick, S. (2013). Motivational interviewing: Helping people change. New York, NY: 2. Miller, W. & Guilford Press.

Brief Interventions: Motivational Interviewing (MI) How to Deliver Motivational Interviewing Intervention Specific communication style Facilitates change talk - patients argue for change, not the provider Maximize motivation Opportunity for patients to make decisions Build on patients resources for change Miller, W. R., & Rollnick, S. (2013). Motivational interviewing: Helping people change. New York, NY: Guilford Press. First Line Available Therapy FDA Approved Evidence-Based Tobacco Cessation Medications Effective Treatments All of the following improve the chances of quitting, with a low-risk of harm NRT (patch, gum, lozenge, inhaler and spray) Bupropion Varenicline Combination NRT = Varenicline more effective than single types of NRT SUMMARIZING MOTIVATIONAL INTERVIEWING Cahill K, Stevens S, Perera R, Lancaster T. Pharmacological interventions for smoking cessation: an overview and network metaanalysis.cochranedatabase of SystematicReviews 2013, Issue 5. Art. No. :CD009329.DOI: 10.1002/14651858.CD009329.pub2.

Second Line Available Therapy FDA Approved Nortriptyline improves the chances of quitting, with little evidence of harmful events Clonidine helped people to quit, but caused side effects Other aids (not 1 st or 2 nd FDA) Cytisine has potential as a safe, effective and affordable treatment Nicotine Replacement Therapy (NRT) Nicotine replacement therapy (NRT) can be used instead of tobacco to aid quitting NRT delivers nicotine without the toxins from tobacco NRT helps combat the symptoms of withdrawal Nicotine dose from NRT is lower and administered more gradually than with smoking and this reduces the addictive potential Most available OTC Cahill K, Stevens S, Perera R, Lancaster T. Pharmacological interventions for smoking cessation: an overview and network metaanalysis.cochranedatabase of SystematicReviews 2013, Issue 5. Art. No. :CD009329.DOI: 10.1002/14651858.CD009329.pub2. Cahill K, Stevens S, Perera R, Lancaster T. Pharmacological interventions for smoking cessation: an overview and network metaanalysis.cochranedatabase of SystematicReviews 2013, Issue 5. Art. No. :CD009329.DOI: 10.1002/14651858.CD009329.pub2. Electronic Nicotine Delivery Systems: The Facts Electronic Nicotine Delivery Systems: The Facts Continued Rapidly emerging and diversified Deliver nicotine, flavorings, and other additives via an inhaled aerosol Referred to as e-cigs, e-hookahs, mods, vape pens, vapes, and tank systems Most commonly used tobacco product among youth Major public health concern among youth and young adults In 2014, young adults (18-24) surpassed adults Young adults doubled use from 2013 to 2014 2014 - more than one-third had tried e-cigarettes Most recent data show that the prevalence of past 30-day use of e-cigarettes was 13.6% among young adults (2014) and 16.0% among high school students (2015) Data available show that the prevalence of past 30-day use of e-cigarettes is similar among middle school students (5.3%) and adults 25 years of age and older (5.7%) U.S. Department of Health and Human Services. E-Cigarette Use Among Youth and Young Adults: A Report of the Surgeon General Executive Summary. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2016. U.S. Department of Health and Human Services. E-Cigarette Use Among Youth and Young Adults: A Report of the Surgeon General Executive Summary. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2016.

Electronic Nicotine Delivery Systems: Safety Considerations Most contain nicotine Adolescent brain development The effects of nicotine exposure during youth and young adulthood Nicotine has potential to prime young brains for addiction Ingestion can cause acute toxicity and possible death The constituents of e-cigarette liquids can include solvents, flavorants, and toxicants Aerosol created by e-cigarettes can contain ingredients that are harmful and potentially harmful to the public s health E-Cigarettes & Current Cessation Practices 3 out of 4 adults who tried to quit in the past three months used multiple quit methods Most commonly used quit methods: cold turkey reducing the number of cigarettes they smoked substituting some cigarettes with e-cigarettes E-cigarettes used by about one-third of smokers making quit attempts and more commonly used than the nicotine patch, gum, or other FDAapproved cessation aids U.S. Department of Health and Human Services. E-Cigarette Use Among Youth and Young Adults: A Report of the Surgeon General Executive Summary. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2016. Caraballo RS, Shafer PR, Patel D, Davis KC, McAfee TA. Quit Methods Used by US Adult Cigarette Smokers, 2014 2016. Prev Chronic Dis 2017; 14:160600. DOI: https://doi.org/10.5888/pcd14.160600. Application: E-cigarettes Cessation: Provider Opportunity Current State Regulations May 2016 Result - patients are using e-cigarettes when talking about cessation: Provide a clear message about e-cigarettes, may be safer but not safe Use this as opportunity to congratulate patient on working toward cessation Ask about what they know about other quit medications (that are proven) Ask about their plan and if they need support Not allowing products to be sold to persons under the age of 18 years (both in person and online); Requiring age verification by photo ID; Not allowing the selling of covered tobacco products in vending machines (unless in an adult only facility); and Not allowing the distribution of free samples. U.S. Department of Health and Human Services. U.S. Food & Drug Administration, Center for Tobacco Products, FDA's New Regulations for E- Cigarettes, Cigars, and All Other Tobacco Products, https://www.fda.gov/tobaccoproducts/labeling/rulesregulationsguidance/ucm394909.htm

Hookah: The Facts Hookah use by youth and college students is increasing 2015 High school use 7% (almost = cigarettes use) Hookah typical use (teens and young adults): hour-long session involves 200 puffs, while smoking an average cigarette involves 20 puffs may absorb more of the toxic substances amount of smoke inhaled 90,000 milliliters vs. 500 600 ml Hookah Safety Considerations Cancer Charcoal produces carbon monoxide, metals, and cancer-causing chemicals 1 Hookah tobacco and smoke contain several toxic agents known to cause lung, bladder, and oral cancers 1 Tobacco juices from hookahs irritate the mouth and increase the risk of developing oral cancers 1 Other Health Effects of Hookah Smoke Hookah tobacco and smoke contain many toxic agents that can cause clogged arteries and heart disease 1 Infections may be passed to other smokers by sharing a hookah 2 1. Cobb CO, Ward KD, Maziak W, Shihadeh AL, Eissenberg T. Waterpipe Tobacco Smoking: An Emerging Health Crisis in the United States. American Journal of Health Behavior 2010;34(3):275 85 [accessed 2015 Sep 14]. 2. American Lung Association. Hookah Smoking: A Growing Threat to Public Health Issue Brief.. [PDF 1.34 MB] Smokefree Communities Project, 2011 [accessed 2015 Sep 14]. U.S. Department of Health and Human Services. Preventing Tobacco Use Among Youth and Young Adults: A Report of the Surgeon General. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Office on Smoking and Health, 2012 [accessed 2015 Sep 14]. References References U.S. Health Service Clinical Practice Guideline on Treating Tobacco Use and Dependence: 2008 (DHHS, 2008) and Recommendation Statement (Annals of Internal Medicine, Oct 2015) Centers for Disease Control and Prevention. Best Practices for Comprehensive Tobacco Control Programs 2014. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014. Transtheoretical Model of Change: Stages of Change (Prochaska & Velicer, 1997) Miller, W. R., & Rollnick, S. (2013). Motivational interviewing: Helping people change. New York, NY: Guilford Press. Cahill K, Stevens S, Perera R, Lancaster T. Pharmacological interventions for smoking cessation: an overview and network meta-analysis.cochranedatabase of SystematicReviews 2013, Issue 5. Art. No. :CD009329.DOI: 10.1002/14651858.CD009329.pub2. U.S. Department of Health and Human Services. E-Cigarette Use Among Youth and Young Adults: A Report of the Surgeon General Executive Summary. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2016. Caraballo RS, Shafer PR, Patel D, Davis KC, McAfee TA. Quit Methods Used by US Adult Cigarette Smokers, 2014 2016. Prev Chronic Dis 2017; 14:160600. DOI: https://doi.org/10.5888/pcd14.160600. U.S. Department of Health and Human Services. U.S. Food & Drug Administration, Center for Tobacco Products, FDA's New Regulations for E-Cigarettes, Cigars, and All Other Tobacco Products, https://www.fda.gov/tobaccoproducts/labeling/rulesregulationsguidance/ucm394909.htm U.S. Department of Health and Human Services. Preventing Tobacco Use Among Youth and Young Adults: A Report of the Surgeon General. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Office on Smoking and Health, 2012 [accessed 2015 Sep 14]. Cobb CO, Ward KD, Maziak W, Shihadeh AL, Eissenberg T. Waterpipe Tobacco Smoking: An Emerging Health Crisis in the United States. American Journal of Health Behavior 2010;34(3):275 85 [accessed 2015 Sep 14]. American Lung Association. Hookah Smoking: A Growing Threat to Public Health Issue Brief.. [PDF 1.34 MB] Smokefree Communities Project, 2011 [accessed 2015 Sep 14].

Questions AMY V. LUKOWSKI, PSY.D. CLINICAL DIRECTOR, ASSOCIATE PROFESSOR NATIONAL JEWISH HEALTH LUKOWSKIA@NJHEALTH.ORG

Tobacco Cessation, E-Cigarettes and Hookahs Posttest Questions 1. What can providers do to help patients with smoking cessation? (Choose the best answer from a-d below.) a. Ask every patient about smoking use b. Advise every patient to quit smoking c. Refer patients to an appropriate program d. All of the above 2. The following gives patients the best chance of quitting tobacco: a. Counseling b. Medication c. Counseling and medication d. All of the above 3. The first-line medications approved by the FDA for smoking cessation are: (Choose all that apply) a. Bupropion b. Gum c. Lozenge d. Cytisine e. Varenicline f. Nortriptyline g. Clonidine h. Inhaler i. Patch j. E-Cigarettes k. Nasal Spray 4. We know that the following changes occur in the brain in response to chronic exposure to nicotine: (Choose the best answer from a-d below.) a. Tolerance b. Increased number of brain receptors sensitive to nicotine c. Psychological dependence d. All the above 5. What are the concept(s) needed to assess readiness for any behavior change: a. Importance and Motivation b. Importance and Confidence c. Motivation 6. Electronic Nicotine Delivery Systems (ENDS) are a proven cessation strategy to quit tobacco. a. True b. False