State of the Art and Innovations in Gliomas. 28 th 29 th May 2018

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Section for Neurosurgical Oncology (ANCO) Austrian Neurosurgical Society 2018 State of the Art and Innovations in Gliomas 28 th 29 th May 2018 Jugendstilhörsaal Rektoratsgebäude (BT 88) Level 02 Medical University Vienna Spitalgasse 23, 1090 Vienna Department of Neurosurgery Medical University Vienna

Dear colleagues! I am very delighted to welcome you to the 25 th Neurosurgical Oncology Meeting at the Medical University in Vienna. The main focus of our Meeting will be on State of the Art and Innovations in Gliomas. We invite participants from all disciplines involved and interested in the management of this challenging tumor entity. National and international experts from 8 different countries are expected to join our Meeting (United States, Russia, Sweden, Germany, Netherlands, Switzerland, Czech Republic and Austria). We are very honored that the Chairman of the Department of Neurological Surgery from the University of California, San Francisco, Mitchel S. Berger will be our special guest and will give two key note lectures. Additionally, also young colleagues and scientists will have the possibility to present their work. Our Meeting will provide a great opportunity to update the knowledge as well as discuss innovations, exchange ideas and create new collaborations between young and experienced colleagues of different disciplines. I am looking forward to welcoming you in Vienna for these interesting and exiting two days. Georg Widhalm

Meeting of the Section for Neurosurgical Oncology (ANCO) of the Austrian Neurosurgical Society 2018 Day 1, Monday May 28 th 10:00-10:10 Welcome Georg Widhalm, Medical University Vienna Keynote Lecture Introduction: Engelbert Knosp, Medical University Vienna 10:10-10:40 Value of brain mapping to achieve maximal safe glioma resection Mitchel S. Berger, University of California, San Francisco, US State of the Art Session I Chairs: Asgeir Jakola (Sahlgrenska University Hospital Goteborg, Sweden) Engelbert Knosp (Medical University Vienna) 10:40-11:00 Epidemiology, histopathology and molecular markers in gliomas Adelheid Wöhrer, Medical University Vienna 11:00-11:20 Anatomical considerations in gliomas Peter Winkler, University Clinic Salzburg (angefragt) 11:20-11:40 Management of seizures in glioma patients Ekaterina Pataraia, Medical University Vienna 11:40-12:00 Radiology and advanced imaging methods in gliomas Franz Payer, Medical University Graz 12:00-12:20 Functional imaging in gliomas Gregor Kasprian, Medical University Vienna 12:20-12:40 Positron emission tomography for investigation of gliomas Tatjana Traub-Weidinger, Medical University Vienna 12:40-13:40 Lunch break

Neurosurgical Session Chairs: Philip C. de Witt Hamer (VU University Medical Center, Amsterdam, Netherlands) Georg Widhalm (Medical University Vienna) 13:40-14:00 The impact of extent of resection in glioma surgery Asgeir Jakola, Sahlgrenska University Hospital Goteborg, Sweden 14:00-14:20 Resection probability maps to evaluate glioma surgery Philip C. de Witt Hamer, VU University Medical Center, Amsterdam, Netherlands 14:20-14:40 Glioma surgery assisted by multimodal imaging Engelbert Knosp, Medical University Vienna 14:40-15:00 Intraoperative visualization of gliomas with fluorescence Georg Widhalm, Medical University Vienna 15:00-15:20 Intraoperative MRI for improved resection of gliomas Christian Senft, University Hospital Frankfurt, Germany 15:20-15:40 Coffee break State of the Art Session II Chairs: Karin Dieckmann (Medical University Vienna) Matthias Preusser (Medical University Vienna) 15:40-16:00 Radiotherapy for treatment of gliomas Meinhard Nevinny-Stickel, Medical University Innsbruck 16:00-16:20 Oncological treatment options in gliomas Stefan Oberndorfer, University Clinic St. Pölten 16:20-16:40 Proton Beam therapy as a new treatment option in gliomas Eugen B. Hug, MedAustron Wiener Neustadt 16:40-17:00 Neuropsychology and quality of life in glioma patients Gabriele Schauer-Maurer, Medical University Innsbruck 17:00 Drinks and Networking

Day 2, Tuesday May 29 th Guest lecture at the Medical University Vienna 09:00-10:00 Current concepts in the management of low-grade gliomas Mitchel S. Berger, University of California, San Francisco, US 10:00-10:30 Coffee break Scientific Session I Basic Research in Gliomas Chairs: Sabine Spiegl-Kreinecker (Johannes Kepler University Linz) Walter Berger (Medical University Vienna) 10:30-10:50 Surgery meets lab: translational research on glioma Sabine Spiegl-Kreinecker, Johannes Kepler University Linz 10:50-11:00 Targetable molecular alterations in gliomas Daniela Lötsch, Medical University Vienna 11:00-11:10 Inflammatory microenvironment in gliomas Anna S. Berghoff, Medical University Vienna 11:10-11:20 Immunological learnings from a phase II glioblastoma immunotherapy trial Friedrich Erhart, Medical University Vienna 11:20-11:30 DNA methylation landscapes in recurrent glioblastomas Barbara Kiesel, Medical University Vienna Scientific Session II Preoperative Imaging and Function in Gliomas Chairs: Martha Nowosielski (Medical University Innsbruck) Gregor Kasprian (Medical University Vienna) 11:20-11:40 Innovations in MRI analysis of gliomas Martha Nowosielski, Medical University Innsbruck 11:40-11:50 First experience with phosphor spectroscopy in gliomas Johannes Kerschbaumer, Medical University Innsbruck

11:50-12:00 High resolution mapping of gliomas with 7 Tesla magnetic resonance imaging Gilbert Hangel, Medical University Vienna 12:00-12:10 Transcranial magnetic stimulation (TMS): a powerful tool to localize brain function? Christian Windischberger, Medical University Vienna 12:10-12:20 Non-Invasive and Intraoperative Language Mapping in Glioma Patients: A Comparative Study Using Continuous Theta Burst TMS and DCS Sascha Freigang, Medical University Graz 12:20-12:30 Resting state MRI: Manifold learning to map functional brain architecture across individuals Georg Langs, Medical University Vienna 12:30-12:40 Impact of epileptogenic gliomas on the language network Olivia Fösleitner, Medical University Vienna 12:40-13:40 Lunch break Scientific Session III Improved Visualization of Gliomas Chairs: Sergey Goryayanov (Burdenko Institute Moscow, Russia) Gord von Campe (Medical University Graz) 13:40-14:00 The value of 5-ALA fluorescence in low-grade gliomas Sergey Goryayanov, Burdenko Institute Moscow, Russia 14:00-14:10 Ex-vivo quantitative analysis of 5-ALA fluorescence for detection of histopathological heterogeneity in gliomas Mauricio Martínez-Moreno, Helios Hospital Schwerin, Germany 14:10-14:20 In-vivo quantitative analysis of 5-ALA fluorescence to visualize suspected low-grade gliomas: Collaborative study of UCSF and Dartmouth Jonathan Weller, University Hospital Zürich, Switzerland 14:20-14:30 Intraoperative detection of glioblastoma tissue in initially suspected low-grade gliomas: Experience at MUV and UCSF Arthur Hosmann, Medical University Vienna 14:30-14:40 Semiquantitative analysis of 5-ALA fluorescence levels in glioblastomas Mario Mischkulnig, Medical University Vienna 14:40-14:50 Combined use of 5-ALA fluorescence and intraoperative MRI in glioma surgery Martin Aichholzer, Johannes Kepler University Linz 14:50-15:00 Ultrasound-based Navigation in Glioma Surgery Michael Bartos, University Hospital Hradec Kralove, Czech Republic

15:00-15:10 New techniques for intraoperative tissue diagnosis Stefan Wolfsberger, Medical University Vienna 15:10-15:20 Ultramicroscopy as a new tool for 3D histopathology of tumors Hans-Ulrich Dodt, Vienna University of Technology 15:20-15:40 Coffee break Scientific Session IV Management of Gliomas Chairs: Christian Freyschlag (Medical University Innsbruck) Christine Marosi (Medical University Vienna) 15:40-16:00 The value of tumor treating fields in high-grade gliomas Christian Freyschlag, Medical University Innsbruck 16:00-16:10 Resection probability maps of glioblastoma in surgical decision-making: A focus on MUV Domenique Mueller, VU University Medical Center, Amsterdam, Netherlands 16:10-16:20 Surgery of recurrent glioblastomas: Indications, surgical outcome and histology Florian Scheichel, University Clinic St. Pölten 16:20-16:30 Radiosurgical treatment of recurrent high-grade gliomas Josa Frischer, Medical University Vienna 15:30-16:40 Perioperative challenges in surgery of complex glioma cases Wolfgang Pfisterer, SMZ Ost Vienna 16:40-16:50 NN Stefan Schweiger, Hospital Wr. Neustadt 16:50-17:00 Management of glioma patients in Europe and South Africa: Personal experience from the Tygerberg Hospital Petra A. Mercea, Medical University Vienna 17:00-17:05 Closing remarks Georg Widhalm, Medical University Vienna