NEUROLOGY/2016/790584 Table e-1: Neuropsychological test battery Cognitive domain Test Attention/processing speed Digit symbol-coding 1 Trail making test A 2,3 Memory Logical memory Story A delayed recall 4,5 Rey auditory verbal learning test (RAVLT) 2,6 RAVLT total learning, trials 1 5 RAVLT short-term delayed recall; trial 6 RAVLT short-term delayed recall; trial 7 Benton visual retention test recognition 7,8 Language Boston naming test; 30 items 9,10 Semantic fluency (animals) 2,11 Visuospatial Block design 12,13 Executive function Controlled oral word association test 2,11 Trail making test B 2,3 Note: memory tests were used to assess (single-domain) amnestic MCI, impairment in any one of the other domains would result in (single-domain) nonamnestic MCI. Combinations contribute to amnestic or nonamnestic multiple-domain MCI.
AERTS Supplemental Tables & Figures 2 Table e-2: MCI prevalence at biennial follow-up Wave 1 Wave 2 Wave 3 Wave 4 n % Total n % Total % Subtotal n % Total % Subtotal n % Total % Subtotal No MCI 451 64.0 409 58.0 62.9 386 55.9 70.1 305 46.1 60.0 MCI 254 36.0 241 34.2 37.1 165 23.9 29.9 203 30.7 40.0 amci 77 10.9 82 11.6 12.6 41 5.9 7.4 64 7.0 12.6 nmci 95 13.5 83 11.8 12.8 63 9.1 11.4 78 11.8 15.4 amdmci 61 8.7 55 7.8 8.5 45 6.5 8.2 43 6.5 8.5 nmdmci 21 3.0 21 2.9 3.2 16 2.3 2.9 18 2.7 3.5 Subtotal 705 650 551 508 Dementia N/A a 14 2.0 30 4.3 32 4.5 No data N/A 41 5.8 110 15.6 121 17.2 Total 705 705 691 b 661 c a individuals with dementia were excluded from the study at baseline b 14 dementia cases at wave 2 subtracted from total sample c 44 dementia cases at waves 2 and 3 subtracted from total sample MCI: Mild cognitivie impairment; amci: single-domain amnestic MCI; nmci: single-domain nonamnestic MCI; amdmci: multi-domain amnestic MCI; nmdmci: multi-domain nonamnestic MCI
AERTS Supplemental Tables & Figures 3 Figure e-1: Data overview Classifications of all participants per assessment wave: no MCI (green), single domain MCI (yellow), multidomain MCI (orange), dementia (red), missing or incomplete data (white). Completers only (n=508) 100 200 300 400 500 WAVE 1 2 3 4 Total sample (n=705) 100 200 300 400 500 600 700 WAVE 1 2 3 4
AERTS Supplemental Tables & Figures 4 Table e-3: Participant characteristics per pattern Total Stable No MCI Stable MCI Decliners Reverters Statistics N 705 265 (37.6%) 92 (13.0%) 172 (24.4%) 176 (25.0%) Age, yrs (SD) 78.18 (4.59) 77.00 (4.16) 78.19 (4.75) 79.90 (4.91) 78.28 (4.27) Gender, % male 44.4 38.9 48.9 43.6 51.1 Education 11.64 (3.52) 11.68 (3.40) 11.04 (3.46) 11.65 (3.48) 11.88 (3.75) MMSE, adj 28.63 (1.31) 28.95 (1.09) 28.07 (1.46) 28.51 (1.26) 28.54 (1.45) a Kruskal-Wallis; b Chi-square test statistic H = 37.97 a p < 0.001 χ 2 = 7.32 b p = 0.06 H = 4.23 a p = 0.24 H = 32.74 a p < 0.001
AERTS Supplemental Tables & Figures 5 Table e-4: Diagnosis prior to dementia classification 2 years prior 4 years prior 6 years prior N % (95% CI) N % (95% CI) N % (95% CI) No MCI 11 16.2 (8.4 27.1) 19 32.2 (20.6 45.6) 16 50.0 (31.9 68.1) MCI 57 83.8 (72.9 91.6) 40 67.8 (54.4 79.4) 16 50.0 (31.9 68.1) amci 17 25.0 (15.3 37.0) 18 30.5 (19.2 43.9) 4 12.5 (3.5 29.0) nmci 6 8.8 (3.3 18.2) 4 6.8 (1.9 16.5) 7 21.9 (9.3 40.0) amdmci 30 44.1 (32.1 56.7) 15 25.4 (15.0 38.4) 4 12.5 (3.5 29.0) nmdmci 4 5.9 (1.6 14.4) 3 5.1 (1.1 14.1) 1 3.1 (0.1 16.2) Subsample 68 59 32 No data 8 10.5 17 22.4 44 57.9 Total sample 76 Amnestic MCI 47 69.1 (56.7 79.8) 33 55.9 (42.4 68.8) 8 25.0 (11.5 43.4) Non-amnestic MCI 10 14.7 (7.3 25.4) 7 11.9 (4.9 22.9) 8 25.0 (11.5 43.4)
AERTS Supplemental Tables & Figures 6 Figure e-2: Cumulative incidence of dementia for (A) amnestic and nonamnestic or (B) single and multiple domain subtypes of MCI
AERTS Supplemental Tables & Figures 7 Figure e-3: The effect of reversion from (A) single- or (B) multiple-domain MCI on cumulative incidence of dementia
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