MTHFR & Genetic Basics The Answers You Need to Take Control of Your Health By Dr. Doni Wilson
Genetics + Stress = Health
Footnote
What are Stresses? Major Life Stresses Daily Stresses Food Sensitivities Infections Medications Physical Trauma Lack of Sleep Elevated Blood Sugar Lack of Nutrients Toxins
Genetics + Stress = Health
How to Read a Genetic Report? Letters, numbers and colors. Genes code for enzymes. Genes have 2 strands and 2 possible SNPs. Heterozygous = 1 SNP (yellow) Homozygous = 2 SNPs (red) We all have some SNPs!
What Are SNPs? Genetic variations. Potential traffic jams.
What are Cofactors? Nutrient(s) required for enzyme to function.
What is MTHFR? Gene and enzyme that turns folic acid into folate. Folic acid and folate are often used interchangeably, but they are different. Folate is found in nature. Folic acid is synthetic. MTHFR A1298C MTHFR C677T
Health Risks Associated with MTHFR? Migraines Anxiety and Depression Miscarriages and Neural Tube Defects Insomnia Cervical Dysplasia (abnormal pap smears) Heart Disease Diabetes Cancer Alzheimer s
How much does it affect me?
What is Methylation? B Vitamin Cycle What our B vitamins are up to! Folate and B12 come together with Homocysteine to make SAM (S-adenosyl methionine). Then SAM recycles back around to Homocysteine. Negatively Affected by Stress.
What is SAM? Used in the body to do all sorts of good! Protects our DNA Helps make healthy new cells Makes and breaks down neurotransmitters and helps get rid of histamine (think of allergies).
What is Homocysteine? Recycling SAM. Connects up with Folate and B12. Can also go down the glutathione pathway. Glutathione is a major anti-oxidant in our bodies - a cell protector. Can be measured in blood work.
What can block Methylation? Inflammation Metals Alcohol LPS from gut bacteria Nitric Oxide (uncoupled)
What can I do to address MTHFR? Avoid Folic Acid. Eat foods high in folate. Find out if you need Folate. What is blocking methylation? Do you have enough cofactors? Address YOUR stress!
What can I do to address MTHFR?
What tests do I need to do? Genetic panel Run software Blood test for Homocysteine May also need to test: SAM, sulfur, organic acids, cortisol, neurotransmitters, food sensitivities, metals, toxins, glutathione, stool/gut bacteria, nutrient levels, methylmalonic acid
Methylation Panel
Organic Acids Panel
Urine Sulfur Strips
Cortisol & Neurotransmitter Panel
Food Sensitivity & Stool Panels
Additional Panels Footnote
Will Supplements Help? Which? Yes - Important to Individualize! Vitamin B6, Magnesium Other B vitamins Minerals/Electrolytes Methyl-Folate (5MTHF) Methyl-Cobalamin (B12)
Will Supplements Help? Which?
Dr. Doni s 5-step Approach
Remove Blocks By decreasing stresses in our bodies, we improve methylation.
Stress Leaky Gut + Dysbiosis + Blood Sugar Issues Inflammation Oxidative Stress + Chronic Infection Decreased Methylation
Address Downstream Pathways
Sulfur & Glutathione Nitric Oxide and Histamine Neurotransmitters
Support Cofactors First! Magnesium Minerals/Electrolytes Vitamin B6 Other B vitamins Hydroxo B12 trial Molybdenum (if needed)
Assess Methylation Know your homocysteine level!
Add Methylation Support only IF needed!! 5MTHF + Methyl B12 + B6 (P5P)
Genetics + Stress = Health
Stress Remedy Program
https://doctordoni.com/pdfs/dr-doni- Wilson_MTHFR-and-Genetic-Profiling- Solutions-Package.pdf
MTHFR 5 Step Approach Workshop
Dr. Doni s 5-Step Approach
Workshop Sessions 1. Identify blocks and assess downstream pathways 2. Address blocks and cofactors 3. Assess progress 4. Implement methylation 5. Assess progress 6. Plan for continued success
MTHFR 5 Step Approach Workshop Sign Up Here
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