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R R Breakthrough! BioCoat Featuring SmartCap Technology The only bioactive pit and fissure sealant that provides relentless protection through daily release of fluoride, calcium and phosphate ions.

Bioactive Release - Remin - Recharge Maximize protection with award-winning BioCoat Bioactive Resin Pit and Fissure Sealant. BioCoat with SmartCap Technology 1 maintains the strength and durability you d expect from a heavily filled resin sealant, while providing the benefits of extended fluoride release. BioCoat is the only resin sealant with bioavailable ions SmartCap Technology utilizes patented semi-permeable resin microcapsules filled with ionic solutions of fluoride, calcium and phosphate. The bioactive ions diffuse in and out of the sealant for long term release*. - Fluoride Release Profile from BioCoat ppm/gram 0.25 0.2 0.15 0.1 0.05 0 0 days 7 days 31 days 180 days Even after 6 months, fluoride, calcium and phosphate ion release continues at a significant rate. Greater fluoride uptake for long-term protection Greater fluoride uptake in the presence of calcium and phosphate ions strengthens enamel. Excellent retention helps support remineralization and seal margins against microleakage and provide an extra line of defense during acid attacks. - ug fluoride /g of enamel 200 150 100 50 0 Fluoride Uptake in Enamel After 90 Days Exposure to BioCoat (Modified Method 40) 3 Sealant without SmartCap Technology BioCoat with SmartCap Technology SmartCaps are rechargeable SmartCap microcapsules have the ability to recharge from free ions of fluoride 4, calcium 5 and phosphate 5 found in saliva through concentration gradient dynamics. 1. Bibliography available upon request. / 2. A. Kava et al. Controlled Release of Microencapsulated Remineralizing Agents from Pit-and-Fissure Sealants IADR poster, Boston, 2015 / 3. S. M. Gross et al. Pit and Fissure Sealant with Ion Permeable Microcapsules Promote Fluoride Uptake in Enamel IADR poster, Boston, 2015 / 4. B. Burbank et al. Enhanced Release of Toothpaste Originated Fluoride from Microcapsule-Containing Dental Materials IADR poster, Boston, 2015 / 5. T. Greving et al Two-way permeability of ion permeable microcapsules for remineralization AADR Annual Meeting, March 21-24, Tampa, FL / 6. Testing by Mark A. Latta, D.M.D., M.S., GL Materials LLC / * Charts represent cumulative release data / UltraSeal XT is not a registered trademark of Premier Dental.

Outstanding barrier protection BioCoat is a 56% filled resin sealant providing excellent long-term resistance to wear with a compressive strength comparable to flowable composites. The resin formula is very resistant to oral solubility - a problem glass ionomer and resin-reinforced glass ionomers sealants cannot overcome. Heavily Filled & High Compressive Strength Excellent retention and durable: resists cracking, chipping and fractures Lowers polymerization shrinkage and gap formation Maintains a smooth surface to avoid accumulation of plaque and debris Excellent Flowability Penetrates and adapts into the smallest pits and fissures for a secure seal Highly retentive (Shear bond strength of 32 MPa) Bubble-free application SBS MPa 35 30 25 20 15 10 5 0 Shear Bond Strength (SBS) to Enamel 6 BioCoat UltraSeal XT BioCoat s impressive shear bond strength of 32MPa ensures BioCoat s retention over the years. See what the dental pros say! I ve never been so impressed with a sealant...ever! - Tim Bizga DDS, Cleveland, OH Extrudes smoothly without any bubbles- high gloss finish Ordering Information 3001530 BioCoat Standard Pack Contains: One 1.2ml syringe and five disposable applicator tips Shade: White 3001535 BioCoat Applicator Tips Contains: 100 disposable applicator tips 3001531 BioCoat Value Pack Contains: Four 1.2ml syringes and 20 disposable applicator tips 3001532 BioCoat Bulk Pack Contains: Twenty 1.2ml syringes BioCoat is not formulated with Bisphenol A (BPA). - Shalom Mehler DMD, Teaneck, NJ The potential remineralizing effect of BioCoat assures me that I am applying the most effective sealant on my patients teeth! With its ease of use and bioactivity, BioCoat is the best choice for my patients protective needs! - Malaina, RDH, Hewlett, NY As technologies continue to evolve in all phases in dentistry, we are excited about the long term prospects of BioCoat and its long-term ion release for promoting remineralization of enamel following acid attack. - Lou Graham DDS, Chicago, IL

BioCoat s thixotropic properties allow for thorough penetration and adaptation into even the tiniest pits and fissures. No dye penetration indicates no microleakage. 7 Figure A Dye Penetration Microleakage Study Ions present in saliva and from toothpaste F Ca PO 4 Sealant Area of Remineralization SmartCap Microcapsules Area of Remineralization Figure B Schematic of clinical situation seen in Figure A SmartCap Technology, developed in partnership with Creighton University, utilizes patented** semi-permeable resin microcapsules. In BioCoat, the rechargeable SmartCap microcapsules are filled with ionic solutions of fluoride, calcium and phosphate. Tooth surfaces, both in contact and adjacent to the sealant, benefit from the extended release of these ions. The demineralization cycle is disrupted and the remineralization is supported. The exchange of ions and recharge of microcapsules extends maximum protection without putting the sealant s physical integrity at risk. Visit www.premusa.com/biocoat for more information. **United States Patent Numbers: 9,119,774, 8, 889,161, 8,735,463 7. BioCoat Micrograph taken after Dye Penetration Microleakage Study (21 days at 37 C and then thermocycled for 2000 cycles)

BioCoat is easy to use: 1 Clean teeth thoroughly with a non-fluoridated prophy paste or pumice, then etch for 20 seconds. 2 Rinse and dry the enamel surface. 3 While maintaining a clean, dry field, apply BioCoat sealant then light cure for 20 seconds. 4 BioCoat has a natural appearance but is visually discernible when air dried. Clinical images courtesy of Shalom Mehler DMD, Teaneck, NJ. 2pro Total Access Disposable Prophy Angle Award-winning 2pro is the versatile 2-in-1 disposable prophy angle that helps you easily access hard-to-reach areas of the mouth quickly. One cup. One tip. No extra cost or time to switch. Premier Etch 37% Phosphoric Acid Dentin/ Enamel Etch Gel Premier Etch contains phosphoric acid for etching tooth enamel and dentin when preparing surfaces for the application of composites, adhesives and cements.

Experience the benefits of ACP Technology with these standard-setting solutions Enamel Pro Prophy Paste The ONLY remineralizing prophy paste with ACP technology for 31% more fluoride uptake Enamel Pro Varnish 5% Sodium Fluoride Varnish The first advanced fluoride varnish optimized to provide valuable tooth-building ions of calcium and phosphate Enamelon Preventive Treatment Gel Everyday Relief. Everyday Protection. Treats Sensitivity Soothes & Moisturizes Dry Mouth Tissues For more information on these and additional products, call 610-239-6000. Order through your authorized dealer. premusa.com/promise Premier Dental Products Company 1710 Romano Drive, Plymouth Meeting, PA 19462, USA Phone 888-670-6100 610-239-6000 Fax 610-239-6171 www.premusa.com E-mail: dentalinfo@premusa.com. Data on file. 8610426 0118100 Rev4 NKP15M