TRANSPLANTS The Gift of Life Boris L. Gala-Lopez. MD, MSc, PhD Multi-Organ Transplant Surgeon
Disclosure I, Boris Gala-Lopez declare that in the past 3 years: I have received manufacturer funding from the following companies*: No I have done consulting work for the following companies*: No I have done speaking engagements for the following companies*: None I or my family hold individual shares in the following*: None *pharmaceutical or medical/dental equipment
Trans plant Move or transfer (something) to another place or situation, typically with some effort or upheaval. "his endeavor to transplant people from Russia to the Argentine" synonyms: transfer, move, remove, shift, relocate, take "our headquarters will be transplanted to Pennsylvania" Replant (a plant) in another place. synonyms: replant, repot, relocate "the seedlings should be transplanted in larger pots" Remove (living tissue or an organ) and implant it in another part of the body or in another body. synonyms: transfer, implant "kidneys must be transplanted within 48 hours of removal"
THE HISTORY OF TRANSPLANTS First successful kidney transplant operation in 1954. Credit: Brigham and Women's Hospital, via Associated Press. The New York Times Nov 27, 2012.
THE HISTORY OF TRANSPLANTS 1668 First successful bone transplant 1818 First successful blood transfusion 1881 First skin graft 1900 Discovery of blood group types 1902 Discovery of technique for connecting blood vessels 1905 First successful cornea transplant 1908 First knee transplant www.organtransplants.org
THE HISTORY OF TRANSPLANTS 1954 First successful kidney transplant 1963 First successful lung transplant 1966 First successful pancreas transplant 1967 First successful liver transplant 1967 First successful heart transplant 1968 First organ donor program established 1970s Researchers refine knowledge about tissue typing and immune response 1970s Discovery of new immunosuppression drugs 1973 First successful bone marrow transplant 1988 First successful small bowel transplant 1989 First successful living donor liver transplant 1998 First successful hand transplant 2005 First successful face transplant www.organtransplants.org
Organ and Tissue Donation Rebirth 2017
Types of Donors Brain Dead: (DBD or NDD) Can donate organs and tissue Donation after Cardiac Death: (DCD) Can donate organs and tissue Living Donor: Can donate some organs and tissue
Organ Donation in Canada
March 2016 Canadian organ donations fall short of meeting demand: report
Expanding the Organ Donor Pool Developing new strategies to use suboptimal organs and tissue Advocating for safe living donation with new concepts Increasing translational research to safely implement bioengineered organs and tissue into medical practice
Expanding the Organ Donor Pool Developing new strategies to use suboptimal organs and tissue Advocating for safe living donation with new concepts Increasing translational research to safely implement bioengineered organs and tissue into medical practice
Expanding the Organ Donor Pool Using Suboptimal Organs Courtesy: Dr. J. Shapiro Quick, Cheap, Practical Standard for 40 years Metabolism 12-fold less, but not zero Ischemic - no O2
Expanding the Organ Donor Pool Using Suboptimal Organs
Expanding the Organ Donor Pool Using Suboptimal Organs
The Rise of the Machines LifePort TransMedics OrganOx Metra Ex Vivo Metrics Tevosol
Feb 19 2015
Expanding the Organ Donor Pool Developing new strategies to use suboptimal organs and tissue Advocating for safe living donation with new concepts Increasing translational research to safely implement bioengineered organs and tissue into medical practice
Expanding the Organ Donor Pool Safer Living Donation with New Concepts University of Illinois at Chicago. Department of Surgery
Sasaki et al. Clin Transpl 2010
Expanding the Organ Donor Pool Safer Living Donation with New Concepts Kidney Paired Donation Program University Health Network
Expanding the Organ Donor Pool Safer Living Donation with New Concepts Kidney Paired Donation Program University Health Network
Expanding the Organ Donor Pool Developing new strategies to use suboptimal organs and tissue Advocating for safe living donation with new concepts Increasing translational research to safely implement bioengineered organs and tissue into medical practice
Expanding the Organ Donor Pool Bioengineering Organ and Tissue Should we redesign humans?
Expanding the Organ Donor Pool Bioengineering Organ and Tissue
Expanding the Organ Donor Pool Bioengineering Organ and Tissue Tissue engineering: How to build a heart https://www.nature.com/news/tissue-engineering-how-to-build-aheart-1.13327
Getting under the skin: UAlberta research reveals new possibilities for islet and stem cell transplantation University of Alberta, April 2015 Cure for diabetes could lie in tiny device; Alberta researchers looking for volunteers December 2015
The Future of Transplants
Science Fact!! Simultaneous machine preservation of: Lungs, liver, two kidneys
The New York Times, Oct 2016
Tonic, March 2017
Take-home message Transplantation is a valuable treatment modality for selected patients with organ failure This therapy has truly enforce the concept of multidisciplinary collaboration The implementation of transplants has become one of the most important revolutions in the field of medicine Research and development will be the key players in the future of transplantation
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