Antipsychotics BMF 84 - Antipsychotics Antipsychotic medications (neuroleptics) are used for the treatment of psychosis, mainly schizophrenia and manic depression (bipolar disorder). They reduce symptoms such as hallucinations, delusions, and paranoia, and can also be used to help severe anxiety or depression. Antipsychotic medications have been available for the treatment of psychosis for over half a century. The first being chlorpromazine (Thorazine), introduced in the early 1950 s. The list now extends to over 20 different compounds. Antipsychotics act by blocking dopamine receptors in the brain and interfering with dopaminergic transmission. Side effects include movement disorders similar to Parkinson s disease, such as shaking/tremor, involuntary body movements and inner restlessness. These are referred to as extrapyramidal symptoms, and can be controlled with anticholinergic drugs such as orphenadrine and procyclidine. Other side effects include lethargy, weight gain and sexual dysfunction. Longer term there is increased risk of developing type 2 diabetes, high blood pressure, heart problems and osteoporosis. Antipsychotics are may be classified as typical or atypical, or first and second generation respectively. Typical antipsychotics include; Chlorpromazine, Haloperidol, Pimozide, Trifluoperazine, and Sulpiride. Atypical include; Amisulpride, Aripiprazole, Clozapine, Olanzapine, Quetiapine and Risperidone. Atypical antipsychotics, are useful in patients that do not respond to treatment with typical antipsychotics. They cause less extrapyramidal side effects and have a greater efficacy to treat negative symptoms. Atypical antipsychotics also block dopamine, but to a lesser degree than the older drugs. They also work on serotonin. Some antipsychotics are available in depot form, i.e. Haloperidol decanoate, Flupenthixol decanoate, Fluphenazine decanoate, Pipothiazine palmitate and Zuclopenthixol decanoate. These are injected into muscle every 2 to 4 weeks and release slowly over time. This prevents patients forgetting to take their medication. www.chiron.no E-mail: sales@chiron.no Tel.: +47 73 87 44 90 Fax.: +47 73 73 87 44 99 BMF 84 p.1/6, 11_16
Chiron offer a range of antipsychotic reference materials and associated internal standards; Catalogue No. Description Cas No. Concentration Solvent Volume Aripiprazole (Abilify) 2305.23-100-AN Aripiprazole 129722-12-9 100 µg/ml acetonitrile 1 ml 2305.23-K-AN Aripiprazole 129722-12-9 1000 µg/ml acetonitrile 1 ml 2305.23-10MG Aripiprazole 129722-12-9 neat neat 10 mg 2305.23-25MG Aripiprazole 129722-12-9 neat neat 25 mg 9653.23-100-AN Aripiprazole-d8 (butyl-d8) 1089115-04-7 100 µg/ml acetonitrile 1 ml 11004.23-K-ME Amisulpride (Solian) Dehydroaripiprazole hydrochloride (Aripiprazole Impurity E) 1008531-60-9 1000 µg base/ml methanol 1 ml 10349.17-10MG (+/-)-Amisulpride 71675-85-9 neat neat 10 mg 10349.17-50MG (+/-)-Amisulpride 71675-85-9 neat neat 50 mg 10349.17-100MG (+/-)-Amisulpride 71675-85-9 neat neat 100 mg Chlorpromazine (Largactil) 10350.17-K-ME Chlorpromazine hydrochloride 69-09-0 1000 µg base/ml methanol 1 ml 10350.17-50MG Chlorpromazine hydrochloride 69-09-0 neat neat 50 mg 10350.17-100MG Chlorpromazine hydrochloride 69-09-0 neat neat 100 mg 10841.17-100-ME Clozapine (Clozaril) Chlorpromazine-d6 oxalate (N,N-dimethyl-d6) 1276197-23-9 100 µg/ml methanol 1 ml 9275.18-100-ME Clozapine 5786-21-0 100 µg/ml methanol 1 ml 9275.18-K-ME Clozapine 5786-21-0 1000 µg/ml methanol 1 ml 9275.18-10MG Clozapine 5786-21-0 neat neat 10 mg 9275.18-25MG Clozapine 5786-21-0 neat neat 25 mg 9275.18-100MG Clozapine 5786-21-0 neat neat 100 mg 9406.18-100-ME 9406.18-K-ME 9406.18-10MG 10807.17-K-ME Clozapine-d4 (4-methylpiperazinyl-2,2,6,6-d4) Clozapine-d4 (4-methylpiperazinyl-2,2,6,6-d4) Clozapine-d4 (4-methylpiperazinyl-2,2,6,6-d4) Norclozapine (N-Desmethylclozapine) 204395-52-8 100 µg/ml methanol 1 ml 204395-52-8 1000 µg/ml methanol 1 ml 204395-52-8 neat neat 10 mg 6104-71-8 1000 µg/ml methanol 1 ml 10808.18-100-ME Clozapine N-oxide 34233-69-7 100 µg/ml methanol 1 ml 10808.18-K-ME Clozapine N-oxide 34233-69-7 1000 µg/ml methanol 1 ml Droperidol 11983.22-10MG Droperidol 548-73-2 neat neat 10 mg Flupentixol 10358.23-K-ME 10358.23-10MG Flupentixol dihydrochloride (cis+trans) Flupentixol dihydrochloride (cis+trans) 2413-38-9 1000 µg base/ml methanol 1 ml 2413-38-9 neat neat 10 mg www.chiron.no E-mail: sales@chiron.no Tel.: +47 73 87 44 90 Fax.: +47 73 73 87 44 99 BMF 84 p.2/6, 11_16
Catalogue No. Description Cas No. Concentration Solvent Volume 10712.23-K-ME 10712.23-10MG Fluphenazine cis-(z)-flupentixol dihydrochloride cis-(z)-flupentixol dihydrochloride 51529-01-2 1000 µg base/ml methanol 1 ml 51529-01-2 neat neat 10 mg 11163.22-K-ME Fluphenazine dihydrochloride 146-56-5 1000 µg base/ml methanol 1 ml 11163.22-10MG Fluphenazine dihydrochloride 146-56-5 neat neat 10 mg Fluspirilene 9748.29-10MG Fluspirilene 1841-19-6 neat neat 10 mg Haloperidol (Haldol) 10345.21-K-ME Haloperidol 52-86-8 1000 µg/ml methanol 1 ml 10345.21-50MG Haloperidol 52-86-8 neat neat 50 mg 10359.21-100-ME Haloperidol-d4 (4-chlorophenyl-d4) 1189986-59-1 100 µg/ml methanol 1 ml Olanzapine (Zyprexa) 11807.23-K-ME Levomepromazine maleate 7104-38-3 1000 µg base/ml methanol 1 ml 11807.23-10MG Levomepromazine maleate 7104-38-3 neat neat 10 mg 11807.23-50MG Levomepromazine maleate 7104-38-3 neat neat 50 mg Olanzapine (Zyprexa) 3761.17-100-AN Olanzapine 132539-06-1 100 µg/ml acetonitrile 1 ml 3761.17-K-AN Olanzapine 132539-06-1 1000 µg/ml acetonitrile 1 ml 3761.17-10MG Olanzapine 132539-06-1 neat neat 10 mg 3761.17-25MG Olanzapine 132539-06-1 neat neat 25 mg 3761.17-100MG Olanzapine 132539-06-1 neat neat 100 mg 3761.17-250MG Olanzapine 132539-06-1 neat neat 250 mg 3761.17-1G Olanzapine 132539-06-1 neat neat 1 g 9766.17-10-AN Olanzapine-d3 (N-methyl-d3) 786686-79-1 10 µg/ml acetonitrile 1 ml 3924.23-10-ME Olanzapine 10-N-β-D-glucuronide 186792-80-3 10 µg/ml methanol 1 ml 11913.16-K-AN Perphenazine N-Demethylolanzapine (4 -Desmethylolanzapine, Olanzapine Impurity A) 161696-76-0 1000 µg/ml acetonitrile 1 ml 9749.21-10MG Perphenazine 58-39-9 neat neat 10 mg 9914.21-10MG Prochloroperazine Perphenazine-d4 (phenothiazine-1,3,7,9-d4) 155593-75-2 neat neat 10 mg 10856.20-10MG Prochloroperazine maleate 84-02-6 neat neat 10 mg Promazine 11164.17-K-ME Promazine hydrochloride 53-60-1 1000 µg base/ml methanol 1 ml 11164.17-10MG Promazine hydrochloride 53-60-1 neat neat 10 mg www.chiron.no E-mail: sales@chiron.no Tel.: +47 73 87 44 90 Fax.: +47 73 73 87 44 99 BMF 84 p.3/6, 11_16
Catalogue No. Description Cas No. Concentration Solvent Volume 11989.20-K-ME 11989.20-10MG Quetiapine 2-(1-Hydroxypropyl)promazine (10H-Phenothiazine-2-methanol) 2-(1-Hydroxypropyl)promazine (10H-Phenothiazine-2-methanol) 110080-35-8 1000 µg/ml methanol 1 ml 110080-35-8 neat neat 10 mg 10835.21-K-ME Quetiapine hemifumarate 111974-72-2 1000 µg base/ml methanol 1 ml 10835.21-10MG Quetiapine hemifumarate 111974-72-2 neat neat 10 mg Risperidone 10337.23-K-ME Risperidone 106266-06-2 1000 µg/ml methanol 1 ml 10337.23-10MG Risperidone 106266-06-2 neat neat 10 mg 10337.23-25MG Risperidone 106266-06-2 neat neat 25 mg 10338.23-K-ME 10338.23-10MG 10338.23-25MG Thioridazine (+/-)-9-Hydroxyrisperidone (Paliperidone, Risperidone Impurity C) 9-Hydroxyrisperidone (Paliperidone, Risperidone Impurity C) 9-Hydroxyrisperidone (Paliperidone, Risperidone Impurity C) 144598-75-4 1000 µg/ml methanol 1 ml 144598-75-4 neat neat 10 mg 144598-75-4 neat neat 25 mg 11419.21-K-ME Thioridazine hydrochloride 130-61-0 1000 µg base/ml methanol 1 ml Trifluoperazine 11192.21-K-ME Trifluoperazine dihydrochloride 440-17-5 1000 µg base/ml methanol 1 ml 11192.21-10MG Trifluoperazine dihydrochloride 440-17-5 neat neat 10 mg Triflupromazine 11195.18-K-ME 11195.18-10MG Trimipramine Triflupromazine hydrochloride (Trifluopromazine HCl) Triflupromazine hydrochloride (Trifluopromazine HCl) 1098-60-8 1000 µg base/ml methanol 1 ml 1098-60-8 neat neat 10 mg 9415.24-K-ME Trimipramine maleate 521-78-8 1000 µg/ml methanol 1 ml 9415.24-10MG Trimipramine maleate 521-78-8 neat neat 10 mg 9416.24-100-ME 9416.24-10MG Zuclopenthixol Trimipramine-d3 maleate (N-methyl-d3) Trimipramine-d3 maleate (N-methyl-d3) 1185245-93-5 100 µg/ml methanol 1 ml 1185245-93-5 neat neat 10 mg 10284.22-10MG Zuclopenthixol (cis+trans) 982-24-1 neat neat 10 mg 10285.24-10MG Zuclopenthixol acetate (cis+trans) 85721-05-7 neat neat 10 mg 10713.26-1MG cis-(z)-zuclopenthixol succinate 53772-83-1 (free base) neat neat 1 mg 10383.22-1MG cis-(z)-zuclopenthixol-d4 succinate (N-hydroxyethyl-d4) 1246833-97-5 (as trans-isomer) neat neat 1 mg www.chiron.no E-mail: sales@chiron.no Tel.: +47 73 87 44 90 Fax.: +47 73 73 87 44 99 BMF 84 p.4/6, 11_16
Catalogue No. Description Cas No. Concentration Component part Antipsychotic & Antidepressant Mix 7 Compounds at 25 μmol/l (0.025 μmol/ml) (freebase) 10345.21 Haloperidol [52-86-8] 25 µmol/l 3761.17 Olanzapine [132539-06-1] 25µmol/L 11913.16 N-Desmethylolanzapine [161696-76-0] 25 µmol/l 10337.23 Risperidone [106266-06-2] 25 µmol/l 10338.23 9-Hydroxyrisperidone [144598-75-4] 25 µmol/l 9288.17 Mirtazapine [85650-52-8] 25 µmol/l 11189.16 Desmethylmirtazapine hydrochloride [61337-68-6] 25 µmol/l S-4932-0.025uM-ME S-4932-0.025uM-MEx5 1 x 1 ml ampoule 5 x 1 ml ampoules! Chiron AS is an authorised distributor of ACQ Science. Please contact us for information on ACQ Science antipsychotic (Neuroleptic) accuracy controls in serum. www.chiron.no E-mail: sales@chiron.no Tel.: +47 73 87 44 90 Fax.: +47 73 73 87 44 99 BMF 84 p.5/6, 11_16
For ordering and information about prices and delivery in your country, please contact your local distributor: www.chiron.no E-mail: sales@chiron.no Tel.: +47 73 87 44 90 Fax.: +47 73 73 87 44 99 BMF 84 p.6/6, 11_16