The Challenge of Accelerating Medical Solutions Through Philanthropy Steve Case, Case Foundation Mike Milken, FasterCures
U.S. BABY BOOMERS Sources: MetLife Mature Market Institute Analysis U.S. Census Bureau
Berkeley 1964
Who are the Baby Boomers?
Who are the Baby Boomers? 78 million Americans 27.5% of U.S.
Who are the Baby Boomers? $1.1 trillion in spending power
Who are the Baby Boomers? 28.5% have college degrees
Who are the Baby Boomers? 69% own their homes
Number of U.S. Non-Profit Organizations (millions) 1.5 1.4 1.3 1.2 1.1 1 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004
Growth of U.S. Non-Profit Organizations 1.5 1.4 1.3 1.2 1.1 (millions) 1 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004
Charitable Giving 2003 Total Size: $240.72 Billion Public-Society Benefit 5% International Environment Affairs & Animals 2% 3% Foundations 9% Religion 36% Arts, Culture & Humanities 5% Unallocated Giving 10% Human Services 8% Health 9% Education 13%
Charitable Giving 2003 By Type of Receipt Organization Total Size: $240.72 Billion Public-Society Benefit $12.13 5% Arts, Culture, Humanities $13.11 5% Environment & Animals $6.95 3% Int l Affairs $5.3 2% Foundations $21.44 9% Religion $86.39 36% Unallocated Giving $24.03 10% Human Services $18.89 8% Health $20.89 9% Education $31.59 13%
Charitable Giving 2003 Total Size: $240.72 Billion Bequests 9% Foundations 11% Corporations 6% Individuals 74%
Large Philanthropic Grants (Number of grants for $10 million or more) 86 62 8 1991 1996 2000 Source: Foundation Center
Worldwide Life Expectancy Growth +35 +17 +18 66 Years 26 Years +5 31 Years 49 Years 1820 1900 1950 2004 United Nations Development Program
Between 1900 and 2000, life expectancy in the U.S. increased 54%, from 50 to 77 years. Sources: Centers for Disease Control
Healthcare Percent of U.S. GDP 18% 17.7% by 2012 16% 12% 8% 4% 1960 1970 1980 1990 2000 Source: U.S. Department of Health and Human Services 2012
Lifestyle Makes a Difference 15% = health care spending $1.7 trillion U.S. Economy $11 trillion
Lifestyle Makes a Difference 70% of health-care spending $1 trillion is spent on lifestyle-related diseases. U.S. Economy $11 trillion
Obese U.S. Children Ages 6 to 11 9M 6M 3M 1970s Today Source: Institute of Medicine
Obese U.S. Children Ages 6 to 11 As a result, there has been a ten-fold increase in type-2 diabetes in children in just 10 years. This could produce the first decline in average lifespans in 200 years! Source: Institute of Medicine
Only in America
Obesity is a factor in 16% of U.S. cancer deaths. That s 90,000 deaths each year. Source: American Cancer Society
Lifetime Risks of Cancer in the U.S. Women: 1 in 3
Lifetime Risks of Cancer in the U.S. Men: 1 in 2
New Cancer Cases U.S. Men 2004 Colorectal 11% Urinary 6% Lung 13% Non-Hodgkins lymphoma 4% Other 32.8% Prostate 33%
Lifetime Risks of Prostate Cancer in the U.S. Men: 1 in 6
Heart Diseases Deaths vs. Cancer Deaths Heart Disease Cancer 1950 1960 1970 1980 1990 2002 Source: FORTUNE magazine / March 2004
Cancer Death Rates Death per 100,000, age adjusted 60 Lung 40 Prostate 20 Colon Breast 00 1975 1980 1985 1990 1995 2001 Source: FORTUNE / NCI, SEER Database
Leveraging Philanthropic Investment Total spent on prostate cancer research $25 million <$500 million 1993 2005
The March
The March
Andrew Von Eschenbach 1993 PCF Awardee Current Director, NCI I'll never forget that evening back in 1993. Walking up the Capitol steps and seeing that beautiful light on the dome and the gleaming white marble, I was awestruck. I couldn't believe that this kid from South Philly was walking into the Capitol of the United States of America and actually going to have dinner there. I only wish that my Dad, who died from prostate cancer, could have been there with me. But in a way he was.
PCF Therapy Consortium
Prostate Cancer Foundation Therapy Consortium Cedars-Sinai Prostate Cancer Center Dana-Farber Cancer Institute Johns Hopkins University Medical Institutions M.D. Anderson Cancer Center Memorial Sloan-Kettering Cancer Center University of California, San Francisco University of Michigan Comp. Cancer Center University of Wisconsin Medical School
PCF Therapy Consortium
2004 Nobel Prize in Chemistry Aaron Ciechanover The Technion, Haifa, Israel
Economic Value of Eliminating Deaths $50T $48.4T $46.5T $57T 40 30 20 10 H E A R T D I S E A S E C A N C E R $7.6T $7.5T 2 0 0 4 U.S. B A L A N C E S H E E T STROKE AIDS Source: Kevin M. Murphy and Robert H. Topel/University of Chicago
Value of Life by Age in 1990 US$ Millions 7 6 5 4 3 2 1 Males Females 0 0-13 14-26 27-39 40-52 53-65 Age 66-78 79-91 92-104 105+ Source: Kevin M. Murphy and Robert H. Topel/University of Chicago
The 21 st Century will see a worldwide competition for human capital.
Comparing Orders of Magnitude Shrek $450M 1
Comparing Orders of Magnitude Shrek $450M 1 DJ/NYT/Wash Post average $5B 10 Yahoo + Google average $53B 100 Cure of cancer $47T 100,000 U.S. human capital $900T 2,000,000 World human capital $3,600T 8,000,000
Genentech 2005 Stock Price 70 65 60 55 50 45 40 Avastin approved for lung cancer Avastin effective for breast cancer 3/15 3/16 4/14 4/15 $45.9 B Market Cap $72.5 B
Can we accelerate medical solutions?
An organization dedicated to shortening the time to find cures and better treatments for the most deadly and debilitating diseases.
In theory, 300 mph
In practice, same speed as 100 years ago.
19 th /20 th -Century Tracks 19 th /20 th -Century Thinking
Revolution Occurring in Medicine Reactive Predictive Preventive
Estimated Cost of Sequencing a Gene 1974 >$100,000,000 1998 $150 2002 $9 2005 $4 2013 $0.03 (That s faster than Moore s Law.) Source: Dr. David Agus-Cedars-Sinai; Dr. Leroy Hood, Institute for Systems Biology
Financial Data Were Accessible
Medical Data Research Genomics Clinical Trials
One Person Cannot Do It
Two People Cannot Do It
Two People Cannot Do It It Takes Teamwork
Lance Armstrong José Azevedo Michael Barry Manuel Beltran Fumiyuki Beppu Volodymyr Bileka Janez Brajkovic Michael Creed Antonio Cruz Tom Danielson Stign Devolder Viatcheslav Ekimov Roger Hammond Ryder Hesjedal George Hincapie Benoît Joachim Jason McCartney Patrick McCarty Gennady Mikhailov Benjamin Noval Yaroslav Popovych Hayden Roulston José Luis Rubiera Paolo Savoldelli Jurgen Van den Broeck Max Van Heeswijk