ZIVAK TECHNOLOGIES Multitasker-LC Walk Away UHPLC Analyzer For LC-MS/MS
Clinical Diagnostic Market Roche, Siemens,Midray Abbott, Beckman Currrent Clinical Diagnostic Market Immunoassay, ELISA, RIA,FIA Sciex, Agilent, Thermo Shimadzu, Waters.. Clinical Diagnosis with LC-MS/MS and HPLC Gold Standart Methods WHY?
2. False positive samples, when the results of the reference assay (LC-MS/MS-total-D) were less than 40 nmol/l but one or more of the immunoassays gave greater than or equal to 40 nmol/l. State-of-the-Art Vitamin D Assays: A Comparison of Automated Immunoassays with Liquid Chromatography Tandem Mass Spectrometry Methods Christopher-John L. Farrell,1,2 Steven Martin,1 Brett McWhinney,3 Isabella Straub,4 Paul Williams,5 and Markus Herrmann1,4* Clinical Chemistry 58:3 531 542 (2012)
NIST USA Traceability Report for Different Technics for Vit D2-D3 (Zivak 243A and 243B)
Limitations of HPLC and LC-MS/MS For Routine Clinical Use Roche, Siemens,Midray Abbott, Beckman Currrent Clinical Diagnostic Market Immunoassay, ELISA, RIA,FIA %95-97 FUTURE Ready to Use Analysis Kits Automation and Barcode Reading Walk-away HPLC and LC-MS/MS Analysers Sciex, Agilent, Thermo Shimadzu, Waters.. Clinical Diagnosis with LC-MS/MS and HPLC Gold Standart Methods %3-5
LC-MS/MS vs Immunoassay Advantages Disadvantages MS/MS methods High Specificity High Sensitivity Lower Kit Costs Multiplexing Measurements High Throughput Non-Automated Qualified staff required The need of rigorous kit validation Automated Barcode Reading Direct injection from Vacu tube Higher maintenance cost (20 K USD / year) Higher owner capital cost (200 K USD / device) Immunoassay Automated No need for qualified staff Validated kits Affordable prices Better traceability (barcode readers, Online LIS connection) Low Specificity Low Sensitivity Higher Kit Costs High Potential for interference
LC-MS/MS vs Immunoassay Advantages Disadvantages Zivak Multitasker Automated LC-MS/MS System High Specificity High Sensitivity Lower Kit Costs Multiplexing Measurements High Throughput Non-Automated Qualified staff required The need of rigorous kit validation Automated Barcode Reading Direct injection from Vacutube Online LIS connection Higher maintenance cost (20 K USD / year) Higher owner capital cost (200 K USD / device) Immunoassay Automated No need for qualified staff Validated kits Affordable prices Better traceability (barcode readers, Online LIS connection) Low Specificity Low Sensitivity Higher Kit Costs High Potential for interference
Turn Your LC-MS/MS Instrument into Walk Away Clinical Analyzer Roche, Siemens, Midray Abbott, Beckman Currrent Clinical Diagnostic Market Immunoassay, ELISA, RIA,FIA Sciex, Agilent, Thermo Shimadzu, Waters.. Clinical Diagnosis with LC-MS/MS and HPLC Gold Standart Methods
Zivak Multitasker-LC OUR VISION Each LC-MS/MS will need an automated sample prep LC Zivak Multitasker Full Automated Sample Preparation and Injection System
Multitasker - LC with TandemGold MS Turkey
Multitasker - LC with Shimadzu 8040 MS India
Multitasker LC with Sciex 4500 MS Italy
Multitasker - LC with Thermo TSQ MS South Korea
HB-100 New Design 2017 The New HBA1c Analyser 1,5 min analysis time for HbA1c and HbF 6,0 min analysis time for A1c, F, A0, A2, S, C, D, E Variants Real walk-away system with unique modules
Zivak NEW VD-200 D2-D3 Analyser UHPLC System World s only Walk-Away 25-OH Vitamin D2-D3 UHPLC-UV System April-2016
HPLC and LC/MS/MS Kits 16
Kit Test Times (sample prep. + run time) Psychoactive Drugs Urine LC-MS/MS Analysis Kit Amino Acid Biological Fluids LC-MS/MS Analysis Kit PKU Serum LC-MS/MS Analysis Kit PKU Dried Blood Spots LC-MS/MS Analysis Kit Organic Acid Urine LC-MS/MS Analysis Kit Neonatal Screening Dried Blood Spots LC-MS/MS Analysis Kit Immunosuppressant Whole Blood LC-MS/MS Analysis Kit VMA HVA 5-HIAA Urine LC-MS/MS Analysis Kit Catecholamines Urine LC-MS/MS Analysis Kit Metanephrine Urine LC-MS/MS Analysis Kit Neurotransmitters in Urine LC-MS/MS Analysis Kit 25-Hydroxyvitamin D2-D3 Serum LC-MS/MS APCIAnalysis Kit Total Homocysteine Serum LC-MS/-MS Analysis Kit Hemoglobin A1c Whole Blood HPLC Analysis Kit Hemoglobin Variant Whole Blood HPLC Analysis Kit PKU Serum HPLC Analysis Kit PKU Dried Blood Spots HPLC Analysis Kit 25-Hydroxyvitamin D2-D3 Serum HPLC Analysis Kit Vitamin A-E Serum HPLC Analysis Kit 25-Hydroxyvitamin D2-D3 Serum VD-200 UHPLC Analysis Kit 7 min 20 min 2 min 2 min 20 min 1.5 min 2 min 15 min 16 min 13 min 13 min 2 min 2.5 min 1.5 min 6.5 min 2 min 2 min 6 min 8 min 3 min
Matrix /IS Labeled Standarts,Controls and Calibrators. 18
Clinical HPLC Analysis Kits HbA1C in Whole Blood Hb Variant and ß-Thalassemia 25-OH Vitamin D2/D3 in Serum Phe, Tyr and Trp in Serum & Plasma and DBS