University of Groningen Complications after liver transplantation Verdonk, Robert Christiaan IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2007 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Verdonk, R. C. (2007). Complications after liver transplantation: a focus on bowel and bile ducts s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 18-06-2018
Complications after liver transplantation: A focus on bowel and bile ducts
The cover shows an artist impression of a bronze mirror displayed in the Museo Gregoriano Etrusco (Vatican City). The mythological figure is Calchas (Κάλχας). Calchas was a priest of Apollo according to the ancient Greek history. He is mentioned in Homer s Iliad. Calchas was famous for his ability to predict the future by reading a sheep s liver. The liver was studied and size, form, different parts such as the right and left lobe, gallbladder and ligaments were systematically judged. In this way a prediction could be made about the things that were about to happen. This practise was known as hepatoscopy. ISBN 90-367-2891-6 Copyright Robert Verdonk, 2007 All rights reserved. No part of this publication may be reproduced, or transmitted in any form or by any means, without permission of the author. Layout+cover: Helga de Graaf, Studio Eye Candy te Groningen. (www.proefschrift.info) Printed by: Ipskamp PrintPartners Enschede, The Netherlands.
RIJKSUNIVERSITEIT GRONINGEN Complications after liver transplantation: A focus on bowel and bile ducts Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op woensdag 7 februari 2007 om 16.15 uur door Robert Christiaan Verdonk geboren op 25 juli 1979 te Apeldoorn
Promotor: Copromotores: Beoordelingscommissie: Prof. dr. J.H. Kleibeuker dr. E.B. Haagsma dr. G. Dijkstra dr. R.J. Porte Prof. dr. J.P.H. Drenth Prof.dr. P.L.M. Jansen Prof.dr. O.T. Terpstra
Paranimfen: drs. M.H.J. Maathuis dr. B.A.S. Knobben The financial support of the following institutions and companies in the publication of this thesis is highly appreciated: Rijksuniversiteit Groningen, Nederlandse Vereniging voor Hepatologie, Roche Nederland BV, Astellas Pharma BV, Novartis Pharma BV, AstraZeneca BV, Janssen-Cilag BV, Tramedico BV, Schering- Plough BV, Zambon Nederland BV.
CONTENTS Chapter 1 Chapter 2 Chapter 3 General introduction and outline of the thesis Part One: Bile ducts Biliary complications after liver transplantation Biliary complications after liver transplantation: a review Scandinavian Journal of Gastroenterology 2006;41 (suppl) 243: 89-101 Anastomotic biliary strictures after liver transplantation: Causes and consequences Liver Transplantation 2006;12 : 726-735 9 17 39 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9 Chapter 10 Non-anastomotic biliary strictures after liver transplantation: Radiological features and risk factors for early versus late presentation Submitted Non-anastomotic biliary strictures after liver transplantation: Management, outcome, and risk factors for disease progression Submitted Part Two: Bowel Inflammatory bowel disease after liver transplantation Inflammatory bowel disease after liver transplantation: A role for cytomegalovirus infection. Scandinavian Journal of Gastroenterology 2006;41: 205-211 Inflammatory bowel disease after liver transplantation: Risk factors for recurrence and de novo disease. American Journal of Transplantation 2006;6: 1422-1439 Effects of different immunosuppressive regimens on regulatory T-cells in the noninflamed colon of liver transplant recipients. Inflammatory Bowel Diseases (accepted) Summary and future perspectives Samenvatting en toekomstperspectieven Curriculum Vitae Dankwoord 59 79 95 109 125 141 149 161 163