WHITE PAPERS PRESENTATION VIDEO DOCUMENTATION EXPERIMENT ARTICLES OUR STUDY BLEEDING CONTROL 5 POINT MODEL WO NDCLOT The WoundClot Principals for Effective Bleeding Control PRESENTATION Harnessing SCIENCE for CARE
the coagulation mechanism
the coagulation mechanism VASOCONSTRICTION
the coagulation mechanism PLATELETS ADHERE TO EXPOSED COLLAGEN
the coagulation mechanism S = SEROTONIN A = ADP T = THROMBOXANE A2
the coagulation mechanism PLATELET PLUG
the coagulation mechanism TISSUE DAMAGE EXTRINSIC MECHANISM FACTOR III SURFACE CONTACT INTRINSIC MECHANISM FACTOR XII ca 2+ FACTOR VII FACTOR XI FACTOR X
the coagulation mechanism FACTOR X PROTHROMBIN ACTIVATOR FACTOR III FACTOR V CA 2+ PF3 Platelet Thromboplastic Factor
the coagulation mechanism PROTHROMBIN ACTIVATOR PROTHROMBIN THROMBIN FIBRINOGEN FIBRIN
the coagulation mechanism CROSS LINKED FIBRIN CLOT
THE WOUNDCLOT PRINCIPAL FOR EFFECTIVE BLEEDING CONTROL: 1. Membrane behavior (Gel) 2. Adhesion 3. Encouraging coagulation 4. Wound managment
Membrane behavior (Gel): Membrane behavior (Gel) > Coagulation is a complex process which varies significantly in time and quality in connection to the type of wound, the blood vessel effected and many other biological and physiological aspects. > As much is unknown, the membrane over the wound has to be able to create a critical mass of gel matter, that would hold the variants of blood pressure erupting, the time to self coagulation and movements of the patient.
For that it needs to: Membrane behavior (Gel) Transform into a complete gel form, slow dissolving to allow mass of gel to form around the broken vessel. Maintain formation and integrity for as much as several hours even in severe arterial pressure. + the gel is designed to maintain its integrity through polymeric chains, interacting with water molecules to form a physical cross linked network, which is manageable and natural. Be flexible enough to form around different types of cavities and stay in tact while moving the patient.
Membrane Integrity & Stability: Membrane behavior (Gel)
How works: Membrane behavior (Gel)
Membrane behavior (Gel)
Membrane behavior (Gel)
Membrane behavior (Gel)
Membrane behavior (Gel) SPECIFIC FUNCTIONAL MOLECULAR GROUPS PROMOTE COAGULATION INTRINSIC SURFACE CONTACT XII XIIa XI XIa IX IXa TF:VIIa TISSUE DAMAGE EXTRINSIC (VIII, PL, CA ++ ) X Xa X (V, PL, CA ++ ) XIII COMMON Prothrombin Thrombin (serine protease) XIIIa Fibrinogen Fibrin STABLE FIBRIN CLOT
Membrane behavior (Gel) CROSS LINKED FIBRIN CLOT
Effectiveness of Membrane & Coagulation Factor Activation Membrane behavior (Gel) The gel holds its formation for up to 90 minutes even when it is soaked in blood. coagulation promotion 3.5 3 2.5 2 1.5 Group 1 Woundclot Trauma Woundclot Product A Group 2 Product B Product C Product D Group 3 1 Product E Product F 0.5 0 10 20 30 40 50 60 70 80 90 100 min Product G membrane integrity
Membrane behavior (Gel) GROUP 1 GROUP 2 GROUP 3
Membrane behavior (Gel)
THE WOUNDCLOT PRINCIPAL FOR EFFECTIVE BLEEDING CONTROL: 1. Membrane behavior (Gel) 2. Adhesion 3. Encouraging coagulation 4. Wound managment
Adhesion: Adhesion The ability to adhere around a wound is important in many aspects: > It allows movement of the patient without compromising the integrity of the membrane. > It reduces the amount of pressure needed to keep the membrane in place, thus reducing the risk of collateral damage due to violent pressure applied. > After bleeding stops, it will help prevent infection and further tissue damage in the wound.
Adhesion
THE WOUNDCLOT PRINCIPAL FOR EFFECTIVE BLEEDING CONTROL: 1. Membrane behavior (Gel) 2. Adhesion 3. Encouraging coagulation 4. Wound managment
Encouraging coagulation Encouraging Coagulation: Coagulation is a complex chain reaction, where different elements are motivated into action, conditioned from other reactions. The ability to influence these reactions speeds the whole coagulation process. > by trapping blood in the thick stable gel membrane, a critical mass of platelets form quicker to start the natural coagulation process.
Encouraging coagulation > WoundClot influences both factor 12 and factor 3 to react, therefore again speeding the whole coagulation process. natural coagulation is accelerated by a specific molecular functional groups created in the manufacturing process.
Encouraging coagulation GROUP 1 GROUP 2 GROUP 3
THE WOUNDCLOT PRINCIPAL FOR EFFECTIVE BLEEDING CONTROL: 1. Membrane behavior (Gel) 2. Adhesion 3. Encouraging coagulation 4. Wound managment
Wound managment We believe there are several principals in good wound management: > Stop the bleeding fast Natural physical pressure caused by adhesion to the wound with coagulation promotion. > Minimal pressure needed in application avoiding further damage due to treatmen. > Keep the wound clean from debris and infection a mechanical membrane is created which sticks and hardens, preventing most debris to stick to the wound.
Wound managment > Do not disrupt higher-level medical treatment easily removed as a whole by rinsing with water or saline. > Easy and painless removal Does not stick to the wound and breaks down with water.