Frontiers in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

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Frontiers in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Course Chair: Anjay Rastogi, MD, PhD Course Co-Chair: Vicente Torres, MD, PhD * Saturday, July 28, 2018 Ronald Reagan UCLA Medical Center Tamkin Auditorium 757 Westwood Plaza Los Angeles, CA 90095

Frontiers in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Course Description ADPKD is the most common inherited cause of kidney disease and the third most common cause of end-stage renal disease (ESRD). Even though it is thought to be primarily a kidney disease, it is truly a systemic disease with significant extra-renal involvement, especially in the liver and intracranial blood vessels. Being an autosomal dominant genetic disease, it impacts families and tends to have significant impact on morbidity, mortality and financial burden that does not only affect the family, but society as well. Because it is a multi-faceted disease, it takes an interdisciplinary team approach to provide the best comprehensive care to the patient and his/her family members. There have been significant advances in our understanding of the pathophysiology of ADPKD and its management. This highly interactive, participatory conference provides clinicians and health care providers with a better understanding and update of the disease state and equips them with the best evidence-based clinical practices. The emphasis will be on practical application of evidencebased medicine and physiological principles to every day clinical care. Course Objectives After completion of this course, the participants should be better able to: Diagnose ADPKD and perform genetic testing when needed Understand the pathogenesis of ADPKD Assess and manage renal complications of ADPKD Assess and manage extra-renal complications of ADPKD Provide comprehensive management of ADPKD Recognize and describe ongoing clinical trials and recent advancements in ADPKD Target Audience Nephrologists, geneticists, pediatricians, hepatologists, neurosurgeons, radiologists, transplant specialists, dialysis specialists, obstetricians, pain management providers, surgeons, interventional radiologists, internists, primary care providers, family physicians, nurse practitioners, physician assistants, trainees, researchers, and other healthcare affiliates involved with ADPKD. General Information SATURDAY, JULY 28, 2018 Course Fees Physicians: $175 Pharmacists: $150 Nurse Practitioners and Physician Assistants: $150 Allied Health Professionals: $100 Trainees: $50 Location Ronald Reagan UCLA Medical Center Tamkin Auditorium 757 Westwood Plaza Los Angeles, CA 90095 * Used with permission of Mayo Foundation for Medical Education and Research, all rights reserved. Accreditation Statement The Office of Continuing Medical Education, David Geffen School of Medicine at UCLA is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Office of Continuing Medical Education, David Geffen School of Medicine at UCLA, designates this live activity for a maximum of 7 AMA PRA Category 1 Credits TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Disclosure Statement The FDA has issued a concept paper that classifies commercial support of scientific and educational programs as promotional unless it can be affirmed that the program is truly independent and free of commercial influence. In addition to independence, the FDA requires that non-promotional, commercially supported education be objective, balanced and scientifically rigorous. The policy further states that all potential conflicts of interest of the CME staff and faculty be fully disclosed to the program s participants. In addition, Accreditation Council for Continuing Medical Education policy mandates that the provider adequately manage all identified potential conflicts of interest prior to the program. UCLA fully endorses the letter and spirit of these concepts.

PROGRAM SCHEDULE 7:00 Registration & Breakfast SESSION I 8:00 Welcome & Introduction Anjay Rastogi, MD, PhD 8:10 Genetics of ADPKD Peter Harris, PhD 8:50 Diagnostic Imaging & Total Kidney Volume in ADPKD Arlene Chapman, MD 9:20 Pregnancy in ADPKD Niloofar Nobakht, MD 9:30 Panel Discussion Moderator: Anjay Rastogi, MD, PhD 10:00 Break SESSION II 10:15 Renal Involvement in ADPKD Theodore Steinman, MD 10:55 Extra-Renal Manifestations of ADPKD: Polycystic Liver Disease Marie Hogan, MD, PhD 11:30 Brain Aneurysms Geoffrey P. Colby, MD, PhD 11:45 Panel Discussion Moderator: Anjay Rastogi, MD, PhD 12:15 Lunch SESSION III 1:00 Management of ADPKD: Blood Pressure Control, Life Style Modifications & More Arlene Chapman, MD 1:30 TEMPO, REPRISE & Beyond Vicente Torres, MD, PhD 2:30 Panel Discussion Moderator: Anjay Rastogi, MD, PhD 3:00 Break SESSION IV 3:15 Alport Syndrome, Fabry s Disease Anjay Rastogi, MD, PhD 3:30 Future: Clinical Research Farid Arman, MD 3:45 Challenges in PKD Care Mohammad Kamgar, MD 4:00 Panel Discussion Moderator: Anjay Rastogi, MD, PhD 4:30 PKD: A Family Perspective 4:45 Closing Remarks, Center of Excellence Anjay Rastogi, MD, PhD 5:00 Adjourn

COURSE CHAIR Anjay Rastogi, MD, PhD COURSE CO-CHAIR Vicente Torres, MD, PhD Mayo Clinic, Rochester FACULTY Arlene Chapman, MD University of Chicago, Medicine Peter Harris, PhD Mayo Clinic, Rochester Marie Hogan, MD, PhD Mayo Clinic, Rochester Theodore Steinman, MD Clinical Harvard Medical School UCLA FACULTY Farid Arman, MD Post-Doctoral Fellow of Medicine/Nephrology Geoffrey P. Colby, MD, PhD Associate Professor of Neurosurgery and Radiology Mohammad Kamgar, MD Assistant Niloofar Nobakht, MD Assistant Early registration is recommended, as space is limited. Directions: From the 405 freeway, exit Wilshire Blvd., East toward Westwood. Turn left on Westwood Blvd., travel past Charles E. Young Dr. South and turn left on Structure 8 driveway. Drive up the ramp to the rooftop level to park. The Ronald Reagan UCLA Medical Center is located on the corner of Westwood Plaza and Charles E. Young Dr. South. Parking: Please park in Structure 8 on the rooftop level. A parking attendant will be on duty from 6:30-8:30 AM. If you arrive outside of this time frame, please visit the parking kiosk on Westwood Plaza to pay for your parking permit. Participants are responsible for their own parking charges at a rate of $12 per vehicle. Refunds: Cancellations must be received in writing by Thursday, June 28, 2018 and will be subject to a $50 processing fee. No refunds will be granted after that date. If, for any reason, the course must be cancelled, discontinued, or rescheduled by the UCLA Office of Continuing Medical Education, a full refund will be provided. Enrollment: Online: Go to www.cme.ucla.edu/courses and click on Frontiers in Autosomal Dominant Polycystic Kidney Disease (ADPKD). You may use your Master- Card, Visa, Discover, or American Express card to register. By Mail: Use the form attached. Mail to the UCLA Office of Continuing Medical Education, David Geffen School of Medicine at UCLA, Autosomal Dominant Polycystic Kidney Disease (ADPKD), 10920 Wilshire Blvd., Suite 1060, Los Angeles, CA 90024-6512 By Fax: Send the completed enrollment form with credit card information and authorizing signature to (310) 794-2624. By Phone: Call (310) 794-2620 to use your MasterCard, Visa, Discover, or American Express card. Please visit our website for other UCLA CME offerings at www.cme.ucla.edu.

Application for Enrollment (Please Print) Course Title and Number Summer 2018 Registration Fee Frontiers in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Physicians: $175 Pharmacists: $150 Nurse Practitioners and Physician Assistants: $150 Allied Health Professionals: $100 Trainees: $50 M189-14 Last four digits of your Social Security Number Name (First/Middle/Last) Male Female Degree Preferred Mailing Address City / State / Zip ( ) ( ) Area Code Phone Area Code Fax E-Mail Address Check enclosed payable to: The Regents of the University of California Charge: MasterCard Visa Discover American Express Card Number Expiration Mo/Yr Authorizing Signature Mail to: UCLA Office of Continuing Medical Education, David Geffen School of Medicine at UCLA, Frontiers in ADPKD, 10920 Wilshire Blvd., Suite 1060, Los Angeles, CA 90024-6512 Fax to: (310) 794-2624 (must include charge card information and authorizing signature) Call: (310) 794-2620 Register online: www.cme.ucla.edu/courses (click on Frontiers in Autosomal Dominant Polycystic Kidney Disease (ADPKD))

UCLA Office of Continuing Medical Education David Geffen School of Medicine at UCLA 405 Hilgard Avenue MC29 Los Angeles, CA 90095-6938 Office of Continuing Medical Education, David Geffen School of Medicine at UCLA Frontiers in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Saturday, July 28, 2018 Register today! Enroll now by mail, fax, phone or online. cme.ucla.edu/courses PAID