Judges Reference Table for the March 2016 Psychotropic Medication Utilization Parameters for Foster Children

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Judges Reference Table for the Psychotropic Medication Utilization Parameters for Foster Children Stimulants for treatment of ADHD Preschool (Ages 3-5 years) Child (Ages 6-12 years) Adolescent (Ages 13-17 years) Amphetamine mixed salts Adderall Approved for children 3 years and 40 mg/day Evekeo Adderall XR 30 mg/day Adzenys XR-ODT (oral disintegrating tablet) Ages 6-12 years: 18.8 mg/day Ages 13-17 years: 12.5 mg/day See note* 18.8 mg 12.5 mg Amphetamine base Dyanavel XR (oral suspension) 20 mg/day See note* 20 mg 20 mg Dextroamphetamine Dexedrine Approved for children 3 years and Dextroamphetamine Zenzedi 40 mg/day Approved for children 3 years and 40 mg/day Dextroamphetamine Procentra (oral suspension) Approved for children 3 years and 40 mg/day Dextroamphetamine Dexedrine Spansule Age 6 years: 40 mg/day

Judges Reference Table for Parameters 2 Stimulants for treatment of ADHD (continued) Preschool (Ages 3-5 years) Child (Ages 6-12 years) Adolescent (Ages 13-17 years) Ritalin Methylin (chewable and oral suspension) Ritalin SR Methylin ER Metadate ER Ritalin LA Methylphenidate Metadate CD Quillivant XR (oral suspension) QuilliChew ER (chewable) Aptensio XR Concerta 54 mg/day lesser of 72 mg/ day or 2 mg/kg/day, whichever is less 36 mg 108 mg 108 mg Daytrana TD patch 30 mg/day 20 mg 30 mg 30 mg Focalin 20 mg/day 10 mg 50 mg 50 mg Dexmethylphenidate Focalin XR 30 mg/day 10 mg 50 mg 50 mg

Judges Reference Table for Parameters 3 Other ADHD Treatments Preschool (Ages 3-5 years) Child (Ages 6-12 years) Adolescent (Ages 13-17 years) Atomoxetine Strattera ADHD (age 6-17 years): 1.4 mg/kg/day or 100 mg/day, whichever is less 1.8 mg/kg/day or 100mg 1.8 mg/kg/day or 100mg Catapres (IR) Not approved for treatment of ADHD in children and 0.4 mg 0.4 mg Clonidine Kapvay (ER) Approved for monotherapy and adjunctive therapy to stimulants for treatment of ADHD (age 6-17 years): 0.4 mg/day 0.4 mg 0.4 mg Tenex (IR) 4 mg 4 mg Guanfacine Intuniv (ER) Approved for monotherapy and adjunctive therapy to stimulants for treatment of ADHD 4 mg 7 mg 4 mg/day 7 mg/day Bupropion Wellbutrin 6 mg/kg/day or 300 mg 6 mg/kg/day or 300 mg Wellbutrin SR 400 mg 400 mg Wellbutrin XL 450 mg 450 mg enuresis in children Imipramine Tofranil Age 6-11 years: 2.5 mg/kg/day or 50 mg/day, whichever is less Age 12 years: 2.5 mg/kg/day or 75 mg/day, whichever is less 4 mg/kg/day or 200mg 4 mg/kg/day or 200 mg depression 12 years: 100 mg/day Aventyl Nortriptyline Pamelor 2 mg/kg/day or 100 mg 2 mg/kg/day or 100 mg Nortrilen

Judges Reference Table for Parameters 4 Antidepressants, SSRIs Citalopram Celexa Age 6-11 years: 40 mg Age 12-17 years: 40 mg Escitalopram Lexapro MDD in (age 12-17 years): 20 mg/day Age 6-11 years: 20 mg Age 12-17 years: 30 mg Fluoxetine Prozac MDD (age 8-18 years): 20 mg/day OCD (age 7-17 years): Age 6-11 years: 60 mg Age 12-17 years: 60 mg Paroxetine Paxil Age 12-17 years: 40 mg Paxil CR Age 12-17 years: 50 mg Luvox OCD (age 8-17 years): Fluvoxamine Luvox CR Ages 8-11 years: 200 mg/day Ages 12-17 years: 300 mg/ day Age 8-11 years: 200 mg Age 12-17 years: 300 mg Sertraline Zoloft OCD (age 6-17 years): 200 mg/day Age 6-11 years: 200 mg Age 12-17 years: 200 mg Vilazodone Viibryd

Judges Reference Table for Parameters 5 Antidepressants, SNRIs Venlafaxine Effexor Effexor XR and Age 7-11 years: 150 mg Age 12-17 years: 375 mg Duloxetine Cymbalta Generalized Anxiety Disorder Age 7-17 years: 120 mg/day Age 7-11 years: 120 mg Age 12-17 years: 120 mg Desvenlafaxine Pristiq and Age 12-17 years: 100 mg Levomilnacipram Fetzima and Clomipramine Anafranil OCD: Age 10-17 years: 3 mg/kg/day or 200 mg/ day, whichever is less Age 10-11 years: 200 mg Age 12-17 years: 200 mg Antidepressants, Other Mechanisms Mirtazapine Remeron and Age 3-5 years: 45 mg Age 6-11 years: 45 mg Age 12-17 years: 45 mg Vortioxetine Trintellix and

Judges Reference Table for Parameters 6 Antipsychotics: Second Generation (Atypical) Aripiprazole Quetiapine Abilify Abilify Discmelt (oral disintegratng tab) Abilify (oral solution Seroquel Seroquel XR Bipolar Mania or Mixed Episodes (age 10-17 years) and Schizophrenia (13-17 years): 30 mg/day irritability associated with Autistic Disorder (age 6-17 years): 15 mg/day Bipolar Mania (age 10-17 years): 600 mg/day Schizophrenia (13-17 years): 800 mg/day Age 4-5 years: 15 mg Age 6-11 years: 15 mg Age 12-17 years: 30 mg Age 6-9 years: 400mg Age 5 years: 400 mg Age 10-11 years: 800 mg Age 12-17 years: 800 mg Olanzapine Zyprexa Zyprexa Zydis Bipolar Mania or Mixed Episodes and Schizophrenia (age 13-17 years): 20 mg/day Age 4-5 years: 12.5 mg Age 6-11 years: 20 mg Age 12-17 years: 20 mg Risperidone Risperdal Risperdal M-Tab (oral disintegrating tab) Risperdal (oral solution) Schizophrenia (age 13-17 years) and Bipolar Mania or Mixed Episodes (age 10-17 years): 6mg/day irritability associated with autistic disorder (age 5-16 years): 3 mg/day Age 4-5 years: 3 mg Age 6-11 years: 3 mg Age 12-17 years: 6 mg Clozaril Clozapine FazaClo (oral disintegrating tablet) Age 8-11 years: 300 mg Age 12-17 years: 600 mg Versacloz oral suspension Asenapine Saphris (sublingual tablet) Approved for acute treatment of Bipolar Mania and Mixed Episodes (age 10-17 years): 10 mg twice daily Age 10-11 years: 20 mg Age 12-17 years: 20 mg Iloperidone Fanapt Paliperidone Invega Schizophrenia (age 12-17 years): Weight < 51 kg: 6 mg/day Weight 51 kg: 12 mg/day Age 12-17 years: 12 mg Ziprasidone Geodon Age 10-11 years: 80 mg Age 12-17 years: 160 mg Lurasidone Latuda Brexpiprazole Rexulti

Judges Reference Table for Parameters 7 Antipsychotics: First Generation (Typical) severe behavioral problems (age 6 months-12 years) Chlorpromazine Thorazine Outpatient Children: 0.55 mg/kg every 4-6 hours, as needed Inpatient Children: 500 mg/ day Age 3-5 years: 40 mg 75 mg 800 mg Approved for the management of manifestations of Psychotic Disorders (age > 12 years): 1000 mg/day Approved for treatment of Psychotic Disorders, Tourette s Disorder, and severe behavioral problems (age 3 years): Haloperidol Haldol Psychosis: 0.15 mg/kg/day Age 3-5 years: 3 mg 6 mg Ages 13-17 years: 15 mg Tourette s Disorder and severe behavioral problems: 0.075 mg/kg/day Severely disturbed children: 6 mg/day Perphenazine Trilafon psychotic disorders (age 12 years): Outpatient: 24 mg/day 64 mg Inpatient: 64 mg/day Pimozide Orap Tourette s Disorder (age 12 years): Age 7-12 years: 6 mg 10 mg 10 mg/day or 0.2 mg/kg/ day, whichever is less

Judges Reference Table for Parameters 8 Mood Stabilizers Carbamazepine Divalproex Sodium Lithium Epitol (tab) Tegretol (tab, oral suspension, chewable) Tegretol XR (tab) Carbatrol (extended release capsule) Equetro (extended release capsule) Depakote delayed- release tablets Depakote ER extendedrelease tablets Depakote sprinkles Seizure Disorders in all ages Age < 6 years: 35 mg/kg/day Age 6-15 years: 1000 mg/day Age >15 years: 1200 mg/day Seizure Disorders (age 10 years) Maximum dose based upon serum level: 50-100 µg/ml, or 60 mg/kg/day Age 4-5 years: 35 mg/kg/day 800 mg 1000 mg Age 16-17 years: 1200 mg Eskalith Eskalith CR manic episodes and maintenance of Bipolar Disorder (age 12 years) Maximum dose based upon 12 hour post dose serum level: 1.2 meq/l Lithobid ER Serum level- 125 µg/ml or 60 mg/kg/day Serum level- 125 µg/ml or 60 mg/kg/day Approved for adjunctive therapy for Seizure Disorders: Lamotrigine Lamictal Age 2-12: 400 mg/ day Age >12: 500 mg/day (use > 200mg/day in adults for bipolar depression has not conferred additional efficacy) 15 mg/kg/day or 500 mg/day 15 mg/kg/day or 500 mg/day Safety and effectiveness for treatment of Bipolar Disorder in patients younger than 18 years had not been established Oxcarbazepine Trileptal Seizure Disorders as mono- therapy (age 4 years), or as adjunctive therapy in (age 2 years): 60 mg/kg/day or 1800 mg/day Age 7-12 years: 60 mg/kg/day or 1500 mg 60 mg/kg/day or 2100 mg Safety and effectiveness for treatment of Bipolar Disorder in patients younger than 18 years had not been established

Judges Reference Table for Parameters 9 Sedatives/Hypnotics Diphenhydramine Benadryl insomnia (age 12 years): 50 mg at bedtime Age 3-5 years: 12.5 mg 25 mg 50 mg Trazodone Desyrel or as a hypnotic 100 mg Eszopiclone Lunesta or Melatonin No brand name Regulated by FDA as a dietary supplement and not as a medication (no FDA approved indications) Age 3-5 years: 3 mg 6 mg 6 mg Ramelteon Rozerem or anxiety and tension: Hydroxyzine Vistaril Age <6 years: 50 mg/day in divided doses Age = 6 years: 50-100 mg/day in divided doses Age 3-5 years: 25 mg Age 6-11 years: 50 mg Age 12-17 years: 100 mg Approved as a sedative when used as a premedication and following general anesthesia: 0.6 mg/kg The full report of the Psychotropic Medication Utilization Parameters for Children and Youth in Foster Care can be found at: http://www.dfps.state.tx.us/child_protection/medical_services/guide-psychotropic.asp